RU2014108478A - Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) - Google Patents
Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) Download PDFInfo
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- RU2014108478A RU2014108478A RU2014108478/10A RU2014108478A RU2014108478A RU 2014108478 A RU2014108478 A RU 2014108478A RU 2014108478/10 A RU2014108478/10 A RU 2014108478/10A RU 2014108478 A RU2014108478 A RU 2014108478A RU 2014108478 A RU2014108478 A RU 2014108478A
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- wnt
- signaling pathway
- stem cell
- catenin signaling
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- 239000000203 mixture Substances 0.000 title claims 10
- 230000003412 degenerative effect Effects 0.000 title claims 4
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- 102000013814 Wnt Human genes 0.000 claims abstract 31
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- 102000015735 Beta-catenin Human genes 0.000 claims abstract 30
- 108060000903 Beta-catenin Proteins 0.000 claims abstract 30
- 230000019491 signal transduction Effects 0.000 claims abstract 28
- 210000004027 cell Anatomy 0.000 claims abstract 25
- -1 indan-5-yloxy Chemical group 0.000 claims abstract 17
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims abstract 16
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims abstract 14
- 239000012190 activator Substances 0.000 claims abstract 13
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims abstract 12
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- 125000005842 heteroatom Chemical group 0.000 claims abstract 11
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- 125000001624 naphthyl group Chemical group 0.000 claims abstract 7
- ALJIEVIJBAJISI-NCELDCMTSA-N (2e)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4h-isoquinolin-1-yl)acetamide Chemical compound C1=CC(C(=O)C)=CC=C1N\N=C(\C(N)=O)C1=NC(C)(C)CC2=CC=CC=C12 ALJIEVIJBAJISI-NCELDCMTSA-N 0.000 claims abstract 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000004913 activation Effects 0.000 claims abstract 6
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims abstract 6
- 229960003964 deoxycholic acid Drugs 0.000 claims abstract 6
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims abstract 6
- 238000002513 implantation Methods 0.000 claims abstract 4
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- MDWJZBVEVLTXDE-UHFFFAOYSA-N 2-methyl-1h-indol-5-ol Chemical compound OC1=CC=C2NC(C)=CC2=C1 MDWJZBVEVLTXDE-UHFFFAOYSA-N 0.000 claims abstract 3
- GOVXKUCVZUROAN-UHFFFAOYSA-N 3-ethyl-1h-indole Chemical compound C1=CC=C2C(CC)=CNC2=C1 GOVXKUCVZUROAN-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims abstract 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims abstract 3
- FABQUVYDAXWUQP-UHFFFAOYSA-N N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine Chemical compound COC1=CC=CC(C=2N=C(N)N=C(NCC=3C=C4OCOC4=CC=3)C=2)=C1 FABQUVYDAXWUQP-UHFFFAOYSA-N 0.000 claims abstract 3
- 102000001708 Protein Isoforms Human genes 0.000 claims abstract 3
- 108010029485 Protein Isoforms Proteins 0.000 claims abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 230000007850 degeneration Effects 0.000 claims 9
- 208000002780 macular degeneration Diseases 0.000 claims 9
- 206010010356 Congenital anomaly Diseases 0.000 claims 8
- 206010064930 age-related macular degeneration Diseases 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 4
- 208000002177 Cataract Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 3
- 208000001140 Night Blindness Diseases 0.000 claims 3
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 3
