AU657591B2 - Stable salts of (+)-(1S,2R)-2-((N-(2-hydroxylamino-2-oxoethyl)-N-methyl- amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them - Google Patents

Stable salts of (+)-(1S,2R)-2-((N-(2-hydroxylamino-2-oxoethyl)-N-methyl- amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
AU657591B2
AU657591B2 AU30871/92A AU3087192A AU657591B2 AU 657591 B2 AU657591 B2 AU 657591B2 AU 30871/92 A AU30871/92 A AU 30871/92A AU 3087192 A AU3087192 A AU 3087192A AU 657591 B2 AU657591 B2 AU 657591B2
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AU
Australia
Prior art keywords
document
international
date
oxoethyl
salts
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Ceased
Application number
AU30871/92A
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English (en)
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AU3087192A (en
Inventor
Raffaello Giorgi
Alessandro Subissi
Luigi Turbanti
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Laboratorio Guidotti SpA
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Laboratorio Guidotti SpA
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Application filed by Laboratorio Guidotti SpA filed Critical Laboratorio Guidotti SpA
Publication of AU3087192A publication Critical patent/AU3087192A/en
Application granted granted Critical
Publication of AU657591B2 publication Critical patent/AU657591B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU30871/92A 1991-12-23 1992-12-12 Stable salts of (+)-(1S,2R)-2-((N-(2-hydroxylamino-2-oxoethyl)-N-methyl- amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them Ceased AU657591B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI91A3448 1991-12-23
ITMI913448A IT1252708B (it) 1991-12-23 1991-12-23 Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
PCT/EP1992/002903 WO1993013056A1 (en) 1991-12-23 1992-12-12 Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
AU3087192A AU3087192A (en) 1993-07-28
AU657591B2 true AU657591B2 (en) 1995-03-16

Family

ID=11361409

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30871/92A Ceased AU657591B2 (en) 1991-12-23 1992-12-12 Stable salts of (+)-(1S,2R)-2-((N-(2-hydroxylamino-2-oxoethyl)-N-methyl- amino)carbonyl)cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
EP (1) EP0575572A1 (pt)
JP (1) JPH06506002A (pt)
CN (1) CN1079474A (pt)
AU (1) AU657591B2 (pt)
BG (1) BG98050A (pt)
BR (1) BR9205652A (pt)
CA (1) CA2104372A1 (pt)
CZ (1) CZ379692A3 (pt)
EE (1) EE9400006A (pt)
FI (1) FI933685A (pt)
HR (1) HRP921454A2 (pt)
HU (1) HUT69287A (pt)
IT (1) IT1252708B (pt)
LV (1) LV10426B (pt)
MA (1) MA22749A1 (pt)
MX (1) MX9207543A (pt)
NZ (1) NZ245547A (pt)
PL (1) PL169086B1 (pt)
PT (1) PT101156A (pt)
RU (1) RU2079489C1 (pt)
SI (1) SI9200409A (pt)
SK (1) SK379692A3 (pt)
TN (1) TNSN92117A1 (pt)
WO (1) WO1993013056A1 (pt)
YU (1) YU110892A (pt)
ZA (1) ZA9210004B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
FR2817241B1 (fr) 2000-11-30 2003-03-07 Cebal Tube aluminium avec embout secable
CN101516191A (zh) * 2006-09-28 2009-08-26 默克公司 Saha的胺碱盐和其多晶型物
EP4030978A1 (en) * 2020-04-27 2022-07-27 Carter-Hoffmann, LLC Door movement system for cabinet

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337348A2 (en) * 1988-04-12 1989-10-18 Laboratori Guidotti S.p.A. Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337348A2 (en) * 1988-04-12 1989-10-18 Laboratori Guidotti S.p.A. Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical activity, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
TNSN92117A1 (fr) 1993-06-08
ITMI913448A0 (it) 1991-12-23
CA2104372A1 (en) 1993-06-24
WO1993013056A1 (en) 1993-07-08
CN1079474A (zh) 1993-12-15
JPH06506002A (ja) 1994-07-07
PL297118A1 (en) 1993-09-06
BR9205652A (pt) 1994-05-03
MX9207543A (es) 1993-08-01
AU3087192A (en) 1993-07-28
LV10426B (en) 1995-08-20
EP0575572A1 (en) 1993-12-29
PL169086B1 (pl) 1996-05-31
HUT69287A (en) 1995-09-28
IT1252708B (it) 1995-06-26
CZ379692A3 (en) 1993-09-15
SI9200409A (en) 1993-09-30
PT101156A (pt) 1994-06-30
SK379692A3 (en) 1995-04-12
EE9400006A (et) 1995-12-15
HU9302389D0 (en) 1993-11-29
NZ245547A (en) 1995-12-21
ZA9210004B (en) 1993-12-13
YU110892A (sh) 1996-01-08
FI933685A0 (fi) 1993-08-20
FI933685A (fi) 1993-08-20
ITMI913448A1 (it) 1993-06-23
HRP921454A2 (en) 1995-02-28
BG98050A (bg) 1994-04-29
MA22749A1 (fr) 1993-07-01
RU2079489C1 (ru) 1997-05-20
LV10426A (lv) 1995-02-20

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