RU2008140040A - Улучшенный способ получения твердой дисперсии активного ингредиента - Google Patents

Улучшенный способ получения твердой дисперсии активного ингредиента Download PDF

Info

Publication number
RU2008140040A
RU2008140040A RU2008140040/15A RU2008140040A RU2008140040A RU 2008140040 A RU2008140040 A RU 2008140040A RU 2008140040/15 A RU2008140040/15 A RU 2008140040/15A RU 2008140040 A RU2008140040 A RU 2008140040A RU 2008140040 A RU2008140040 A RU 2008140040A
Authority
RU
Russia
Prior art keywords
elements
reverse thread
zone
thread
worm
Prior art date
Application number
RU2008140040/15A
Other languages
English (en)
Other versions
RU2442568C2 (ru
Inventor
Томас КЕССЛЕР (DE)
Томас Кесслер
Йорг БРАЙТЕНБАХ (DE)
Йорг Брайтенбах
Кристоф ШМИДТ (DE)
Кристоф ШМИДТ
Маттиас ДЕГЕНХАРДТ (DE)
Маттиас ДЕГЕНХАРДТ
Йорг РОЗЕНБЕРГ (DE)
Йорг Розенберг
Харальд КРУЛЛЬ (DE)
Харальд КРУЛЛЬ
Гунтер БЕРНДЛ (DE)
Гунтер БЕРНДЛ
Original Assignee
Эббетт ГмбХ унд Ко. КГ (DE)
Эббетт ГмбХ унд Ко. КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36754000&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2008140040(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эббетт ГмбХ унд Ко. КГ (DE), Эббетт ГмбХ унд Ко. КГ filed Critical Эббетт ГмбХ унд Ко. КГ (DE)
Publication of RU2008140040A publication Critical patent/RU2008140040A/ru
Application granted granted Critical
Publication of RU2442568C2 publication Critical patent/RU2442568C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/115—Stirrers characterised by the configuration of the stirrers comprising discs or disc-like elements essentially perpendicular to the stirrer shaft axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
    • B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
    • B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
    • B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
    • B29B7/482—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs
    • B29B7/483—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws provided with screw parts in addition to other mixing parts, e.g. paddles, gears, discs the other mixing parts being discs perpendicular to the screw axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/34—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices
    • B29B7/38—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary
    • B29B7/46—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft
    • B29B7/48—Mixing; Kneading continuous, with mechanical mixing or kneading devices with movable mixing or kneading devices rotary with more than one shaft with intermeshing devices, e.g. screws
    • B29B7/488—Parts, e.g. casings, sealings; Accessories, e.g. flow controlling or throttling devices
    • B29B7/489—Screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/80—Component parts, details or accessories; Auxiliary operations
    • B29B7/82—Heating or cooling
    • B29B7/826—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C31/00—Handling, e.g. feeding of the material to be shaped, storage of plastics material before moulding; Automation, i.e. automated handling lines in plastics processing plants, e.g. using manipulators or robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/04—Particle-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/07—Flat, e.g. panels
    • B29C48/08—Flat, e.g. panels flexible, e.g. films
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/405—Intermeshing co-rotating screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/41—Intermeshing counter-rotating screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/54—Screws with additional forward-feeding elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/55—Screws having reverse-feeding elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/56—Screws having grooves or cavities other than the thread or the channel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/57—Screws provided with kneading disc-like elements, e.g. with oval-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/625—Screws characterised by the ratio of the threaded length of the screw to its outside diameter [L/D ratio]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/64—Screws with two or more threads
    • B29C48/65—Screws with two or more threads neighbouring threads or channels having different configurations, e.g. one thread being lower than its neighbouring thread
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/505—Screws
    • B29C48/67—Screws having incorporated mixing devices not provided for in groups B29C48/52 - B29C48/66
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/86—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the nozzle zone
    • B29C48/865—Heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/875—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling for achieving a non-uniform temperature distribution, e.g. using barrels having both cooling and heating zones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/256—Exchangeable extruder parts
    • B29C48/2564—Screw parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/268—Throttling of the flow, e.g. for cooperating with plasticising elements or for degassing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/285—Feeding the extrusion material to the extruder
    • B29C48/288—Feeding the extrusion material to the extruder in solid form, e.g. powder or granules
    • B29C48/2886—Feeding the extrusion material to the extruder in solid form, e.g. powder or granules of fibrous, filamentary or filling materials, e.g. thin fibrous reinforcements or fillers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/285—Feeding the extrusion material to the extruder
    • B29C48/29—Feeding the extrusion material to the extruder in liquid form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/404—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having non-intermeshing parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/50—Details of extruders
    • B29C48/76—Venting, drying means; Degassing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/78—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling
    • B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
    • B29C48/83—Heating or cooling the cylinders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
    • B29C48/90—Thermal treatment of the stream of extruded material, e.g. cooling with calibration or sizing, i.e. combined with fixing or setting of the final dimensions of the extruded article
    • B29C48/906—Thermal treatment of the stream of extruded material, e.g. cooling with calibration or sizing, i.e. combined with fixing or setting of the final dimensions of the extruded article using roller calibration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
    • B29C48/911—Cooling
    • B29C48/9135—Cooling of flat articles, e.g. using specially adapted supporting means
    • B29C48/914—Cooling of flat articles, e.g. using specially adapted supporting means cooling drums
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0038—Plasticisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0058—Liquid or visquous
    • B29K2105/0064—Latex, emulsion or dispersion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/16—Fillers

