RU2010154517A - Микрофлюидальная тонкопленочная структура для дозирования текучих сред - Google Patents
Микрофлюидальная тонкопленочная структура для дозирования текучих сред Download PDFInfo
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- RU2010154517A RU2010154517A RU2010154517/05A RU2010154517A RU2010154517A RU 2010154517 A RU2010154517 A RU 2010154517A RU 2010154517/05 A RU2010154517/05 A RU 2010154517/05A RU 2010154517 A RU2010154517 A RU 2010154517A RU 2010154517 A RU2010154517 A RU 2010154517A
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- Prior art keywords
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- 239000012530 fluid Substances 0.000 title claims 3
- 239000010409 thin film Substances 0.000 title 1
- 239000000758 substrate Substances 0.000 claims abstract 44
- 239000010410 layer Substances 0.000 claims abstract 13
- 238000007789 sealing Methods 0.000 claims abstract 8
- 239000000463 material Substances 0.000 claims abstract 6
- 239000011247 coating layer Substances 0.000 claims abstract 4
- 238000002844 melting Methods 0.000 claims abstract 4
- 230000008018 melting Effects 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 230000008569 process Effects 0.000 claims abstract 2
- 230000007704 transition Effects 0.000 claims abstract 2
- 238000005452 bending Methods 0.000 claims 3
- 238000003475 lamination Methods 0.000 claims 3
- 230000009471 action Effects 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000004858 capillary barrier Effects 0.000 claims 1
- 230000008859 change Effects 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 238000010030 laminating Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
- B29C65/18—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
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- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/32—Measures for keeping the burr form under control; Avoiding burr formation; Shaping the burr
- B29C66/328—Leaving the burrs unchanged for providing particular properties to the joint, e.g. as decorative effect
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
- B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
- B29C66/53—Joining single elements to tubular articles, hollow articles or bars
- B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
- B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
- B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
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- B29C66/723—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/082—Active control of flow resistance, e.g. flow controllers
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
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- B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
- B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
- B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
- B29C66/81411—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
- B29C66/81415—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being bevelled
- B29C66/81419—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being bevelled and flat
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
- B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
- B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
- B29C66/81411—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
- B29C66/81421—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave
- B29C66/81422—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave being convex
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
- B29C66/818—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps
- B29C66/8181—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the cooling constructional aspects
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/832—Reciprocating joining or pressing tools
- B29C66/8322—Joining or pressing tools reciprocating along one axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
- Laminated Bodies (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
1. Микрофлюидальная структура, включающая подложку (1) и пленку (2), прикрепленную по плоскости к подложке (1) с неприкрепленными частями (25) так, что над плоскостью (21) подложки в неприкрепленной части (25) сформированы камера (6) или канал (5), отличающаяся тем, что пленка (2) является многослойной пленкой, в частности двухслойной пленкой, включающей герметизирующий слой (4), расположенный на подложке, и покрывающий слой (3), расположенный над ним, причем температура плавления и/или размягчения герметизирующего слоя (4) ниже, чем у покрывающего слоя (3), а в области кромки между неприкрепленной частью (25) и прикрепленной частью (24) за счет вязкого течения материала пленки в процессе прикрепления пленки (2) к подожке (1) сформирован клин материала (11), образующий переход между стенкой камеры и подложкой (1) и поднимающий стенку камеры от плоскости (21) подложки. ! 2. Микрофлюидальная структура по п.1, отличающаяся тем, что температура размягчения герметизирующего слоя (4) составляет от 60°C до 200°C, в частности от 85°C до 110°C, а температура размягчения покрывающего слоя (3) составляет от 150°C до 350°C, в частности от 200°C до 300°C. ! 3. Микрофлюидальная структура по п.1, отличающаяся тем, что камерой (6) и (или) каналами (5) над плоскостью подложки формируется микрофлюидальная цепь. ! 4. Микрофлюидальная структура по п.1, отличающаяся тем, что в подложке (1) сформированы углубления (22) в форме каналов (5), и камера (6) или канал (5) в пленке прикрывают один конец отрезка (5) канала в подложке, а стенки отрезка канала в подложке (1) образуют уступ перед камерой (6) или перед каналом (5) в пленке (2). ! 5. Микрофлюидальная структура по одному из пп.3 или 4, отличающаяся тем, что кам�
Claims (15)
1. Микрофлюидальная структура, включающая подложку (1) и пленку (2), прикрепленную по плоскости к подложке (1) с неприкрепленными частями (25) так, что над плоскостью (21) подложки в неприкрепленной части (25) сформированы камера (6) или канал (5), отличающаяся тем, что пленка (2) является многослойной пленкой, в частности двухслойной пленкой, включающей герметизирующий слой (4), расположенный на подложке, и покрывающий слой (3), расположенный над ним, причем температура плавления и/или размягчения герметизирующего слоя (4) ниже, чем у покрывающего слоя (3), а в области кромки между неприкрепленной частью (25) и прикрепленной частью (24) за счет вязкого течения материала пленки в процессе прикрепления пленки (2) к подожке (1) сформирован клин материала (11), образующий переход между стенкой камеры и подложкой (1) и поднимающий стенку камеры от плоскости (21) подложки.
