RU2017128211A3 - - Google Patents
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- Publication number
- RU2017128211A3 RU2017128211A3 RU2017128211A RU2017128211A RU2017128211A3 RU 2017128211 A3 RU2017128211 A3 RU 2017128211A3 RU 2017128211 A RU2017128211 A RU 2017128211A RU 2017128211 A RU2017128211 A RU 2017128211A RU 2017128211 A3 RU2017128211 A3 RU 2017128211A3
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- RU
- Russia
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Birds (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2015/050043 WO2016110662A1 (en) | 2015-01-09 | 2015-01-09 | Cationic neurotoxins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017128211A RU2017128211A (ru) | 2019-02-11 |
| RU2017128211A3 true RU2017128211A3 (enExample) | 2019-02-11 |
| RU2733493C2 RU2733493C2 (ru) | 2020-10-02 |
Family
ID=52424029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017128211A RU2733493C2 (ru) | 2015-01-09 | 2015-01-09 | Катионные нейротоксины |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10647750B2 (enExample) |
| EP (2) | EP3242884B1 (enExample) |
| JP (1) | JP6601922B2 (enExample) |
| CN (2) | CN116333068A (enExample) |
| DK (1) | DK3242884T3 (enExample) |
| ES (1) | ES2873479T3 (enExample) |
| HU (1) | HUE053935T2 (enExample) |
| PL (1) | PL3242884T3 (enExample) |
| PT (1) | PT3242884T (enExample) |
| RU (1) | RU2733493C2 (enExample) |
| TW (1) | TWI700289B (enExample) |
| WO (1) | WO2016110662A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201718627A (zh) * | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| AU2017227978B2 (en) | 2016-03-02 | 2022-03-10 | Merz Pharma Gmbh & Co. Kgaa | Composition comprising botulinum toxin |
| GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP4212545A1 (en) * | 2016-07-08 | 2023-07-19 | Children's Medical Center Corporation | A novel botulinum neurotoxin and its derivatives |
| TW201814045A (zh) * | 2016-09-16 | 2018-04-16 | 英商艾普森生物製藥有限公司 | 製造雙鏈梭狀芽孢桿菌神經毒素之方法 |
| WO2018175688A1 (en) * | 2017-03-22 | 2018-09-27 | Bonti, Inc. | Botulinum neurotoxins for use in therapy |
| US11952601B2 (en) | 2017-06-20 | 2024-04-09 | Merz Pharma Gmbh & Co. Kgaa | Recombinant botulinum toxin with increased duration of effect |
| ES2930237T3 (es) | 2017-07-06 | 2022-12-09 | Merz Pharma Gmbh & Co Kgaa | Neurotoxinas botulínicas recombinantes nuevas con mayor duración de efectos |
| GB201815817D0 (en) * | 2018-09-28 | 2018-11-14 | Ispen Biopharm Ltd | Clostridial neurotoxins comprising and exogenous activation loop |
| US20220016221A1 (en) | 2018-12-05 | 2022-01-20 | Ipsen Biopharm Limited | Treatment of symptoms of traumatic brain injury |
| KR20210129682A (ko) * | 2019-02-20 | 2021-10-28 | 리그레사 메디컬, 인코포레이티드 | 조성물을 국소화시키는 방법 및 장치 |
| GB201914034D0 (en) | 2019-09-30 | 2019-11-13 | Ipsen Biopharm Ltd | Treatment of neurological disorders |
| GB202001353D0 (en) | 2020-01-31 | 2020-03-18 | Ipsen Biopharm Ltd | Treatment of skin conditions |
| GB202100566D0 (en) | 2021-01-15 | 2021-03-03 | Ipsen Biopharm Ltd | Treatment of brain damage |
| CA3213914A1 (en) | 2021-03-30 | 2022-10-06 | Mikhail KALINICHEV | Treatment of pain & inflammatory disorders |
| AU2021438810B2 (en) | 2021-03-30 | 2024-07-18 | Ipsen Biopharm Limited | Catalytically inactive clostridial neurotoxins for the treatment of pain & inflammatory disorders |
| GB202116795D0 (en) | 2021-11-22 | 2022-01-05 | Ipsen Biopharm Ltd | Treatment of visceral pain |
| GB202213479D0 (en) | 2022-09-14 | 2022-10-26 | Ipsen Biopharm Ltd | Cell-free clostridial neurotoxin assays |
| GB202320108D0 (en) | 2023-12-28 | 2024-02-14 | Ipsen Biopharm Ltd | Biosensor |
| GB202404021D0 (en) | 2024-03-20 | 2024-05-01 | Ipsen Biopharm Ltd | Cell-based neurotoxin assay |
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| WO1993015766A1 (en) | 1992-02-10 | 1993-08-19 | Seragen, Inc. | Desensitization to specific allergens |
| GB9305735D0 (en) | 1993-03-19 | 1993-05-05 | North John R | Novel agent for controlling cell activity |
| DE69429619T2 (de) | 1993-06-10 | 2002-09-12 | Allergan, Inc. | Behandlung von neuromusculaeren stoerungen und zustaenden mit botulism serotyp e |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US20040126396A1 (en) | 1993-12-28 | 2004-07-01 | Allergan, Inc. | Botulinum toxin treatment for strabismus |
| US6974578B1 (en) | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| US5670484A (en) | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
| US5714469A (en) | 1994-09-01 | 1998-02-03 | Smithkline Beecham Corporation | Method of treating sepsis |
| GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| WO1996039166A1 (en) * | 1995-06-06 | 1996-12-12 | Wisconsin Alumni Research Foundation | Analogs of botulinum toxin and pharmaceutical compositions of botulinum toxin |
| WO1997032599A1 (en) * | 1996-03-08 | 1997-09-12 | The Regents Of The University Of California | Chemically-modified clostridiatoxin with improved properties |
| US7192596B2 (en) | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| GB9721189D0 (en) | 1997-10-08 | 1997-12-03 | Speywood Lab The Limited | Analgesic conjugates |
| AU755513B2 (en) | 1998-05-13 | 2002-12-12 | Merz Pharma Gmbh & Co. Kgaa | Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof |
| DE69934337T2 (de) | 1998-07-22 | 2007-05-24 | Osprey Pharmaceuticals Ltd., Calgary | Konjugate zur Behandlung von Entzündungskrankheiten und von assozierter Gewebeschädigung |
| GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| US6776990B2 (en) | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
| US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
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| US6767544B2 (en) | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
| US6358917B1 (en) | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
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| GB9922554D0 (en) | 1999-09-23 | 1999-11-24 | Microbiological Res Authority | Inhibition of secretion from non-neuronal cells |
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| US6299893B1 (en) | 2000-04-17 | 2001-10-09 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
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| BR0315319A (pt) | 2002-10-15 | 2005-08-16 | Allergan Inc | Terapias e procedimentos dentais com toxina botulìnica |
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| SG182691A1 (en) * | 2010-01-25 | 2012-08-30 | Allergan Inc | Methods of intracellular conversion of single-chain proteins into their di-chain form |
| US8853360B2 (en) | 2010-06-23 | 2014-10-07 | Wisconsin Alumni Research Foundation | Engineered botulinum neurotoxin C1 with selective substrate specificity |
| TWI583792B (zh) * | 2011-11-09 | 2017-05-21 | 曼茲法瑪股份有限公司 | 展現減短的生物活性之神經毒素 |
| EP2948174B1 (en) * | 2013-01-28 | 2019-09-11 | New York University | Treatment methods using atoxic neurotoxin derivatives |
| US20140242110A1 (en) * | 2013-02-28 | 2014-08-28 | Dt Scimed, Llc | Dose, localization, and formulation of botulinum toxins in skin and muscle |
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-
2015
- 2015-01-09 RU RU2017128211A patent/RU2733493C2/ru active
- 2015-01-09 EP EP15701379.8A patent/EP3242884B1/en active Active
- 2015-01-09 CN CN202211012695.6A patent/CN116333068A/zh active Pending
- 2015-01-09 WO PCT/GB2015/050043 patent/WO2016110662A1/en not_active Ceased
- 2015-01-09 JP JP2017536513A patent/JP6601922B2/ja active Active
- 2015-01-09 HU HUE15701379A patent/HUE053935T2/hu unknown
- 2015-01-09 PL PL15701379T patent/PL3242884T3/pl unknown
- 2015-01-09 EP EP20210686.0A patent/EP3822286A1/en active Pending
- 2015-01-09 DK DK15701379.8T patent/DK3242884T3/da active
- 2015-01-09 ES ES15701379T patent/ES2873479T3/es active Active
- 2015-01-09 US US15/540,637 patent/US10647750B2/en active Active
- 2015-01-09 CN CN201580071947.4A patent/CN107108703B/zh active Active
- 2015-01-09 PT PT157013798T patent/PT3242884T/pt unknown
- 2015-12-30 TW TW104144440A patent/TWI700289B/zh active
-
2020
- 2020-02-25 US US16/800,109 patent/US11014968B2/en active Active
-
2021
- 2021-04-19 US US17/301,897 patent/US12037369B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK3242884T3 (da) | 2021-04-19 |
| TWI700289B (zh) | 2020-08-01 |
| EP3242884A1 (en) | 2017-11-15 |
| JP2018502580A (ja) | 2018-02-01 |
| CN107108703A (zh) | 2017-08-29 |
| US20180141982A1 (en) | 2018-05-24 |
| TW201629092A (zh) | 2016-08-16 |
| EP3822286A1 (en) | 2021-05-19 |
| HK1245292A1 (en) | 2018-08-24 |
| CN107108703B (zh) | 2022-09-23 |
| ES2873479T3 (es) | 2021-11-03 |
| US20210246175A1 (en) | 2021-08-12 |
| WO2016110662A1 (en) | 2016-07-14 |
| US10647750B2 (en) | 2020-05-12 |
| EP3242884B1 (en) | 2021-02-24 |
| CN116333068A (zh) | 2023-06-27 |
| US11014968B2 (en) | 2021-05-25 |
| RU2017128211A (ru) | 2019-02-11 |
| PT3242884T (pt) | 2021-04-22 |
| US12037369B2 (en) | 2024-07-16 |
| US20200291073A1 (en) | 2020-09-17 |
| RU2733493C2 (ru) | 2020-10-02 |
| JP6601922B2 (ja) | 2019-11-06 |
| PL3242884T3 (pl) | 2021-08-16 |
| HUE053935T2 (hu) | 2021-08-30 |