CN116333068A - 阳离子神经毒素 - Google Patents

阳离子神经毒素 Download PDF

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Publication number
CN116333068A
CN116333068A CN202211012695.6A CN202211012695A CN116333068A CN 116333068 A CN116333068 A CN 116333068A CN 202211012695 A CN202211012695 A CN 202211012695A CN 116333068 A CN116333068 A CN 116333068A
Authority
CN
China
Prior art keywords
amino acid
clostridial toxin
engineered
engineered clostridial
bont
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202211012695.6A
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English (en)
Chinese (zh)
Inventor
D·B·安德森
G·S·哈克特
S·M·刘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Bioinnovation Ltd
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Ipsen Bioinnovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Bioinnovation Ltd filed Critical Ipsen Bioinnovation Ltd
Priority to CN202211012695.6A priority Critical patent/CN116333068A/zh
Publication of CN116333068A publication Critical patent/CN116333068A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24069Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202211012695.6A 2015-01-09 2015-01-09 阳离子神经毒素 Pending CN116333068A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211012695.6A CN116333068A (zh) 2015-01-09 2015-01-09 阳离子神经毒素

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201580071947.4A CN107108703B (zh) 2015-01-09 2015-01-09 阳离子神经毒素
PCT/GB2015/050043 WO2016110662A1 (en) 2015-01-09 2015-01-09 Cationic neurotoxins
CN202211012695.6A CN116333068A (zh) 2015-01-09 2015-01-09 阳离子神经毒素

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580071947.4A Division CN107108703B (zh) 2015-01-09 2015-01-09 阳离子神经毒素

Publications (1)

Publication Number Publication Date
CN116333068A true CN116333068A (zh) 2023-06-27

Family

ID=52424029

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202211012695.6A Pending CN116333068A (zh) 2015-01-09 2015-01-09 阳离子神经毒素
CN201580071947.4A Active CN107108703B (zh) 2015-01-09 2015-01-09 阳离子神经毒素

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201580071947.4A Active CN107108703B (zh) 2015-01-09 2015-01-09 阳离子神经毒素

Country Status (12)

Country Link
US (3) US10647750B2 (enExample)
EP (2) EP3242884B1 (enExample)
JP (1) JP6601922B2 (enExample)
CN (2) CN116333068A (enExample)
DK (1) DK3242884T3 (enExample)
ES (1) ES2873479T3 (enExample)
HU (1) HUE053935T2 (enExample)
PL (1) PL3242884T3 (enExample)
PT (1) PT3242884T (enExample)
RU (1) RU2733493C2 (enExample)
TW (1) TWI700289B (enExample)
WO (1) WO2016110662A1 (enExample)

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EP3423084B1 (en) 2016-03-02 2021-09-01 Merz Pharma GmbH & Co. KGaA Composition comprising botulinum toxin
GB201607901D0 (en) 2016-05-05 2016-06-22 Ipsen Biopharm Ltd Chimeric neurotoxins
PL3481852T3 (pl) * 2016-07-08 2023-07-24 Children's Medical Center Corporation Nowa neurotoksyna botulinowa i jej pochodne
TW201814045A (zh) * 2016-09-16 2018-04-16 英商艾普森生物製藥有限公司 製造雙鏈梭狀芽孢桿菌神經毒素之方法
JP7604222B2 (ja) * 2017-03-22 2024-12-23 ボンチ インコーポレイテッド 治療用のボツリヌス神経毒素
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GB201914034D0 (en) 2019-09-30 2019-11-13 Ipsen Biopharm Ltd Treatment of neurological disorders
GB202001353D0 (en) 2020-01-31 2020-03-18 Ipsen Biopharm Ltd Treatment of skin conditions
GB202100566D0 (en) 2021-01-15 2021-03-03 Ipsen Biopharm Ltd Treatment of brain damage
EP4313120A1 (en) 2021-03-30 2024-02-07 Ipsen Biopharm Limited Treatment of pain & inflammatory disorders
JP7659653B2 (ja) 2021-03-30 2025-04-09 イプセン バイオファーム リミテッド 疼痛及び炎症性障害の処置
GB202116795D0 (en) 2021-11-22 2022-01-05 Ipsen Biopharm Ltd Treatment of visceral pain
GB202213479D0 (en) 2022-09-14 2022-10-26 Ipsen Biopharm Ltd Cell-free clostridial neurotoxin assays
GB202320108D0 (en) 2023-12-28 2024-02-14 Ipsen Biopharm Ltd Biosensor
GB202404021D0 (en) 2024-03-20 2024-05-01 Ipsen Biopharm Ltd Cell-based neurotoxin assay

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Also Published As

Publication number Publication date
RU2733493C2 (ru) 2020-10-02
RU2017128211A (ru) 2019-02-11
TW201629092A (zh) 2016-08-16
US20200291073A1 (en) 2020-09-17
PL3242884T3 (pl) 2021-08-16
CN107108703B (zh) 2022-09-23
CN107108703A (zh) 2017-08-29
US10647750B2 (en) 2020-05-12
EP3822286A1 (en) 2021-05-19
JP2018502580A (ja) 2018-02-01
ES2873479T3 (es) 2021-11-03
US12037369B2 (en) 2024-07-16
HK1245292A1 (en) 2018-08-24
EP3242884A1 (en) 2017-11-15
EP3242884B1 (en) 2021-02-24
JP6601922B2 (ja) 2019-11-06
TWI700289B (zh) 2020-08-01
DK3242884T3 (da) 2021-04-19
US20210246175A1 (en) 2021-08-12
US20180141982A1 (en) 2018-05-24
WO2016110662A1 (en) 2016-07-14
US11014968B2 (en) 2021-05-25
HUE053935T2 (hu) 2021-08-30
PT3242884T (pt) 2021-04-22
RU2017128211A3 (enExample) 2019-02-11

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