RU2016102922A - Способы идентификации, изоляции и применения рецепторов пахучих веществ и ароматов - Google Patents
Способы идентификации, изоляции и применения рецепторов пахучих веществ и ароматов Download PDFInfo
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- RU2016102922A RU2016102922A RU2016102922A RU2016102922A RU2016102922A RU 2016102922 A RU2016102922 A RU 2016102922A RU 2016102922 A RU2016102922 A RU 2016102922A RU 2016102922 A RU2016102922 A RU 2016102922A RU 2016102922 A RU2016102922 A RU 2016102922A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- olfactory
- receptor
- receptors
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 8
- 239000000126 substance Substances 0.000 title claims 2
- 235000019568 aromas Nutrition 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 102000012547 Olfactory receptors Human genes 0.000 claims 12
- 108050002069 Olfactory receptors Proteins 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 102000005962 receptors Human genes 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000002569 neuron Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000269370 Xenopus <genus> Species 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 150000001491 aromatic compounds Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000001706 olfactory mucosa Anatomy 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- ZFRKQXVRDFCRJG-UHFFFAOYSA-N skatole Chemical compound C1=CC=C2C(C)=CNC2=C1 ZFRKQXVRDFCRJG-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361841282P | 2013-06-29 | 2013-06-29 | |
| US61/841,282 | 2013-06-29 | ||
| US201361921664P | 2013-12-30 | 2013-12-30 | |
| US61/921,664 | 2013-12-30 | ||
| PCT/US2014/044770 WO2014210585A2 (en) | 2013-06-29 | 2014-06-28 | Methods of identifying, isolating and using odorant and aroma receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016102922A true RU2016102922A (ru) | 2017-08-03 |
Family
ID=51261224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016102922A RU2016102922A (ru) | 2013-06-29 | 2014-06-28 | Способы идентификации, изоляции и применения рецепторов пахучих веществ и ароматов |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9914760B2 (enExample) |
| EP (1) | EP3013978B1 (enExample) |
| JP (2) | JP2016523546A (enExample) |
| CN (1) | CN105339509A (enExample) |
| BR (1) | BR112015032700B1 (enExample) |
| ES (1) | ES2768338T3 (enExample) |
| MX (1) | MX371282B (enExample) |
| RU (1) | RU2016102922A (enExample) |
| WO (1) | WO2014210585A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5222307A (en) * | 1989-11-21 | 1993-06-29 | Interface Technical Laboratories Co., Ltd. | Drying method and apparatus therefor |
| EP3013978B1 (en) | 2013-06-29 | 2019-11-20 | Firmenich SA | Methods of identifying, isolating and using odorant and aroma receptors |
| ES2807440T3 (es) | 2015-06-10 | 2021-02-23 | Firmenich & Cie | Procedimiento de identificación de compuestos de almizcle |
| JP6122181B2 (ja) | 2015-06-17 | 2017-04-26 | 花王株式会社 | スルフィド化合物の臭いの抑制剤の評価又は選択方法 |
| CA2994409A1 (en) | 2015-08-03 | 2017-02-09 | Research Foundation Of The City University Of New York | Dna sequence that increases odorant receptor representation in the olfactory system |
| EP3425057A4 (en) * | 2016-03-02 | 2019-07-24 | Kyushu University, National University Corporation | METHOD FOR DETERMINING A NUCLEIC ACID SEQUENCE OF A TARGET |
| WO2018081588A1 (en) * | 2016-10-27 | 2018-05-03 | Duke University | Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells |
| JP6371817B2 (ja) * | 2016-11-09 | 2018-08-08 | ハウス食品株式会社 | 消臭用組成物又はマスキング用組成物及びそれらの使用方法 |
| WO2018091686A1 (en) | 2016-11-18 | 2018-05-24 | Firmenich Sa | Use of volatile compositions to limit or eliminate perception of fecal malodour |
| ES2962680T3 (es) | 2016-11-18 | 2024-03-20 | Firmenich & Cie | Uso de composiciones volátiles para limitar o eliminar la percepción del mal olor de la materia fecal |
| ES2774132T3 (es) | 2016-12-14 | 2020-07-16 | Takasago Perfumery Co Ltd | Método para identificar neutralizadores de malos olores |
