JP2016525890A5 - - Google Patents
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- JP2016525890A5 JP2016525890A5 JP2016516661A JP2016516661A JP2016525890A5 JP 2016525890 A5 JP2016525890 A5 JP 2016525890A5 JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016516661 A JP2016516661 A JP 2016516661A JP 2016525890 A5 JP2016525890 A5 JP 2016525890A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- animal
- catsper
- chromosome
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 241001465754 Metazoa Species 0.000 claims 18
- -1 meganuclease Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 230000014509 gene expression Effects 0.000 claims 7
- 102100028014 Cation channel sperm-associated protein 4 Human genes 0.000 claims 6
- 101710132763 Cation channel sperm-associated protein 4 Proteins 0.000 claims 6
- 102100031780 Endonuclease Human genes 0.000 claims 5
- 108010042407 Endonucleases Proteins 0.000 claims 5
- 102000001133 Fertilins Human genes 0.000 claims 4
- 108010069446 Fertilins Proteins 0.000 claims 4
- 101710163270 Nuclease Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000000349 chromosome Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000014639 sexual reproduction Effects 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 102000018120 Recombinases Human genes 0.000 claims 3
- 108010091086 Recombinases Proteins 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 102000029791 ADAM Human genes 0.000 claims 2
- 108091022885 ADAM Proteins 0.000 claims 2
- 101150040384 ATP2B4 gene Proteins 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 2
- 102100032578 Adenosine deaminase domain-containing protein 1 Human genes 0.000 claims 2
- 241000271566 Aves Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 102100028012 Cation channel sperm-associated auxiliary subunit delta Human genes 0.000 claims 2
- 101710119341 Cation channel sperm-associated auxiliary subunit delta Proteins 0.000 claims 2
- 102100028004 Cation channel sperm-associated protein 1 Human genes 0.000 claims 2
- 101710132751 Cation channel sperm-associated protein 1 Proteins 0.000 claims 2
- 102100028062 Cation channel sperm-associated protein 2 Human genes 0.000 claims 2
- 101710132770 Cation channel sperm-associated protein 2 Proteins 0.000 claims 2
- 102100028061 Cation channel sperm-associated protein 3 Human genes 0.000 claims 2
- 101710132768 Cation channel sperm-associated protein 3 Proteins 0.000 claims 2
- 102100027826 Complexin-1 Human genes 0.000 claims 2
- 102100033672 Deleted in azoospermia-like Human genes 0.000 claims 2
- 102100031637 Dynein axonemal heavy chain 8 Human genes 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 2
- 101000797006 Homo sapiens Adenosine deaminase domain-containing protein 1 Proteins 0.000 claims 2
- 101000871280 Homo sapiens Deleted in azoospermia-like Proteins 0.000 claims 2
- 101000866323 Homo sapiens Dynein axonemal heavy chain 8 Proteins 0.000 claims 2
- 101000944004 Homo sapiens Potassium channel subfamily U member 1 Proteins 0.000 claims 2
- 108700011259 MicroRNAs Proteins 0.000 claims 2
- 101100160972 Mus musculus Zmynd15 gene Proteins 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 102100033525 Potassium channel subfamily U member 1 Human genes 0.000 claims 2
- 101150002402 Smcp gene Proteins 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 210000001766 X chromosome Anatomy 0.000 claims 2
- 210000002593 Y chromosome Anatomy 0.000 claims 2
- 102000001307 androgen receptors Human genes 0.000 claims 2
- 108010080146 androgen receptors Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 235000013330 chicken meat Nutrition 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 2
