SG10201603288XA - Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine - Google Patents

Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine

Info

Publication number
SG10201603288XA
SG10201603288XA SG10201603288XA SG10201603288XA SG10201603288XA SG 10201603288X A SG10201603288X A SG 10201603288XA SG 10201603288X A SG10201603288X A SG 10201603288XA SG 10201603288X A SG10201603288X A SG 10201603288XA SG 10201603288X A SG10201603288X A SG 10201603288XA
Authority
SG
Singapore
Prior art keywords
arabinofuranosyl
deoxy
cytosine
thio
fluoro
Prior art date
Application number
SG10201603288XA
Other languages
English (en)
Inventor
Yasutaka Baba
Tatsuya Murakami
Junko Shintani
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of SG10201603288XA publication Critical patent/SG10201603288XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SG10201603288XA 2012-03-28 2013-03-27 Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine SG10201603288XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012074525 2012-03-28
JP2013050846 2013-03-13

Publications (1)

Publication Number Publication Date
SG10201603288XA true SG10201603288XA (en) 2016-05-30

Family

ID=49260082

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201406080VA SG11201406080VA (en) 2012-03-28 2013-03-27 SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE
SG10201603288XA SG10201603288XA (en) 2012-03-28 2013-03-27 Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201406080VA SG11201406080VA (en) 2012-03-28 2013-03-27 SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE

Country Status (19)

Country Link
US (1) US9896471B2 (ru)
EP (1) EP2832740B1 (ru)
JP (1) JP5833225B2 (ru)
KR (2) KR101770246B1 (ru)
CN (1) CN104203969B (ru)
AU (1) AU2013241341B2 (ru)
BR (1) BR112014020416B1 (ru)
CA (2) CA2865742C (ru)
DK (1) DK2832740T3 (ru)
ES (1) ES2730679T3 (ru)
HK (1) HK1201273A1 (ru)
IL (1) IL234222A (ru)
MX (2) MX352423B (ru)
NZ (1) NZ701245A (ru)
PL (1) PL2832740T3 (ru)
RU (1) RU2600734C2 (ru)
SG (2) SG11201406080VA (ru)
TW (1) TWI637963B (ru)
WO (1) WO2013146833A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013303534B2 (en) 2012-08-13 2016-06-30 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
TWI787201B (zh) * 2016-08-31 2022-12-21 日商富士軟片股份有限公司 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用套組
AU2018404329B2 (en) 2018-01-29 2021-09-09 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
TW202002989A (zh) * 2018-03-13 2020-01-16 日商富士軟片股份有限公司 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒
JP7520822B2 (ja) 2018-09-25 2024-07-23 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ２’－ハロゲン化－４’－チオ－２’－デオキシ－５－アザシチジンアナログおよびその使用
KR102106096B1 (ko) 2019-08-19 2020-04-29 이명준 경추 지압 마사지기
EP4378466A1 (en) 2021-07-29 2024-06-05 FUJIFILM Corporation Pharmaceutical composition and anti-tumor agent for tumors that have at least either impaired bap1 or pbrm1 function
KR102454186B1 (ko) 2022-05-23 2022-10-14 이명준 경추 지압장치

