RU2010114001A - Применение пептида в качестве терапевтического средства - Google Patents
Применение пептида в качестве терапевтического средства Download PDFInfo
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- RU2010114001A RU2010114001A RU2010114001/15A RU2010114001A RU2010114001A RU 2010114001 A RU2010114001 A RU 2010114001A RU 2010114001/15 A RU2010114001/15 A RU 2010114001/15A RU 2010114001 A RU2010114001 A RU 2010114001A RU 2010114001 A RU2010114001 A RU 2010114001A
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 11
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 10
- 208000015181 infectious disease Diseases 0.000 claims abstract 7
- 239000000203 mixture Substances 0.000 claims abstract 7
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 5
- 208000035473 Communicable disease Diseases 0.000 claims abstract 5
- 206010016654 Fibrosis Diseases 0.000 claims abstract 5
- 208000019693 Lung disease Diseases 0.000 claims abstract 5
- 201000011510 cancer Diseases 0.000 claims abstract 5
- 201000010099 disease Diseases 0.000 claims abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 5
- 230000004761 fibrosis Effects 0.000 claims abstract 5
- 208000027866 inflammatory disease Diseases 0.000 claims abstract 5
- 208000030159 metabolic disease Diseases 0.000 claims abstract 5
- 230000004770 neurodegeneration Effects 0.000 claims abstract 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract 5
- 239000007788 liquid Substances 0.000 claims abstract 4
- 210000004204 blood vessel Anatomy 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 3
- 206010001076 Acute sinusitis Diseases 0.000 claims abstract 2
- 206010053555 Arthritis bacterial Diseases 0.000 claims abstract 2
- 208000004020 Brain Abscess Diseases 0.000 claims abstract 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims abstract 2
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims abstract 2
- 208000004575 Infectious Arthritis Diseases 0.000 claims abstract 2
- 206010031252 Osteomyelitis Diseases 0.000 claims abstract 2
- 208000005141 Otitis Diseases 0.000 claims abstract 2
- 206010033078 Otitis media Diseases 0.000 claims abstract 2
- 206010035664 Pneumonia Diseases 0.000 claims abstract 2
- 206010040047 Sepsis Diseases 0.000 claims abstract 2
- 208000037815 bloodstream infection Diseases 0.000 claims abstract 2
- 239000000872 buffer Substances 0.000 claims abstract 2
- 239000007853 buffer solution Substances 0.000 claims abstract 2
- 239000002577 cryoprotective agent Substances 0.000 claims abstract 2
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- 208000016097 disease of metabolism Diseases 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 208000019258 ear infection Diseases 0.000 claims abstract 2
- 206010014665 endocarditis Diseases 0.000 claims abstract 2
- 208000019622 heart disease Diseases 0.000 claims abstract 2
- -1 lyoprotector Substances 0.000 claims abstract 2
- 208000022949 middle ear disease Diseases 0.000 claims abstract 2
- 208000008494 pericarditis Diseases 0.000 claims abstract 2
- 206010034674 peritonitis Diseases 0.000 claims abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 2
- 201000001223 septic arthritis Diseases 0.000 claims abstract 2
- 201000009890 sinusitis Diseases 0.000 claims abstract 2
- 208000019553 vascular disease Diseases 0.000 claims abstract 2
- 210000004251 human milk Anatomy 0.000 claims 2
- 235000020256 human milk Nutrition 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 1
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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Abstract
1. Применение пептида Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 2. Применение пептида по п.1, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции Streptococus pneumoniae, связанных с инфекцией Streptococus pneumoniae заболеваний, а именно гемолитического уремического синдрома, пневмонии, осложнения кистозного фиброза, заболеваний среднего уха, инфекций в кровотоке, инфекции синусов и ушей, острого синусита, отита среднего уха, остеомиелита, септического артрита, эндокардита, перитонита, перикардита и абсцесса головного мозга. ! 3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава. ! 5. Фармацевтическая композиция, содержащая пептид Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем. ! 6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора. ! 7. Фармацевтическая композиция по п.5 или 6, пригодная для
Claims (9)
1. Применение пептида Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
2. Применение пептида по п.1, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции Streptococus pneumoniae, связанных с инфекцией Streptococus pneumoniae заболеваний, а именно гемолитического уремического синдрома, пневмонии, осложнения кистозного фиброза, заболеваний среднего уха, инфекций в кровотоке, инфекции синусов и ушей, острого синусита, отита среднего уха, остеомиелита, септического артрита, эндокардита, перитонита, перикардита и абсцесса головного мозга.
3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава.
5. Фармацевтическая композиция, содержащая пептид Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора.
7. Фармацевтическая композиция по п.5 или 6, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
8. Фармацевтическая композиция по п.5 или 6 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
9. Фармацевтическая композиция по п.5 или 6, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезней обмена веществ.
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Publication number | Priority date | Publication date | Assignee | Title |
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RU2528094C2 (ru) * | 2012-08-03 | 2014-09-10 | Татьяна Георгиевна Емельянова | Средство пептидной структуры, обладающее анальгетическим, противовоспалительным действием, и лекарственные формы на его основе |
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