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Robotics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Colloid Chemistry (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Formation And Processing Of Food Products (AREA)

Abstract

1. Способ получения твердой дисперсии активного ингредиента, который включает загрузку активного ингредиента и матрицеобразующего агента в экструдер и получение однородного экструдата, где экструдер включает, по меньшей мере, два вращающихся вала (2), где каждый из валов (2) несет множество обрабатывающих элементов, расположенных аксиально друг за другом, где обрабатывающие элементы образуют ! (i) зону загрузки и перемещения (А), ! (ii) по меньшей мере, одну зону с обратной резьбой (R; D) и ! (iii) зону выгрузки (Е), ! где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, один элемент с обратной резьбой (14), который основан на червячном элементе, имеющий направление перемещения, противоположное общему направлению перемещения экструдера. ! 2. Способ по п.1, где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, два элемента с обратной резьбой (14) и, по меньшей мере, один червячный элемент с резьбой по часовой стрелке (3), который расположен между указанными двумя элементами с обратной резьбой. ! 3. Способ по п.1 или 2, где обрабатывающие элементы, образующие зону загрузки и перемещения (А), содержат червячные элементы с резьбой по часовой стрелке (3), и где шаг резьбы указанного, по меньшей мере, одного элемента с обратной резьбой (14) составляет от (-0,5) раза до (-1,5) раза от шага резьбы червячных элементов (3) зоны загрузки и перемещения (А) и/или червячных элементов (3), расположенных между двумя элементами с обратной резьбой (14). ! 4. Способ по п.1 или 2, где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, три элемента с обра

Claims (27)

