RU2015156801A - Генетически стерильные животные - Google Patents
Генетически стерильные животные Download PDFInfo
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- RU2015156801A RU2015156801A RU2015156801A RU2015156801A RU2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A RU 2015156801 A RU2015156801 A RU 2015156801A
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- 241001465754 Metazoa Species 0.000 title claims 41
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 210000004027 cell Anatomy 0.000 claims 15
- 241000282414 Homo sapiens Species 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000006378 damage Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 108010069446 Fertilins Proteins 0.000 claims 6
- 102000001133 Fertilins Human genes 0.000 claims 6
- 210000000349 chromosome Anatomy 0.000 claims 6
- -1 CatSper Proteins 0.000 claims 5
- 101710163270 Nuclease Proteins 0.000 claims 5
- 241000251468 Actinopterygii Species 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 4
- 241000283707 Capra Species 0.000 claims 4
- 241000283073 Equus caballus Species 0.000 claims 4
- 241000282326 Felis catus Species 0.000 claims 4
- 241000287828 Gallus gallus Species 0.000 claims 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 4
- 241001494479 Pecora Species 0.000 claims 4
- 241000009328 Perro Species 0.000 claims 4
- 241000282898 Sus scrofa Species 0.000 claims 4
- 238000010459 TALEN Methods 0.000 claims 4
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 4
- 230000002759 chromosomal effect Effects 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 230000006543 gametophyte development Effects 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000014639 sexual reproduction Effects 0.000 claims 4
- 230000019100 sperm motility Effects 0.000 claims 4
- 102100032578 Adenosine deaminase domain-containing protein 1 Human genes 0.000 claims 3
- 102100033672 Deleted in azoospermia-like Human genes 0.000 claims 3
- 102100031780 Endonuclease Human genes 0.000 claims 3
- 108010042407 Endonucleases Proteins 0.000 claims 3
- 101000797006 Homo sapiens Adenosine deaminase domain-containing protein 1 Proteins 0.000 claims 3
- 101000871280 Homo sapiens Deleted in azoospermia-like Proteins 0.000 claims 3
- 241000288906 Primates Species 0.000 claims 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 3
- 210000002593 Y chromosome Anatomy 0.000 claims 3
- 238000010171 animal model Methods 0.000 claims 3
- 108010072122 calmegin Proteins 0.000 claims 3
- 108010084071 complexin I Proteins 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 230000021595 spermatogenesis Effects 0.000 claims 3
- 238000012360 testing method Methods 0.000 claims 3
- 210000001550 testis Anatomy 0.000 claims 3
- 108091022885 ADAM Proteins 0.000 claims 2
- 102000029791 ADAM Human genes 0.000 claims 2
- 101150040384 ATP2B4 gene Proteins 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 2
- 102100026092 Calmegin Human genes 0.000 claims 2
- 101710200976 Cation channel sperm-associated auxiliary subunit beta Proteins 0.000 claims 2
- 102100028013 Cation channel sperm-associated auxiliary subunit beta Human genes 0.000 claims 2
- 101710119341 Cation channel sperm-associated auxiliary subunit delta Proteins 0.000 claims 2
- 102100028012 Cation channel sperm-associated auxiliary subunit delta Human genes 0.000 claims 2
- 101710132751 Cation channel sperm-associated protein 1 Proteins 0.000 claims 2
- 102100028004 Cation channel sperm-associated protein 1 Human genes 0.000 claims 2
- 101710132770 Cation channel sperm-associated protein 2 Proteins 0.000 claims 2
- 102100028062 Cation channel sperm-associated protein 2 Human genes 0.000 claims 2
- 101710132768 Cation channel sperm-associated protein 3 Proteins 0.000 claims 2
- 102100028061 Cation channel sperm-associated protein 3 Human genes 0.000 claims 2
- 102100027826 Complexin-1 Human genes 0.000 claims 2
- 102100031637 Dynein axonemal heavy chain 8 Human genes 0.000 claims 2
- 101000866323 Homo sapiens Dynein axonemal heavy chain 8 Proteins 0.000 claims 2
