RU2010154517A - Микрофлюидальная тонкопленочная структура для дозирования текучих сред - Google Patents

Микрофлюидальная тонкопленочная структура для дозирования текучих сред Download PDF

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Publication number
RU2010154517A
RU2010154517A RU2010154517/05A RU2010154517A RU2010154517A RU 2010154517 A RU2010154517 A RU 2010154517A RU 2010154517/05 A RU2010154517/05 A RU 2010154517/05A RU 2010154517 A RU2010154517 A RU 2010154517A RU 2010154517 A RU2010154517 A RU 2010154517A
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Russia
Prior art keywords
substrate
film
chamber
channel
region
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RU2010154517/05A
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English (en)
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RU2515287C2 (ru
Inventor
Дирк КУРОВСКИ (DE)
Дирк КУРОВСКИ
Марио ХЕМПЕЛЬ (DE)
Марио ХЕМПЕЛЬ
Герт БЛАНКЕНШТАЙН (DE)
Герт БЛАНКЕНШТАЙН
Тобиас РОДЕНФЕЛЬС (DE)
Тобиас РОДЕНФЕЛЬС
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Бёрингер Ингельхайм Майкропартс Гмбх (De)
Бёрингер Ингельхайм Майкропартс Гмбх
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00Subject matter not provided for in other groups of this subclass
    • F16K99/0001Microvalves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/10Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112Single lapped joints
    • B29C66/1122Single lap to lap joints, i.e. overlap joints
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/32Measures for keeping the burr form under control; Avoiding burr formation; Shaping the burr
    • B29C66/328Leaving the burrs unchanged for providing particular properties to the joint, e.g. as decorative effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/50General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/72General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined
    • B29C66/723General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the structure of the material of the parts to be joined being multi-layered
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04Pumps having electric drive
    • F04B43/043Micropumps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0689Sealing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0638Valves, specific forms thereof with moving parts membrane valves, flap valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/082Active control of flow resistance, e.g. flow controllers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/80General aspects of machine operations or constructions and parts thereof
    • B29C66/81General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81411General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
    • B29C66/81415General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being bevelled
    • B29C66/81419General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being bevelled and flat
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/80General aspects of machine operations or constructions and parts thereof
    • B29C66/81General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8141General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
    • B29C66/81411General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
    • B29C66/81421General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave
    • B29C66/81422General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave being convex
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    • B29C66/80General aspects of machine operations or constructions and parts thereof
    • B29C66/81General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/818General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps
    • B29C66/8181General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the cooling constructional aspects
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C66/80General aspects of machine operations or constructions and parts thereof
    • B29C66/83General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/832Reciprocating joining or pressing tools
    • B29C66/8322Joining or pressing tools reciprocating along one axis
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/756Microarticles, nanoarticles

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Laminated Bodies (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

1. Микрофлюидальная структура, включающая подложку (1) и пленку (2), прикрепленную по плоскости к подложке (1) с неприкрепленными частями (25) так, что над плоскостью (21) подложки в неприкрепленной части (25) сформированы камера (6) или канал (5), отличающаяся тем, что пленка (2) является многослойной пленкой, в частности двухслойной пленкой, включающей герметизирующий слой (4), расположенный на подложке, и покрывающий слой (3), расположенный над ним, причем температура плавления и/или размягчения герметизирующего слоя (4) ниже, чем у покрывающего слоя (3), а в области кромки между неприкрепленной частью (25) и прикрепленной частью (24) за счет вязкого течения материала пленки в процессе прикрепления пленки (2) к подожке (1) сформирован клин материала (11), образующий переход между стенкой камеры и подложкой (1) и поднимающий стенку камеры от плоскости (21) подложки. ! 2. Микрофлюидальная структура по п.1, отличающаяся тем, что температура размягчения герметизирующего слоя (4) составляет от 60°C до 200°C, в частности от 85°C до 110°C, а температура размягчения покрывающего слоя (3) составляет от 150°C до 350°C, в частности от 200°C до 300°C. ! 3. Микрофлюидальная структура по п.1, отличающаяся тем, что камерой (6) и (или) каналами (5) над плоскостью подложки формируется микрофлюидальная цепь. ! 4. Микрофлюидальная структура по п.1, отличающаяся тем, что в подложке (1) сформированы углубления (22) в форме каналов (5), и камера (6) или канал (5) в пленке прикрывают один конец отрезка (5) канала в подложке, а стенки отрезка канала в подложке (1) образуют уступ перед камерой (6) или перед каналом (5) в пленке (2). ! 5. Микрофлюидальная структура по одному из пп.3 или 4, отличающаяся тем, что кам�

