RU2009138047A - Стабилизация витамина в12 - Google Patents
Стабилизация витамина в12 Download PDFInfo
- Publication number
- RU2009138047A RU2009138047A RU2009138047/15A RU2009138047A RU2009138047A RU 2009138047 A RU2009138047 A RU 2009138047A RU 2009138047/15 A RU2009138047/15 A RU 2009138047/15A RU 2009138047 A RU2009138047 A RU 2009138047A RU 2009138047 A RU2009138047 A RU 2009138047A
- Authority
- RU
- Russia
- Prior art keywords
- butanol
- composition according
- vitamin
- phosphonic acid
- pharmacologically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Композиция, содержащая витамин B12 и бутанол. ! 2. Композиция по п.1, отличающаяся тем, что она является жидкой. ! 3. Композиция по п.1, отличающаяся тем, что бутанол выбирают из н-бутанола или изо-бутанола. ! 4. Композиция по п.1, содержащая н-бутанол. ! 5. Композиция по одному из пп.1-4, которая дополнительно содержит фармакологически приемлемое производное фосфоновой кислоты. ! 6. Композиция по п.5, содержащая в качестве фармакологически приемлемого производного фосфоновой кислоты бутафосфан и толдимфос. ! 7. Композиция по п.5, содержащая в качестве фармакологически приемлемого производного фосфоновой кислоты бутафосфан. ! 8. Применение композиции по одному из пп.1-7 для получения лекарственного средства. ! 9. Применение бутанола для стабилизации витамина B12. ! 10. Применение бутанола для получения композиций витамина B12 с улучшенной стабильностью витамина B12.
Claims (10)
1. Композиция, содержащая витамин B12 и бутанол.
2. Композиция по п.1, отличающаяся тем, что она является жидкой.
3. Композиция по п.1, отличающаяся тем, что бутанол выбирают из н-бутанола или изо-бутанола.
4. Композиция по п.1, содержащая н-бутанол.
5. Композиция по одному из пп.1-4, которая дополнительно содержит фармакологически приемлемое производное фосфоновой кислоты.
6. Композиция по п.5, содержащая в качестве фармакологически приемлемого производного фосфоновой кислоты бутафосфан и толдимфос.
7. Композиция по п.5, содержащая в качестве фармакологически приемлемого производного фосфоновой кислоты бутафосфан.
8. Применение композиции по одному из пп.1-7 для получения лекарственного средства.
9. Применение бутанола для стабилизации витамина B12.
10. Применение бутанола для получения композиций витамина B12 с улучшенной стабильностью витамина B12.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007012644A DE102007012644A1 (de) | 2007-03-16 | 2007-03-16 | Stabilisierung von Vitamin B12 |
| DE102007012644.3 | 2007-03-16 | ||
| PCT/EP2008/001819 WO2008113483A2 (de) | 2007-03-16 | 2008-03-07 | Stabilisierung von vitamin b12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009138047A true RU2009138047A (ru) | 2011-04-27 |
| RU2472528C2 RU2472528C2 (ru) | 2013-01-20 |
Family
ID=39688186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009138047/15A RU2472528C2 (ru) | 2007-03-16 | 2008-03-07 | Стабилизация витамина в12 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20080261914A1 (ru) |
| EP (1) | EP2121024B1 (ru) |
| JP (1) | JP5558838B2 (ru) |
| KR (1) | KR101508602B1 (ru) |
| CN (1) | CN101631564B (ru) |
| AU (1) | AU2008228597B2 (ru) |
| BR (2) | BR122019021714B8 (ru) |
| CA (1) | CA2680756C (ru) |
| CO (1) | CO6231001A2 (ru) |
| CR (1) | CR11018A (ru) |
| DE (1) | DE102007012644A1 (ru) |
| DK (1) | DK2121024T3 (ru) |
| DO (1) | DOP2009000213A (ru) |
| EC (1) | ECSP099616A (ru) |
| ES (1) | ES2560102T3 (ru) |
| GT (1) | GT200900240A (ru) |
| HK (1) | HK1138198A1 (ru) |
| HR (1) | HRP20160048T1 (ru) |
| HU (1) | HUE026554T2 (ru) |
| IL (1) | IL200499A (ru) |
| MX (1) | MX2009009439A (ru) |
| MY (1) | MY154485A (ru) |
| NI (1) | NI200900165A (ru) |
| NZ (1) | NZ579627A (ru) |
| PL (1) | PL2121024T3 (ru) |
| PT (1) | PT2121024E (ru) |
| RU (1) | RU2472528C2 (ru) |
| SI (1) | SI2121024T1 (ru) |
| SV (1) | SV2009003366A (ru) |
| UA (1) | UA97141C2 (ru) |
| WO (1) | WO2008113483A2 (ru) |
| ZA (1) | ZA200905974B (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008022520A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
| ES2686299T3 (es) * | 2010-10-29 | 2018-10-17 | Troikaa Pharmaceuticals Ltd | Composiciones nasales de vitamina B12 |
| CA2868343A1 (en) * | 2011-03-24 | 2012-09-27 | Seachaid Pharmaceuticals, Inc. | Vancomycin derivatives |