- 101001002508 Homo sapiens Immunoglobulin-binding protein 1 Proteins 0.000 claims 2
- 101000944004 Homo sapiens Potassium channel subfamily U member 1 Proteins 0.000 claims 2
- 102100021042 Immunoglobulin-binding protein 1 Human genes 0.000 claims 2
- 101100322565 Mus musculus Adam3 gene Proteins 0.000 claims 2
- 101100222253 Mus musculus Catsper4 gene Proteins 0.000 claims 2
- 101100160972 Mus musculus Zmynd15 gene Proteins 0.000 claims 2
- 102100033525 Potassium channel subfamily U member 1 Human genes 0.000 claims 2
- 102000018120 Recombinases Human genes 0.000 claims 2
- 108010091086 Recombinases Proteins 0.000 claims 2
- 101150002402 Smcp gene Proteins 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 210000003794 male germ cell Anatomy 0.000 claims 2
- 210000000287 oocyte Anatomy 0.000 claims 2
- 101150079865 Atp1a4 gene Proteins 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 101000728117 Homo sapiens Plasma membrane calcium-transporting ATPase 4 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102100029743 Plasma membrane calcium-transporting ATPase 4 Human genes 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000001448 gametogenic effect Effects 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000034004 oogenesis Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829656P | 2013-05-31 | 2013-05-31 | |
| US61/829,656 | 2013-05-31 | ||
| US201361870558P | 2013-08-27 | 2013-08-27 | |
| US61/870,558 | 2013-08-27 | ||
| PCT/US2014/035847 WO2014193583A2 (en) | 2013-05-31 | 2014-04-29 | Genetically sterile animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015156801A true RU2015156801A (ru) | 2017-07-06 |
Family
ID=51986779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015156801A RU2015156801A (ru) | 2013-05-31 | 2014-04-29 | Генетически стерильные животные |
Country Status (13)
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| US9745561B2 (en) * | 2014-01-08 | 2017-08-29 | Iowa State University Research Foundation, Inc. | Genetic test and genetic basis for SCID in pigs |
| AU2015253352A1 (en) | 2014-04-28 | 2016-12-08 | Recombinetics, Inc. | Multiplex Gene Editing |
| FI3169778T3 (fi) | 2014-07-14 | 2023-12-13 | Univ Washington State | Ituradan soluja ablatoiva nanos-geeninpoisto |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| KR102636332B1 (ko) | 2015-04-08 | 2024-02-14 | 내셔날 페더레이션 오브 애그리컬쳐 코오퍼레이티브 어소우시에이션스 | 이개체 유래의 배우자를 생산하는 비인간 대형 포유 동물 또는 어류의 작출 방법 |
| CN108368502B (zh) | 2015-06-03 | 2022-03-18 | 内布拉斯加大学董事委员会 | 使用单链dna的dna编辑 |
| US20170099813A1 (en) * | 2015-10-07 | 2017-04-13 | Recombinetics, Inc. | Method of generating sterile terminal sires in livestock and animals produced thereby |
| SG11201803173VA (en) | 2015-10-23 | 2018-05-30 | Harvard College | Nucleobase editors and uses thereof |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| AU2018352592C1 (en) | 2017-10-16 | 2025-09-25 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| EP3498096A1 (en) * | 2017-12-18 | 2019-06-19 | IMV Technologies | Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel |
| CN110184296B (zh) * | 2018-02-07 | 2023-06-09 | 上海大学 | 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物 |
| BR112020017020A2 (pt) * | 2018-02-26 | 2020-12-29 | Aggenetics, Inc. | Materiais e métodos para impedir a transmissão de um cromossomo particular |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020047514A2 (en) * | 2018-08-31 | 2020-03-05 | Recombinetics, Inc. | Production method for animal models with disease associated phenotypes |
| GB201816633D0 (en) | 2018-10-12 | 2018-11-28 | Univ Edinburgh | Genetically modified avians and method for the reconstitution thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| CN109837347B (zh) * | 2019-01-02 | 2021-01-29 | 华中农业大学 | Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB2601617B (en) | 2019-03-19 | 2024-02-21 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| JP2022526836A (ja) * | 2019-04-09 | 2022-05-26 | リコンビネティクス・インコーポレイテッド | 不稔魚 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
