RU2014127270A - Аналог человеческого инсулина и его ацилированное производное - Google Patents
Аналог человеческого инсулина и его ацилированное производное Download PDFInfo
- Publication number
- RU2014127270A RU2014127270A RU2014127270A RU2014127270A RU2014127270A RU 2014127270 A RU2014127270 A RU 2014127270A RU 2014127270 A RU2014127270 A RU 2014127270A RU 2014127270 A RU2014127270 A RU 2014127270A RU 2014127270 A RU2014127270 A RU 2014127270A
- Authority
- RU
- Russia
- Prior art keywords
- human insulin
- insulin
- absent
- analogue
- chain
- Prior art date
Links
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title claims abstract 38
- 150000003839 salts Chemical class 0.000 claims abstract 20
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims abstract 13
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims abstract 8
- 125000000539 amino acid group Chemical group 0.000 claims abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 28
- 108090001061 Insulin Proteins 0.000 claims 9
- 102000004877 Insulin Human genes 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- -1 diamine compound Chemical class 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102220092852 rs754853086 Human genes 0.000 claims 3
- 108010033276 Peptide Fragments Proteins 0.000 claims 2
- 102000007079 Peptide Fragments Human genes 0.000 claims 2
- 230000010933 acylation Effects 0.000 claims 2
- 238000005917 acylation reaction Methods 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001371 alpha-amino acids Chemical class 0.000 claims 2
- 235000008206 alpha-amino acids Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 239000004026 insulin derivative Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002288 cocrystallisation Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000006911 enzymatic reaction Methods 0.000 claims 1
- 239000000446 fuel Substances 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000006320 pegylation Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110422095.2 | 2011-12-15 | ||
| CN201110422095 | 2011-12-15 | ||
| PCT/CN2012/085054 WO2013086927A1 (zh) | 2011-12-15 | 2012-11-22 | 人胰岛素类似物及其酰化衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014127270A true RU2014127270A (ru) | 2016-02-10 |
Family
ID=48611849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014127270A RU2014127270A (ru) | 2011-12-15 | 2012-11-22 | Аналог человеческого инсулина и его ацилированное производное |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9458219B2 (enExample) |
| EP (1) | EP2784085A4 (enExample) |
| JP (1) | JP6153206B2 (enExample) |
| KR (1) | KR20140104994A (enExample) |
| CN (2) | CN103443122B (enExample) |
| AU (1) | AU2012350586B2 (enExample) |
| BR (1) | BR112014013483A2 (enExample) |
| CA (1) | CA2858253A1 (enExample) |
| IN (1) | IN2014MN00933A (enExample) |
| MX (1) | MX2014006698A (enExample) |
| RU (1) | RU2014127270A (enExample) |
| TW (1) | TW201323439A (enExample) |
| WO (1) | WO2013086927A1 (enExample) |
| ZA (1) | ZA201404417B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3341403B1 (en) | 2015-08-25 | 2022-01-05 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| CN106496322A (zh) * | 2015-09-07 | 2017-03-15 | 江苏恒瑞医药股份有限公司 | 人胰岛素或其类似物的酰化衍生物的制备方法 |
| CN105491227A (zh) * | 2015-11-20 | 2016-04-13 | 努比亚技术有限公司 | 一种消息排列方法和终端 |
| EP3260548A1 (en) | 2016-06-21 | 2017-12-27 | Enzypep B.V. | Enzymatic coupling of (oligo)peptides to the b-chain of an insulin receptor ligand |
| US10815287B2 (en) | 2016-08-02 | 2020-10-27 | Jiangsu Hengrui Medicine Co., Ltd. | Acylated derivative of human insulin or analogue thereof |
| CA3090199A1 (en) * | 2018-02-01 | 2019-08-08 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising acylated derivative of human insulin analog and preparation method thereof |
| AU2019218315A1 (en) * | 2018-02-09 | 2020-07-09 | Jiangsu Hengrui Medicine Co., Ltd. | Codon optimized precursor gene and signal peptide gene of human insulin analogue |
| CA3122636A1 (en) | 2018-12-11 | 2020-06-18 | Sanofi | Insulin analogs having reduced insulin receptor binding affinity |
| CN111909255A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 胰岛素衍生物及其制备方法 |
| MY208364A (en) | 2019-12-11 | 2025-05-01 | Novo Nordisk As | Novel insulin analogues and uses thereof |
| CA3166494A1 (en) | 2019-12-30 | 2021-07-08 | Gan & Lee Pharmaceuticals Co., Ltd. | Insulin derivative |
| CN113773398B (zh) * | 2020-06-10 | 2023-05-23 | 宁波鲲鹏生物科技有限公司 | 一种德谷胰岛素衍生物及其应用 |
| US20240374692A1 (en) * | 2021-05-24 | 2024-11-14 | Sunshine Lake Pharma Co., Ltd. | A novel acylated insulin analog |