Claims (15)

1. Микрофлюидальная структура, включающая подложку (1) и пленку (2), прикрепленную по плоскости к подложке (1) с неприкрепленными частями (25) так, что над плоскостью (21) подложки в неприкрепленной части (25) сформированы камера (6) или канал (5), отличающаяся тем, что пленка (2) является многослойной пленкой, в частности двухслойной пленкой, включающей герметизирующий слой (4), расположенный на подложке, и покрывающий слой (3), расположенный над ним, причем температура плавления и/или размягчения герметизирующего слоя (4) ниже, чем у покрывающего слоя (3), а в области кромки между неприкрепленной частью (25) и прикрепленной частью (24) за счет вязкого течения материала пленки в процессе прикрепления пленки (2) к подожке (1) сформирован клин материала (11), образующий переход между стенкой камеры и подложкой (1) и поднимающий стенку камеры от плоскости (21) подложки.
2. Микрофлюидальная структура по п.1, отличающаяся тем, что температура размягчения герметизирующего слоя (4) составляет от 60°C до 200°C, в частности от 85°C до 110°C, а температура размягчения покрывающего слоя (3) составляет от 150°C до 350°C, в частности от 200°C до 300°C.
3. Микрофлюидальная структура по п.1, отличающаяся тем, что камерой (6) и (или) каналами (5) над плоскостью подложки формируется микрофлюидальная цепь.
4. Микрофлюидальная структура по п.1, отличающаяся тем, что в подложке (1) сформированы углубления (22) в форме каналов (5), и камера (6) или канал (5) в пленке прикрывают один конец отрезка (5) канала в подложке, а стенки отрезка канала в подложке (1) образуют уступ перед камерой (6) или перед каналом (5) в пленке (2).
5. Микрофлюидальная структура по одному из пп.3 или 4, отличающаяся тем, что камера (6) или канал (5) прикрывают сквозное окно (8), в частности поперечное отверстие (8) в подложке (1), и наружная кромка камеры (6) расположена над поперечным отверстием (8) так, что между стенкой камеры и кромкой (12) уступа образуется капиллярный зазор от 1 до 20 мкм, в частности от 3 до 10 мкм, и (или) канал (5) открывается в поперечное отверстие (8) сверху и снизу, и (или) пленки (2) расположены сверху и снизу подложки.
6. Микрофлюидальная структура по п.1, отличающаяся тем, что камера (6) и (или) канал (5) имеют дискообразное поперечное сечение, в частности, в форме сегмента сферы, причем ширина сечения по меньшей мере в 20 раз больше высоты сечения, а угол, сформированный между стенкой камеры в области кромки поперечного сечения и плоскостью подложки (21), составляет от 1° до 20°, в частности от 5° до 12°.
7. Микрофлюидальная структура по п.6, отличающаяся тем, что высота камеры составляет от 10 до 15 мкм в первой области поперечного сечения в наивысшей точке (13) камеры, 5-10 мкм во второй области поперечного сечения между наивысшей точкой (13) и кромкой и от 0,1 до 5 мкм в третьей области кромки так, что в результате изменяющейся высоты поперечного сечения частицы жидкой крови различных размеров распределяются по различным областям потока, благодаря чему красные кровяные тельца протекают преимущественно в первой области, тромбоциты протекают преимущественно во второй области, а плазма крови протекает преимущественно в третьей области.
8. Микрофлюидальная структура по п.6, отличающаяся тем, что центр (13) свода или купола относительно плоскости (21) подложки понижен относительно наружной области так, что расстояние плоскости (21) подложки от центра купола меньше половины максимального вертикального расстояния между стенкой купола и плоскостью (21) подложки, а сквозное окно (8), в частности поперечное отверстие (8), расположено под куполом (13) камеры так, что опущенный центр купола действует как точка создания капилляра.
9. Микрофлюидальная структура по п.4, отличающаяся тем, что кромка (12) уступа формирует капиллярный барьер, в то время как активизацией гибкой стенки камеры зазор между стенкой камеры и краем уступа может быть изменен так, что зазор смачивается.
