RU93052414A - Стабильные соли (+)-(1s, 2r)-2-[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]карбонил]-циклогексан-1-карбоновой кислоты, способ их получения и фармацевтические композиции, содержащие их - Google Patents
Стабильные соли (+)-(1s, 2r)-2-[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]карбонил]-циклогексан-1-карбоновой кислоты, способ их получения и фармацевтические композиции, содержащие ихInfo
- Publication number
- RU93052414A RU93052414A RU93052414/04A RU93052414A RU93052414A RU 93052414 A RU93052414 A RU 93052414A RU 93052414/04 A RU93052414/04 A RU 93052414/04A RU 93052414 A RU93052414 A RU 93052414A RU 93052414 A RU93052414 A RU 93052414A
- Authority
- RU
- Russia
- Prior art keywords
- hydroxyamino
- oxoethyl
- methylamino
- carbonyl
- cyclogexan
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims 2
- 239000011780 sodium chloride Substances 0.000 title claims 2
- 101700066411 APHR Proteins 0.000 title 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title 1
- 150000007530 organic bases Chemical class 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N Imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000005984 hydrogenation reaction Methods 0.000 claims 2
- QKIVRALZQSUWHH-SFYZADRCSA-N (1S,2R)-2-[[2-(hydroxyamino)-2-oxoethyl]-methylcarbamoyl]cyclohexane-1-carboxylic acid Chemical class ONC(=O)CN(C)C(=O)[C@@H]1CCCC[C@@H]1C(O)=O QKIVRALZQSUWHH-SFYZADRCSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Chemical group 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate dianion Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 229960001231 Choline Drugs 0.000 claims 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N Diethanolamine Chemical group OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000004472 Lysine Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- CRBHXDCYXIISFC-UHFFFAOYSA-N choline Chemical group C[N+](C)(C)CC[O-] CRBHXDCYXIISFC-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 239000011591 potassium Chemical group 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 150000003385 sodium Chemical group 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Claims (1)
- Предлагаются новые соли (+)-(1S, 2R)-2-[[N-(2-оксиамино-2-оксоэтил)- N-метиламинo] карбонил] циклогексан-1-карбоновой кислоты с металлами и органическими основаниями, представленные общей формулой, где R и R' взятые вместе, являются двухвалентным катионом, выбранным среди кальция, этилендиамина и других фармацевтически приемлемых катионов или органических оснований, или, если R' = H+, то R является натрием, калием, имидазольной группой, лизином, холином, диэтаноламином, аргинином или гистидином, обладают АСЕ-ингибирующей активностью и следовательно являются полезными в качестве активного ингредиента антигипертензивных лекарств. Способ их получения заключается во взаимодействии исходной кислоты, защищенной бензильной группой с подходящим гидратом, карбонатом или органическим основанием в условиях гидрирования в присутствии катализатора гидрирования.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913448A IT1252708B (it) | 1991-12-23 | 1991-12-23 | Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| ITM191A003448 | 1991-12-23 | ||
| PCT/EP1992/002903 WO1993013056A1 (en) | 1991-12-23 | 1992-12-12 | Stable salts of (+)-(1s,2r)-2-[[n-(2-hydroxylamino-2-oxoethyl)-n-methyl-amino]carbonyl]cyclohexane-1-carboxylic acid, process for their preparation and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93052414A true RU93052414A (ru) | 1996-06-20 |