| WO2018151875A2 (en) | 2016-12-30 | 2018-08-23 | Research Foundation Of The City University Of New York | Biosensor exhibiting sensitivity to trinitrotoluene |
| WO2018162638A1 (en) | 2017-03-09 | 2018-09-13 | Firmenich Sa | Method of identifying malodor modulating compounds |
| WO2019008089A1 (en) | 2017-07-06 | 2019-01-10 | Firmenich Sa | 2,4-DISUBSTITUTED PYRIDINES AS INGREDIENTS THAT NEUTRALIZE BAD ODORS |
| EP3648763B1 (en) | 2017-07-06 | 2022-11-30 | Firmenich SA | 2,4-disubstituted pyridines as malodor counteracting ingredients |
| EP4632382A2 (en) | 2017-11-22 | 2025-10-15 | Firmenich SA | Method of identifying laundry malodor, moldy malodor and/or sweat malodor modulating compounds |
| CN111432851B (zh) * | 2017-11-22 | 2023-06-23 | 弗门尼舍有限公司 | 挥发性成分限制或消除对恶臭的感知的用途 |
| CN111050856B (zh) | 2017-12-21 | 2024-12-31 | 弗门尼舍有限公司 | 鉴定气味剂受体的正变构调节剂的方法 |
| WO2021064208A1 (en) | 2019-10-04 | 2021-04-08 | Firmenich Sa | Fragrance composition tonality determination method, fragrance composition determination method and corresponding systems |
| JP7383453B2 (ja) * | 2019-10-31 | 2023-11-20 | 花王株式会社 | インドール臭抑制剤の選択方法 |
| WO2021125139A1 (ja) | 2019-12-19 | 2021-06-24 | 花王株式会社 | 嗅覚感受性の向上方法 |
| US12377711B2 (en) | 2020-08-20 | 2025-08-05 | Denso International America, Inc. | Vehicle feature control systems and methods based on smoking |
| US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
| US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
| US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
| US12269315B2 (en) | 2020-08-20 | 2025-04-08 | Denso International America, Inc. | Systems and methods for measuring and managing odor brought into rental vehicles |
| US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
| US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
| US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
| US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
| US12251991B2 (en) | 2020-08-20 | 2025-03-18 | Denso International America, Inc. | Humidity control for olfaction sensors |
| US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
| CN113663463B (zh) * | 2021-08-26 | 2022-08-02 | 日东生物科技(浙江)有限公司 | 一种异味抑制剂 |
| CN113504378B (zh) * | 2021-09-08 | 2022-01-04 | 汉王科技股份有限公司 | 嗅觉受体、重组细胞、试剂盒及其用途 |
| US20250043349A1 (en) * | 2021-12-02 | 2025-02-06 | President And Fellows Of Harvard College | Deorphanizing odors using single cell sequencing |
| JP2024159344A (ja) * | 2023-04-28 | 2024-11-08 | 住友化学株式会社 | センサタンパク質の活性測定用細胞の製造方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434084A (en) | 1981-09-23 | 1984-02-28 | E. I. Du Pont De Nemours And Company | Base metal conductor cathode coating for tantalum capacitors |
| EP0578784A4 (en) * | 1991-04-05 | 1994-11-02 | Univ Columbia | RECEPTORS OF SMELLING SUBSTANCES AND THEIR USES. |
| US5891646A (en) | 1997-06-05 | 1999-04-06 | Duke University | Methods of assaying receptor activity and constructs useful in such methods |
| US7541151B2 (en) | 1997-06-05 | 2009-06-02 | Duke University | Single-cell biosensor for the measurement of GPCR ligands in a test sample |
| AU2196200A (en) | 1998-12-17 | 2000-07-03 | Johns Hopkins University School Of Medicine, The | Olfactory receptor expression libraries and methods of making and using them |
| JP2004504010A (ja) * | 2000-03-13 | 2004-02-12 | セノミックス インコーポレイテッド | ヒト嗅覚レセプター及びそれをコードする遺伝子 |
| US7374878B2 (en) | 2000-06-22 | 2008-05-20 | Senomyx, Inc. | Receptor fingerprinting, sensory perception, and biosensors of chemical sensants |
| US20020048811A1 (en) | 2000-10-16 | 2002-04-25 | Devreotes Peter N. | Receptor mediated activation of heterotrimeric G-proteins |
| WO2002036622A2 (en) | 2000-10-30 | 2002-05-10 | Senomyx, Inc. | GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS |
| US7041457B2 (en) | 2000-10-30 | 2006-05-09 | Senomyx, Inc. | Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors |
| US20030232332A1 (en) | 2000-12-18 | 2003-12-18 | Muralidhara Padigaru | Novel proteins and nucleic acids encoding same |
| US20070003980A1 (en) | 2001-03-27 | 2007-01-04 | Woods Daniel F | Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior |
