RU2019100033A - Композиции и способы для лечения и восстановления сухожилий - Google Patents
Композиции и способы для лечения и восстановления сухожилий Download PDFInfo
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- RU2019100033A RU2019100033A RU2019100033A RU2019100033A RU2019100033A RU 2019100033 A RU2019100033 A RU 2019100033A RU 2019100033 A RU2019100033 A RU 2019100033A RU 2019100033 A RU2019100033 A RU 2019100033A RU 2019100033 A RU2019100033 A RU 2019100033A
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- tendon
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- dermal membrane
- hair
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- 239000000203 mixture Substances 0.000 title claims 10
- 210000002435 tendon Anatomy 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 5
- 230000002500 effect on skin Effects 0.000 claims 9
- 239000012528 membrane Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- 210000004209 hair Anatomy 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 4
- 210000003780 hair follicle Anatomy 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 208000023835 Tendon disease Diseases 0.000 claims 1
- 208000004760 Tenosynovitis Diseases 0.000 claims 1
- 210000001361 achilles tendon Anatomy 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 230000006862 enzymatic digestion Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000000426 patellar ligament Anatomy 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 210000001732 sebaceous gland Anatomy 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 208000013515 tendinosis Diseases 0.000 claims 1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
- C12N5/0628—Hair stem cells; Hair progenitors
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/066—Tenocytes; Tendons, Ligaments
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- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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Claims (21)
1. Композиция для лечения или предупреждения повреждений сухожилий, содержащая выделенные клетки внелуковичной дермальной оболочки.
2. Композиция по п.1, дополнительно содержащая по меньшей мере одно из сыворотки и плазмы.
3. Композиция по п.1, где композиция не содержит либо сыворотки, либо плазмы.
4. Композиция по п.1, дополнительно содержащая фибрин, гиалуроновую кислоту, компоненты внеклеточного матрикса, цитокины, хемокины, анальгетики, противовоспалительные средства или иммуномодулирующие средства.
5. Композиция по п.1, где указанное повреждение сухожилия представляет собой отрыв сухожилия, полный разрыв, частичный разрыв или микроразрыв.
6. Композиция по п.1, где указанное повреждение сухожилия выбрано из группы, состоящей из тендиноза, тендосиновита и авульсии.
7. Композиция по п.1, где указанное сухожилие представляет собой ахиллово сухожилие, сухожилие надколенника, сухожилие сгибателя или сухожилие разгибателя.
8. Способ получения композиции по любому из предыдущих пунктов, при этом способ включает:
a. получение жизнеспособных волос;
b. разрезание волос, полученных на стадии (a), с удалением луковицы волосяного фолликула и выделением волосяного фолликула;
c. разрезание выделенного волосяного фолликула выше луковичной части корня волоса, но ниже основания канала сальной железы с получением выделенной ткани внелуковичной дермальной оболочки и
d. культивирование выделенной ткани внелуковичной дермальной оболочки с получением клеток внелуковичной дермальной оболочки.
9. Способ по п.8, где:
a. указанные жизнеспособные волосы получают при помощи биопсии из затылочной области волосистой части кожи головы субъекта;
b. указанное культивирование выделенной ткани внелуковичной дермальной оболочки предусматривает:
i. проведение ферментативного расщепления указанной выделенной ткани внелуковичной дермальной оболочки и
ii. культивирование продукта из стадии i) в среде, которая стимулирует пролиферацию клеток, с получением клеток внелуковичной дермальной оболочки.
10. Способ по п.9, где:
a. указанные жизнеспособные волосы разрезают с использованием микроманипулятора и скальпеля;
b. указанное ферментативное расщепление проводят с использованием коллагеназы и
c. указанные клетки внелуковичной дермальной оболочки культивируют в течение нескольких пассажей либо в среде, содержащей сыворотку, либо в бессывороточной среде с получением указанных клеток внелуковичной дермальной оболочки.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361763908P | 2013-02-12 | 2013-02-12 | |
| US61/763,908 | 2013-02-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015138403A Division RU2678878C2 (ru) | 2013-02-12 | 2014-02-12 | Композиции и способы для лечения и восстановления сухожилий |
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| Publication Number | Publication Date |
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| RU2019100033A true RU2019100033A (ru) | 2019-02-12 |
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| RU2015138403A RU2678878C2 (ru) | 2013-02-12 | 2014-02-12 | Композиции и способы для лечения и восстановления сухожилий |
| RU2019100033A RU2019100033A (ru) | 2013-02-12 | 2014-02-12 | Композиции и способы для лечения и восстановления сухожилий |
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| RU2015138403A RU2678878C2 (ru) | 2013-02-12 | 2014-02-12 | Композиции и способы для лечения и восстановления сухожилий |
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| Country | Link |
|---|---|
| US (2) | US10272118B2 (ru) |
| EP (2) | EP3461886A1 (ru) |
| JP (3) | JP6581908B2 (ru) |
| KR (1) | KR102252223B1 (ru) |
| CN (2) | CN109251883B (ru) |
| AU (1) | AU2014216300B2 (ru) |
| BR (1) | BR112015019395B1 (ru) |
| CA (1) | CA2900976A1 (ru) |
| DK (1) | DK2956543T3 (ru) |
| ES (1) | ES2701006T3 (ru) |
| IL (1) | IL240469B (ru) |
| MX (1) | MX366410B (ru) |
| RU (2) | RU2678878C2 (ru) |
| SG (2) | SG11201506312TA (ru) |
| WO (1) | WO2014127047A1 (ru) |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2678878C2 (ru) | 2013-02-12 | 2019-02-05 | Репликэл Лайф Сайенсиз Инк. | Композиции и способы для лечения и восстановления сухожилий |
| MX2015017095A (es) * | 2013-06-18 | 2016-04-06 | Replicel Life Sciences Inc | Composiciones y metodos para tratamiento de la piel. |
| WO2015123476A1 (en) * | 2014-02-12 | 2015-08-20 | Replicel Life Sciences Inc. | Compositions and methods relating to treatments of the oral cavity |
| US10500233B2 (en) | 2014-02-12 | 2019-12-10 | Replicel Life Sciences Inc. | Compositions and methods for treating bone, joints and cartilage |
| CN109310800B (zh) * | 2016-07-29 | 2022-01-07 | 医药研究有限公司 | 包含核酸和壳聚糖的肩袖撕裂修复用组合物 |
| RU2712763C1 (ru) * | 2019-02-22 | 2020-01-31 | Вероника Андреевна Гусева | Способ комплексного лечения травм связок и сухожилий у лошадей |
| EP3766963A1 (en) | 2019-07-15 | 2021-01-20 | Universität Leipzig | Method of culturing mesenchymal stem cells |
| KR20230091232A (ko) | 2021-12-15 | 2023-06-23 | 주식회사 파인메딕스 | 담즙 배출을 위한 스텐트 기구 및 그 제어방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5759830A (en) | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| US5556783A (en) * | 1991-03-27 | 1996-09-17 | Trustees Of Univ. Of Penna | Methods of culturing and modulating the growth of hair follicular stem cells |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US7556825B2 (en) | 1993-04-02 | 2009-07-07 | Anticancer, Inc. | Method for promoting hair growth |
| US7419661B2 (en) | 1997-04-30 | 2008-09-02 | The Centre Of Excellence For Life Sciences Limited | Dermal sheath tissue in wound healing |
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