JP2016529904A5 - - Google Patents
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- JP2016529904A5 JP2016529904A5 JP2016538910A JP2016538910A JP2016529904A5 JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5 JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016538910 A JP2016538910 A JP 2016538910A JP 2016529904 A5 JP2016529904 A5 JP 2016529904A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- target
- hdr
- sequence
- chromosomal dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 18
- 108700028369 Alleles Proteins 0.000 claims 11
- 101710163270 Nuclease Proteins 0.000 claims 11
- 108010042407 Endonucleases Proteins 0.000 claims 10
- 102000004533 Endonucleases Human genes 0.000 claims 10
- 239000013611 chromosomal DNA Substances 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 6
- 108020005004 Guide RNA Proteins 0.000 claims 5
- 108091033409 CRISPR Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 210000002459 blastocyst Anatomy 0.000 claims 2
- 230000034431 double-strand break repair via homologous recombination Effects 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 235000013372 meat Nutrition 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 208000035240 Disease Resistance Diseases 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 108091081548 Palindromic sequence Proteins 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361870401P | 2013-08-27 | 2013-08-27 | |
| US61/870,401 | 2013-08-27 | ||
| PCT/US2014/035854 WO2015030881A1 (en) | 2013-08-27 | 2014-04-29 | Efficient non-meiotic allele introgression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Division JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016529904A JP2016529904A (ja) | 2016-09-29 |
| JP2016529904A5 true JP2016529904A5 (cg-RX-API-DMAC7.html) | 2017-06-15 |
Family
ID=52585270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538910A Pending JP2016529904A (ja) | 2013-08-27 | 2014-04-29 | 効率的な非減数分裂対立遺伝子移入 |
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023018A Pending JP2020089386A (ja) | 2013-08-27 | 2020-02-14 | 効率的な非減数分裂対立遺伝子移入 |
Country Status (14)
Families Citing this family (69)
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
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-
2014
- 2014-04-28 US US14/263,446 patent/US9528124B2/en active Active
- 2014-04-29 EP EP14840061.7A patent/EP3039145B1/en active Active
- 2014-04-29 WO PCT/US2014/035854 patent/WO2015030881A1/en not_active Ceased
- 2014-04-29 BR BR112016004020-1A patent/BR112016004020B1/pt active IP Right Grant
- 2014-04-29 JP JP2016538910A patent/JP2016529904A/ja active Pending
- 2014-04-29 RU RU2016110827A patent/RU2016110827A/ru not_active Application Discontinuation
- 2014-04-29 CN CN201480057624.5A patent/CN105960461B/zh active Active
- 2014-04-29 CN CN202010106589.9A patent/CN111471719B/zh active Active
- 2014-04-29 KR KR1020167008152A patent/KR20160048179A/ko not_active Ceased
- 2014-04-29 AR ARP140101771A patent/AR096143A1/es unknown
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- 2014-04-29 AU AU2014311855A patent/AU2014311855A1/en not_active Abandoned
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