RU2018122965A - Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания - Google Patents
Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания Download PDFInfo
- Publication number
- RU2018122965A RU2018122965A RU2018122965A RU2018122965A RU2018122965A RU 2018122965 A RU2018122965 A RU 2018122965A RU 2018122965 A RU2018122965 A RU 2018122965A RU 2018122965 A RU2018122965 A RU 2018122965A RU 2018122965 A RU2018122965 A RU 2018122965A
- Authority
- RU
- Russia
- Prior art keywords
- il1b
- allele
- copies
- copy
- periodontal disease
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 15
- 208000028169 periodontal disease Diseases 0.000 title claims 12
- 230000002250 progressing effect Effects 0.000 title 1
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 59
- 102100039065 Interleukin-1 beta Human genes 0.000 claims 59
- 108700028369 Alleles Proteins 0.000 claims 54
- 239000002131 composite material Substances 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 239000013615 primer Substances 0.000 claims 4
- 239000003155 DNA primer Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108090001008 Avidin Proteins 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 210000000601 blood cell Anatomy 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 239000006249 magnetic particle Substances 0.000 claims 2
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 101150012417 IL1B gene Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 102000054766 genetic haplotypes Human genes 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/18—Dental and oral disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42162810P | 2010-12-09 | 2010-12-09 | |
| US61/421,628 | 2010-12-09 | ||
| US201161452157P | 2011-03-13 | 2011-03-13 | |
| US61/452,157 | 2011-03-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013131239A Division RU2664431C2 (ru) | 2010-12-09 | 2011-12-09 | Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018122965A true RU2018122965A (ru) | 2019-03-06 |
| RU2018122965A3 RU2018122965A3 (enExample) | 2019-04-11 |
Family
ID=46207769
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018122965A RU2018122965A (ru) | 2010-12-09 | 2011-12-09 | Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания |
| RU2013131239A RU2664431C2 (ru) | 2010-12-09 | 2011-12-09 | Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013131239A RU2664431C2 (ru) | 2010-12-09 | 2011-12-09 | Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20120208187A1 (enExample) |
| EP (1) | EP2649203B1 (enExample) |
| JP (2) | JP6138692B2 (enExample) |
| CN (1) | CN103547680B (enExample) |
| AU (2) | AU2011338210B2 (enExample) |
| BR (1) | BR112013014479B1 (enExample) |
| NZ (2) | NZ701432A (enExample) |
| RU (2) | RU2018122965A (enExample) |
| SG (1) | SG191078A1 (enExample) |
| WO (1) | WO2012079010A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106918706B (zh) * | 2015-12-25 | 2019-05-21 | 广州瑞博奥生物科技有限公司 | 一种检测牙周病相关蛋白的抗体芯片试剂盒 |
| CA3011363A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| GB201818627D0 (en) * | 2018-11-15 | 2019-01-02 | Mars Inc | Analytical systems |
| JP7097855B2 (ja) * | 2019-04-24 | 2022-07-08 | ジェネシスヘルスケア株式会社 | 歯周病のリスクを判定する方法 |
| CA3142662A1 (en) | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
| KR102571131B1 (ko) * | 2021-06-01 | 2023-08-24 | 부산대학교 산학협력단 | 치주염 감별용 바이오마커 조성물, 치주염 중증도 감별용 바이오마커 조성물, 및 이를 이용한 진단 키트 |
| EP4430621A1 (en) * | 2021-11-12 | 2024-09-18 | Mars, Incorporated | Systems and methods for generating health reports based on veterinary oral care health test |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110920A (en) | 1982-01-22 | 1992-05-05 | Cetus Corporation | HLA typing method and DNA probes used therein |