1. Способ получения твердой дисперсии активного ингредиента, который включает загрузку активного ингредиента и матрицеобразующего агента в экструдер и получение однородного экструдата, где экструдер включает, по меньшей мере, два вращающихся вала (2), где каждый из валов (2) несет множество обрабатывающих элементов, расположенных аксиально друг за другом, где обрабатывающие элементы образуют
(i) зону загрузки и перемещения (А),
(ii) по меньшей мере, одну зону с обратной резьбой (R; D) и
(iii) зону выгрузки (Е),
где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, один элемент с обратной резьбой (14), который основан на червячном элементе, имеющий направление перемещения, противоположное общему направлению перемещения экструдера.
2. Способ по п.1, где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, два элемента с обратной резьбой (14) и, по меньшей мере, один червячный элемент с резьбой по часовой стрелке (3), который расположен между указанными двумя элементами с обратной резьбой.
3. Способ по п.1 или 2, где обрабатывающие элементы, образующие зону загрузки и перемещения (А), содержат червячные элементы с резьбой по часовой стрелке (3), и где шаг резьбы указанного, по меньшей мере, одного элемента с обратной резьбой (14) составляет от (-0,5) раза до (-1,5) раза от шага резьбы червячных элементов (3) зоны загрузки и перемещения (А) и/или червячных элементов (3), расположенных между двумя элементами с обратной резьбой (14).
4. Способ по п.1 или 2, где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, три элемента с обратной резьбой (14-1 до 14-3), где, по меньшей мере, один червячный элемент с резьбой по часовой стрелке (3) расположен между соответствующими последовательными элементами с обратной резьбой (14).
5. Способ по п.4, где длина червячного элемента с резьбой по часовой стрелке (3), расположенного между вторым и третьим элементами с обратной резьбой (14-2, 14-3), от 1 до 15 раз больше длины червячного элемента с резьбой по часовой стрелке (3), расположенного между первым и вторым элементами с обратной резьбой (14-1, 14-2).
6. Способ по п.1 или 2, где обрабатывающие элементы, образующие зону с обратной резьбой (R; D), содержат, по меньшей мере, четыре элемента с обратной резьбой (14-1 до 14-4), где, по меньшей мере, один червячный элемент с резьбой по часовой стрелке расположен между соответствующими последовательными элементами с обратной резьбой, и где червячные элементы с резьбой по часовой стрелке (3), расположенные между последовательными элементами с обратной резьбой, имеют одинаковую длину.
7. Способ по п.1 или 2, где обрабатывающие элементы содержат дополнительно, по меньшей мере, один смешивающий элемент (11, 12, 13), основанный на червячном элементе, где смешивающий(е) элемент(ы) (11, 12, 13) имеет (имеют) канавки, образованные в спиральной нарезке червячного элемента.
8. Способ по п.7, где, по меньшей мере, один элемент с обратной резьбой (14) расположен пониже по ходу потока к смешивающим элементам (11, 12, 13).
9. Способ по п.7, где, по меньшей мере, один смешивающий элемент (11, 12, 13) имеет множество концентрических кольцевых частей (16; 25), образованных желобками, выточенными в червячном элементе.
10. Способ по п.7, где, по меньшей мере, один смешивающий элемент (11, 12, 13) не имеет плоской области поверхности с нормалью, параллельной противоположной общему направлению перемещения.
11. Способ по п.7, где, по меньшей мере, один смешивающий элемент (11, 12, 13) не имеет поверхности, которая перпендикулярна общему направлению перемещения.