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| CN111378663B (zh) * | 2020-03-18 | 2021-07-13 | 吉林省农业科学院 | lncRNA SFR1及其应用、调控卵泡发育的产品和方法 |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN111549032A (zh) * | 2020-05-26 | 2020-08-18 | 肇庆学院 | 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
| KR102285906B1 (ko) | 2021-02-18 | 2021-08-04 | 주식회사 엔에이피 | 수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물 |
| IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| AU2023331292A1 (en) * | 2022-08-22 | 2025-04-10 | Ramot At Tel-Aviv University Ltd. | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations |
| CN116064541B (zh) * | 2022-10-21 | 2025-03-18 | 华南农业大学 | 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法 |
| KR20250033452A (ko) | 2023-08-30 | 2025-03-10 | 서울대학교산학협력단 | Cyp17a1 형질전환 비만 및 불임치료제 개발 모델 제조방법 및 용도 |
| CN116884488B (zh) * | 2023-09-07 | 2023-11-24 | 中国医学科学院基础医学研究所 | 一种男性不育标志物的筛查方法、系统及设备 |
| CN118910165A (zh) * | 2024-10-11 | 2024-11-08 | 上海南方模式生物科技股份有限公司 | 一种cxcl16基因人源化动物模型的构建方法及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU781014B2 (en) * | 1999-05-13 | 2005-04-28 | Cedars-Sinai Medical Center | Genetic modification of male germ cells for generation of transgenic species and genetic therapies |
| CA2400292A1 (en) * | 2000-02-24 | 2001-08-30 | James M. Robl | Production of mammals which produce progeny of a single sex |
| US20050081256A1 (en) * | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
| AU2003213813A1 (en) * | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| EP2369916A4 (en) * | 2008-12-01 | 2013-04-10 | Univ Texas | PREPARATION AND USE OF SPERMATOGONIAL STEM CELL LINES FROM THE RAT |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| WO2011023740A1 (en) * | 2009-08-28 | 2011-03-03 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| WO2012116274A2 (en) * | 2011-02-25 | 2012-08-30 | Recombinetics, Inc. | Genetically modified animals and methods for making the same |
| WO2012158985A2 (en) * | 2011-05-17 | 2012-11-22 | Transposagen Biopharmaceuticals, Inc. | Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms |
| KR20150100651A (ko) * | 2012-10-30 | 2015-09-02 | 리컴비네틱스 인코포레이티드 | 동물의 성적 성숙 조절 |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
-
2014
- 2014-04-28 US US14/263,408 patent/US20140359796A1/en not_active Abandoned
- 2014-04-29 CN CN201480042269.4A patent/CN105473714A/zh active Pending
- 2014-04-29 AP AP2015008963A patent/AP2015008963A0/en unknown
- 2014-04-29 EP EP14804562.8A patent/EP3004345A4/en not_active Withdrawn
- 2014-04-29 MX MX2015016385A patent/MX2015016385A/es unknown
- 2014-04-29 BR BR112015029904A patent/BR112015029904A2/pt not_active Application Discontinuation
- 2014-04-29 WO PCT/US2014/035847 patent/WO2014193583A2/en not_active Ceased
- 2014-04-29 CA CA2913411A patent/CA2913411A1/en not_active Abandoned
- 2014-04-29 KR KR1020157037273A patent/KR20160013219A/ko not_active Ceased
- 2014-04-29 JP JP2016516661A patent/JP2016525890A/ja active Pending
- 2014-04-29 AU AU2014272106A patent/AU2014272106A1/en not_active Abandoned
- 2014-04-29 RU RU2015156801A patent/RU2015156801A/ru not_active Application Discontinuation
-
2015
- 2015-11-26 PH PH12015502640A patent/PH12015502640A1/en unknown
-
2019
- 2019-06-03 US US16/430,251 patent/US20190335725A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN105473714A (zh) | 2016-04-06 |
| PH12015502640A1 (en) | 2016-03-07 |
| EP3004345A2 (en) | 2016-04-13 |
| KR20160013219A (ko) | 2016-02-03 |
| NZ715540A (en) | 2021-04-30 |
| JP2016525890A (ja) | 2016-09-01 |
| US20140359796A1 (en) | 2014-12-04 |
| AU2014272106A1 (en) | 2016-01-21 |
| AP2015008963A0 (en) | 2016-01-31 |
| EP3004345A4 (en) | 2017-02-15 |
| US20190335725A1 (en) | 2019-11-07 |
| MX2015016385A (es) | 2016-04-11 |
| CA2913411A1 (en) | 2014-12-04 |
| BR112015029904A2 (pt) | 2017-09-26 |
| WO2014193583A2 (en) | 2014-12-04 |
| WO2014193583A3 (en) | 2015-01-22 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180604 |