JP2016519955A5 - - Google Patents
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- Publication number
- JP2016519955A5 JP2016519955A5 JP2016516662A JP2016516662A JP2016519955A5 JP 2016519955 A5 JP2016519955 A5 JP 2016519955A5 JP 2016516662 A JP2016516662 A JP 2016516662A JP 2016516662 A JP2016516662 A JP 2016516662A JP 2016519955 A5 JP2016519955 A5 JP 2016519955A5
- Authority
- JP
- Japan
- Prior art keywords
- animal
- chromosome
- factor
- marker
- exogenous gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001465754 Metazoa Species 0.000 claims 19
- 210000002593 Y chromosome Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 239000003550 marker Substances 0.000 claims 6
- 244000144972 livestock Species 0.000 claims 5
- 101710163270 Nuclease Proteins 0.000 claims 3
- 210000001161 mammalian embryo Anatomy 0.000 claims 3
- 230000035935 pregnancy Effects 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 238000012800 visualization Methods 0.000 claims 3
- 241000251468 Actinopterygii Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241001493546 Suina Species 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000002257 embryonic structure Anatomy 0.000 claims 2
- 230000001448 gametogenic effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 1
- 239000000729 antidote Substances 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 210000003495 flagella Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829672P | 2013-05-31 | 2013-05-31 | |
| US61/829,672 | 2013-05-31 | ||
| US201361870586P | 2013-08-27 | 2013-08-27 | |
| US61/870,586 | 2013-08-27 | ||
| PCT/US2014/035851 WO2014193584A2 (en) | 2013-05-31 | 2014-04-29 | Genetic techniques for making animals with sortable sperm |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016519955A JP2016519955A (ja) | 2016-07-11 |
| JP2016519955A5 true JP2016519955A5 (cg-RX-API-DMAC7.html) | 2017-06-15 |
Family
ID=51986778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516662A Pending JP2016519955A (ja) | 2013-05-31 | 2014-04-29 | 選別可能な精子を有する動物を作製するための遺伝子技術 |
Country Status (13)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200136508A (ko) | 2013-04-16 | 2020-12-07 | 리제너론 파마슈티칼스 인코포레이티드 | 랫트 게놈의 표적화된 변형 |
| US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
| AU2014337790B2 (en) | 2013-10-25 | 2019-09-26 | Livestock Improvement Corporation Limited | Genetic markers and uses therefor |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US10787684B2 (en) * | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| JP6174811B2 (ja) | 2013-12-11 | 2017-08-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ゲノムの標的改変のための方法及び組成物 |
| AU2015253352A1 (en) | 2014-04-28 | 2016-12-08 | Recombinetics, Inc. | Multiplex Gene Editing |
| PT3161128T (pt) | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| EP3521437B1 (en) | 2014-11-21 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Methods for targeted genetic modification using paired guide rnas |
| CN108368502B (zh) | 2015-06-03 | 2022-03-18 | 内布拉斯加大学董事委员会 | 使用单链dna的dna编辑 |
| CN107315092B (zh) * | 2017-07-11 | 2019-03-19 | 上海市第一人民医院 | 一种快速评估睾丸生精功能的免疫荧光染色法及其试剂盒 |
| WO2020102565A2 (en) * | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Systems and methods for nondestructive testing of gametes |
| CN111500530A (zh) * | 2020-04-30 | 2020-08-07 | 延安大学 | 一种通用型动物精子分选方法及x精子质控方法 |
| CN114015705A (zh) * | 2021-11-28 | 2022-02-08 | 华中科技大学同济医学院附属协和医院 | 一种小鼠体外受精繁育性别选择方法 |
| WO2024249570A2 (en) * | 2023-06-02 | 2024-12-05 | New York University | Single-sex chicken with toxin-antitoxin system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003526326A (ja) * | 1998-11-13 | 2003-09-09 | セダーシナイ メディカル センター | 選択可能トランスジェニック幹細胞作成を目的とする雄性生殖細胞の形質移入 |
| GB9916810D0 (en) * | 1999-07-16 | 1999-09-22 | Cancer Res Campaign Tech | Killing cells |
| JP2003516134A (ja) * | 1999-12-07 | 2003-05-13 | ユニバーシティ オブ グェルフ | 性染色体特異的タンパク質、種特異的および精子特異的タンパク質、ならびにそれらの同定および単離の方法 |
| AR035326A1 (es) * | 1999-12-27 | 2004-05-12 | Chengyu Liu | Control de la relacion de sexos de la progenie mediante transgenes diana en los cromosomas sexuales |
| CA2400292A1 (en) * | 2000-02-24 | 2001-08-30 | James M. Robl | Production of mammals which produce progeny of a single sex |
| US20050081256A1 (en) * | 2001-03-22 | 2005-04-14 | Forsberg Erik J. | Sex- specific selection of sperm from transgenic animals |
| CN1313061C (zh) * | 2002-03-11 | 2007-05-02 | 刘凤鸣 | 一种动物精子的性别分选方法 |
| JP4271120B2 (ja) * | 2003-10-14 | 2009-06-03 | 独立行政法人科学技術振興機構 | Ｙ染色体標識トランスジェニック非ヒト動物 |
| CN101014350A (zh) * | 2004-03-29 | 2007-08-08 | 孟山都技术公司 | 用于授精的精子悬浮液 |
| US20060123489A1 (en) * | 2004-12-03 | 2006-06-08 | Envivo Pharmaceuticals, Inc. | Sex-specific automated sorting of non-human animals |
| CA2793945A1 (en) * | 2009-04-01 | 2011-10-21 | Biocern, Inc. | Sperm cell separation methods and compositions containing sperm cell targeting ligands for use therein |
| WO2011023740A1 (en) * | 2009-08-28 | 2011-03-03 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Genetic vasectomy by overexpression of prml-egfp fusion protein in spermatids |
| WO2012116274A2 (en) * | 2011-02-25 | 2012-08-30 | Recombinetics, Inc. | Genetically modified animals and methods for making the same |
| CN102199606B (zh) * | 2011-03-09 | 2012-12-26 | 塔里木大学 | 一种筛选非人哺乳动物xy精子差异表达基因的方法 |
-
2014
- 2014-04-28 US US14/263,431 patent/US20140359795A1/en not_active Abandoned
- 2014-04-29 CN CN201480042059.5A patent/CN105658050A/zh active Pending
- 2014-04-29 WO PCT/US2014/035851 patent/WO2014193584A2/en not_active Ceased
- 2014-04-29 KR KR1020157037264A patent/KR20160015333A/ko not_active Withdrawn
- 2014-04-29 AU AU2014272107A patent/AU2014272107A1/en not_active Abandoned
- 2014-04-29 JP JP2016516662A patent/JP2016519955A/ja active Pending
- 2014-04-29 AP AP2015008966A patent/AP2015008966A0/xx unknown
- 2014-04-29 RU RU2015156824A patent/RU2015156824A/ru not_active Application Discontinuation
- 2014-04-29 CA CA2913412A patent/CA2913412A1/en not_active Abandoned
- 2014-04-29 BR BR112015029905A patent/BR112015029905A2/pt not_active Application Discontinuation
- 2014-04-29 EP EP14804017.3A patent/EP3003021A4/en not_active Withdrawn
- 2014-04-29 MX MX2015016383A patent/MX2015016383A/es unknown
-
2015
- 2015-11-26 PH PH12015502646A patent/PH12015502646A1/en unknown
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