RU2014143277A - СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ) ЦИТОЗИНА - Google Patents

СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ) ЦИТОЗИНА Download PDF

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RU2014143277A
RU2014143277A RU2014143277A RU2014143277A RU2014143277A RU 2014143277 A RU2014143277 A RU 2014143277A RU 2014143277 A RU2014143277 A RU 2014143277A RU 2014143277 A RU2014143277 A RU 2014143277A RU 2014143277 A RU2014143277 A RU 2014143277A
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salt
arabinofuranosyl
deoxy
thio
fluoro
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Ясутака БАБА
Тацуя МУРАКАМИ
Дзунко СИНТАНИ
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Фуджифилм Корпорэйшн
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Abstract

1. Фармацевтически приемлемая соль 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина.2. Соль по п. 1, которая представляет собой соль неорганической кислоты или сульфонат.3. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид, гидробромид, йодогидрат, нитрат, фосфат или сульфат; а сульфонат представляет собой метансульфонат, бензолсульфонат, п-толуолсульфонат, мезитиленсульфонат или нафталинсульфонат.4. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид, йодогидрат, нитрат или сульфат; а сульфонат представляет собой метансульфонат.5. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид; а сульфонат представляет собой метансульфонат.6. Кристалл метансульфоната 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина, демонстрирующий характеристические пики при дифракционных углах (2θ) 19,8, 21,8, 27,5, 28,4 и 29,9 градусов при рентгеновской порошковой дифрактометрии, или кристалл гидрохлорида 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина, демонстрирующий характеристические пики при дифракционных углах (2θ) 9,2, 14,7, 15,7, 22,9 и 27,3 градусов при рентгеновской порошковой дифрактометрии.7. Фармацевтическая композиция, содержащая соль по любому из пп. 1-5 или кристалл по п. 6.8. Фармацевтическая композиция по п. 7, предназначенная для применения при лечении опухоли.9. Способ получения соли по любому из пп. 1-5, который включает стадию переведения 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина в его фармацевтически приемлемую соль.

Claims (9)

1. Фармацевтически приемлемая соль 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина.
2. Соль по п. 1, которая представляет собой соль неорганической кислоты или сульфонат.
3. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид, гидробромид, йодогидрат, нитрат, фосфат или сульфат; а сульфонат представляет собой метансульфонат, бензолсульфонат, п-толуолсульфонат, мезитиленсульфонат или нафталинсульфонат.
4. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид, йодогидрат, нитрат или сульфат; а сульфонат представляет собой метансульфонат.
5. Соль по п. 2, где соль неорганической кислоты представляет собой гидрохлорид; а сульфонат представляет собой метансульфонат.
6. Кристалл метансульфоната 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина, демонстрирующий характеристические пики при дифракционных углах (2θ) 19,8, 21,8, 27,5, 28,4 и 29,9 градусов при рентгеновской порошковой дифрактометрии, или кристалл гидрохлорида 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина, демонстрирующий характеристические пики при дифракционных углах (2θ) 9,2, 14,7, 15,7, 22,9 и 27,3 градусов при рентгеновской порошковой дифрактометрии.
7. Фармацевтическая композиция, содержащая соль по любому из пп. 1-5 или кристалл по п. 6.
8. Фармацевтическая композиция по п. 7, предназначенная для применения при лечении опухоли.
9. Способ получения соли по любому из пп. 1-5, который включает стадию переведения 1-(2-дезокси-2-фтор-4-тио-β-D-арабинофуранозил)цитозина в его фармацевтически приемлемую соль.
RU2014143277/04A 2012-03-28 2013-03-27 СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА RU2600734C2 (ru)

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