- 208000017442 Retinal disease Diseases 0.000 claims 3
- 208000027073 Stargardt disease Diseases 0.000 claims 3
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 2
- BHFFSIFXFHJJNJ-UHFFFAOYSA-N 5-(benzenesulfonyl)-n-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide Chemical compound C1=C(S(=O)(=O)NCCCN(C)C)C(CC)=CC=C1S(=O)(=O)C1=CC=CC=C1 BHFFSIFXFHJJNJ-UHFFFAOYSA-N 0.000 claims 2
- 241000508725 Elymus repens Species 0.000 claims 2
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000003533 Leber congenital amaurosis Diseases 0.000 claims 1
- 208000014769 Usher Syndromes Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000790 retinal pigment Substances 0.000 claims 1
- 210000004127 vitreous body Anatomy 0.000 claims 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- XTVTWYSUSYRBQW-RGURZIINSA-N OC[C@H](Cc1c[nH]cn1)NC1N=CC=CN1 Chemical compound OC[C@H](Cc1c[nH]cn1)NC1N=CC=CN1 XTVTWYSUSYRBQW-RGURZIINSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/0623—Stem cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176713A EP2554662A1 (en) | 2011-08-05 | 2011-08-05 | Methods of treatment of retinal degeneration diseases |
| EP11176713.3 | 2011-08-05 | ||
| PCT/EP2012/065327 WO2013020945A1 (en) | 2011-08-05 | 2012-08-06 | Methods of treatment of retinal degeneration diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014108478A true RU2014108478A (ru) | 2015-09-10 |
Family
ID=46826437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014108478/10A RU2014108478A (ru) | 2011-08-05 | 2012-08-06 | Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140199277A1 (https=) |
| EP (2) | EP2554662A1 (https=) |
| JP (1) | JP2014527407A (https=) |
| KR (1) | KR20140068936A (https=) |
| CN (1) | CN104011203A (https=) |
| AR (1) | AR087471A1 (https=) |
| AU (1) | AU2012293681A1 (https=) |
| BR (1) | BR112014002718A8 (https=) |
| CA (1) | CA2844106A1 (https=) |
| CO (1) | CO7081142A2 (https=) |
| IL (1) | IL230830A0 (https=) |
| MX (1) | MX2014001475A (https=) |
| RU (1) | RU2014108478A (https=) |
| SG (1) | SG2014008080A (https=) |
| WO (1) | WO2013020945A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889441A (zh) | 2011-09-29 | 2014-06-25 | 伊丽莎白女王在都柏林附近神圣不可分割的三一学院教务长、研究员、学者及董事会其他成员 | 用于治疗退行性视网膜病况的组合物和方法 |
| AU2014378349B2 (en) | 2014-01-17 | 2021-06-03 | Riken | Method for manufacturing ciliary margin stem cells |
| BR112017005235B1 (pt) * | 2014-09-16 | 2023-10-31 | Genzyme Corporation | Vetores virais adeno-associados para o tratamento de glaucoma de miocilina (myoc) |
| RU2569481C1 (ru) * | 2014-12-25 | 2015-11-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения культуры клеток ретинального пигментного эпителия из глаза взрослого донора-трупа |
| RU2578526C1 (ru) * | 2014-12-25 | 2016-03-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения органной культуры хороидально-пигментного комплекса из глаза взрослого донора-трупа |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| KR101674622B1 (ko) * | 2016-07-07 | 2016-11-09 | 국민대학교산학협력단 | 세스퀴테르펜 유도체의 신규한 용도 |
| WO2018034945A1 (en) * | 2016-08-19 | 2018-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration |
| WO2018106369A2 (en) * | 2016-11-06 | 2018-06-14 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| JP2020518915A (ja) | 2017-04-27 | 2020-06-25 | パスハラキス スタブロスＰＡＳＣＨＡＬＡＫＩＳ， Ｓｔａｖｒｏｓ | 自動眼底画像分析用のシステムおよび方法 |
| PL3625228T3 (pl) | 2017-05-18 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Pochodne pirymidyny jako modulatory receptora pge2 |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| CN110621667A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 嘧啶衍生物 |
| EP3625224B1 (en) | 2017-05-18 | 2021-08-04 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
