RU2009102973A - Композиции и способы получения фотоактивного агента - Google Patents
Композиции и способы получения фотоактивного агента Download PDFInfo
- Publication number
- RU2009102973A RU2009102973A RU2009102973/04A RU2009102973A RU2009102973A RU 2009102973 A RU2009102973 A RU 2009102973A RU 2009102973/04 A RU2009102973/04 A RU 2009102973/04A RU 2009102973 A RU2009102973 A RU 2009102973A RU 2009102973 A RU2009102973 A RU 2009102973A
- Authority
- RU
- Russia
- Prior art keywords
- chlorin
- formula
- reaction product
- pharmaceutically acceptable
- composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 38
- 239000000203 mixture Substances 0.000 title claims abstract 38
- 239000000906 photoactive agent Substances 0.000 title claims 2
- 150000003839 salts Chemical class 0.000 claims abstract 38
- 239000007795 chemical reaction product Substances 0.000 claims abstract 29
- 150000001875 compounds Chemical class 0.000 claims abstract 24
- 239000002243 precursor Substances 0.000 claims abstract 18
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims abstract 16
- 150000004035 chlorins Chemical class 0.000 claims abstract 15
- 238000002156 mixing Methods 0.000 claims abstract 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract 11
- 238000006243 chemical reaction Methods 0.000 claims abstract 10
- -1 chlorin e6 anhydride Chemical class 0.000 claims abstract 10
- 230000003213 activating effect Effects 0.000 claims abstract 9
- 150000001718 carbodiimides Chemical class 0.000 claims abstract 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 8
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical group Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims abstract 7
- 239000000047 product Substances 0.000 claims abstract 3
- 239000011541 reaction mixture Substances 0.000 claims 24
- SURLGNKAQXKNSP-DBLYXWCISA-N chlorin Chemical compound C\1=C/2\N/C(=C\C3=N/C(=C\C=4NC(/C=C\5/C=CC/1=N/5)=CC=4)/C=C3)/CC\2 SURLGNKAQXKNSP-DBLYXWCISA-N 0.000 claims 22
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 10
- 238000000926 separation method Methods 0.000 claims 8
- 150000001412 amines Chemical class 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- VSEIDZLLWQQJGK-CHOZPQDDSA-N CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O Chemical compound CCC1=C(C)C2=N\C\1=C/C1=C(C)C(C(O)=O)=C(N1)\C(CC(=O)N[C@@H](CC(O)=O)C(O)=O)=C1/N=C(/C=C3\N/C(=C\2)C(C=C)=C3C)[C@@H](C)[C@@H]1CCC(O)=O VSEIDZLLWQQJGK-CHOZPQDDSA-N 0.000 claims 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 5
- 238000004587 chromatography analysis Methods 0.000 claims 5
- 238000001556 precipitation Methods 0.000 claims 5
- 238000000746 purification Methods 0.000 claims 5
- 229910052708 sodium Inorganic materials 0.000 claims 5
- 239000011734 sodium Substances 0.000 claims 5
- 229950010924 talaporfin Drugs 0.000 claims 5
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 4
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical class OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- 150000008064 anhydrides Chemical class 0.000 claims 4
- 229960005261 aspartic acid Drugs 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000605 extraction Methods 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Chemical class [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 claims 2
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 1
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- CSCPPACGZOOCGX-WFGJKAKNSA-N acetone d6 Chemical compound [2H]C([2H])([2H])C(=O)C([2H])([2H])[2H] CSCPPACGZOOCGX-WFGJKAKNSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000012670 alkaline solution Substances 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- OYINILBBZAQBEV-UWJYYQICSA-N (17s,18s)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid Chemical compound N1C2=C(C)C(C=C)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1C(O)=O)=NC1=C(CC(O)=O)C([C@@H](CCC(O)=O)[C@@H]1C)=NC1=C2 OYINILBBZAQBEV-UWJYYQICSA-N 0.000 abstract 2
- WHHGEUSMCGKLKF-PNSCUERTSA-N CCC1=C(C)C(/C=C(/C(C=C)=C2C)\N/C2=C\C(CC23C(CC(O)=O)C2)=N/C3=C2/CC(OC3=O)=O)=N/C1=C\c1c(C)c3c2[nH]1 Chemical compound CCC1=C(C)C(/C=C(/C(C=C)=C2C)\N/C2=C\C(CC23C(CC(O)=O)C2)=N/C3=C2/CC(OC3=O)=O)=N/C1=C\c1c(C)c3c2[nH]1 WHHGEUSMCGKLKF-PNSCUERTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81776906P | 2006-06-30 | 2006-06-30 | |
