JP2011524815A - 流体計量のためのマイクロフルイディック箔構造体 - Google Patents
流体計量のためのマイクロフルイディック箔構造体 Download PDFInfo
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- JP2011524815A JP2011524815A JP2011510902A JP2011510902A JP2011524815A JP 2011524815 A JP2011524815 A JP 2011524815A JP 2011510902 A JP2011510902 A JP 2011510902A JP 2011510902 A JP2011510902 A JP 2011510902A JP 2011524815 A JP2011524815 A JP 2011524815A
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- microfluidic structure
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Abstract
Description
したがって、本発明の目的は、マイクロフルイディック構造体の作製方法及びこの作製方法により経済的に作製できるマイクロフルイディック構造体を提供することにある。
曲げ中、チャネル又はチャンバの断面積は、曲げの数学的符号に応じて、小さくなり又は大きくなる。チャネル又はチャンバ内の流れをこのようにして故意に絞ることができる。
マイクロフルイディック構造体は、基板(1)によって形成され、この基板は、ボアの形態をした切れ目又は開口部(8)を有する。
フィルム(2)が基板キャリヤ(1)に少なくとも部分的に又は別々の領域で取り付けられている。
フィルム部分は、好ましくは、チャンバ(6)を環境から流体密状態に密封する。
2 フィルム
3 カバーフィルム
4 密封フィルム
5 チャネル
6 チャンバ
7 液体
8 ボア/貫流開口部
9 メニスカス
10 アクチュエータ
11 材料のウェッジ
12 段部/縁部
13 頂点
15 血小板
16 赤血球
17 血漿
20 チャネル端部
21 支持体平面
22 凹部/切欠き
23 接触点
24 取り付け領域
25 非取り付け領域
26 支持部材
27 疎水性ベント
28 容器/ブリスタ
29 粘着性層
30 圧縮空気
31 加圧ダイ
32 支持板
33 ベント
34 針
35 入口
36 出口
Claims (48)
- 基板(1)と、非取り付け部分(25)を備えた状態で前記基板(1)に平らに取り付けられたフィルム(2)とを有するマイクロフルイディック構造体であって、チャンバ(6)又はチャネル(5)が前記非取り付け部分(25)内において前記基板の平面(21)の上方に形成されるように構成されているマイクロフルイディック構造体において、
前記フィルム(2)を前記基板(1)に結合しているときに前記フィルム材料の粘性流れによって材料のウェッジ(11)が前記非取り付け部分(25)と取り付け部分(24)との間のエッジゾーンに形成され、前記材料ウェッジ(11)は、前記チャンバ壁と前記基板(1)との間の移行部となり、前記チャンバ壁を持ち上げて前記基板平面(21)から離している、
ことを特徴とするマイクロフルイディック構造体。 - 前記フィルム(2)は、多層フィルム、特に二層フィルムである、
請求項1記載のマイクロフルイディック構造体。 - 前記フィルム(2)は、前記基板に被着された密封層(4)と、前記密封層の上方に配置された被覆層(3)とから成る、
請求項2記載のマイクロフルイディック構造体。 - 前記密封層(4)は、前記被覆層(3)よりも低い融解温度及び/又は軟化温度を有する、
請求項3記載のマイクロフルイディック構造体。 - 前記密封層(4)の軟化温度は、60℃〜200℃、特に85℃〜110℃である、
請求項4記載のマイクロフルイディック構造体。 - 前記被覆層(3)の軟化温度は、150℃〜350℃、特に200℃〜300℃である、
請求項4記載のマイクロフルイディック構造体。 - 前記チャンバ(6)及び/又は前記チャネル(5)によってマイクロフルイディックネットワークが前記基板平面の上方に形成されている、
請求項1ないし6のいずれか1項に記載のマイクロフルイディック構造体。 - チャネル(5)の形態をした凹部(22)が前記基板(1)に形成され、前記フィルム内に設けられたチャンバ(6)又はチャネル(5)が前記基板内のチャネル区分(5)の一端部を覆うように位置している、
請求項1ないし7のいずれか1項に記載のマイクロフルイディック構造体。 - 前記基板(1)の前記チャネル区分の壁は、前記フィルム(2)内における前記チャンバ(6)又は前記チャネル(5)に対して段部を形成している、
請求項8記載のマイクロフルイディック構造体。 - 前記チャンバ(6)又は前記チャネル(5)は、前記基板(1)を貫通した貫流開口部(8)、特に横方向ボア(8)に被さるように位置している、
請求項7又は9記載のマイクロフルイディック構造体。 - 前記チャンバ(6)の外縁部は、1ミクロン〜20μm、特に3〜10ミクロンの毛管隙間が前記チャンバ壁と前記段部の縁(12)との間に作られるよう前記横方向ボア(8)の上方に配置されている、
請求項10記載のマイクロフルイディック構造体。 - チャネル(5)は、前記横方向ボア(8)内に頂部及び底部のところで開口している、