| WO2018232258A1 (en) * | 2017-06-15 | 2018-12-20 | University Of North Texas Health Science Center | Reprogramming fibroblasts to retinal cells |
| CN117379543A (zh) * | 2017-08-20 | 2024-01-12 | 加州大学董事会 | 治疗青光眼的Wnt5a的调节 |
| WO2019195717A1 (en) * | 2018-04-06 | 2019-10-10 | Icahn School Of Medicine At Mount Sinai | Compositions and methods of treatment of vision loss through generation of rod photoreceptors from müller glial cells |
| WO2020190848A1 (en) * | 2019-03-15 | 2020-09-24 | The Schepens Eye Research Institute, Inc. | Isolation, enrichment and expansion of cone progenitor cells and uses thereof |
| CN110706164A (zh) * | 2019-09-03 | 2020-01-17 | 北京爱博同心医学科技有限公司 | 基于增强现实的管状视野图像变形显示方法及眼镜 |
| US12558336B2 (en) | 2019-09-25 | 2026-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Metabolic rescue of retinal degeneration |
| KR20210119766A (ko) * | 2020-03-25 | 2021-10-06 | 서울대학교병원 | 인간 배아줄기세포 유래 중간엽 줄기세포를 포함하는 망막색소변성의 예방 또는 치료용 약학적 조성물 |
| KR102655748B1 (ko) * | 2023-06-08 | 2024-04-05 | 충북대학교 산학협력단 | 고포도당 조건에서의 중간엽 줄기세포의 생존율을 증가시키는 방법 |
| KR102655735B1 (ko) * | 2023-06-09 | 2024-04-05 | 충북대학교 산학협력단 | 당뇨성 망막병증의 예방 및 치료를 위한 타크로리무스 전처리 줄기세포 |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
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| US6128654A (en) | 1997-02-14 | 2000-10-03 | Advanced Micro Devices, Inc. | Method and apparatus for transmitting multiple copies by replicating data identifiers |
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-
2011
- 2011-08-05 EP EP11176713A patent/EP2554662A1/en not_active Withdrawn
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2012
- 2012-08-06 MX MX2014001475A patent/MX2014001475A/es not_active Application Discontinuation
- 2012-08-06 US US14/237,297 patent/US20140199277A1/en not_active Abandoned
- 2012-08-06 CA CA2844106A patent/CA2844106A1/en not_active Abandoned
- 2012-08-06 AU AU2012293681A patent/AU2012293681A1/en not_active Abandoned
- 2012-08-06 RU RU2014108478/10A patent/RU2014108478A/ru not_active Application Discontinuation
- 2012-08-06 KR KR1020147006060A patent/KR20140068936A/ko not_active Withdrawn
- 2012-08-06 CN CN201280049453.2A patent/CN104011203A/zh active Pending
- 2012-08-06 AR ARP120102872A patent/AR087471A1/es unknown
- 2012-08-06 BR BR112014002718A patent/BR112014002718A8/pt not_active IP Right Cessation
- 2012-08-06 SG SG2014008080A patent/SG2014008080A/en unknown
- 2012-08-06 WO PCT/EP2012/065327 patent/WO2013020945A1/en not_active Ceased
- 2012-08-06 JP JP2014523346A patent/JP2014527407A/ja active Pending
- 2012-08-06 EP EP12756386.4A patent/EP2739723A1/en not_active Withdrawn
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2014
- 2014-02-05 IL IL230830A patent/IL230830A0/en unknown
- 2014-03-05 CO CO14047158A patent/CO7081142A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012293681A1 (en) | 2014-03-06 |
| WO2013020945A1 (en) | 2013-02-14 |
| JP2014527407A (ja) | 2014-10-16 |
| MX2014001475A (es) | 2014-07-22 |
| US20140199277A1 (en) | 2014-07-17 |
| EP2554662A1 (en) | 2013-02-06 |
| AR087471A1 (es) | 2014-03-26 |
| CN104011203A (zh) | 2014-08-27 |
| WO2013020945A9 (en) | 2013-04-04 |
| IL230830A0 (en) | 2014-03-31 |
| CA2844106A1 (en) | 2013-02-14 |
| SG2014008080A (en) | 2014-03-28 |
| NZ621345A (en) | 2015-09-25 |
| CO7081142A2 (es) | 2014-10-10 |
| EP2739723A1 (en) | 2014-06-11 |
| BR112014002718A8 (pt) | 2017-06-20 |
| BR112014002718A2 (pt) | 2017-06-13 |
| KR20140068936A (ko) | 2014-06-09 |
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| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
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