RU2019116867A - Реакционный сосуд и реакционное устройство - Google Patents

Реакционный сосуд и реакционное устройство Download PDF

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RU2019116867A
RU2019116867A RU2019116867A RU2019116867A RU2019116867A RU 2019116867 A RU2019116867 A RU 2019116867A RU 2019116867 A RU2019116867 A RU 2019116867A RU 2019116867 A RU2019116867 A RU 2019116867A RU 2019116867 A RU2019116867 A RU 2019116867A
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channel
temperature
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Такаси ФУКУДЗАВА
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Ниппон Шит Глас Кампани, Лимитед
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
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Claims (20)

1. Реакционный сосуд для проведения полимеразной цепной реакции, содержащий
подложку;
канал для перемещения образца, выполненный на подложке;
отверстие ввода образца для введения образца внутрь канала;
пару воздушных коммуникационных отверстий, обеспеченных на соответствующих концах канала; и
область термического цикла, служащую для обеспечения воздействия термического цикла на образец, расположенную между указанной парой воздушных коммуникационных отверстий в канале,
причем канал содержит множество каналов ответвления между областью термического цикла и по меньшей мере одним из указанных воздушных коммуникационных отверстий,
причем область термического цикла содержит первую температурную область, в которой поддерживается первая температура, и вторую температурную область, в которой поддерживается вторая температура, которая выше первой температуры,
при этом указанное множество каналов ответвления расположено между второй температурной областью и воздушным коммуникационным отверстием на стороне второй температурной области,
причем вторая температурная область и воздушное коммуникационное отверстие, расположенное на стороне второй температурной области, сообщаются друг с другом через указанное множество каналов ответвления, расположенное между ними,
причем канал в области термического цикла разветвляется на указанное множество каналов ответвления в точке разветвления,
при этом расстояние между указанной точкой разветвления и второй температурной областью меньше, чем расстояние между указанной точкой разветвления и первой температурной областью.
2. Реакционный сосуд по п. 1, в котором расстояние между по меньшей мере одним из указанного множества каналов ответвления и второй температурной областью меньше, чем расстояние между другим каналом ответвления и второй температурной областью.
3. Реакционный сосуд по п. 1 или 2,
в котором каждый из указанного множества каналов ответвления имеет изогнутую часть, и
изогнутая часть по меньшей мере одного из указанного множества каналов ответвления имеет радиус кривизны больше радиуса кривизны изогнутых частей других каналов ответвления.
4. Реакционное устройство для проведения полимеразной цепной реакции, содержащее
реакционный сосуд по любому из пп. 1-3;
температурный регулятор для регулирования температуры области термического цикла; и
систему подачи жидкости, осуществляющую перемещение и остановку образца в канале для перемещения образца.
RU2019116867A 2016-11-01 2017-10-24 Реакционный сосуд и реакционное устройство, предназначенные для проведения полимеразной цепной реакции RU2739951C2 (ru)

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PCT/JP2017/038252 WO2018084017A1 (ja) 2016-11-01 2017-10-24 反応処理容器および反応処理装置

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WO2018084017A1 (ja) 2018-05-11
EP3536775A1 (en) 2019-09-11
JP2019180422A (ja) 2019-10-24
JP2022066343A (ja) 2022-04-28
BR112019008753A2 (pt) 2019-07-16
JP6568663B2 (ja) 2019-08-28
JP7034992B2 (ja) 2022-03-14
JP7369475B2 (ja) 2023-10-26
EP3536775A4 (en) 2020-06-03
US20190255525A1 (en) 2019-08-22
CN109844091B (zh) 2022-12-30
RU2019116867A3 (ru) 2020-12-03
JPWO2018084017A1 (ja) 2019-06-24

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