RU2016105310A - Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора - Google Patents
Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора Download PDFInfo
- Publication number
- RU2016105310A RU2016105310A RU2016105310A RU2016105310A RU2016105310A RU 2016105310 A RU2016105310 A RU 2016105310A RU 2016105310 A RU2016105310 A RU 2016105310A RU 2016105310 A RU2016105310 A RU 2016105310A RU 2016105310 A RU2016105310 A RU 2016105310A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- mediated
- formula
- disorders
- pharmaceutically acceptable
- Prior art date
Links
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 206010027654 Allergic conditions Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 206010038997 Retroviral infections Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000003959 neuroinflammation Effects 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- -1 2- (4-methylpiperazin-1-yl) ethyl Chemical group 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2013/055906 | 2013-07-18 | ||
| IB2013055906 | 2013-07-18 | ||
| PCT/EP2014/065351 WO2015007830A1 (en) | 2013-07-18 | 2014-07-17 | Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016105310A true RU2016105310A (ru) | 2017-08-23 |
Family
ID=51205401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016105310A RU2016105310A (ru) | 2013-07-18 | 2014-07-17 | Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9533964B2 (enExample) |
| EP (1) | EP3022188B1 (enExample) |
| JP (1) | JP6330038B2 (enExample) |
| KR (1) | KR20160033747A (enExample) |
| CN (1) | CN105377824B (enExample) |
| AU (1) | AU2014292064B2 (enExample) |
| BR (1) | BR112016001106A8 (enExample) |
| CA (1) | CA2915757A1 (enExample) |
| ES (1) | ES2639798T3 (enExample) |
| MX (1) | MX360699B (enExample) |
| RU (1) | RU2016105310A (enExample) |
| TW (1) | TW201536289A (enExample) |
| WO (1) | WO2015007830A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016105310A (ru) | 2013-07-18 | 2017-08-23 | Актелион Фармасьютиклз Лтд | Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| MX377796B (es) | 2014-05-13 | 2025-03-11 | Novartis Ag | Compuestos y composiciones para inducir condrogenesis. |
| EP3303284B1 (en) | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| AR104751A1 (es) | 2015-05-27 | 2017-08-09 | Kyorin Seiyaku Kk | Derivado de urea o una sal de este aceptable desde el punto de vista farmacológico |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995002587A1 (en) | 1993-07-16 | 1995-01-26 | Merck & Co., Inc. | Substituted piperazinylcamphor derivatives as oxytocin antagonists |
| AU2000227546B2 (en) | 2000-02-04 | 2007-08-30 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Ligands for FPR class receptors that induce a host immune response to a pathogen or inhibit HIV infection |
| US20050164305A1 (en) | 2002-04-03 | 2005-07-28 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| WO2005047899A2 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| TWI434685B (zh) | 2007-12-18 | 2014-04-21 | Actelion Pharmaceuticals Ltd | 胺基三唑衍生物 |
| ES2431298T3 (es) * | 2009-05-18 | 2013-11-25 | Actelion Pharmaceuticals Ltd. | Derivados de espiro[2.4]heptano puenteados como agonistas del receptor de ALX y/o FPRL2 |
| MY161243A (en) | 2009-06-09 | 2017-04-14 | Actelion Pharmaceuticals Ltd | Fluorinated aminotriazole derivatives |
| CN102803237B (zh) | 2009-06-12 | 2014-09-24 | 埃科特莱茵药品有限公司 | 作为alx受体激动剂的噁唑和噻唑衍生物 |
| EP2585054A1 (en) | 2010-06-24 | 2013-05-01 | Allergan, Inc. | Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity |
| CA2814826C (en) * | 2010-11-17 | 2019-02-12 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| PT2649068E (pt) | 2010-12-07 | 2014-12-23 | Actelion Pharmaceuticals Ltd | Derivados de éter oxazolil-metílico como agonistas do receptor de alx |
| JP5923108B2 (ja) | 2010-12-07 | 2016-05-24 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ａｌｘ受容体アゴニストとしてのヒドロキシル化アミノトリアゾール誘導体 |
| EP2731931A1 (en) | 2011-07-11 | 2014-05-21 | Allergan, Inc. | Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (fprl-1) receptor modulators |
| ES2596521T3 (es) * | 2012-05-16 | 2017-01-10 | Actelion Pharmaceuticals Ltd. | Derivados de espiro[2.4]heptano sustituidos con puente 1-(p-tolil)ciclopropilo como agonistas de receptor de ALX |