| US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5268267A (en) | 1987-08-21 | 1993-12-07 | The General Hospital Corporation | Method for diagnosing small cell carcinoma |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5328829A (en) | 1990-07-05 | 1994-07-12 | Forsyth Dental Infirmary For Children | Method of determining sites of active periodontal disease |
| US5686246A (en) * | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| US20050282198A1 (en) * | 1997-05-29 | 2005-12-22 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype |
| US6130042A (en) * | 1998-03-05 | 2000-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for diagnosing periodontal disease |
| ES2356167T3 (es) * | 2004-05-03 | 2011-04-05 | Interleukin Genetics, Inc. | Método de diagnóstico y terapia para enfermedades asociadas con un haplotipo inflamatorio il-1. |
| US20080118920A1 (en) * | 2004-05-03 | 2008-05-22 | Duff Gordon W | Diagnostics And Therapeutics For Diseases Associated With An Il-1 Inflammatory Haplotype |
| EP2304052A2 (en) * | 2008-05-02 | 2011-04-06 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
-
2011
- 2011-12-09 SG SG2013044383A patent/SG191078A1/en unknown
- 2011-12-09 CN CN201180067082.6A patent/CN103547680B/zh not_active Expired - Fee Related
- 2011-12-09 RU RU2018122965A patent/RU2018122965A/ru not_active Application Discontinuation
- 2011-12-09 BR BR112013014479-3A patent/BR112013014479B1/pt not_active IP Right Cessation
- 2011-12-09 NZ NZ701432A patent/NZ701432A/en not_active IP Right Cessation
- 2011-12-09 WO PCT/US2011/064216 patent/WO2012079010A2/en not_active Ceased
- 2011-12-09 US US13/316,198 patent/US20120208187A1/en not_active Abandoned
- 2011-12-09 RU RU2013131239A patent/RU2664431C2/ru not_active IP Right Cessation
- 2011-12-09 AU AU2011338210A patent/AU2011338210B2/en not_active Ceased
- 2011-12-09 EP EP11846577.2A patent/EP2649203B1/en not_active Not-in-force
- 2011-12-09 NZ NZ612799A patent/NZ612799A/en not_active IP Right Cessation
- 2011-12-09 JP JP2013543383A patent/JP6138692B2/ja active Active
-
2013
- 2013-08-08 US US13/962,637 patent/US9347090B2/en active Active
-
2016
- 2016-04-08 AU AU2016202211A patent/AU2016202211B2/en not_active Ceased
- 2016-05-02 US US15/144,263 patent/US20160244841A1/en not_active Abandoned
-
2017
- 2017-01-20 JP JP2017008513A patent/JP6622731B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6138692B2 (ja) | 2017-05-31 |
| JP2017121237A (ja) | 2017-07-13 |
| JP6622731B2 (ja) | 2019-12-18 |
| EP2649203A2 (en) | 2013-10-16 |
| AU2016202211B2 (en) | 2017-02-23 |
| EP2649203A4 (en) | 2014-05-07 |
| CN103547680A (zh) | 2014-01-29 |
| AU2016202211A1 (en) | 2016-05-05 |
| AU2011338210A1 (en) | 2013-07-25 |
| WO2012079010A2 (en) | 2012-06-14 |
| RU2018122965A3 (enExample) | 2019-04-11 |
| BR112013014479A2 (pt) | 2016-09-20 |
| JP2013544536A (ja) | 2013-12-19 |
| RU2013131239A (ru) | 2015-01-20 |
| US20120208187A1 (en) | 2012-08-16 |
| RU2664431C2 (ru) | 2018-08-17 |
| CN103547680B (zh) | 2017-05-24 |
| NZ701432A (en) | 2016-06-24 |
| BR112013014479B1 (pt) | 2020-10-27 |
| US20160244841A1 (en) | 2016-08-25 |
| SG191078A1 (en) | 2013-07-31 |
| EP2649203B1 (en) | 2019-07-24 |
| US9347090B2 (en) | 2016-05-24 |
| WO2012079010A3 (en) | 2012-08-23 |
| AU2011338210B2 (en) | 2016-05-12 |
| NZ612799A (en) | 2015-04-24 |
| US20130337448A1 (en) | 2013-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20191126 |