| WO2022268208A1 (zh) | 2021-06-25 | 2022-12-29 | 甘李药业股份有限公司 | 含酰化胰岛素的药物组合物 |
| CN118574842A (zh) | 2022-01-28 | 2024-08-30 | 甘李药业股份有限公司 | 酰化胰岛素 |
| CN118063589A (zh) * | 2024-02-04 | 2024-05-24 | 乐普健糖药业(重庆)有限公司 | 一种超长效胰岛素类似物及其制备方法和用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5008241A (en) | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| AU616205B2 (en) | 1988-07-20 | 1991-10-24 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
| KR910700262A (ko) | 1988-12-23 | 1991-03-14 | 안네 제케르 | 사람 인슐린 유사체 |
| DE69428134T2 (de) * | 1993-09-17 | 2002-05-02 | Novo Nordisk A/S, Bagsvaerd | Acyliertes insulin |
| CN1195777A (zh) | 1997-05-28 | 1998-10-14 | 姚维明 | 电力拖动实验仪 |
| KR20030004317A (ko) * | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법 |
| US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
| US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| CN1780854A (zh) | 2003-04-29 | 2006-05-31 | 伊莱利利公司 | 具有延长时间作用的胰岛素类似物 |
| CN1829738B (zh) * | 2003-08-05 | 2012-07-04 | 诺沃挪第克公司 | 新型胰岛素衍生物 |
| BRPI0413276B8 (pt) * | 2003-08-05 | 2021-05-25 | Novo Nordisk As | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
| CN101721712A (zh) * | 2008-10-21 | 2010-06-09 | 何明磊 | 一种双链聚乙二醇－胰岛素复合物及其制备方法 |
-
2012
- 2012-11-22 KR KR1020147018616A patent/KR20140104994A/ko not_active Withdrawn
- 2012-11-22 BR BR112014013483A patent/BR112014013483A2/pt not_active IP Right Cessation
- 2012-11-22 RU RU2014127270A patent/RU2014127270A/ru not_active Application Discontinuation
- 2012-11-22 WO PCT/CN2012/085054 patent/WO2013086927A1/zh not_active Ceased
- 2012-11-22 AU AU2012350586A patent/AU2012350586B2/en not_active Ceased
- 2012-11-22 CA CA2858253A patent/CA2858253A1/en not_active Abandoned
- 2012-11-22 US US14/363,328 patent/US9458219B2/en not_active Expired - Fee Related
- 2012-11-22 CN CN201280011736.8A patent/CN103443122B/zh active Active
- 2012-11-22 CN CN201510174792.9A patent/CN104788556A/zh active Pending
- 2012-11-22 MX MX2014006698A patent/MX2014006698A/es unknown
- 2012-11-22 IN IN933MUN2014 patent/IN2014MN00933A/en unknown
- 2012-11-22 JP JP2014546293A patent/JP6153206B2/ja not_active Expired - Fee Related
- 2012-11-22 EP EP12857862.2A patent/EP2784085A4/en not_active Withdrawn
- 2012-11-30 TW TW101144976A patent/TW201323439A/zh unknown
-
2014
- 2014-06-17 ZA ZA2014/04417A patent/ZA201404417B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2858253A1 (en) | 2013-06-20 |
| CN104788556A (zh) | 2015-07-22 |
| US20140329745A1 (en) | 2014-11-06 |
| JP6153206B2 (ja) | 2017-06-28 |
| CN103443122B (zh) | 2016-05-11 |
| US9458219B2 (en) | 2016-10-04 |
| KR20140104994A (ko) | 2014-08-29 |
| EP2784085A4 (en) | 2015-07-08 |
| WO2013086927A1 (zh) | 2013-06-20 |
| MX2014006698A (es) | 2014-07-09 |
| CN103443122A (zh) | 2013-12-11 |
| AU2012350586B2 (en) | 2017-02-02 |
| JP2015501819A (ja) | 2015-01-19 |
| TW201323439A (zh) | 2013-06-16 |
| IN2014MN00933A (enExample) | 2015-05-01 |
| EP2784085A1 (en) | 2014-10-01 |
| HK1188795A1 (zh) | 2014-05-16 |
| BR112014013483A2 (pt) | 2019-09-24 |
| AU2012350586A1 (en) | 2014-07-03 |
| ZA201404417B (en) | 2016-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014127270A (ru) | Аналог человеческого инсулина и его ацилированное производное | |
| ES2628063T3 (es) | Análogos de glucagón que muestran una mayor solubilidad en tampones de pH fisiológicos | |
| JP6525471B2 (ja) | ヘプシジン類似体及びその使用 | |
| TWI809515B (zh) | 腸促胰島素(incretin)類似物及其用途 | |
| ES2558155T3 (es) | Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1 | |
| CN103649115B (zh) | 多肽 | |
| ES2662501T3 (es) | Derivados de amilina | |
| JP2014088384A (ja) | Ｐｅｇ修飾エキセンジンまたはエキセンジン類似体およびそれらの組成物および使用 | |
| JP2012512901A5 (enExample) | ||
| JP2011511778A5 (enExample) | ||
| KR20120128129A (ko) | 심장 병태의 치료 | |
| JP2024520861A (ja) | 遺伝性ヘモクロマトーシスの治療のためのヘプシジン模倣体 | |
| KR20150021087A (ko) | 페길화된 옥신토모둘린 변이체 | |
| RU2014101697A (ru) | Коагонисты рецепторов глюкагона/glp-1 | |
| EP2190871A1 (en) | Improved derivatives of amylin | |
| RU2012105355A (ru) | Производное аналога glp-1 или его фармацевтически приемлемые соли и их применение | |
| JP2005530732A5 (enExample) | ||
| RU2424246C2 (ru) | Способы сайт-специфического пегилирования | |
| CN104395338A (zh) | 人胰岛淀粉样多肽类似物 | |
| KR20200010353A (ko) | Mic-1 화합물 및 그 용도 | |
| US20160303245A1 (en) | Fatty acid derivatives of dimeric inhibitors of psd-95 | |
| JP2025519535A (ja) | 鎌状赤血球病の治療のためのヘプシジン模倣体 | |
| KR20230146040A (ko) | 글루카곤 유사 펩타이드-1 수용체 길항물질 | |
| JP2014500244A5 (enExample) | ||
| TW202415676A (zh) | 升糖素樣肽-1受體拮抗劑 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170329 |