| CA2871991C (en) | 2012-05-14 | 2019-02-26 | Warburton Technology Limited | Trace element solution |
| KR101400791B1 (ko) * | 2012-10-04 | 2014-05-29 | 주식회사대성미생물연구소 | 동물용 복합 기능성 항생제 조성물 |
| CN102908354A (zh) * | 2012-11-02 | 2013-02-06 | 青岛康地恩药业股份有限公司 | 一种布他磷注射液的制备方法 |
| RU2529814C1 (ru) * | 2013-05-20 | 2014-09-27 | Федеральное государственное бюджетное учреждение "Научный центр экспертизы средств медицинского применения" Министерства здравоохранения Российской Федерации | Способ определения подлинности и количественного содержания бензэтония хлорида в лекарственных препаратах |
| WO2016199165A2 (en) * | 2015-06-08 | 2016-12-15 | Zim Laboratories Limited | Improved mucosal delivery of vitamin b12 |
| DE102018005078A1 (de) | 2018-06-26 | 2020-01-02 | Ilma biochem GmbH | Verfahren zur Herstellung und Zusammensetzung von stabilisierten Cob(II)alamin- und Cob(II)inamide-Lösungen als Ausgangszubereitungen zur Herstellung von Arzneimitteln, Medizinprodukten, Nahrungsergänzungsmitteln und Kosmetika |
| KR102058133B1 (ko) * | 2019-02-22 | 2019-12-20 | 우진 비앤지 주식회사 | 혼합제제 내 항생제 용해도를 향상시킬 수 있는 면역 증강용 조성물 및 이의 용도 |
| JP2020196672A (ja) * | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンｂ１２類含有組成物 |
| JP7270465B2 (ja) * | 2019-05-31 | 2023-05-10 | 小林製薬株式会社 | ビタミンｂ１２類の光安定化方法 |
| JP7368108B2 (ja) * | 2019-05-31 | 2023-10-24 | 小林製薬株式会社 | 水性組成物 |
| NZ785052A (en) * | 2019-07-12 | 2022-08-26 | Chemvet Australia Pty Ltd | Injectable nutritional supplement |
| WO2023198854A1 (en) * | 2022-04-14 | 2023-10-19 | Dsm Ip Assets B.V. | Novel use of psicose |
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2007
- 2007-03-16 DE DE102007012644A patent/DE102007012644A1/de not_active Withdrawn
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2008
- 2008-03-07 PT PT87163341T patent/PT2121024E/pt unknown
- 2008-03-07 MX MX2009009439A patent/MX2009009439A/es active IP Right Grant
- 2008-03-07 HU HUE08716334A patent/HUE026554T2/en unknown
- 2008-03-07 EP EP08716334.1A patent/EP2121024B1/de active Active
- 2008-03-07 RU RU2009138047/15A patent/RU2472528C2/ru active
- 2008-03-07 BR BR122019021714A patent/BR122019021714B8/pt active IP Right Grant
- 2008-03-07 DK DK08716334.1T patent/DK2121024T3/en active
- 2008-03-07 CA CA2680756A patent/CA2680756C/en active Active
- 2008-03-07 SI SI200831569T patent/SI2121024T1/sl unknown
- 2008-03-07 AU AU2008228597A patent/AU2008228597B2/en active Active
- 2008-03-07 KR KR1020097019154A patent/KR101508602B1/ko active IP Right Grant
- 2008-03-07 MY MYPI20093766A patent/MY154485A/en unknown
- 2008-03-07 BR BRPI0808979A patent/BRPI0808979B8/pt active IP Right Grant
- 2008-03-07 JP JP2009553947A patent/JP5558838B2/ja active Active
- 2008-03-07 CN CN200880008418XA patent/CN101631564B/zh active Active
- 2008-03-07 PL PL08716334T patent/PL2121024T3/pl unknown
- 2008-03-07 UA UAA200910462A patent/UA97141C2/ru unknown
- 2008-03-07 WO PCT/EP2008/001819 patent/WO2008113483A2/de active Application Filing
- 2008-03-07 ES ES08716334.1T patent/ES2560102T3/es active Active
- 2008-03-07 NZ NZ579627A patent/NZ579627A/en unknown
- 2008-03-11 US US12/045,831 patent/US20080261914A1/en not_active Abandoned
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2009
- 2009-08-20 IL IL200499A patent/IL200499A/en active IP Right Grant
- 2009-08-28 ZA ZA2009/05974A patent/ZA200905974B/en unknown
- 2009-09-04 CO CO09094516A patent/CO6231001A2/es active IP Right Grant
- 2009-09-07 GT GT200900240A patent/GT200900240A/es unknown
- 2009-09-07 SV SV2009003366A patent/SV2009003366A/es unknown
- 2009-09-07 DO DO2009000213A patent/DOP2009000213A/es unknown
- 2009-09-08 CR CR11018A patent/CR11018A/es unknown
- 2009-09-08 EC EC2009009616A patent/ECSP099616A/es unknown
- 2009-09-08 NI NI200900165A patent/NI200900165A/es unknown
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2010
- 2010-04-30 HK HK10104307.8A patent/HK1138198A1/xx unknown
- 2010-11-22 US US12/951,581 patent/US9089582B2/en active Active
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2015
- 2015-07-24 US US14/808,425 patent/US9610297B2/en active Active
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2016
- 2016-01-15 HR HRP20160048TT patent/HRP20160048T1/hr unknown
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