12. Способ по п.7, где, по меньшей мере, один смешивающий элемент (11, 12, 13) не имеет примыкающих поверхностей, которые перпендикулярны общему направлению перемещения.
13. Способ по п.7, где обрабатывающие элементы образуют
(i) зону загрузки и перемещения (А),
(ii) первую зону смешивания (В),
(iii) промежуточную зону перемещения (С),
(iv) зону с обратной резьбой (D) и
(v) зону выгрузки (Е),
где обрабатывающие элементы, образующие первую зону смешивания (В), содержат, по меньшей мере, один смешивающий элемент (11, 12, 13), и обрабатывающие элементы, образующие зону с обратной резьбой (D), содержат, по меньшей мере, один смешивающий элемент (11, 12, 13) и ниже по ходу потока от него, по меньшей мере, один элемент с обратной резьбой (14).
14. Способ по п.1 или 13, где, по меньшей мере, часть матрицеобразующего агента загружают в бункер экструдера и, по меньшей мере, один компонент, выбранный из
(i) оставшегося матрицеобразующего агента,
(ii) активного ингредиента,
(iii) добавки и
(iv) их сочетания,
вводят в экструдер через отверстие (8) в цилиндре экструдера (1), в месте выше по ходу потока от зоны смешивания (В), или в зоне смешивания (В), или в зоне с обратной резьбой (R; D).
15. Способ по п.14, где, по меньшей мере, один компонент вводят в экструдер в месте соединения зоны загрузки и перемещения и зоны смешивания (В) или зоны с обратной резьбой (R; D) или вблизи этого места.
16. Способ по п.14, где, по меньшей мере, один компонент является жидким или сжиженным.
17. Способ по п.14, где, по меньшей мере, один компонент содержит фармацевтически приемлемое поверхностно-активное вещество.
18. Способ по п.14, где активный ингредиент диспергирован в полимере в состоянии твердого раствора.
19. Способ по п.14, где матрицеобразующий агент содержит фармацевтически приемлемый полимер.
20. Способ по п.19, где фармацевтически приемлемый полимер выбирают из группы, включающей гомополимеры N-виниллактамов, сополимеры N-виниллактама и одного или более сомономеров, выбранных из азотсодержащих мономеров и кислородсодержащих мономеров, сложные эфиры целлюлозы и простые эфиры целлюлозы, оксиды высокомолекулярных полиалкиленоксидов, полиакрилаты и полиметакрилаты, олиго- и полисахариды, поли(гидроксикислоты) или их смеси.
21. Способ по п.1 или 13, где матрицеобразующий агент содержит соединение, выбранное из полиолов, восков и липидов.
22. Способ по п.1 или 13, дополнительно включающий загрузку в экструдер, по меньшей мере, одной добавки, выбранной из группы, включающей регуляторы потока; смазывающие агенты, наполнители, дезинтеграторы, пластификаторы, стабилизаторы или консерванты.
23. Способ по п.1 или 13, где экструдат формуют непосредственно в лекарственную форму.
24. Способ по п.23, где формование проводят каландрованием, инжекционным формованием или экструзией профилированных изделий.
25. Способ по п.23, дополнительно включающий измельчение отвержденного экструдата.
26. Способ по п.25, дополнительно включающий прессование указанной твердой дисперсии в таблетку или заполнение капсулы указанной твердой дисперсией.
27. Способ по п.26, дополнительно включающий нанесение пленочного покрытия на таблетку.
RU2008140040/15A 2006-03-10 2007-03-12 Улучшенный способ получения твердой дисперсии активного ингредиента RU2442568C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78139806P 2006-03-10 2006-03-10
EP06004999.6 2006-03-10
US60/781,398 2006-03-10
EP06004999A EP1832281A1 (en) 2006-03-10 2006-03-10 Process for producing a solid dispersion of an active ingredient