請求項9又は10記載のマイクロフルイディック構造体。 - 前記フィルム(2)は、前記基板の頂部及び底部に被着されている、
請求項12記載のマイクロフルイディック構造体。 - 前記チャンバ(6)及び/又は前記チャネル(5)は、断面が円板の形、特に球台の形をしており、その断面幅は、断面高さの少なくとも20倍であり、前記断面の縁領域の前記チャンバ壁と前記基板平面(21)とのなす角度は、1°〜20°、特に5°〜12°である、
請求項1又は2記載のマイクロフルイディック構造体。 - 前記チャンバ高さは、前記チャンバの頂点(13)のところの第1の断面領域では10〜15ミクロンであり、前記頂点(13)と前記縁部との間の第2の断面領域では5〜10μmであり、第3の縁領域では0.1μm〜5μmであり、断面高さが変化している結果として、互いに異なるサイズの流体粒子がこれら自体互いに異なる流れ領域内に位置するようになる、
請求項14記載のマイクロフルイディック構造体。 - 前記流体は、血液である、
請求項15記載のマイクロフルイディック構造体。 - 主として赤血球が前記第1の領域中を流れ、主として血小板が前記第2の領域中を流れ、主として結晶が前記第3の領域中を流れる、
請求項16記載のマイクロフルイディック構造体。 - 前記基板の平面(21)に対するキュポラ又はドームの中心(13)は、前記ドームの前記中心からの前記基板平面(21)の距離が前記ドームと前記基板平面(21)との間の最大垂直距離の半分未満であるよう外側領域に対して下げられている、
請求項14記載のマイクロフルイディック構造体。 - チャネル(5)又は貫流開口部(8)、特に横方向ボア(8)が前記チャンバドーム(13)の下に配置され、前記ドームの前記下げられている中心は、毛管作用開始箇所として働く、
請求項18記載のマイクロフルイディック構造体。 - 前記段部の縁(12)は、毛管作用停止部を形成し、柔軟性の前記チャンバ壁の作動により、前記チャンバ壁と前記段部の前記縁との間の隙間間隔を変更することができ、前記隙間が湿潤させるようにする、
請求項9ないし11のいずれか1項に記載のマイクロフルイディック構造体。 - 前記基板に形成された少なくとも2つのチャネル端部は、前記ドーム形チャンバによって覆われている、
請求項14記載のマイクロフルイディック構造体。 - 前記基板(1)は、前記フィルムから見て遠くに位置する前記非取り付け状態のフィルム部分の下の領域に、特に基板の底部に設けられた凹部(22)を有する、
請求項21記載のマイクロフルイディック構造体。 - 前記凹部(22)は、くさび形、球形、半球形、又は長方形である、
請求項22記載のマイクロフルイディック構造体。 - 前記基板(1)は、柔軟性であり、特に曲げ応力を受けることができ、特に、前記くさび領域について可逆的に弾性的に曲げ可能である、
請求項22記載のマイクロフルイディック構造体。 - 前記基板(1)は、機械的クランプ手段を有する、
請求項24記載のマイクロフルイディック構造体。 - 前記クランプ手段は、ガイド及び接触点(23)である、
請求項25記載のマイクロフルイディック構造体。 - 前記基板材料は、弾性である、
請求項1又は2記載のマイクロフルイディック構造体。 - 前記基板厚さは、チャンバ及び/又はチャネルの広がりの一部分に沿って減少しており、この領域は、小さな曲げ力を受けて変形し、特に前記フィルム内の前記流体チャンバ又は流体チャネルの断面の変化を生じさせるようになっている、
請求項27記載のマイクロフルイディック構造体。 - 厚さの減少した基板を支持するための支持部材(26)、特にアンビルが前記基板(1)の下に配置されている、
請求項28記載のマイクロフルイディック構造体。 - 前記流体チャネルは、前記マイクロフルイディック構造体を曲げることによって調節できる絞りを形成している、
請求項28又は29記載のマイクロフルイディック構造体。 - 特に請求項1ないし30のいずれか1項に記載のマイクロフルイディック構造体を作製する方法であって、平べったい平面状フィルム(2)を平べったいシート状基板(1)に積層する方法において、
前記積層のため、少なくとも1つの凹部(22)又は開口部を備えたマスク(31)を圧力下で且つ/或いは熱の作用下で前記基板上の前記フィルム(2)に押し付け、それにより、前記フィルムを少なくとも前記凹部又は前記開口部の付近へのフィルム及び/又は基板媒体の粘性流れが生じる温度に至らせて材料のウェッジを形成すると共にフィルムを凹部の付近で膨出させてチャンバを形成するようにする、
ことを特徴とする方法。 - 板状マスク(31)が用いられる、
請求項31記載の方法。 - 少なくとも二層フィルム(2)を前記フィルム層が前記基板に隣接した状態で前記基板に積層し、特に、前記密封層(4)は、外側被覆フィルム(3)よりも低い軟化温度及び/又は融解温度を有し、前記積層中、前記密封フィルム(4)の前記融解温度及び/又は前記軟化温度に近い温度を設定する、
請求項31又は32記載の方法。 - 70℃〜350℃、特に120℃〜150℃の積層温度を設定する、
請求項33記載の方法。 - ローラダイの形態をしたマスクを用いて前記フィルム(2)を前記基板(1)上に積層する、
請求項31ないし34のいずれか1項に記載の方法。 - 前記フィルムをダイラミネータの形態をしたマスクによって前記基板上に積層する、