| MA37618B1 (fr) * | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| BR122017004254B1 (pt) | 2013-03-06 | 2021-04-13 | Allergan, Inc. | Uso de agonistas de receptor de formil peptídeo 2 para tratar doenças inflamatórias oculares |
| BR112015021392B1 (pt) | 2013-03-06 | 2021-11-16 | Allergan, Inc | Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas |
| RU2016105310A (ru) | 2013-07-18 | 2017-08-23 | Актелион Фармасьютиклз Лтд | Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
-
2014
- 2014-07-17 RU RU2016105310A patent/RU2016105310A/ru unknown
- 2014-07-17 BR BR112016001106A patent/BR112016001106A8/pt not_active IP Right Cessation
- 2014-07-17 MX MX2016000731A patent/MX360699B/es active IP Right Grant
- 2014-07-17 EP EP14739472.0A patent/EP3022188B1/en not_active Not-in-force
- 2014-07-17 AU AU2014292064A patent/AU2014292064B2/en not_active Ceased
- 2014-07-17 WO PCT/EP2014/065351 patent/WO2015007830A1/en not_active Ceased
- 2014-07-17 CA CA2915757A patent/CA2915757A1/en not_active Abandoned
- 2014-07-17 CN CN201480039969.8A patent/CN105377824B/zh not_active Expired - Fee Related
- 2014-07-17 ES ES14739472.0T patent/ES2639798T3/es active Active
- 2014-07-17 US US14/905,768 patent/US9533964B2/en not_active Expired - Fee Related
- 2014-07-17 KR KR1020167004127A patent/KR20160033747A/ko not_active Withdrawn
- 2014-07-17 JP JP2016526635A patent/JP6330038B2/ja not_active Expired - Fee Related
- 2014-07-17 TW TW103124607A patent/TW201536289A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016001106A8 (pt) | 2017-12-26 |
| TW201536289A (zh) | 2015-10-01 |
| AU2014292064A1 (en) | 2016-03-03 |
| MX2016000731A (es) | 2016-04-13 |
| JP6330038B2 (ja) | 2018-05-23 |
| KR20160033747A (ko) | 2016-03-28 |
| AU2014292064B2 (en) | 2018-07-05 |
| US9533964B2 (en) | 2017-01-03 |
| MX360699B (es) | 2018-11-14 |
| US20160152584A1 (en) | 2016-06-02 |
| EP3022188A1 (en) | 2016-05-25 |
| ES2639798T3 (es) | 2017-10-30 |
| CN105377824A (zh) | 2016-03-02 |
| WO2015007830A1 (en) | 2015-01-22 |
| CA2915757A1 (en) | 2015-01-22 |
| EP3022188B1 (en) | 2017-06-07 |
| JP2016525107A (ja) | 2016-08-22 |
| CN105377824B (zh) | 2017-08-04 |
| BR112016001106A2 (enExample) | 2017-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2683355T3 (es) | Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades | |
| MY167423A (en) | Quinoline carboxamide and quinoline carbonitrile derivatives as mglur2-negative allosteric modulators,compositions,and their use | |
| EA201800064A1 (ru) | 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl | |
| RU2016105310A (ru) | Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора | |
| JP2005538099A5 (enExample) | ||
| JP2013512903A5 (enExample) | ||
| RU2013130878A (ru) | Гидроксилированные производные аминотриазола в качестве агонистов рецептора alx | |
| JP2016517857A5 (enExample) | ||
| EA201992162A1 (ru) | Составы на основе нирапариба | |
| RU2017145646A (ru) | Производное пиперидина, способ его получения и его фармацевтическое применение | |
| HRP20171848T1 (hr) | Upotreba malononitrilamida za neuropatsku bol | |
| EA202090573A1 (ru) | Составы нирапариба | |
| RU2014106611A (ru) | Производные гетероциклических амидов в качестве антагонистов р2х7 рецептора | |
| HRP20211278T1 (hr) | Supstituirani derivati indolina kao inhibitori replikacije denga virusa | |
| RU2015126015A (ru) | Новые улавливатели в лечении макулодистрофии | |
| RU2006130000A (ru) | Органические соединения | |
| JP2015522018A5 (enExample) | ||
| RU2016102059A (ru) | Дифторэтил-оксазол замещенные мостиковые производные спиро-[2,4] гептана в качестве агонистов alх рецептора | |
| EA201990818A1 (ru) | ПРОИЗВОДНЫЕ ХРОМАНА, ИЗОХРОМАНА И ДИГИДРОИЗОБЕНЗОФУРАНА В КАЧЕСТВЕ НЕГАТИВНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2, ИХ КОМПОЗИЦИИ И ПРИМЕНЕНИЕ | |
| RU2013130879A (ru) | Производные оксазолилметилового эфира в качестве агонистов рецептора alx | |
| RU2019135261A (ru) | Фармацевтическая композиция, содержащая ингибитор pde9 | |
| JP2017525721A (ja) | 認知欠損または認知障害に伴って進行する神経障害のおよび神経変性疾患の処置および予防のための製品 | |
| EA202190586A1 (ru) | N-замещенные диоксоциклобутениламино-3-гидроксипиколинамиды, приемлемые в качестве ингибиторов ccr6 | |
| MX2022004878A (es) | Derivados de n-(heteroaril)quinazolin-2-amina a manera de inhibidores de lrrk2, composiciones farmaceuticas y usos de los mismos. | |
| HRP20191869T1 (hr) | Fluoroindol derivati kao pozitivni alosterički modulatori muskarinskog m1 receptora |