Publications (2)

Publication Number Publication Date
RU2008140040A true RU2008140040A (ru) 2010-04-20
RU2442568C2 RU2442568C2 (ru) 2012-02-20

Family

ID=36754000

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2008140040/15A RU2442568C2 (ru) 2006-03-10 2007-03-12 Улучшенный способ получения твердой дисперсии активного ингредиента
RU2008140039/15A RU2448688C2 (ru) 2006-03-10 2007-03-12 Устройство для получения твердой дисперсии активного ингредиента

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2008140039/15A RU2448688C2 (ru) 2006-03-10 2007-03-12 Устройство для получения твердой дисперсии активного ингредиента

Country Status (20)

Country Link
US (4) US20090302493A1 (ru)
EP (5) EP1832281A1 (ru)
JP (3) JP5670023B2 (ru)
KR (2) KR101417892B1 (ru)
CN (2) CN101400341B (ru)
AT (1) ATE531359T1 (ru)
AU (2) AU2007224486B2 (ru)
BR (2) BRPI0708709A2 (ru)
CA (2) CA2644035C (ru)
CY (1) CY1112273T1 (ru)
DK (2) DK1996164T3 (ru)
ES (2) ES2425176T3 (ru)
HK (3) HK1215188A1 (ru)
MX (2) MX2008011041A (ru)
PL (2) PL1996164T3 (ru)
PT (1) PT1996163E (ru)
RU (2) RU2442568C2 (ru)
SI (1) SI1996163T1 (ru)
WO (2) WO2007104747A2 (ru)
ZA (2) ZA200808564B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2502599C1 (ru) * 2012-11-14 2013-12-27 Станислав Васильевич Володин Способ изготовления пластмассовых изделий