| RU2079489C1 RU2079489C1 (ru) | 1997-05-20 |
Family
ID=11361409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9293052414A RU2079489C1 (ru) | 1991-12-23 | 1992-12-12 | Стабильные соли (+)-(1s,2r)-2[[n-(2-гидроксиамино-2-оксоэтил)-n-метиламино]-карбонил]циклогексан-1-карбоновой кислоты, способ их получения и фармацевтическая композиция |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0575572A1 (ru) |
| JP (1) | JPH06506002A (ru) |
| CN (1) | CN1079474A (ru) |
| AU (1) | AU657591B2 (ru) |
| BG (1) | BG98050A (ru) |
| BR (1) | BR9205652A (ru) |
| CA (1) | CA2104372A1 (ru) |
| CZ (1) | CZ379692A3 (ru) |
| EE (1) | EE9400006A (ru) |
| FI (1) | FI933685A0 (ru) |
| HR (1) | HRP921454A2 (ru) |
| HU (1) | HUT69287A (ru) |
| IT (1) | IT1252708B (ru) |
| LV (1) | LV10426B (ru) |
| MA (1) | MA22749A1 (ru) |
| MX (1) | MX9207543A (ru) |
| NZ (1) | NZ245547A (ru) |
| PL (1) | PL169086B1 (ru) |
| PT (1) | PT101156A (ru) |
| RU (1) | RU2079489C1 (ru) |
| SI (1) | SI9200409A (ru) |
| SK (1) | SK379692A3 (ru) |
| TN (1) | TNSN92117A1 (ru) |
| WO (1) | WO1993013056A1 (ru) |
| YU (1) | YU110892A (ru) |
| ZA (1) | ZA9210004B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264860B1 (it) * | 1993-06-21 | 1996-10-17 | Guidotti & C Spa Labor | Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| FR2817241B1 (fr) | 2000-11-30 | 2003-03-07 | Cebal | Tube aluminium avec embout secable |
| AU2007302670A1 (en) * | 2006-09-28 | 2008-04-10 | Merck & Co., Inc. | Amine base salts of SAHA and polymorphs thereof |
| WO2021221984A1 (en) * | 2020-04-27 | 2021-11-04 | Carter-Hoffmann, Llc | Door movement system for cabinet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1224627B (it) * | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
-
1991
- 1991-12-23 IT ITMI913448A patent/IT1252708B/it active IP Right Grant
-
1992
- 1992-12-12 JP JP5511398A patent/JPH06506002A/ja active Pending
- 1992-12-12 RU RU9293052414A patent/RU2079489C1/ru active
- 1992-12-12 HU HU9302389A patent/HUT69287A/hu unknown
- 1992-12-12 WO PCT/EP1992/002903 patent/WO1993013056A1/en not_active Application Discontinuation
- 1992-12-12 EP EP92924726A patent/EP0575572A1/en not_active Withdrawn
- 1992-12-12 BR BR9205652A patent/BR9205652A/pt not_active Application Discontinuation
- 1992-12-12 AU AU30871/92A patent/AU657591B2/en not_active Ceased
- 1992-12-12 CA CA002104372A patent/CA2104372A1/en not_active Abandoned
- 1992-12-21 CZ CS923796A patent/CZ379692A3/cs unknown
- 1992-12-21 NZ NZ245547A patent/NZ245547A/en unknown
- 1992-12-21 SK SK3796-92A patent/SK379692A3/sk unknown
- 1992-12-22 HR HR921454A patent/HRP921454A2/hr not_active Application Discontinuation
- 1992-12-22 SI SI9200409A patent/SI9200409A/sl unknown
- 1992-12-22 MA MA23040A patent/MA22749A1/fr unknown
- 1992-12-23 MX MX9207543A patent/MX9207543A/es unknown
- 1992-12-23 PL PL92297118A patent/PL169086B1/pl unknown
- 1992-12-23 LV LVP-92-358A patent/LV10426B/lv unknown
- 1992-12-23 YU YU110892A patent/YU110892A/sh unknown
- 1992-12-23 ZA ZA9210004A patent/ZA9210004B/xx unknown
- 1992-12-23 PT PT101156A patent/PT101156A/pt not_active Application Discontinuation
- 1992-12-23 TN TNTNSN92117A patent/TNSN92117A1/fr unknown
- 1992-12-23 CN CN92113839A patent/CN1079474A/zh active Pending
-
1993
- 1993-08-18 BG BG98050A patent/BG98050A/bg unknown
- 1993-08-20 FI FI933685A patent/FI933685A0/fi not_active Application Discontinuation
-
1994
- 1994-05-23 EE EE9400006A patent/EE9400006A/xx unknown
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