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
US3243425A (en) 1962-10-29 1966-03-29 Purdue Research Foundation Novel sulfur-containing compounds
JPS5148682A (ja) * 1974-10-15 1976-04-26 Asahi Chemical Ind Nukureochidojudotainoseiho
JPS53119810A (en) 1977-03-25 1978-10-19 Mitsubishi Chem Ind Ltd Preparation of aldehyde chloride
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4220774A (en) 1978-10-26 1980-09-02 Omnium Chimique Vincadifformine synthesis process
JPS5692239A (en) 1979-12-27 1981-07-25 Sagami Chem Res Center Preparation of 5-oxohexyl compound
US4803272A (en) 1987-02-24 1989-02-07 E. I. Du Pont De Nemours And Company S-modified adenosyl-1,8-diamino-3-thiooctane derivatives
IE74701B1 (en) 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
CA2079413C (en) * 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
JP3138834B2 (ja) 1991-12-26 2001-02-26 生化学工業株式会社 フコピラノース類縁体の製造方法およびその合成中間化合物
GB9218810D0 (en) 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
GB9515279D0 (en) * 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
EP0770621A4 (en) 1994-07-12 1998-01-28 Yamasa Corp 2'-DESOXY-2 '- (METHYLIDENE SUBSTITUTED OR NON-SUBSTITUTED) -4'-THIONUCLEOSIDE
JPH0853490A (ja) 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド
JP4202327B2 (ja) 1996-04-09 2008-12-24 ヤマサ醤油株式会社 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
EP0839813A1 (en) 1996-04-09 1998-05-06 Yamasa Corporation 9-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)purine derivatives
DK0841344T3 (da) * 1996-04-09 2002-12-23 Yamasa Corp 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner
HUP9601756A3 (en) 1996-06-25 1999-05-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical compositions containing them
JP4087471B2 (ja) 1997-03-31 2008-05-21 大日本印刷株式会社 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法
HUP9702348A3 (en) 1997-12-04 2000-12-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them
WO1999043690A1 (fr) 1998-02-25 1999-09-02 Rational Drug Design Laboratories Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant
EP2335706B1 (en) 1998-07-23 2013-10-23 Southern Research Institute Preparation of thioarabinofuranosyl compounds
WO2001066118A1 (en) 2000-03-08 2001-09-13 Southern Research Institute 4'-thio-l-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
KR100426030B1 (ko) 2000-07-22 2004-04-03 (주) 한켐 락톤계 당화합물에서의 키랄성 전환방법
TWI247609B (en) 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
US6949522B2 (en) 2001-06-22 2005-09-27 Pharmasset, Inc. β-2′- or 3′-halonucleosides
JP2003172990A (ja) 2001-08-03 2003-06-20 Fuji Photo Film Co Ltd ハロゲン化銀乳剤及びハロゲン化銀写真感光材料
WO2004014931A1 (ja) 2002-08-09 2004-02-19 Taisho Pharmaceutical Co., Ltd. アリール５−チオ−β−Ｄ−グルコピラノシド誘導体及びそれを含有する糖尿病治療薬
AU2003200960B2 (en) 2002-09-18 2005-01-06 Mackinnon, Sebastian Mr System for Ordering, Tracking and Payment of Goods and Services
JP2006528691A (ja) 2003-05-12 2006-12-21 パーデュー・リサーチ・ファウンデーション 細胞傷害性インデノおよびイソインドロイソキノロン
CA2527203C (en) 2003-05-28 2010-08-17 Japan Tobacco Inc. Casr antagonist
WO2004106352A1 (ja) 2003-05-29 2004-12-09 Taisho Pharmaceutical Co., Ltd. アルドヘキソピラノース中間体の製造法
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
AU2004274021B2 (en) 2003-09-18 2009-08-13 Isis Pharmaceuticals, Inc. 4'-thionucleosides and oligomeric compounds
TW200637839A (en) 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
JP5317257B2 (ja) 2005-02-21 2013-10-16 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
JP2006335737A (ja) 2005-06-03 2006-12-14 Ihara Nikkei Kagaku Kogyo Kk ベンゾ［ｃ］ヘテロ５員環化合物の製造方法
WO2007068113A1 (en) 2005-12-16 2007-06-21 Mcgill University 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof
CN100513395C (zh) 2006-04-17 2009-07-15 中国科学院化学研究所 一种制备多羟基环状硝酮的方法
EP2012799B1 (en) * 2006-05-03 2016-08-24 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
CN101200463B (zh) 2007-12-11 2011-06-22 复旦大学 全酰化-4-硫代-d-核糖及其制备方法
US8859589B2 (en) 2008-03-12 2014-10-14 Southern Research Institute Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
CN101880287B (zh) 2009-05-05 2012-07-25 上海医药工业研究院 一类四氢噻吩核苷类似物的中间体化合物及其制备方法
EP2431376B2 (en) * 2009-05-15 2024-02-07 Delta-Fly Pharma, Inc. Novel stable crystal of 1-(2'-cyano-2'-deoxy-beta -d-arabinofuranosyl)cytosine monohydrochloride
BR112012014490B1 (pt) 2009-12-18 2021-07-13 Libramedicina, Inc Processos para a preparação de 1-o-acil-2-desóxi-2-fluoro-4-tio-?-d-arabinofuranoses e compostos intermediários dos mesmos
GB201016855D0 (en) 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
DE102010042013A1 (de) 2010-10-06 2012-04-12 Robert Bosch Gmbh Verfahren zur Einstellung einer Temperatur eines Sensorelements
JP5776564B2 (ja) 2012-01-20 2015-09-09 日本精工株式会社 ワーク処理装置、及びワーク処理方法
US20140029864A1 (en) 2012-07-30 2014-01-30 Dror Reif Compression encoding and decoding method and apparatus
AU2013303534B2 (en) 2012-08-13 2016-06-30 Fujifilm Corporation Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
CA2975990A1 (en) 2015-04-03 2016-10-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Novel compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof

Also Published As

Publication number Publication date
NZ701245A (en) 2015-12-24
JP5833225B2 (ja) 2015-12-16
PL2832740T3 (pl) 2019-09-30
KR20170082650A (ko) 2017-07-14
CA2865742C (en) 2017-04-18
RU2600734C2 (ru) 2016-10-27
KR20140139108A (ko) 2014-12-04
ES2730679T3 (es) 2019-11-12
IL234222A (en) 2017-11-30
KR101770246B1 (ko) 2017-08-22
TW201343665A (zh) 2013-11-01
BR112014020416A2 (pt) 2021-07-06
CN104203969B (zh) 2016-08-31
BR112014020416B1 (pt) 2022-03-29
EP2832740A1 (en) 2015-02-04
US9896471B2 (en) 2018-02-20
EP2832740A4 (en) 2015-11-11
MX2014011182A (es) 2014-11-13
RU2014143277A (ru) 2016-05-27
CA2865742A1 (en) 2013-10-03
SG11201406080VA (en) 2014-11-27
MX352423B (es) 2017-11-24
JPWO2013146833A1 (ja) 2015-12-14
WO2013146833A1 (ja) 2013-10-03
CA2943998A1 (en) 2013-10-03
EP2832740B1 (en) 2019-04-24
AU2013241341B2 (en) 2016-09-08
US20150011499A1 (en) 2015-01-08
CA2943998C (en) 2018-03-27
TWI637963B (zh) 2018-10-11
MX370733B (es) 2019-12-20
HK1201273A1 (zh) 2015-08-28
DK2832740T3 (da) 2019-07-15
AU2013241341A1 (en) 2014-09-11
CN104203969A (zh) 2014-12-10

Similar Documents

Publication Publication Date Title
IL273276A (en) salt crystals
HK1201273A1 (zh) -β- -脫氧- -氟- -硫代-β- -阿拉伯呋喃糖基 胞嘧啶的鹽
HK1215023A1 (zh) 雜環谷氨酰胺酶抑制劑
GB201507921D0 (en) Mapping cytosine modifications
ZA201406082B (en) Use of ccr3-inhibitors
EP2866893A4 (en) HETEROCYCLIC GUANIDINE F1FO ATPASE INHIBITORS
HK1211024A1 (en) Inhibitors of syk syk
HK1209422A1 (en) Fbxo3 inhibitors fbxo3
HK1209105A1 (en) Vegfr3 inhibitors vegfr3
HK1209104A1 (en) Vegfr3 inhibitors vegfr3
EP2881113A4 (en) NEW APPLICATION OF POGOSTONE
PL2888228T3 (pl) Inhibitory oddziaływania CD40-TRAF6
HK1215571A1 (zh) 二鹽酸科比思特
IL238391A (en) Rock inhibitors
EP2812807A4 (en) REAL PROPERTY OF SHARED DATA
GB2523919B (en) Mapping cytosine modifications
GB201201857D0 (en) Pseudonymisation/de-pseudonymisation of data
GB201217666D0 (en) Construction of surfaces