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1832281A1 (en) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
JP4746014B2 (ja) * 2007-07-09 2011-08-10 株式会社日本製鋼所 溶融混練脱揮押出機
JP5750266B2 (ja) * 2008-02-28 2015-07-15 アッヴィ・インコーポレイテッド 錠剤およびその調製
AU2009291764A1 (en) * 2008-09-10 2010-03-18 Transcu Ltd. Apparatus and method to dispense HPC-based viscous liquids into porous substrates, e.g., continuous web-based process
US20110201575A1 (en) * 2008-09-17 2011-08-18 Cj Cheiljedang Corporation Stabilized solid dispersion of adefovir dipivoxil and preparation method thereof
US20110034489A1 (en) * 2009-07-31 2011-02-10 Ranbaxy Laboratories Limited Solid dosage forms of hiv protease inhibitors
DE102009040047A1 (de) * 2009-09-04 2011-03-17 Bayer Materialscience Ag Verfahren zur Einarbeitung von Feststoffen in Polymere
WO2012049253A1 (en) * 2010-10-14 2012-04-19 Abbott Gmbh & Co. Kg Curcuminoid solid dispersion formulation
ES2598235T3 (es) 2010-12-23 2017-01-26 AbbVie Deutschland GmbH & Co. KG Formulaciones de retardo sólidas basadas en dispersiones sólidas
US10968129B1 (en) * 2011-04-26 2021-04-06 Mansour S. Bader Minimizing wastes: method for de-oiling, de-scaling and distilling source water
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated
WO2013080148A1 (en) * 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited A process for the preparation of solid dispersion of lopinavir and ritonavir
US20130172375A1 (en) * 2011-12-13 2013-07-04 Hoffmann-La Roche Inc. Pharmaceutical composition
GB2503710A (en) * 2012-07-05 2014-01-08 Res Ct Pharmaceutical Engineering Gmbh System for producing a solid preparation from a suspension
PE20151778A1 (es) 2013-01-31 2015-12-16 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales
WO2014192026A2 (en) 2013-05-27 2014-12-04 Steer Engineering Private Limited A hot melt fragmentation extruder and process
FR3007685B1 (fr) * 2013-06-27 2016-02-05 Clextral Element de vis pour une extrudeuse bivis corotative, ainsi qu'extrudeuse bivis corotative correspondante
PT3038601T (pt) 2013-08-27 2020-06-30 Gilead Pharmasset Llc Formulação combinada de dois compostos antivirais
GB201316023D0 (en) * 2013-09-09 2013-10-23 Res Ct Pharmaceutical Engineering Gmbh Continuous low dosing of an active ingredient
WO2015128853A1 (en) * 2014-02-28 2015-09-03 Sun Pharmaceutical Industries Limited Dapagliflozin compositions
FR3022823B1 (fr) * 2014-06-30 2017-03-10 Michelin & Cie Extrudeuse comportant un fourreau filete
US9586371B2 (en) * 2014-09-02 2017-03-07 Empire Technology Development Llc Method of bonding material layers in an additive manufacturing process
US10933572B2 (en) 2015-07-29 2021-03-02 The Boeing Company 2-stage extrusion apparatus and method of extrusion
US10195779B2 (en) * 2015-07-29 2019-02-05 The Boeing Company Systems and methods for making composite structures
US10086548B2 (en) 2015-07-29 2018-10-02 The Boeing Company Extrusion apparatus and method using variable extrusion gate
US10105889B2 (en) * 2015-07-29 2018-10-23 The Boeing Company 2-stage extrusion apparatus and method of extrusion
ES2915324T3 (es) * 2015-07-31 2022-06-21 Steerlife India Private Ltd Proceso y aparato para granulación continua de material en polvo
RU2619981C2 (ru) * 2015-08-24 2017-05-22 Федеральное Государственное Бюджетное Научное Учреждение "Аграрный Научный Центр "Донской" Способ производства экструдированного комбикорма с добавкой зеленой массы кормовых трав и экструдер-измельчитель
CN106539689B (zh) 2015-09-18 2020-05-22 天士力医药集团股份有限公司 一种连续性的液体凝固的智能滴丸机
US11045977B2 (en) * 2015-12-16 2021-06-29 Covestro Deutschland Ag Device and method for dispersing solids, liquids and gases in an extruder
US10327994B2 (en) * 2016-05-02 2019-06-25 Dose Pack Llc System and methods for customized medicine dosages in a capsule
DE102017114841B4 (de) * 2017-07-04 2022-09-15 Aim3D Gmbh Vorrichtung und Verfahren zur Extrusion von thermo-mechanisch verformbaren granulatförmigen Materialien
EP3459527B1 (en) 2017-09-20 2022-11-23 Tillotts Pharma Ag Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization
KR102104257B1 (ko) * 2018-05-18 2020-04-24 강원대학교산학협력단 열용융압출법을 이용하여 제조된 망간 나노콜로이드 분산체 및 이의 용도
DE102018004355A1 (de) * 2018-06-01 2019-12-05 Entex Rust & Mitschke Gmbh Mischen von extrudierbaren Kunststoffen mit geringen Mengen anderer Stoffe