10. Микрофлюидальная структура по п.6, отличающаяся тем, что по меньшей мере два конца канала, сформированные в подложке, покрыты куполообразной камерой, и подложка (1) имеет углубление (22) в области под неприкрепленной пленкой, в частности, снизу подложки, удаленное от пленки и имеющее форму клина, или сферы, или полусферы, или прямоугольную.
11. Микрофлюидальная структура по п.10, отличающаяся тем, что подложка (1) обладает гибкостью, в частности, может быть подвергнута напряжениям изгиба, в частности, может быть упруго изогнута в противоположные стороны в клиновой области, и подложка (1) включает средства для механического зажима, которые являются направляющими и контактными точками (23).
12. Микрофлюидальная структура по п.1, отличающаяся тем, что материал подложки обладает эластичностью, причем толщина подложки уменьшена вдоль части протяженности камеры и (или) канала так, что эта область деформируется при уменьшенной изгибающей силе, в частности, вызывает изменение поперечного сечения камеры или канала для текучей среды в пленке, и под подложкой (1) расположен опорный элемент (26), в частности упор для поддерживания подложки с уменьшенной толщиной так, чтобы в канале для текучей среды формировалось сужение, которое может регулироваться изгибом структуры.
13. Способ изготовления микрофлюидальной структуры, имеющей конструкцию, в частности, в соответствии с предыдущими пунктами, в которой плоская планарная пленка (2) ламинирована на плоскую листообразную подложку (1), отличающийся тем, что для ламинирования прижимают шаблон (31), имеющий по меньшей мере одно углубление (22) или отверстие, на пленку (2) на подложке под давлением и (или) под действием тепла, благодаря чему пленку доводят до по меньшей мере температуры, при которой происходит вязкое течение пленки и (или) среды подложки в область углубления или окна так, что образуется клин материала (11), и пленка вспучивается в области углубления, формируя камеру.
14. Способ по п.13, отличающийся тем, что на подложку ламинируется по меньшей мере двухслойная пленка (2), причем слой пленки, прилегающий к подложке, в частности герметизирующий слой (4), имеет более низкую температуру размягчения и (или) температуру плавления, чем наружная закрывающая пленка (3), и при ламинировании устанавливают температуру, близкую к температуре плавления и (или) размягчения герметизирующей пленки (4), при этом температура ламинирования составляет от 70°C до 350°C, в частности от 120°C до 150°C.
15. Способ по любому из пп.13 или 14, отличающийся тем, что пленку (2) ламинируют на подложку (1) с использованием шаблона в форме роликовой волоки и (или) пластинчатого шаблона (31) и (или) пленки ламинируют на подложку посредством шаблона в форме матричного пресса для ламинирования.
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CN102112229B (zh) 2014-08-06
EP2138233A1 (de) 2009-12-30
ATE485101T1 (de) 2010-11-15
WO2009156045A3 (en) 2010-03-18
WO2009156045A2 (en) 2009-12-30
KR101566182B1 (ko) 2015-11-05
CA2726219A1 (en) 2009-12-30
RU2515287C2 (ru) 2014-05-10
US20110135546A1 (en) 2011-06-09
DK2138233T3 (da) 2011-01-31
CN102112229A (zh) 2011-06-29
CA2726219C (en) 2016-03-15
ES2352581T3 (es) 2011-02-21
NZ589466A (en) 2013-08-30
JP5436550B2 (ja) 2014-03-05
ZA201008267B (en) 2011-07-27
BRPI0913340A2 (pt) 2015-11-24
MX2010013204A (es) 2011-02-25
JP2011524815A (ja) 2011-09-08
EP2138233B1 (de) 2010-10-20
KR20110021999A (ko) 2011-03-04
CL2010001328A1 (es) 2011-06-10
WO2009156045A4 (en) 2010-05-20
IL209405A (en) 2016-07-31
IL209405A0 (en) 2011-01-31
DE502008001596D1 (de) 2010-12-02
BRPI0913340B1 (pt) 2019-06-25
AU2009262555B2 (en) 2015-05-07
AU2009262555A1 (en) 2009-12-30
US8580209B2 (en) 2013-11-12

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