RU2014146111A - Композиции статинов и омега-3 жирных кислот - Google Patents
Композиции статинов и омега-3 жирных кислот Download PDFInfo
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Abstract
1. Фармацевтическая композиция, содержащая статин, растворенный в системе растворителей на основе свободных PUFA(полиненасыщенная жирная кислота)-кислот.2. Фармацевтическая композиция по п. 1, где в системе растворителей являются нерастворенными не более чем примерно 10% масс, статина.3. Фармацевтическая композиция по п. 1, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 5 мг статина на грамм системы растворителей.4. Фармацевтическая композиция по п. 3, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 7,5 мг/г.5. Фармацевтическая композиция по п. 4, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 10 мг/г.6. Фармацевтическая композиция по п. 5, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 20 мг/г.7. Фармацевтическая композиция по п. 1, где статин выбран из группы, состоящей из: правастатина, ловастатина, симвастатина, аторвастатина, флувастатина, розувастатина и питавастатина.8. Фармацевтическая композиция по п. 7, где статин представляет собой розувастатин.9. Фармацевтическая композиция по п. 7, где статин представляет собой аторвастатин.10. Фармацевтическая композиция по п.7, где статин представляет собой симвастатин.11. Фармацевтическая композиция по п. 1, где система растворителей на основе свободных PUFA-кислот содержит ЕРА (эйкозапентаеновая кислота).12. Фармацевтическая композиция по п. 11, где ЕРА присутствует в системе растворителей на основе свободных PUFA-кислот в количестве по меньшей мере примерно 40% (площадь/площадь).13. Фа
Claims (40)
1. Фармацевтическая композиция, содержащая статин, растворенный в системе растворителей на основе свободных PUFA(полиненасыщенная жирная кислота)-кислот.
2. Фармацевтическая композиция по п. 1, где в системе растворителей являются нерастворенными не более чем примерно 10% масс, статина.
3. Фармацевтическая композиция по п. 1, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 5 мг статина на грамм системы растворителей.
4. Фармацевтическая композиция по п. 3, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 7,5 мг/г.
5. Фармацевтическая композиция по п. 4, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 10 мг/г.
6. Фармацевтическая композиция по п. 5, где статин растворен в системе растворителей на основе свободных PUFA-кислот в концентрации по меньшей мере примерно 20 мг/г.
7. Фармацевтическая композиция по п. 1, где статин выбран из группы, состоящей из: правастатина, ловастатина, симвастатина, аторвастатина, флувастатина, розувастатина и питавастатина.
8. Фармацевтическая композиция по п. 7, где статин представляет собой розувастатин.
9. Фармацевтическая композиция по п. 7, где статин представляет собой аторвастатин.
10. Фармацевтическая композиция по п.7, где статин представляет собой симвастатин.
11. Фармацевтическая композиция по п. 1, где система растворителей на основе свободных PUFA-кислот содержит ЕРА (эйкозапентаеновая кислота).
12. Фармацевтическая композиция по п. 11, где ЕРА присутствует в системе растворителей на основе свободных PUFA-кислот в количестве по меньшей мере примерно 40% (площадь/площадь).
13. Фармацевтическая композиция по п. 12, где DHA (докозагексаеновая кислота) присутствует в системе растворителей на основе свободных PUFA-кислот в количестве по меньшей мере примерно 13% (площадь/площадь).
14. Фармацевтическая композиция по п. 13, где DPA (докозапентаеновая кислота) (С22:5 n-3) присутствует в системе растворителей на основе свободных PUFA-кислот в количестве по меньшей мере примерно 1% (площадь/площадь).
15. Фармацевтическая композиция по п. 14, где система растворителей на основе свободных PUFA-кислот содержит от примерно 45% (площадь/площадь) до примерно 65% (площадь/площадь) ЕРА, от примерно 15% (площадь/площадь) до примерно 25% (площадь/площадь) DHA, и от примерно 1% (площадь/площадь) до примерно 8% (площадь/площадь) DPA (С22:5 n-3).
16. Фармацевтическая композиция по п. 1, где система растворителей на основе свободных PUFA-кислот содержит не более чем примерно 10% (площадь/площадь) омега-6 жирных кислот в форме свободных кислот.
17. Пероральная стандартная лекарственная форма, включающая капсулу, содержащую фармацевтическую композицию по п. 1.
18. Пероральная стандартная лекарственная форма по п. 17, где капсула содержит желатин.
19. Пероральная стандартная лекарственная форма по п. 18, где капсула представляет собой мягкую желатиновую капсулу.
20. Пероральная стандартная лекарственная форма по п. 19, где мягкая желатиновая капсула содержит желатин типа A.
21. Пероральная стандартная лекарственная форма по п. 20, где по меньшей мере примерно 1% (масс/масс.) желатина представляет собой желатин типа A.
22. Пероральная стандартная лекарственная форма по п. 21, где желатин типа A представляет собой свиной желатин типа A.
23. Пероральная стандартная лекарственная форма по п. 17, дополнительно содержащая покрытие на наружной стороне капсулы.
