RU2020115264A - Диагностика на основе эффекторной системы crispr - Google Patents
Диагностика на основе эффекторной системы crispr Download PDFInfo
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- RU2020115264A RU2020115264A RU2020115264A RU2020115264A RU2020115264A RU 2020115264 A RU2020115264 A RU 2020115264A RU 2020115264 A RU2020115264 A RU 2020115264A RU 2020115264 A RU2020115264 A RU 2020115264A RU 2020115264 A RU2020115264 A RU 2020115264A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/126—Paper
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/301—Endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/101—Interaction between at least two labels
- C12Q2565/1015—Interaction between at least two labels labels being on the same oligonucleotide
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762568309P | 2017-10-04 | 2017-10-04 | |
US62/568,309 | 2017-10-04 | ||
US201762610144P | 2017-12-22 | 2017-12-22 | |
US62/610,144 | 2017-12-22 | ||
US201862623529P | 2018-01-29 | 2018-01-29 | |
US62/623,529 | 2018-01-29 | ||
US201862630787P | 2018-02-14 | 2018-02-14 | |
US62/630,787 | 2018-02-14 | ||
PCT/US2018/054472 WO2019071051A1 (en) | 2017-10-04 | 2018-10-04 | DIAGNOSTICS BASED ON A CRISPR EFFECTOR SYSTEM |
Publications (2)
Publication Number | Publication Date |
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RU2020115264A true RU2020115264A (ru) | 2021-11-08 |
RU2020115264A3 RU2020115264A3 (zh) | 2022-02-24 |
Family
ID=65995340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2020115264A RU2020115264A (ru) | 2017-10-04 | 2018-10-04 | Диагностика на основе эффекторной системы crispr |
Country Status (11)
Country | Link |
---|---|
US (1) | US11633732B2 (zh) |
EP (1) | EP3692146A4 (zh) |
JP (1) | JP2020537121A (zh) |
KR (1) | KR102628577B1 (zh) |
CN (1) | CN111630162A (zh) |
AU (1) | AU2018346530A1 (zh) |
BR (1) | BR112020006757A2 (zh) |
CA (1) | CA3076518A1 (zh) |
IL (1) | IL273360A (zh) |
RU (1) | RU2020115264A (zh) |
WO (1) | WO2019071051A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2778855C1 (ru) * | 2021-12-24 | 2022-08-26 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для идентификации РНК коронавируса человека SARS-CoV-2 методом изотермической ПЦР с гибридизационно-флуоресцентной детекцией в режиме реального времени |
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US8673267B2 (en) | 2009-03-02 | 2014-03-18 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
CA3214092A1 (en) | 2011-03-15 | 2012-09-20 | Massachusetts Institute Of Technology | Multiplexed detection with isotope-coded reporters |
CN118010994A (zh) | 2013-06-07 | 2024-05-10 | 麻省理工学院 | 基于亲和力检测配体编码的合成性生物标记物 |
WO2017177115A1 (en) | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
EP3452407B1 (en) | 2016-05-05 | 2024-04-03 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
EP3607085A1 (en) | 2017-04-07 | 2020-02-12 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
US11584955B2 (en) * | 2017-07-14 | 2023-02-21 | Shanghai Tolo Biotechnology Company Limited | Application of Cas protein, method for detecting target nucleic acid molecule and kit |
WO2019071051A1 (en) | 2017-10-04 | 2019-04-11 | The Broad Institute, Inc. | DIAGNOSTICS BASED ON A CRISPR EFFECTOR SYSTEM |
WO2020028729A1 (en) | 2018-08-01 | 2020-02-06 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
CN113286884A (zh) * | 2018-08-07 | 2021-08-20 | 博德研究所 | 新型cas12b酶和系统 |
WO2020102610A1 (en) * | 2018-11-14 | 2020-05-22 | The Broad Institute, Inc. | Crispr system based droplet diagnostic systems and methods |
WO2020142754A2 (en) | 2019-01-04 | 2020-07-09 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
EP3911753A1 (en) | 2019-01-17 | 2021-11-24 | Massachusetts Institute of Technology | Sensors for detecting and imaging of cancer metastasis |
US20220154258A1 (en) | 2019-03-14 | 2022-05-19 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
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CN110453011B (zh) * | 2019-07-19 | 2021-09-07 | 中山大学 | 一种基于CRISPR/Cas12a快速精准检测非洲猪瘟病毒的方法及应用 |
CN110468188B (zh) * | 2019-08-22 | 2023-08-22 | 广州微远医疗器械有限公司 | 用于二代测序的标签序列集及其设计方法和应用 |
CN116171198A (zh) * | 2019-09-03 | 2023-05-26 | 科罗拉多大学董事会,法人团体 | 用于快速早期检测感染的宿主rna生物标志物和早期鉴定人的covid-19冠状病毒感染的系统、方法和组合物 |
CN110894557A (zh) * | 2019-09-20 | 2020-03-20 | 武汉大学 | 基于CRISPR方式检测非洲猪瘟病毒的crRNA及试剂盒 |
US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
US20210262025A1 (en) * | 2020-02-18 | 2021-08-26 | Massachusetts Institute Of Technology | Multiplexed in vivo disease sensing with nucleic acid-barcoded reporters |
CN111893211B (zh) * | 2020-03-02 | 2021-07-06 | 广东药科大学 | 一种检测新型冠状病毒及流感病毒的试剂盒 |