| US20100248268A1 (en) * | 2001-03-27 | 2010-09-30 | Woods Daniel F | Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses |
| US20030096260A1 (en) * | 2001-10-09 | 2003-05-22 | Zhenhua Miao | Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof |
| US7344845B2 (en) * | 2001-12-21 | 2008-03-18 | Senomyx, Inc. | Olfactory receptor for isovaleric acid and related malodorants and use thereof in assays for identification of blockers of malodor |
| WO2004067717A2 (en) | 2003-01-24 | 2004-08-12 | Duke University | Modified trafficking patterns for arrestin and g-protein-coupled receptors via arrestin-ubiquitin chimera |
| DE10311769A1 (de) | 2003-03-18 | 2004-09-30 | Bayer Healthcare Ag | Testmethoden zur Bestimmung der intrazellulären Konzentration zyklischer Nukleotide |
| WO2006002161A2 (en) | 2004-06-18 | 2006-01-05 | Duke University | Modulators of odorant receptors |
| JP2008529540A (ja) * | 2005-02-17 | 2008-08-07 | ケムコム エス．エー． | 揮発性化合物を認識する受容体を試験するための新規なインビトロ方法 |
| EP1700865A1 (en) | 2005-03-11 | 2006-09-13 | AXXAM S.r.l. | Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators |
| US8298781B2 (en) | 2007-05-08 | 2012-10-30 | Duke University | Compositions and methods for characterizing and regulating olfactory sensation |
| JP5690467B2 (ja) | 2008-04-11 | 2015-03-25 | 花王株式会社 | 嗅覚感度抑制剤のスクリーニング法 |
| US20100248390A1 (en) | 2009-03-02 | 2010-09-30 | Duke University | Compositions and methods for identifying ligands of odorant receptors |
| JP5127783B2 (ja) * | 2009-06-29 | 2013-01-23 | 日本電信電話株式会社 | においセンサおよびにおい検知方法 |
| WO2011069156A2 (en) | 2009-12-04 | 2011-06-09 | Duke University | Compositions and methods for enhancing odorant receptor activity |
| US9233082B2 (en) | 2010-09-03 | 2016-01-12 | Kao Corporation | Method for searching for malodor control agent, malodor control agent, and malodor control method |
| US8637259B1 (en) | 2011-02-09 | 2014-01-28 | Chemcom S.A. | Methods of identifying modulators of olfactory receptors involved in the perception of sweat carboxylic acids |
| GB201106254D0 (en) * | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| JP5593271B2 (ja) * | 2011-06-06 | 2014-09-17 | 花王株式会社 | 悪臭抑制剤の探索方法 |
| JP5798382B2 (ja) * | 2011-06-06 | 2015-10-21 | 花王株式会社 | 悪臭抑制剤 |
| AU2013201287B2 (en) | 2012-03-06 | 2015-05-14 | Duke University | Synthetic regulation of gene expression |
| JP5350563B1 (ja) * | 2012-03-22 | 2013-11-27 | パナソニック株式会社 | １個の嗅覚細胞に含まれる嗅覚受容体を特定する方法 |
| EP3013978B1 (en) | 2013-06-29 | 2019-11-20 | Firmenich SA | Methods of identifying, isolating and using odorant and aroma receptors |
-
2014
- 2014-06-28 EP EP14745271.8A patent/EP3013978B1/en active Active
- 2014-06-28 US US14/318,641 patent/US9914760B2/en active Active
- 2014-06-28 RU RU2016102922A patent/RU2016102922A/ru not_active Application Discontinuation
- 2014-06-28 BR BR112015032700-1A patent/BR112015032700B1/pt active IP Right Grant
- 2014-06-28 ES ES14745271T patent/ES2768338T3/es active Active
- 2014-06-28 JP JP2016524276A patent/JP2016523546A/ja active Pending
- 2014-06-28 MX MX2015017943A patent/MX371282B/es active IP Right Grant
- 2014-06-28 WO PCT/US2014/044770 patent/WO2014210585A2/en not_active Ceased
- 2014-06-28 CN CN201480036935.3A patent/CN105339509A/zh active Pending
-
2018
- 2018-01-22 US US15/877,215 patent/US20180208637A1/en not_active Abandoned
- 2018-07-10 JP JP2018130409A patent/JP6835773B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014210585A3 (en) | 2015-04-16 |
| CN105339509A (zh) | 2016-02-17 |
| BR112015032700B1 (pt) | 2022-12-20 |
| JP2019004883A (ja) | 2019-01-17 |
| MX371282B (es) | 2020-01-24 |
| BR112015032700A2 (enExample) | 2017-08-22 |
| US20180208637A1 (en) | 2018-07-26 |
| JP6835773B2 (ja) | 2021-02-24 |
| US9914760B2 (en) | 2018-03-13 |
| MX2015017943A (es) | 2016-05-10 |
| US20150005177A1 (en) | 2015-01-01 |
| WO2014210585A2 (en) | 2014-12-31 |
| EP3013978A2 (en) | 2016-05-04 |
| JP2016523546A (ja) | 2016-08-12 |
| EP3013978B1 (en) | 2019-11-20 |
| ES2768338T3 (es) | 2020-06-22 |
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