BR9205652A - Sais estáveis de (+) - (15,2R)-N- (2-hidroxilamina-2-oxoetil)N-metilamino carbonil ciclohexano-ácido carboxilico, processo de sua preparaçao, e composiçao farmaceutica - Google Patents

Sais estáveis de (+) - (15,2R)-N- (2-hidroxilamina-2-oxoetil)N-metilamino carbonil ciclohexano-ácido carboxilico, processo de sua preparaçao, e composiçao farmaceutica

Info

Publication number
BR9205652A
BR9205652A BR9205652A BR9205652A BR9205652A BR 9205652 A BR9205652 A BR 9205652A BR 9205652 A BR9205652 A BR 9205652A BR 9205652 A BR9205652 A BR 9205652A BR 9205652 A BR9205652 A BR 9205652A
Authority
BR
Brazil
Prior art keywords
oxoethyl
hydroxylamine
preparation
carboxylic acid
pharmaceutical composition
Prior art date
Application number
BR9205652A
Other languages
English (en)
Inventor
Raffaello Giorgi
Alessandro Subissi
Luigi Turbanti
Original Assignee
Guidotti & C Spa Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor
Publication of BR9205652A publication Critical patent/BR9205652A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BR9205652A 1991-12-23 1992-12-12 Sais estáveis de (+) - (15,2R)-N- (2-hidroxilamina-2-oxoetil)N-metilamino carbonil ciclohexano-ácido carboxilico, processo de sua preparaçao, e composiçao farmaceutica BR9205652A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI913448A IT1252708B (it) 1991-12-23 1991-12-23 Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
PCT/EP1992/002903 WO1993013056A1 (en) 1991-12-23 1992-12-12 Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR9205652A true BR9205652A (pt) 1994-05-03

Family

ID=11361409

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9205652A BR9205652A (pt) 1991-12-23 1992-12-12 Sais estáveis de (+) - (15,2R)-N- (2-hidroxilamina-2-oxoetil)N-metilamino carbonil ciclohexano-ácido carboxilico, processo de sua preparaçao, e composiçao farmaceutica

Country Status (26)

Country Link
EP (1) EP0575572A1 (pt)
JP (1) JPH06506002A (pt)
CN (1) CN1079474A (pt)
AU (1) AU657591B2 (pt)
BG (1) BG98050A (pt)
BR (1) BR9205652A (pt)
CA (1) CA2104372A1 (pt)
CZ (1) CZ379692A3 (pt)
EE (1) EE9400006A (pt)
FI (1) FI933685A (pt)
HR (1) HRP921454A2 (pt)
HU (1) HUT69287A (pt)
IT (1) IT1252708B (pt)
LV (1) LV10426B (pt)
MA (1) MA22749A1 (pt)
MX (1) MX9207543A (pt)
NZ (1) NZ245547A (pt)
PL (1) PL169086B1 (pt)
PT (1) PT101156A (pt)
RU (1) RU2079489C1 (pt)
SI (1) SI9200409A (pt)
SK (1) SK379692A3 (pt)
TN (1) TNSN92117A1 (pt)
WO (1) WO1993013056A1 (pt)
YU (1) YU110892A (pt)
ZA (1) ZA9210004B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
FR2817241B1 (fr) 2000-11-30 2003-03-07 Cebal Tube aluminium avec embout secable
JP2010504969A (ja) * 2006-09-28 2010-02-18 メルク エンド カムパニー インコーポレーテッド Sahaのアミン塩基塩及びその多形
AU2021263319B2 (en) * 2020-04-27 2022-12-01 Carter-Hoffmann, Llc Door movement system for cabinet

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1224627B (it) * 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Also Published As

Publication number Publication date
FI933685A0 (fi) 1993-08-20
FI933685A (fi) 1993-08-20
NZ245547A (en) 1995-12-21
ZA9210004B (en) 1993-12-13
MX9207543A (es) 1993-08-01
PT101156A (pt) 1994-06-30
BG98050A (bg) 1994-04-29
TNSN92117A1 (fr) 1993-06-08
HUT69287A (en) 1995-09-28
SK379692A3 (en) 1995-04-12
CN1079474A (zh) 1993-12-15
WO1993013056A1 (en) 1993-07-08
LV10426B (en) 1995-08-20
YU110892A (sh) 1996-01-08
MA22749A1 (fr) 1993-07-01
IT1252708B (it) 1995-06-26
CZ379692A3 (en) 1993-09-15
HRP921454A2 (en) 1995-02-28
EP0575572A1 (en) 1993-12-29
ITMI913448A0 (it) 1991-12-23
PL297118A1 (en) 1993-09-06
LV10426A (lv) 1995-02-20
ITMI913448A1 (it) 1993-06-23
RU2079489C1 (ru) 1997-05-20
AU657591B2 (en) 1995-03-16
PL169086B1 (pl) 1996-05-31
EE9400006A (et) 1995-12-15
SI9200409A (en) 1993-09-30
CA2104372A1 (en) 1993-06-24
HU9302389D0 (en) 1993-11-29
JPH06506002A (ja) 1994-07-07
AU3087192A (en) 1993-07-28

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
FC Decision: refusal