RU2020135968A - T-клеточные рецепторы и модифицированные клетки, экспрессирующие - Google Patents

T-клеточные рецепторы и модифицированные клетки, экспрессирующие Download PDF

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RU2020135968A
RU2020135968A RU2020135968A RU2020135968A RU2020135968A RU 2020135968 A RU2020135968 A RU 2020135968A RU 2020135968 A RU2020135968 A RU 2020135968A RU 2020135968 A RU2020135968 A RU 2020135968A RU 2020135968 A RU2020135968 A RU 2020135968A
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amino acid
cdr
seq
acid sequence
tcr
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RU2020135968A
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Russian (ru)
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Стефен Джейкоб ГОЛДФЛЕСС
Брайан БЕЛМОНТ
Камерон БРАНДТ
Александра КРОФТ
Дэвид Джеффри ХАСС
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Джуно Терапьютикс, Инк.
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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RU2020135968A 2018-04-05 2019-04-03 T-клеточные рецепторы и модифицированные клетки, экспрессирующие RU2020135968A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862653516P 2018-04-05 2018-04-05
US62/653,516 2018-04-05
US201862739145P 2018-09-28 2018-09-28
US62/739,145 2018-09-28
PCT/US2019/025676 WO2019195486A1 (en) 2018-04-05 2019-04-03 T cell receptors and engineered cells expressing same

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RU2020135968A true RU2020135968A (ru) 2022-05-06

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US (2) US11471489B2 (enExample)
EP (1) EP3773908A1 (enExample)
JP (1) JP7410868B2 (enExample)
KR (1) KR102764123B1 (enExample)
CN (1) CN112566698A (enExample)
AU (1) AU2019249209A1 (enExample)
BR (1) BR112020019313A2 (enExample)
CA (1) CA3095027A1 (enExample)
CL (1) CL2020002545A1 (enExample)
CO (1) CO2020013499A2 (enExample)
IL (1) IL277703A (enExample)
MA (1) MA52193A (enExample)
MX (1) MX2020010460A (enExample)
PE (1) PE20201345A1 (enExample)
RU (1) RU2020135968A (enExample)
SG (1) SG11202009284TA (enExample)
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WO (1) WO2019195486A1 (enExample)

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