2. Микрофлюидальная структура по п.1, отличающаяся тем, что температура размягчения герметизирующего слоя (4) составляет от 60°C до 200°C, в частности от 85°C до 110°C, а температура размягчения покрывающего слоя (3) составляет от 150°C до 350°C, в частности от 200°C до 300°C.
3. Микрофлюидальная структура по п.1, отличающаяся тем, что камерой (6) и (или) каналами (5) над плоскостью подложки формируется микрофлюидальная цепь.
4. Микрофлюидальная структура по п.1, отличающаяся тем, что в подложке (1) сформированы углубления (22) в форме каналов (5), и камера (6) или канал (5) в пленке прикрывают один конец отрезка (5) канала в подложке, а стенки отрезка канала в подложке (1) образуют уступ перед камерой (6) или перед каналом (5) в пленке (2).
5. Микрофлюидальная структура по одному из пп.3 или 4, отличающаяся тем, что камера (6) или канал (5) прикрывают сквозное окно (8), в частности поперечное отверстие (8) в подложке (1), и наружная кромка камеры (6) расположена над поперечным отверстием (8) так, что между стенкой камеры и кромкой (12) уступа образуется капиллярный зазор от 1 до 20 мкм, в частности от 3 до 10 мкм, и (или) канал (5) открывается в поперечное отверстие (8) сверху и снизу, и (или) пленки (2) расположены сверху и снизу подложки.
6. Микрофлюидальная структура по п.1, отличающаяся тем, что камера (6) и (или) канал (5) имеют дискообразное поперечное сечение, в частности, в форме сегмента сферы, причем ширина сечения по меньшей мере в 20 раз больше высоты сечения, а угол, сформированный между стенкой камеры в области кромки поперечного сечения и плоскостью подложки (21), составляет от 1° до 20°, в частности от 5° до 12°.
7. Микрофлюидальная структура по п.6, отличающаяся тем, что высота камеры составляет от 10 до 15 мкм в первой области поперечного сечения в наивысшей точке (13) камеры, 5-10 мкм во второй области поперечного сечения между наивысшей точкой (13) и кромкой и от 0,1 до 5 мкм в третьей области кромки так, что в результате изменяющейся высоты поперечного сечения частицы жидкой крови различных размеров распределяются по различным областям потока, благодаря чему красные кровяные тельца протекают преимущественно в первой области, тромбоциты протекают преимущественно во второй области, а плазма крови протекает преимущественно в третьей области.
8. Микрофлюидальная структура по п.6, отличающаяся тем, что центр (13) свода или купола относительно плоскости (21) подложки понижен относительно наружной области так, что расстояние плоскости (21) подложки от центра купола меньше половины максимального вертикального расстояния между стенкой купола и плоскостью (21) подложки, а сквозное окно (8), в частности поперечное отверстие (8), расположено под куполом (13) камеры так, что опущенный центр купола действует как точка создания капилляра.
9. Микрофлюидальная структура по п.4, отличающаяся тем, что кромка (12) уступа формирует капиллярный барьер, в то время как активизацией гибкой стенки камеры зазор между стенкой камеры и краем уступа может быть изменен так, что зазор смачивается.
10. Микрофлюидальная структура по п.6, отличающаяся тем, что по меньшей мере два конца канала, сформированные в подложке, покрыты куполообразной камерой, и подложка (1) имеет углубление (22) в области под неприкрепленной пленкой, в частности, снизу подложки, удаленное от пленки и имеющее форму клина, или сферы, или полусферы, или прямоугольную.
11. Микрофлюидальная структура по п.10, отличающаяся тем, что подложка (1) обладает гибкостью, в частности, может быть подвергнута напряжениям изгиба, в частности, может быть упруго изогнута в противоположные стороны в клиновой области, и подложка (1) включает средства для механического зажима, которые являются направляющими и контактными точками (23).
12. Микрофлюидальная структура по п.1, отличающаяся тем, что материал подложки обладает эластичностью, причем толщина подложки уменьшена вдоль части протяженности камеры и (или) канала так, что эта область деформируется при уменьшенной изгибающей силе, в частности, вызывает изменение поперечного сечения камеры или канала для текучей среды в пленке, и под подложкой (1) расположен опорный элемент (26), в частности упор для поддерживания подложки с уменьшенной толщиной так, чтобы в канале для текучей среды формировалось сужение, которое может регулироваться изгибом структуры.