JP2022502418A (ja) * 2018-09-26 2022-01-11 インベンティア ヘルスケア リミテッド クルクミノイドコンポジット
CN111941798A (zh) * 2020-06-08 2020-11-17 东南大学 一种双螺杆挤出机的双头-三头捏合块的组合
CN112931317B (zh) * 2021-03-23 2022-04-12 浙江省海洋水产研究所 一种提高刀鲚育苗成活率的方法
CN116330616B (zh) * 2023-05-30 2023-08-29 河北凯力华维包装科技有限公司 一种改性pet材料及其制备方法与应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829733B2 (ja) 1977-11-19 1983-06-24 積水化学工業株式会社 押出機
DE3612211A1 (de) 1986-04-11 1987-10-15 Basf Ag Kontinuierliches verfahren zum tablettieren
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
US5075291A (en) * 1989-11-22 1991-12-24 Ici Americas Inc. Crystalline sugar alcohol containing uniformly dispersed particulate pharmaceutical compound
AU1537292A (en) * 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
DE4134026C2 (de) * 1991-10-15 1994-04-21 Werner & Pfleiderer Gleichdrallschneckenkneter
DE4226753A1 (de) * 1992-08-13 1994-02-17 Basf Ag Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
US5266256A (en) * 1993-02-16 1993-11-30 Rohm And Haas Company Extruder and process modifying residence time distribution
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US6238710B1 (en) * 1993-09-24 2001-05-29 Wm. Wrigley, Jr. Company Method for continuous gum base manufacture
GB9415810D0 (en) * 1994-08-04 1994-09-28 Jerrow Mohammad A Z Composition
HUT77777A (hu) 1994-08-04 1998-08-28 Quadrant Holdings Cambridge Limited Szilárd vivőrendszerek molekulák kontrollált kibocsátására és eljárások a vivőrendszerek előállítására
US5472733A (en) * 1994-11-14 1995-12-05 Warner-Lambert Company Dry extrusion cooking of sugar or sugarless products
US5549920A (en) * 1994-12-22 1996-08-27 University Of Alaska Extrusion inactivation of protease enzyme in fish and fish food products
PL189122B1 (pl) * 1995-11-23 2005-06-30 Janssen Pharmaceutica Nv Sposób wytwarzania mieszaniny stałej zawierającejjedną lub wiele cyklodekstryn, mieszanina stała ikompozycja farmaceutyczna
HRP970485A2 (en) * 1996-09-13 1998-08-31 Joerg Rosenberg Process for producing solid pharmaceutical forms
DE19641235A1 (de) * 1996-10-07 1998-05-28 Compex Gmbh Compoundier Und Ex Mehrwellige kontinuierlich arbeitende Mischmaschine für plastifizierbare Massen
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
ES2565163T3 (es) * 1996-10-28 2016-03-31 General Mills, Inc. Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
IT1308870B1 (it) * 1999-11-09 2002-01-11 L M P Impianti S R L Procedimento per la produzione di materiali polimerici espansi eestrusore per la sua attuazione.
US6499984B1 (en) * 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
JP2003011193A (ja) * 2001-07-03 2003-01-15 Ono Sangyo Kk 射出および押出成形用スクリュ
WO2003077827A1 (fr) * 2002-03-19 2003-09-25 Nippon Shinyaku Co., Ltd. Procede de production de medicament solide en dispersion
DE10233213B4 (de) * 2002-07-22 2004-09-09 3+Extruder Gmbh Extruder
DE10242062B4 (de) 2002-09-11 2007-02-15 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Hydrierte kondensierte Palatinose, Verfahren zu deren Herstellung und deren Verwendung
US7188992B2 (en) * 2003-07-30 2007-03-13 Americhem, Inc. Kneading element and related articles
DE10338180B3 (de) * 2003-08-17 2005-04-28 Erich Roos Verfahren zur Herstellung einer Extruderschnecke, sowie eine danach hergestellte Extruderschnecke
US20050048112A1 (en) * 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US20050186427A1 (en) * 2004-02-19 2005-08-25 The Procter & Gamble Company Lubricious coated applicator
ES2452733T3 (es) * 2004-05-28 2014-04-02 Abbvie Deutschland Gmbh & Co Kg Forma de dosificación obtenible a partir de una mezcla pulverulenta que comprende un pigmento inorgánico
GB2418854B (en) * 2004-08-31 2009-12-23 Euro Celtique Sa Multiparticulates
DE102005005173A1 (de) * 2005-01-31 2006-09-14 Beiersdorf Ag Wirkstoffhaltige Selbstklebemassen und deren Herstellung
US20060193896A1 (en) * 2005-02-25 2006-08-31 Cadbury Adams Usa Llc Process for manufacturing a delivery system for active components as part of an edible composition
US7655728B2 (en) * 2005-06-27 2010-02-02 Exxonmobil Chemical Patents Inc. Preparation of thermoplastic elastomers by dynamic vulcanization in multi-screw extruders
EP1832281A1 (en) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
JP2011501050A (ja) 2007-10-26 2011-01-06 新日鉄エンジニアリング株式会社 構造物の免震構造