- 108010084071 complexin I Proteins 0.000 claims 2
- 230000006543 gametophyte development Effects 0.000 claims 2
- 244000144972 livestock Species 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 230000034004 oogenesis Effects 0.000 claims 2
- 210000000717 sertoli cell Anatomy 0.000 claims 2
- 230000021595 spermatogenesis Effects 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000004581 coalescence Methods 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000019100 sperm motility Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829656P | 2013-05-31 | 2013-05-31 | |
| US61/829,656 | 2013-05-31 | ||
| US201361870558P | 2013-08-27 | 2013-08-27 | |
| US61/870,558 | 2013-08-27 | ||
| PCT/US2014/035847 WO2014193583A2 (en) | 2013-05-31 | 2014-04-29 | Genetically sterile animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016525890A JP2016525890A (ja) | 2016-09-01 |
| JP2016525890A5 true JP2016525890A5 (cg-RX-API-DMAC7.html) | 2017-06-15 |
Family
ID=51986779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516661A Pending JP2016525890A (ja) | 2013-05-31 | 2014-04-29 | 遺伝的不妊性動物 |
Country Status (13)
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
| US9745561B2 (en) * | 2014-01-08 | 2017-08-29 | Iowa State University Research Foundation, Inc. | Genetic test and genetic basis for SCID in pigs |
| AU2015253352A1 (en) | 2014-04-28 | 2016-12-08 | Recombinetics, Inc. | Multiplex Gene Editing |
| FI3169778T3 (fi) | 2014-07-14 | 2023-12-13 | Univ Washington State | Ituradan soluja ablatoiva nanos-geeninpoisto |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| KR102636332B1 (ko) | 2015-04-08 | 2024-02-14 | 내셔날 페더레이션 오브 애그리컬쳐 코오퍼레이티브 어소우시에이션스 | 이개체 유래의 배우자를 생산하는 비인간 대형 포유 동물 또는 어류의 작출 방법 |
| CN108368502B (zh) | 2015-06-03 | 2022-03-18 | 内布拉斯加大学董事委员会 | 使用单链dna的dna编辑 |
| US20170099813A1 (en) * | 2015-10-07 | 2017-04-13 | Recombinetics, Inc. | Method of generating sterile terminal sires in livestock and animals produced thereby |
| SG11201803173VA (en) | 2015-10-23 | 2018-05-30 | Harvard College | Nucleobase editors and uses thereof |
| CN105543257A (zh) * | 2016-01-18 | 2016-05-04 | 安徽农业大学 | 一种pAPN基因定点修饰猪 |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071868A1 (en) | 2016-10-14 | 2018-04-19 | President And Fellows Of Harvard College | Aav delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| AU2018352592C1 (en) | 2017-10-16 | 2025-09-25 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| EP3498096A1 (en) * | 2017-12-18 | 2019-06-19 | IMV Technologies | Method for increasing the lifespan and motility of animal sperm using an inhibitor of slo3 potassium channel |
| CN110184296B (zh) * | 2018-02-07 | 2023-06-09 | 上海大学 | 一种制备雌雄均高度不育的鳞翅目昆虫的方法及其核酸构建物 |
| BR112020017020A2 (pt) * | 2018-02-26 | 2020-12-29 | Aggenetics, Inc. | Materiais e métodos para impedir a transmissão de um cromossomo particular |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020047514A2 (en) * | 2018-08-31 | 2020-03-05 | Recombinetics, Inc. | Production method for animal models with disease associated phenotypes |
| GB201816633D0 (en) | 2018-10-12 | 2018-11-28 | Univ Edinburgh | Genetically modified avians and method for the reconstitution thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| CN109837347B (zh) * | 2019-01-02 | 2021-01-29 | 华中农业大学 | Catsper4基因第三外显子的snp作为猪精液品质性状的遗传标记 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB2601617B (en) | 2019-03-19 | 2024-02-21 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| JP2022526836A (ja) * | 2019-04-09 | 2022-05-26 | リコンビネティクス・インコーポレイテッド | 不稔魚 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN111378663B (zh) * | 2020-03-18 | 2021-07-13 | 吉林省农业科学院 | lncRNA SFR1及其应用、调控卵泡发育的产品和方法 |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| CN111549032A (zh) * | 2020-05-26 | 2020-08-18 | 肇庆学院 | 一种诱导型精原细胞Tubb4b基因敲除细胞系的构建方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