請求項31ないし34のいずれか1項に記載の方法。 - 少なくとも1種類の液体をマイクロフルイディックネットワーク内で計量する方法であって、前記ネットワークは、基板平面上に成形されたフィルム(2)によってそれぞれ形成された少なくとも1つの液体運搬チャネル(5)及び/又は液体運搬チャンバ(6)を有し、貫流開口部又は横方向ボア(8)を覆う前記チャネル(5)及び/又は前記チャンバ(6)は、毛管停止部を形成し、前記フィルムを作動させることによって、前記チャンバの壁と前記横方向ボアとの間の隙間のサイズを減少させて前記フィルムが前記毛管停止部がなくなることによって湿潤されるようになる、
ことを特徴とする方法。 - ダイ(10)を用いて前記チャンバ(6)又はチャネルの頂部を前記貫流開口部(8)の方向に押し下げる、
請求項37記載の方法。 - 前記フィルム(2)と前記基板(1)との間に配置されたメンブレンを前記メンブレンが湿潤されるまで押し下げる、
請求項38記載の方法。 - 少なくとも1種類の液体をマイクロフルイディックネットワーク内で計量する方法であって、前記ネットワークは、基板平面(21)上に成形されたフィルム(2)によってそれぞれ形成された少なくとも1つの液体運搬チャネル(5)及び/又は液体運搬チャンバ(6)を有する方法において、
前記基板(1)を曲げることにより、前記液体運搬チャネル(5)又は液体運搬チャンバ(6)の高さを少なくとも部分的に変化させる、
ことを特徴とする方法。 - 前記基板(1)を前記基板(1)に設けられた凹部(22)の付近で曲げる、
請求項40記載の方法。 - 前記基板(1)を曲げることにより、その断面を変更して前記マイクロフルイディック構造体を通る流量を調節することができるようにし、前記マイクロフルイディック構造体は、特に、絞りとして働く、
請求項40又は41記載の方法。 - 前記基板(1)を曲げることにより、前記流体運搬構造体の断面を閉じ、その結果、前記マイクロフルイディック構造体は、特に弁又はポンプとして働く、
請求項40又は41記載の方法。 - 前記基板(1)の前記曲げは、調波の固有共振による励振によって実施される、
請求項40又は41記載の方法。 - 前記基板の前記曲げは、前記流体の運搬及び/又は伝搬方向における毛管による湿潤を助ける横波、特に垂直連続波により実施される、
請求項40又は41記載の方法。 - 少なくとも1種類の液体をマイクロフルイディックネットワーク内で計量する方法であって、前記ネットワークは、基板平面(21)上に成形されたフィルム(2)によってそれぞれ形成された少なくとも1つの液体運搬チャネル(5)及び/又は液体運搬チャンバ(6)を有する方法において、
前記フィルム材料を活性化温度よりも高い温度に加熱し、それにより前記フィルム材料が特に該フィルム材料の形状記憶効果により形状を変える、
ことを特徴とする方法。 - 前記形状変化中、弁を開き又は閉じる、
請求項46記載の方法。 - チャネル(5)を開き又は閉じる、
請求項46記載の方法。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
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US11305236B2 (en) | 2014-06-13 | 2022-04-19 | Gattaco Inc. | Surface tension driven filtration |
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US9914116B2 (en) * | 2015-09-10 | 2018-03-13 | Panasonic Intellectual Property Management Co., Ltd. | Microelement |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001510275A (ja) * | 1997-07-21 | 2001-07-31 | ワイエスアイ インコーポレーテッド | 微小流体分析モジュール |
JP2003139660A (ja) * | 2001-11-02 | 2003-05-14 | Kawamura Inst Of Chem Res | マイクロ流体デバイス及びその製造方法 |
JP2008284626A (ja) * | 2007-05-16 | 2008-11-27 | Miraial Kk | マイクロ流路デバイス |
JP2010515924A (ja) * | 2007-01-16 | 2010-05-13 | ラブ901 リミテッド | マイクロ流体デバイス |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU975056A1 (ru) * | 1981-03-18 | 1982-11-23 | Предприятие П/Я М-5534 | Автоматическа бюретка-дозатор |
FI844320A (fi) * | 1984-11-02 | 1986-05-03 | Labsystems Oy | Utspaedningsdoseringsanordning. |
EP0418836A3 (en) * | 1989-09-22 | 1991-11-21 | Hercules Incorporated | Multilayer oriented film containing polypropylene and co-polyester |