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2502599C1 (ru) * 2012-11-14 2013-12-27 Станислав Васильевич Володин Способ изготовления пластмассовых изделий

Also Published As

Publication number Publication date
HK1123729A1 (en) 2009-06-26
PL1996163T3 (pl) 2012-03-30
AU2007224486B2 (en) 2013-01-31
RU2442568C2 (ru) 2012-02-20
JP5861057B2 (ja) 2016-02-16
CY1112273T1 (el) 2015-12-09
KR20090004947A (ko) 2009-01-12
ZA200808564B (en) 2009-11-25
HK1215188A1 (zh) 2016-08-19
RU2448688C2 (ru) 2012-04-27
MX2008011041A (es) 2008-09-10
EP1832281A1 (en) 2007-09-12
US9414992B2 (en) 2016-08-16
US9205027B2 (en) 2015-12-08
JP2015038115A (ja) 2015-02-26
AU2007224487A1 (en) 2007-09-20
BRPI0708709A2 (pt) 2011-06-07
EP2959890A1 (en) 2015-12-30
CA2644372A1 (en) 2007-09-20
WO2007104747A3 (en) 2007-11-29
CA2644035A1 (en) 2007-09-20
KR101417892B1 (ko) 2014-07-16
EP1996163A2 (en) 2008-12-03
EP1996164B1 (en) 2013-05-15
PT1996163E (pt) 2012-02-06
EP2386293A1 (en) 2011-11-16
ZA200808563B (en) 2009-11-25
CN101400340B (zh) 2012-07-11
EP1996163B1 (en) 2011-11-02
CN101400341A (zh) 2009-04-01
CA2644035C (en) 2013-12-24
CN101400340A (zh) 2009-04-01
PL1996164T3 (pl) 2013-10-31
KR101453399B1 (ko) 2014-10-22
US20140094479A1 (en) 2014-04-03
JP5670023B2 (ja) 2015-02-18
KR20090010955A (ko) 2009-01-30
WO2007104748A2 (en) 2007-09-20
ES2376764T3 (es) 2012-03-16
EP1996164A2 (en) 2008-12-03
DK1996164T3 (da) 2013-08-05
US20090302493A1 (en) 2009-12-10
ES2425176T3 (es) 2013-10-11
BRPI0708734A2 (pt) 2011-06-14
US20090311414A1 (en) 2009-12-17
JP2009533320A (ja) 2009-09-17
JP2009529516A (ja) 2009-08-20
DK1996163T3 (da) 2012-02-13
WO2007104747A2 (en) 2007-09-20
JP5512134B2 (ja) 2014-06-04
AU2007224486A1 (en) 2007-09-20
CA2644372C (en) 2015-04-28
RU2008140039A (ru) 2010-04-20
HK1125861A1 (en) 2009-08-21
AU2007224487B2 (en) 2012-06-28
ATE531359T1 (de) 2011-11-15
CN101400341B (zh) 2012-04-25
SI1996163T1 (sl) 2012-03-30
US20140087060A1 (en) 2014-03-27
MX2008010956A (es) 2008-09-08
WO2007104748A3 (en) 2007-11-29

Similar Documents

Publication Publication Date Title
RU2008140040A (ru) Улучшенный способ получения твердой дисперсии активного ингредиента
JP5560184B2 (ja) 延伸流動に基づく高分子材料の可塑化運搬方法及びその装置
US5044757A (en) Extrusion device for incorporating additives
KR20010032234A (ko) 고효율 압출기
MXPA04003639A (es) Aparato para moldear por inyeccion articulos de multiples capas.
CN107814996B (zh) 一种可交联聚乙烯改性料的制备方法
US4659230A (en) Mixing element for compounds and extruding machinery
US4925313A (en) Mixing screw for extrusion and injection molding
JP4303115B2 (ja) 可塑化装置内のスクリューの混合エレメント／セクション
DE19715229A1 (de) Verfahren und Vorrichtung zur Kopplung kontinuierlicher Plastifizierung mit zyklischer diskontinuierlicher Schmelzeaustragung
US20080267002A1 (en) Method for Dosing Additive in Injection-Moulding Unit, and Injection-Moulding Unit
US4280802A (en) Screw-type extruder for polyvinylidene fluoride filaments
JPH0538738A (ja) 可塑化部を分離したタイプの成形機
JP2005014272A (ja) 射出ブロー装置用可塑化スクリューの構造
US4134688A (en) Thermosetting resin injection molding machine and method
EP1697108B1 (de) Spritzgussanlage und spritzgiessanlage mit einem mehrwellenextruder, insbesondere ringextruder
JP7033594B2 (ja) 成形体の製造方法及び製造装置
JP4911633B2 (ja) 可塑化装置及びそれを用いた成形方法
CN210634101U (zh) 一种注吹机注塑用移动底座
KR0185698B1 (ko) 성형기용 스크류
Bhairav et al. Hot melt extrusion technique-A review
JP2021094835A (ja) 単軸スクリュー式押出装置
CN218966103U (zh) 一种聚氨酯流延薄膜挤出机专用螺杆
SU1599222A1 (ru) Ротор инжекции роторно-конвейерной литьевой машины дл изготовлени изделий из полимерного материала
JPS62208907A (ja) プラスチツク、ゴム等の可塑化装置

Legal Events

Date Code Title Description
TK4A Correction to the publication in the bulletin (patent)

Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 5-2012

PC41 Official registration of the transfer of exclusive right

Effective date: 20141128

MM4A The patent is invalid due to non-payment of fees

Effective date: 20200313