RU2015138403A - Композиции и способы для лечения и восстановления сухожилий - Google Patents
Композиции и способы для лечения и восстановления сухожилий Download PDFInfo
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- RU2015138403A RU2015138403A RU2015138403A RU2015138403A RU2015138403A RU 2015138403 A RU2015138403 A RU 2015138403A RU 2015138403 A RU2015138403 A RU 2015138403A RU 2015138403 A RU2015138403 A RU 2015138403A RU 2015138403 A RU2015138403 A RU 2015138403A
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- growth factor
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- 239000000203 mixture Substances 0.000 title claims 18
- 238000000034 method Methods 0.000 title claims 15
- 210000002435 tendon Anatomy 0.000 title claims 10
- 210000004027 cell Anatomy 0.000 claims 5
- 230000002500 effect on skin Effects 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 4
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 4
- 102000013275 Somatomedins Human genes 0.000 claims 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000002744 extracellular matrix Anatomy 0.000 claims 4
- 229940126864 fibroblast growth factor Drugs 0.000 claims 4
- 210000004209 hair Anatomy 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 4
- 229960003160 hyaluronic acid Drugs 0.000 claims 4
- 229940100601 interleukin-6 Drugs 0.000 claims 4
- 102000049853 macrophage stimulating protein Human genes 0.000 claims 4
- 108010053292 macrophage stimulating protein Proteins 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
- 102000011782 Keratins Human genes 0.000 claims 2
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- 102000043299 Parathyroid hormone-related Human genes 0.000 claims 2
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- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 2
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 210000002536 stromal cell Anatomy 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000004760 Tenosynovitis Diseases 0.000 claims 1
- 210000001361 achilles tendon Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 210000000426 patellar ligament Anatomy 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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Claims (31)
1. Способ выделения клеток NBDS, предусматривающий
(a) получение жизнеспособных волос;
(b) разрезание волос, полученных на стадии (a), с удалением луковицы волосяного фолликула;
(c) выделение ткани внелуковичной дермальной оболочки и
(d) культивирование выделенной ткани внелуковичной дермальной оболочки с получением клеток NBDS.
2. Способ по п. 1, где жизнеспособные волосы получают при помощи биопсии из затылочной области волосистой части кожи головы субъекта.
3. Способ по п. 1, где указанные волосы разрезают с использованием микроманипулятора и скальпеля.
4. Способ по п. 1, дополнительно предусматривающий стадию проведения ферментативного расщепления указанной выделенной ткани внелуковичной дермальной оболочки.
5. Способ по п. 4, где указанное ферментативное расщепление проводят с использованием коллагеназы.
6. Способ по п. 1, где указанные клетки NBDS культивируют в течение нескольких пассажей либо в среде, содержащей сыворотку, либо в бессывороточной среде.
7. Композиция, содержащая выделенные клетки внелуковичной дермальной оболочки, полученные в соответствии со способом по любому из пп. 1-6.
8. Композиция по п. 7, дополнительно содержащая сыворотку и/или плазму.
9. Композиция по п. 7, где указанная композиция не содержит сыворотку или плазму.
10. Композиция по п. 7, дополнительно содержащая фибрин, гиалуроновую кислоту, компоненты внеклеточного матрикса, цитокины, хемокины и терапевтические средства.
11. Композиция по п. 10, где указанные компоненты внеклеточного матрикса выбраны из группы, включающей гликозаминогликаны (GAG), гепарин-сульфат, хондроитин-сульфат, кератин-сульфат, гиалуроновую кислоту, эластин, фибронектины и ламинины.
12. Композиция по п. 10, где указанные цитокины выбраны из группы, включающей трансформирующий фактор роста бета (TGF-бета) и его изоформы, инсулиноподобный фактор роста (IGF) и его изоформы, гранулоцитарно-макрофагальный колониестимулирующий фактор (GM-CSF), белок, родственный паратиреоидному гормону, фактор роста гепатоцитов/"рассеивающий фактор" (HGF/SF), стимулирующий макрофаги белок (MSP), эпидермальный фактор роста (EGF), интерлейкин 6 (IL-6), фактор стромальных клеток 1 (SDF-1), тромбоцитарный фактор роста (PDGF) и фактор роста фибробластов (FGF).