24. Пероральная стандартная лекарственная форма по п. 23, где покрытие представляет собой чувствительное к pH кишечнорастворимое покрытие.
25. Пероральная стандартная лекарственная форма по п. 23, где покрытие представляет собой не чувствительное к pH покрытие.
26. Пероральная стандартная лекарственная форма по п.25, где покрытие представляет собой сополимер поли(этилакрилат-метилакрилат).
27. Пероральная стандартная лекарственная форма по п. 26, где покрытие представляет собой Eudragit NE-30D.
28. Пероральная стандартная лекарственная форма по п. 17, где капсула содержит от примерно 1 до примерно 100 мг статина, растворенного в от примерно 500 до примерно 1 г системы растворителей на основе свободных PUFA-кислот.
29. Пероральная стандартная лекарственная форма по п. 28, где капсула содержит от примерно 2,5 мг до примерно 40 мг статина, растворенного примерно в 1 г системы растворителей на основе свободных PUFA-кислот.
30. Пероральная стандартная лекарственная форма по п. 17, где статин представляет собой розувастатин.
31. Пероральная стандартная лекарственная форма по п. 17, где статин представляет собой аторвастатин.
32. Пероральная стандартная лекарственная форма по п. 17, где статин представляет собой симвастатин.
33. Способ лечения нарушения липидного спектра крови, включающий введение фармацевтической композиции по п. 1 субъекту с нарушением липидного спектра крови в количестве и в течение периода времени, которые являются достаточными для лечения нарушения липидного спектра крови.
34. Способ по п. 33, где нарушение липидного спектра крови выбрано из группы, состоящей из: гипертриглицеридемии, гиперлипидемии, гиперхолистеринемии, смешанной дислипидемии и атеросклероза.
35. Способ по п. 33, включающий введение по меньшей мере 2 г фармацевтической композиции ежесуточно.
36. Способ по п. 35, включающий введение по меньшей мере примерно 10 мг статина ежесуточно.
37. Способ по п. 33, где система растворителей на основе свободных PUFA-кислот фармацевтической композиции содержит по меньшей мере примерно 45% (площадь/площадь) ЕРА.
38. Способ по п. 37, где статин в фармацевтической композиции представляет собой розувастатин.
39. Способ по п. 37, где статин в фармацевтической композиции представляет собой аторвастатин.
40. Способ по п. 37, где статин в фармацевтической композиции представляет собой симвастатин.
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US201261643764P | 2012-05-07 | 2012-05-07 | |
US61/643,764 | 2012-05-07 | ||
PCT/US2013/039972 WO2013169797A1 (en) | 2012-05-07 | 2013-05-07 | Compositions of statins and omega-3 fatty acids |
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RU2645075C2 RU2645075C2 (ru) | 2018-02-15 |
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JP (1) | JP6173437B2 (ru) |
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WO2010028067A1 (en) | 2008-09-02 | 2010-03-11 | Amarin Corporation Plc | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
LT2424356T (lt) | 2009-04-29 | 2017-11-27 | Amarin Pharmaceuticals Ireland Limited | Stabili farmacinė kompozicija ir jos panaudojimo būdai |
MY198422A (en) | 2009-04-29 | 2023-08-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
NZ597193A (en) | 2009-06-15 | 2014-01-31 | Amarin Pharmaceuticals Ie Ltd | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
WO2012074930A2 (en) | 2010-11-29 | 2012-06-07 | Amarin Pharma, Inc. | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
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- 2013-05-07 JP JP2015511631A patent/JP6173437B2/ja not_active Expired - Fee Related
- 2013-05-07 TW TW102116275A patent/TW201347754A/zh unknown
- 2013-05-07 EP EP13787637.1A patent/EP2846779A4/en not_active Withdrawn
- 2013-05-07 WO PCT/US2013/039972 patent/WO2013169797A1/en active Application Filing
- 2013-05-07 RU RU2014146111A patent/RU2645075C2/ru not_active IP Right Cessation
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- 2013-05-07 US US13/889,202 patent/US20130295173A1/en not_active Abandoned
- 2013-05-07 CN CN201380036039.2A patent/CN104661654A/zh active Pending
- 2013-05-07 KR KR20147033627A patent/KR20150028233A/ko active Search and Examination
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RU2645075C2 (ru) | 2018-02-15 |
US9492545B2 (en) | 2016-11-15 |
HK1206248A1 (en) | 2016-01-08 |
AR095182A1 (es) | 2015-09-30 |
CN104661654A (zh) | 2015-05-27 |
US20130295173A1 (en) | 2013-11-07 |
WO2013169797A1 (en) | 2013-11-14 |
JP6173437B2 (ja) | 2017-08-02 |
EP2846779A4 (en) | 2015-12-16 |
JP2015520150A (ja) | 2015-07-16 |
EP2846779A1 (en) | 2015-03-18 |
KR20150028233A (ko) | 2015-03-13 |
TW201347754A (zh) | 2013-12-01 |
US20150104504A1 (en) | 2015-04-16 |
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