| US60/817,769 | 2006-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009102973A true RU2009102973A (ru) | 2010-08-10 |
Family
ID=38739490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009102973/04A RU2009102973A (ru) | 2006-06-30 | 2007-06-29 | Композиции и способы получения фотоактивного агента |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8198312B2 (enExample) |
| EP (1) | EP2057169A2 (enExample) |
| JP (1) | JP5323693B2 (enExample) |
| KR (1) | KR101456839B1 (enExample) |
| CN (1) | CN101490057B (enExample) |
| AU (1) | AU2007269784B2 (enExample) |
| CA (1) | CA2655723C (enExample) |
| RU (1) | RU2009102973A (enExample) |
| SG (1) | SG172733A1 (enExample) |
| WO (1) | WO2008005308A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2885311Y (zh) | 2006-01-18 | 2007-04-04 | 郑成福 | 经尿道光动力疗法前列腺治疗仪 |
| US7465312B2 (en) | 2006-05-02 | 2008-12-16 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
| WO2007130465A2 (en) * | 2006-05-02 | 2007-11-15 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
| JP5323693B2 (ja) | 2006-06-30 | 2013-10-23 | ライト、サイエンシーズ、オンコロジー、インコーポレイテッド | 光活性剤としてのクロリンｅ６誘導体の組成物およびクロリンｅ６誘導体を製造する方法 |
| CN103030644B (zh) * | 2011-09-30 | 2015-01-14 | 齐鲁制药有限公司 | 一种他拉泊芬及其中间体的制备方法 |
| US10740438B2 (en) | 2012-08-16 | 2020-08-11 | Ginger.io, Inc. | Method and system for characterizing and/or treating poor sleep behavior |
| CN109785972B (zh) | 2012-08-16 | 2023-09-26 | 橙点公司 | 用于对行为和健康变化进行建模的方法 |
| US10741285B2 (en) | 2012-08-16 | 2020-08-11 | Ginger.io, Inc. | Method and system for providing automated conversations |
| US10650920B2 (en) | 2012-08-16 | 2020-05-12 | Ginger.io, Inc. | Method and system for improving care determination |
| US10748645B2 (en) | 2012-08-16 | 2020-08-18 | Ginger.io, Inc. | Method for providing patient indications to an entity |
| US10276260B2 (en) | 2012-08-16 | 2019-04-30 | Ginger.io, Inc. | Method for providing therapy to an individual |
| RU2523380C1 (ru) * | 2013-05-21 | 2014-07-20 | Общество с ограниченной ответственностью "ГЕЛИОХЛОРИН" | Фотосенсибилизатор и способ его получения |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4693885A (en) | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4977177A (en) * | 1985-04-30 | 1990-12-11 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents |
| US4656186A (en) | 1985-04-30 | 1987-04-07 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| JP3565442B2 (ja) * | 1993-04-22 | 2004-09-15 | 新日本石油化学株式会社 | 哺乳類の関節炎の診断剤および／または治療剤 |
| JP5323693B2 (ja) | 2006-06-30 | 2013-10-23 | ライト、サイエンシーズ、オンコロジー、インコーポレイテッド | 光活性剤としてのクロリンｅ６誘導体の組成物およびクロリンｅ６誘導体を製造する方法 |
-
2007
- 2007-06-29 JP JP2009518280A patent/JP5323693B2/ja not_active Expired - Fee Related
- 2007-06-29 KR KR1020097002051A patent/KR101456839B1/ko not_active Expired - Fee Related
- 2007-06-29 AU AU2007269784A patent/AU2007269784B2/en not_active Ceased
- 2007-06-29 CA CA2655723A patent/CA2655723C/en active Active
- 2007-06-29 US US11/772,024 patent/US8198312B2/en active Active
- 2007-06-29 CN CN2007800274940A patent/CN101490057B/zh not_active Expired - Fee Related
- 2007-06-29 WO PCT/US2007/015087 patent/WO2008005308A2/en not_active Ceased
- 2007-06-29 RU RU2009102973/04A patent/RU2009102973A/ru unknown
- 2007-06-29 EP EP07810026A patent/EP2057169A2/en not_active Ceased
- 2007-06-29 SG SG2011046810A patent/SG172733A1/en unknown
-
2010
- 2010-11-01 US US12/917,353 patent/US8063203B2/en active Active
-
2012
- 2012-05-16 US US13/473,395 patent/US8822677B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20080021210A1 (en) | 2008-01-24 |
| CA2655723A1 (en) | 2008-01-10 |
| WO2008005308A3 (en) | 2008-03-06 |
| JP5323693B2 (ja) | 2013-10-23 |
| JP2009542672A (ja) | 2009-12-03 |
| AU2007269784A1 (en) | 2008-01-10 |
| US8198312B2 (en) | 2012-06-12 |
| CN101490057B (zh) | 2013-02-27 |
| US8063203B2 (en) | 2011-11-22 |
| US20130281689A1 (en) | 2013-10-24 |
| WO2008005308A2 (en) | 2008-01-10 |
| KR20090033463A (ko) | 2009-04-03 |
| US8822677B2 (en) | 2014-09-02 |
| KR101456839B1 (ko) | 2014-11-03 |
| SG172733A1 (en) | 2011-07-28 |
| US20110105745A1 (en) | 2011-05-05 |
| CN101490057A (zh) | 2009-07-22 |
| AU2007269784B2 (en) | 2012-07-05 |
| EP2057169A2 (en) | 2009-05-13 |
| CA2655723C (en) | 2014-11-18 |
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