13. Композиция по п. 10, где указанные терапевтические средства выбраны из группы, включающей анальгетики, противовоспалительные средства и иммуномодулирующие средства.
14. Композиция, содержащая выделенные клетки внелуковичной дермальной оболочки.
15. Композиция по п. 14, дополнительно содержащая сыворотку и/или плазму.
16. Композиция по п. 14, где указанная композиция не содержит сыворотку или плазму.
17. Композиция по п. 14, дополнительно содержащая фибрин, гиалуроновую кислоту, компоненты внеклеточного матрикса, цитокины, хемокины и терапевтические средства.
18. Композиция по п. 17, где указанные компоненты внеклеточного матрикса выбраны из группы, включающей гликозаминогликаны (GAG), гепарин-сульфат, хондроитин-сульфат, кератин-сульфат, гиалуроновую кислоту, эластин, фибронектины и ламинины.
19. Композиция по п. 17, где указанные цитокины выбраны из группы, включающей трансформирующий фактор роста бета (TGF-бета) и его изоформы, инсулиноподобный фактор роста (IGF) и его изоформы, гранулоцитарно-макрофагальный колониестимулирующий фактор (GM-CSF), белок, родственный паратиреоидному гормону, фактор роста гепатоцитов/"рассеивающий фактор" (HGF/SF), стимулирующий макрофаги белок (MSP), эпидермальный фактор роста (EGF), интерлейкин 6 (IL-6), фактор стромальных клеток 1 (SDF-1), тромбоцитарный фактор роста (PDGF) и фактор роста фибробластов (FGF).
20. Композиция по п. 17, где указанные терапевтические средства выбраны из группы, включающей анальгетики, противовоспалительные средства и иммуномодулирующие средства.
21. Способ лечения или предупреждения повреждений сухожилий, предусматривающий стадию введения субъекту композиции по любому из пп. 7-20.
22. Способ по п. 21, где указанный субъект представляет собой млекопитающее, выбранное из группы, включающей людей, лошадей, собак и кошек.
23. Способ по п. 21, где указанное повреждение сухожилия представляет собой отрыв сухожилия, полный, частичный разрыв или микроразрыв.
24. Способ по п. 21, где указанное повреждение сухожилия выбрано из группы, включающей тендиноз, тендосиновит и авульсию.
25. Способ по п. 21, где указанное сухожилие представляет собой ахиллово сухожилие или сухожилие надколенника.
26. Способ по п. 21, где указанное сухожилие представляет собой сухожилие сгибателя.
27. Способ по п. 21, где указанное сухожилие представляет собой сухожилие разгибателя.
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| NZ715905A (en) * | 2013-06-18 | 2021-12-24 | Replicel Life Sciences Inc | Compositions and methods for treating skin |
| US10500233B2 (en) | 2014-02-12 | 2019-12-10 | Replicel Life Sciences Inc. | Compositions and methods for treating bone, joints and cartilage |
| TW201538729A (zh) * | 2014-02-12 | 2015-10-16 | Replicel Life Sciences Inc | 與口腔治療有關之組合物及方法 |
| CN109310800B (zh) * | 2016-07-29 | 2022-01-07 | 医药研究有限公司 | 包含核酸和壳聚糖的肩袖撕裂修复用组合物 |
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| KR20230091232A (ko) | 2021-12-15 | 2023-06-23 | 주식회사 파인메딕스 | 담즙 배출을 위한 스텐트 기구 및 그 제어방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2712763C1 (ru) * | 2019-02-22 | 2020-01-31 | Вероника Андреевна Гусева | Способ комплексного лечения травм связок и сухожилий у лошадей |
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