13. Способ изготовления микрофлюидальной структуры, имеющей конструкцию, в частности, в соответствии с предыдущими пунктами, в которой плоская планарная пленка (2) ламинирована на плоскую листообразную подложку (1), отличающийся тем, что для ламинирования прижимают шаблон (31), имеющий по меньшей мере одно углубление (22) или отверстие, на пленку (2) на подложке под давлением и (или) под действием тепла, благодаря чему пленку доводят до по меньшей мере температуры, при которой происходит вязкое течение пленки и (или) среды подложки в область углубления или окна так, что образуется клин материала (11), и пленка вспучивается в области углубления, формируя камеру.
14. Способ по п.13, отличающийся тем, что на подложку ламинируется по меньшей мере двухслойная пленка (2), причем слой пленки, прилегающий к подложке, в частности герметизирующий слой (4), имеет более низкую температуру размягчения и (или) температуру плавления, чем наружная закрывающая пленка (3), и при ламинировании устанавливают температуру, близкую к температуре плавления и (или) размягчения герметизирующей пленки (4), при этом температура ламинирования составляет от 70°C до 350°C, в частности от 120°C до 150°C.
15. Способ по любому из пп.13 или 14, отличающийся тем, что пленку (2) ламинируют на подложку (1) с использованием шаблона в форме роликовой волоки и (или) пластинчатого шаблона (31) и (или) пленки ламинируют на подложку посредством шаблона в форме матричного пресса для ламинирования.
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WO1997010435A2 (de) * | 1995-09-15 | 1997-03-20 | Institut Für Mikro- Und Informationstechnik Hahn-Schickard-Gesellschaft | Rückschlagventillose fluidpumpe |
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JP2008284626A (ja) * | 2007-05-16 | 2008-11-27 | Miraial Kk | マイクロ流路デバイス |
-
2008
- 2008-06-02 AT AT08010082T patent/ATE485101T1/de active
- 2008-06-02 ES ES08010082T patent/ES2352581T3/es active Active
- 2008-06-02 DE DE200850001596 patent/DE502008001596D1/de active Active
- 2008-06-02 DK DK08010082T patent/DK2138233T3/da active
- 2008-06-02 EP EP20080010082 patent/EP2138233B1/de active Active
-
2009
- 2009-06-02 KR KR1020107029790A patent/KR101566182B1/ko active IP Right Grant
- 2009-06-02 JP JP2011510902A patent/JP5436550B2/ja active Active
- 2009-06-02 NZ NZ589466A patent/NZ589466A/xx unknown
- 2009-06-02 AU AU2009262555A patent/AU2009262555B2/en active Active
- 2009-06-02 WO PCT/EP2009/003908 patent/WO2009156045A2/en active Application Filing
- 2009-06-02 BR BRPI0913340-2A patent/BRPI0913340B1/pt active IP Right Grant
- 2009-06-02 CN CN200980130360.0A patent/CN102112229B/zh active Active
- 2009-06-02 MX MX2010013204A patent/MX2010013204A/es active IP Right Grant
- 2009-06-02 CA CA2726219A patent/CA2726219C/en active Active
- 2009-06-02 US US12/995,550 patent/US8580209B2/en active Active
- 2009-06-02 RU RU2010154517/05A patent/RU2515287C2/ru active
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2010
- 2010-11-18 IL IL209405A patent/IL209405A/en active IP Right Grant
- 2010-11-18 ZA ZA2010/08267A patent/ZA201008267B/en unknown
- 2010-12-01 CL CL2010001328A patent/CL2010001328A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN102112229B (zh) | 2014-08-06 |
EP2138233A1 (de) | 2009-12-30 |
ATE485101T1 (de) | 2010-11-15 |
WO2009156045A3 (en) | 2010-03-18 |
WO2009156045A2 (en) | 2009-12-30 |
KR101566182B1 (ko) | 2015-11-05 |
CA2726219A1 (en) | 2009-12-30 |
RU2515287C2 (ru) | 2014-05-10 |
US20110135546A1 (en) | 2011-06-09 |
DK2138233T3 (da) | 2011-01-31 |
CN102112229A (zh) | 2011-06-29 |
CA2726219C (en) | 2016-03-15 |
ES2352581T3 (es) | 2011-02-21 |
NZ589466A (en) | 2013-08-30 |
JP5436550B2 (ja) | 2014-03-05 |
ZA201008267B (en) | 2011-07-27 |
BRPI0913340A2 (pt) | 2015-11-24 |
MX2010013204A (es) | 2011-02-25 |
JP2011524815A (ja) | 2011-09-08 |
EP2138233B1 (de) | 2010-10-20 |
KR20110021999A (ko) | 2011-03-04 |
CL2010001328A1 (es) | 2011-06-10 |
WO2009156045A4 (en) | 2010-05-20 |
IL209405A (en) | 2016-07-31 |
IL209405A0 (en) | 2011-01-31 |
DE502008001596D1 (de) | 2010-12-02 |
BRPI0913340B1 (pt) | 2019-06-25 |
AU2009262555B2 (en) | 2015-05-07 |
AU2009262555A1 (en) | 2009-12-30 |
US8580209B2 (en) | 2013-11-12 |
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