RU2015114990A - Способы, композиции и приборы для облегчения регенерации - Google Patents

Способы, композиции и приборы для облегчения регенерации Download PDF

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RU2015114990A
RU2015114990A RU2015114990/10A RU2015114990A RU2015114990A RU 2015114990 A RU2015114990 A RU 2015114990A RU 2015114990/10 A RU2015114990/10 A RU 2015114990/10A RU 2015114990 A RU2015114990 A RU 2015114990A RU 2015114990 A RU2015114990 A RU 2015114990A
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antibody
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Льюис С. ГРУБЕР
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Сива Корпорейшн
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract

1. Гуманизированное антитело, которое связывается с конечным продуктом гликирования клетки.2. Гуманизированное антитело по п. 1, где антитело является моноклональным антителом.3. Гуманизированное антитело по п. 1, где антитело конъюгировано с токсином.4. Гуманизированное антитело по п. 2, где антитело конъюгировано с токсином.5. Применение антитела, которое связывается с конечным продуктом гликирования клетки, для промотирования регенерации ткани или органа у пациента путем уничтожения частично функциональных или не функциональных клеток, которые содержат указанный конечный продукт гликирования клетки.6. Применение по п. 5, где антитело является гуманизированным.7. Применение по п. 5, где антитело является моноклональным антителом.8. Применение по п. 5, где антитело конъюгировано с токсином.9. Применение по п. 6, где антитело является моноклональным антителом.10. Применение по п. 6, где антитело конъюгировано с токсином.11. Применение по п. 7, где антитело конъюгировано с токсином.12. Применение по п. 9, где антитело конъюгировано стоксином.13. Применение композиции для промотирования регенеративных процессов или для преодоления эффектов старения, где композиция селективно уничтожает стареющие клетки, при этом композиция содержит антитела, которые связываются с конечным продуктом гликирования клетки.14. Применение по п. 13, где антитело является гуманизированным.15. Применение по п. 13, где антитело является моноклональным антителом.16. Применение по п. 13, где антитело конъюгировано с токсином.17. Применение по п. 14, где антитело является моноклональным антителом.18. Применение по п. 14, где антитело конъюгировано с токсином.19. Приме�

Claims (20)

1. Гуманизированное антитело, которое связывается с конечным продуктом гликирования клетки.
2. Гуманизированное антитело по п. 1, где антитело является моноклональным антителом.
3. Гуманизированное антитело по п. 1, где антитело конъюгировано с токсином.
4. Гуманизированное антитело по п. 2, где антитело конъюгировано с токсином.
5. Применение антитела, которое связывается с конечным продуктом гликирования клетки, для промотирования регенерации ткани или органа у пациента путем уничтожения частично функциональных или не функциональных клеток, которые содержат указанный конечный продукт гликирования клетки.
6. Применение по п. 5, где антитело является гуманизированным.
7. Применение по п. 5, где антитело является моноклональным антителом.
8. Применение по п. 5, где антитело конъюгировано с токсином.
9. Применение по п. 6, где антитело является моноклональным антителом.
10. Применение по п. 6, где антитело конъюгировано с токсином.
11. Применение по п. 7, где антитело конъюгировано с токсином.
12. Применение по п. 9, где антитело конъюгировано с
токсином.
13. Применение композиции для промотирования регенеративных процессов или для преодоления эффектов старения, где композиция селективно уничтожает стареющие клетки, при этом композиция содержит антитела, которые связываются с конечным продуктом гликирования клетки.
14. Применение по п. 13, где антитело является гуманизированным.
15. Применение по п. 13, где антитело является моноклональным антителом.
16. Применение по п. 13, где антитело конъюгировано с токсином.
17. Применение по п. 14, где антитело является моноклональным антителом.
18. Применение по п. 14, где антитело конъюгировано с токсином.
19. Применение по п. 15, где антитело конъюгировано с токсином.
20. Применение по п. 17, где антитело конъюгировано с токсином.
RU2015114990A 2008-05-23 2009-05-22 Способы, композиции и приборы для облегчения регенерации RU2640249C2 (ru)

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IL240242A0 (en) 2015-09-24
CN102037119B (zh) 2015-06-24
US20120183534A1 (en) 2012-07-19
PL2789684T3 (pl) 2017-06-30
WO2009143411A3 (en) 2010-01-14
AU2009248945A1 (en) 2009-11-26
KR101592156B1 (ko) 2016-02-04
US20180044411A1 (en) 2018-02-15
US9161810B2 (en) 2015-10-20
CA2724886C (en) 2017-11-14
KR20120127543A (ko) 2012-11-21
RU2640249C2 (ru) 2017-12-27
EP2294178A4 (en) 2011-12-07
KR20130132658A (ko) 2013-12-04
JP2015131846A (ja) 2015-07-23
DK2789684T3 (en) 2017-02-20
JP6359051B2 (ja) 2018-07-18
US20180111982A2 (en) 2018-04-26
EP2789684B1 (en) 2016-12-21
JP6637465B2 (ja) 2020-01-29
EP2789684A1 (en) 2014-10-15
IL248652A0 (en) 2016-12-29
US11261241B2 (en) 2022-03-01
JP2011521009A (ja) 2011-07-21
AU2009248945B2 (en) 2014-02-13
RU2010152693A (ru) 2012-06-27
ES2499395T3 (es) 2014-09-29
PT2789684T (pt) 2017-02-14
EP2294178B1 (en) 2014-07-16
CN104987416A (zh) 2015-10-21
JP2016152815A (ja) 2016-08-25
RU2553225C2 (ru) 2015-06-10
US20110105961A1 (en) 2011-05-05
HK1150628A1 (en) 2012-01-06
WO2009143411A2 (en) 2009-11-26
EP3170888A1 (en) 2017-05-24

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