TW313588B (ja) * | 1992-10-23 | 1997-08-21 | Eastman Kodak Co | |
DK24493D0 (ja) | 1993-03-05 | 1993-03-05 | Novo Nordisk As | |
EP0826109B1 (de) * | 1995-09-15 | 1998-12-09 | Hahn-Schickard-Gesellschaft Für Angewandte Forschung E.V. | Rückschlagventillose fluidpumpe |
US5753429A (en) * | 1996-08-09 | 1998-05-19 | Lifescan, Inc. | Analyte concentration measurement using a hollow frustum |
US6293012B1 (en) | 1997-07-21 | 2001-09-25 | Ysi Incorporated | Method of making a fluid flow module |
FR2795476B1 (fr) * | 1999-06-22 | 2001-07-27 | Biomerieux Sa | Vanne permettant de diriger un fluide dans une carte d'analyse |
US6428901B1 (en) * | 1999-12-20 | 2002-08-06 | Exxonmobil Chemical Patents Inc. | Films formed from blends of polyethylene and polypropylene |
US6734401B2 (en) * | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
DE60103924T2 (de) * | 2000-11-06 | 2005-07-14 | Nanostream, Inc., Pasadena | Mikrofluidische durchflussregelvorrichtung |
CA2431237A1 (en) * | 2001-01-08 | 2002-07-11 | President And Fellows Of Harvard College | Valves and pumps for microfluidic systems and method for making microfluidic systems |
US20020148992A1 (en) | 2001-04-03 | 2002-10-17 | Hayenga Jon W. | Pneumatic valve interface for use in microfluidic structures |
GB0128350D0 (en) * | 2001-11-27 | 2002-01-16 | Lab901 Ltd | Non-rigid apparatus for microfluidic applications |
GB0303920D0 (en) * | 2003-02-21 | 2003-03-26 | Sophion Bioscience As | Capillary stop |
US7832429B2 (en) | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
JP2009507655A (ja) * | 2005-09-09 | 2009-02-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | マイクロシステムの製造方法、当該マイクロシステム、当該マクロシステムを有するホイルの積層体、当該マイクロシステムを有するエレクトロニクス素子、及び該エレクトロニクス素子の使用 |
-
2008
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- 2010-11-18 ZA ZA2010/08267A patent/ZA201008267B/en unknown
- 2010-12-01 CL CL2010001328A patent/CL2010001328A1/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001510275A (ja) * | 1997-07-21 | 2001-07-31 | ワイエスアイ インコーポレーテッド | 微小流体分析モジュール |
JP2003139660A (ja) * | 2001-11-02 | 2003-05-14 | Kawamura Inst Of Chem Res | マイクロ流体デバイス及びその製造方法 |
JP2010515924A (ja) * | 2007-01-16 | 2010-05-13 | ラブ901 リミテッド | マイクロ流体デバイス |
JP2008284626A (ja) * | 2007-05-16 | 2008-11-27 | Miraial Kk | マイクロ流路デバイス |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017506298A (ja) * | 2013-11-22 | 2017-03-02 | リーアニクス・インコーポレイテッドRheonix, Inc. | チャネルレスポンプ、方法およびその利用 |