| KR102285906B1 (ko) | 2021-02-18 | 2021-08-04 | 주식회사 엔에이피 | 수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물 |
| IL282597B (en) * | 2021-04-22 | 2022-08-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Birds for producing female hatchling and methods of producing same |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| AU2023331292A1 (en) * | 2022-08-22 | 2025-04-10 | Ramot At Tel-Aviv University Ltd. | Genetically engineered eukaryotic organisms, systems and methods for in vivo biasing sex-ratio of populations |
| CN116064541B (zh) * | 2022-10-21 | 2025-03-18 | 华南农业大学 | 一种基于CRISPR/Cas9系统敲除猪细胞Y染色体的方法 |
| KR20250033452A (ko) | 2023-08-30 | 2025-03-10 | 서울대학교산학협력단 | Cyp17a1 형질전환 비만 및 불임치료제 개발 모델 제조방법 및 용도 |
| CN116884488B (zh) * | 2023-09-07 | 2023-11-24 | 中国医学科学院基础医学研究所 | 一种男性不育标志物的筛查方法、系统及设备 |
| CN118910165A (zh) * | 2024-10-11 | 2024-11-08 | 上海南方模式生物科技股份有限公司 | 一种cxcl16基因人源化动物模型的构建方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU781014B2 (en) * | 1999-05-13 | 2005-04-28 | Cedars-Sinai Medical Center | Genetic modification of male germ cells for generation of transgenic species and genetic therapies |
| CA2400292A1 (en) * | 2000-02-24 | 2001-08-30 | James M. Robl | Production of mammals which produce progeny of a single sex |
| US20050081256A1 (en) * | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
| AU2003213813A1 (en) * | 2002-03-22 | 2003-10-13 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| EP2369916A4 (en) * | 2008-12-01 | 2013-04-10 | Univ Texas | PREPARATION AND USE OF SPERMATOGONIAL STEM CELL LINES FROM THE RAT |
| JP2013500018A (ja) * | 2009-07-24 | 2013-01-07 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | ゲノム編集のための方法 |
| WO2011023740A1 (en) * | 2009-08-28 | 2011-03-03 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| WO2012116274A2 (en) * | 2011-02-25 | 2012-08-30 | Recombinetics, Inc. | Genetically modified animals and methods for making the same |
| WO2012158985A2 (en) * | 2011-05-17 | 2012-11-22 | Transposagen Biopharmaceuticals, Inc. | Methods for site-specific genetic modification in spermatogonial stem cells using zinc finger nuclease (zfn) for the creation of model organisms |
| KR20150100651A (ko) * | 2012-10-30 | 2015-09-02 | 리컴비네틱스 인코포레이티드 | 동물의 성적 성숙 조절 |
| US20140359795A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetic techniques for making animals with sortable sperm |
-
2014
- 2014-04-28 US US14/263,408 patent/US20140359796A1/en not_active Abandoned
- 2014-04-29 CN CN201480042269.4A patent/CN105473714A/zh active Pending
- 2014-04-29 AP AP2015008963A patent/AP2015008963A0/en unknown
- 2014-04-29 EP EP14804562.8A patent/EP3004345A4/en not_active Withdrawn
- 2014-04-29 MX MX2015016385A patent/MX2015016385A/es unknown
- 2014-04-29 BR BR112015029904A patent/BR112015029904A2/pt not_active Application Discontinuation
- 2014-04-29 WO PCT/US2014/035847 patent/WO2014193583A2/en not_active Ceased
- 2014-04-29 CA CA2913411A patent/CA2913411A1/en not_active Abandoned
- 2014-04-29 KR KR1020157037273A patent/KR20160013219A/ko not_active Ceased
- 2014-04-29 JP JP2016516661A patent/JP2016525890A/ja active Pending
- 2014-04-29 AU AU2014272106A patent/AU2014272106A1/en not_active Abandoned
- 2014-04-29 RU RU2015156801A patent/RU2015156801A/ru not_active Application Discontinuation
-
2015
- 2015-11-26 PH PH12015502640A patent/PH12015502640A1/en unknown
-
2019
- 2019-06-03 US US16/430,251 patent/US20190335725A1/en not_active Abandoned
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