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CN111500771B (zh) * | 2020-04-20 | 2021-03-23 | 上海国际旅行卫生保健中心(上海海关口岸门诊部) | 一种新型冠状病毒SARS-CoV-2检测的引物组和试剂盒 |
WO2021231459A2 (en) * | 2020-05-11 | 2021-11-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for quantifying transcription and biosensing of small molecules using a type vi crispr-cas assay |
JP2023527150A (ja) * | 2020-05-19 | 2023-06-27 | マンモス バイオサイエンシズ インコーポレイテッド | 核酸の検出のための装置、アッセイ、及び方法 |
CN111996291A (zh) * | 2020-08-21 | 2020-11-27 | 深圳海关动植物检验检疫技术中心 | 用于西尼罗河病毒检测的试剂、试剂盒、检测方法及应用 |
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CN112301162B (zh) * | 2020-10-22 | 2023-09-22 | 清华-伯克利深圳学院筹备办公室 | 同时检测dna病毒和rna病毒的病毒核酸检测方法 |
CN112280877B (zh) * | 2020-11-09 | 2022-12-20 | 中国人民解放军军事科学院军事医学研究院 | 一种用于贝氏柯克斯体核酸检测的CRISPR-Cas13a系统 |
CN112538550B (zh) * | 2020-12-26 | 2023-05-09 | 江苏省农业科学院 | 基于RT-RPA和CRISPR/Cas的DHAV-1和DHAV-3检测体系及应用 |
KR20230137343A (ko) * | 2020-12-31 | 2023-10-04 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | 활성화 분해 및 계수 (acc) 기술을 사용하는 핵산 서열의특이적 검출 |
US20240084408A1 (en) * | 2021-02-05 | 2024-03-14 | University Of Connecticut | Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2 in Autonomous Microfluidic Device |
CN113061650A (zh) * | 2021-02-19 | 2021-07-02 | 中国科学院深圳先进技术研究院 | 一种病原体核酸的即时检测系统及方法 |
CN113274555B (zh) * | 2021-05-31 | 2022-05-03 | 清华大学 | 一种具有仿生螺旋取向化微结构的人工心室及其制备方法 |
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CN113667718B (zh) * | 2021-08-25 | 2023-11-28 | 山东舜丰生物科技有限公司 | 利用双链核酸检测器进行靶核酸检测的方法 |
CN113637804B (zh) * | 2021-09-16 | 2023-10-20 | 赣南师范大学 | 一种基于rt-pcr技术检测rb-n1基因型柑橘衰退病毒用试剂盒及其检测方法 |
CN113933302B (zh) * | 2021-10-15 | 2024-01-05 | 牡丹江医学院 | 一种血液检验平台及其使用方法 |
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CN114836579B (zh) * | 2022-06-02 | 2024-05-07 | 昆明理工大学 | 中枢神经系统感染性病原体的多重荧光定量pcr检测引物组合 |
WO2024055019A1 (en) * | 2022-09-09 | 2024-03-14 | The Forsyth Institute | Methods and systems for detection of oral bacteria |
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PT3551753T (pt) * | 2016-12-09 | 2022-09-02 | Harvard College | Diagnósticos baseados num sistema efetor de crispr |
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WO2019071051A1 (en) | 2017-10-04 | 2019-04-11 | The Broad Institute, Inc. | DIAGNOSTICS BASED ON A CRISPR EFFECTOR SYSTEM |
AU2018392709A1 (en) * | 2017-12-22 | 2020-07-16 | Massachusetts Institute Of Technology | CRISPR effector system based multiplex diagnostics |
US11608519B2 (en) * | 2018-07-30 | 2023-03-21 | Tokitae Llc | Specific detection of deoxyribonucleic acid sequences using novel CRISPR enzyme-mediated detection strategies |
WO2020028729A1 (en) * | 2018-08-01 | 2020-02-06 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
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2018
- 2018-10-04 WO PCT/US2018/054472 patent/WO2019071051A1/en active Application Filing
- 2018-10-04 KR KR1020207010078A patent/KR102628577B1/ko active IP Right Grant
- 2018-10-04 EP EP18864541.0A patent/EP3692146A4/en active Pending
- 2018-10-04 CA CA3076518A patent/CA3076518A1/en active Pending
- 2018-10-04 US US16/753,896 patent/US11633732B2/en active Active
- 2018-10-04 JP JP2020519256A patent/JP2020537121A/ja active Pending
- 2018-10-04 CN CN201880078358.2A patent/CN111630162A/zh active Pending
- 2018-10-04 AU AU2018346530A patent/AU2018346530A1/en active Pending
- 2018-10-04 BR BR112020006757-1A patent/BR112020006757A2/pt unknown
- 2018-10-04 RU RU2020115264A patent/RU2020115264A/ru unknown
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2020
- 2020-03-17 IL IL273360A patent/IL273360A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2778855C1 (ru) * | 2021-12-24 | 2022-08-26 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для идентификации РНК коронавируса человека SARS-CoV-2 методом изотермической ПЦР с гибридизационно-флуоресцентной детекцией в режиме реального времени |
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Publication number | Publication date |
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JP2020537121A (ja) | 2020-12-17 |
EP3692146A4 (en) | 2021-06-30 |
CA3076518A1 (en) | 2019-04-11 |
CN111630162A (zh) | 2020-09-04 |
RU2020115264A3 (zh) | 2022-02-24 |
AU2018346530A1 (en) | 2020-04-30 |
US20200254443A1 (en) | 2020-08-13 |
KR20200074102A (ko) | 2020-06-24 |
IL273360A (en) | 2020-05-31 |
BR112020006757A2 (pt) | 2020-10-06 |
KR102628577B1 (ko) | 2024-01-23 |
EP3692146A1 (en) | 2020-08-12 |
US11633732B2 (en) | 2023-04-25 |
WO2019071051A1 (en) | 2019-04-11 |
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