US11248596B2 (en) | 2013-11-22 | 2022-02-15 | Rheonix, Inc. | Channel-less pump, methods, and applications thereof |
GB2548943B (en) * | 2014-06-05 | 2020-02-19 | Hitachi High Tech Corp | Device for storing biochemical reagents, and biochemical analyzer |
JPWO2015186454A1 (ja) * | 2014-06-05 | 2017-04-20 | 株式会社日立ハイテクノロジーズ | 生化学用試薬類保存デバイス、及び生化学用分析装置 |
WO2015186454A1 (ja) * | 2014-06-05 | 2015-12-10 | 株式会社日立ハイテクノロジーズ | 生化学用試薬類保存デバイス、及び生化学用分析装置 |
GB2548943A (en) * | 2014-06-05 | 2017-10-04 | Hitachi High Tech Corp | Device for storing biochemical reagents, and biochemical analyzer |
US10884008B2 (en) | 2014-06-05 | 2021-01-05 | Hitachi High-Tech Corporation | Device for storing biochemical reagents, and biochemical analyzer |
WO2017069256A1 (ja) * | 2015-10-23 | 2017-04-27 | 国立研究開発法人科学技術振興機構 | ナノ流体デバイス及び化学分析装置 |
CN108139419A (zh) * | 2015-10-23 | 2018-06-08 | 国立研究开发法人科学技术振兴机构 | 纳米流体设备以及化学分析装置 |
US11565253B2 (en) | 2015-10-23 | 2023-01-31 | Japan Science And Technology Agency | Nano-fluidic device and chemical analysis apparatus |
JP2021139503A (ja) * | 2016-08-08 | 2021-09-16 | 株式会社エンプラス | 流体取扱装置および流体取扱方法 |
JP2018023962A (ja) * | 2016-08-08 | 2018-02-15 | 株式会社エンプラス | 流体取扱装置、流体取扱方法および流路チップ |
WO2020175455A1 (ja) * | 2019-02-28 | 2020-09-03 | 株式会社エンプラス | 流体取扱装置の製造方法 |
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DE502008001596D1 (de) | 2010-12-02 |
CN102112229A (zh) | 2011-06-29 |
RU2010154517A (ru) | 2012-07-20 |
IL209405A (en) | 2016-07-31 |
ZA201008267B (en) | 2011-07-27 |
EP2138233B1 (de) | 2010-10-20 |
BRPI0913340A2 (pt) | 2015-11-24 |
CN102112229B (zh) | 2014-08-06 |
CA2726219C (en) | 2016-03-15 |
EP2138233A1 (de) | 2009-12-30 |
ES2352581T3 (es) | 2011-02-21 |
AU2009262555A1 (en) | 2009-12-30 |
KR101566182B1 (ko) | 2015-11-05 |
RU2515287C2 (ru) | 2014-05-10 |
IL209405A0 (en) | 2011-01-31 |
NZ589466A (en) | 2013-08-30 |
KR20110021999A (ko) | 2011-03-04 |
ATE485101T1 (de) | 2010-11-15 |
BRPI0913340B1 (pt) | 2019-06-25 |
US20110135546A1 (en) | 2011-06-09 |
CA2726219A1 (en) | 2009-12-30 |
WO2009156045A2 (en) | 2009-12-30 |
WO2009156045A4 (en) | 2010-05-20 |
DK2138233T3 (da) | 2011-01-31 |
CL2010001328A1 (es) | 2011-06-10 |
MX2010013204A (es) | 2011-02-25 |
US8580209B2 (en) | 2013-11-12 |
AU2009262555B2 (en) | 2015-05-07 |
JP5436550B2 (ja) | 2014-03-05 |
WO2009156045A3 (en) | 2010-03-18 |
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