JP2016525890A - 遺伝的不妊性動物 - Google Patents

遺伝的不妊性動物 Download PDF

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Publication number
JP2016525890A
JP2016525890A JP2016516661A JP2016516661A JP2016525890A JP 2016525890 A JP2016525890 A JP 2016525890A JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016525890 A JP2016525890 A JP 2016525890A
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gene
animal
cell
animals
sperm
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Japanese (ja)
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JP2016525890A5 (cg-RX-API-DMAC7.html
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ダニエル・エフ・カールソン
スコット・シー・ファーレンクラッグ
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Recombinetics Inc
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Recombinetics Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
JP2016516661A 2013-05-31 2014-04-29 遺伝的不妊性動物 Pending JP2016525890A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829656P 2013-05-31 2013-05-31
US61/829,656 2013-05-31
US201361870558P 2013-08-27 2013-08-27
US61/870,558 2013-08-27
PCT/US2014/035847 WO2014193583A2 (en) 2013-05-31 2014-04-29 Genetically sterile animals

Publications (2)

Publication Number Publication Date
JP2016525890A true JP2016525890A (ja) 2016-09-01
JP2016525890A5 JP2016525890A5 (cg-RX-API-DMAC7.html) 2017-06-15

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JP2016516661A Pending JP2016525890A (ja) 2013-05-31 2014-04-29 遺伝的不妊性動物

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US (2) US20140359796A1 (cg-RX-API-DMAC7.html)
EP (1) EP3004345A4 (cg-RX-API-DMAC7.html)
JP (1) JP2016525890A (cg-RX-API-DMAC7.html)
KR (1) KR20160013219A (cg-RX-API-DMAC7.html)
CN (1) CN105473714A (cg-RX-API-DMAC7.html)
AP (1) AP2015008963A0 (cg-RX-API-DMAC7.html)
AU (1) AU2014272106A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015029904A2 (cg-RX-API-DMAC7.html)
CA (1) CA2913411A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015016385A (cg-RX-API-DMAC7.html)
PH (1) PH12015502640A1 (cg-RX-API-DMAC7.html)
RU (1) RU2015156801A (cg-RX-API-DMAC7.html)
WO (1) WO2014193583A2 (cg-RX-API-DMAC7.html)

Cited By (1)

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JP2022502064A (ja) * 2018-10-12 2022-01-11 ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ エジンバラThe University Court Of The University Of Edinburgh 遺伝子改変不妊鳥類およびその再構成方法

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US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
AU2014337790B2 (en) 2013-10-25 2019-09-26 Livestock Improvement Corporation Limited Genetic markers and uses therefor
US20150166982A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting pi3k point mutations
US9745561B2 (en) * 2014-01-08 2017-08-29 Iowa State University Research Foundation, Inc. Genetic test and genetic basis for SCID in pigs
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FI3169778T3 (fi) 2014-07-14 2023-12-13 Univ Washington State Ituradan soluja ablatoiva nanos-geeninpoisto
EP3177718B1 (en) 2014-07-30 2022-03-16 President and Fellows of Harvard College Cas9 proteins including ligand-dependent inteins
KR102636332B1 (ko) 2015-04-08 2024-02-14 내셔날 페더레이션 오브 애그리컬쳐 코오퍼레이티브 어소우시에이션스 이개체 유래의 배우자를 생산하는 비인간 대형 포유 동물 또는 어류의 작출 방법
CN108368502B (zh) 2015-06-03 2022-03-18 内布拉斯加大学董事委员会 使用单链dna的dna编辑
US20170099813A1 (en) * 2015-10-07 2017-04-13 Recombinetics, Inc. Method of generating sterile terminal sires in livestock and animals produced thereby
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CN105543257A (zh) * 2016-01-18 2016-05-04 安徽农业大学 一种pAPN基因定点修饰猪
JP7231935B2 (ja) 2016-08-03 2023-03-08 プレジデント アンド フェローズ オブ ハーバード カレッジ アデノシン核酸塩基編集因子およびそれらの使用
CA3033327A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
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Publication number Priority date Publication date Assignee Title
JP2022502064A (ja) * 2018-10-12 2022-01-11 ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ エジンバラThe University Court Of The University Of Edinburgh 遺伝子改変不妊鳥類およびその再構成方法
JP7535792B2 (ja) 2018-10-12 2024-08-19 ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ エジンバラ 遺伝子改変不妊鳥類およびその再構成方法

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CN105473714A (zh) 2016-04-06
PH12015502640A1 (en) 2016-03-07
EP3004345A2 (en) 2016-04-13
KR20160013219A (ko) 2016-02-03
NZ715540A (en) 2021-04-30
US20140359796A1 (en) 2014-12-04
AU2014272106A1 (en) 2016-01-21
AP2015008963A0 (en) 2016-01-31
EP3004345A4 (en) 2017-02-15
RU2015156801A (ru) 2017-07-06
US20190335725A1 (en) 2019-11-07
MX2015016385A (es) 2016-04-11
CA2913411A1 (en) 2014-12-04
BR112015029904A2 (pt) 2017-09-26
WO2014193583A2 (en) 2014-12-04
WO2014193583A3 (en) 2015-01-22

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