RU2008140039A - Способ получения твердой дисперсии активного ингредиента - Google Patents

Способ получения твердой дисперсии активного ингредиента Download PDF

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Publication number
RU2008140039A
RU2008140039A RU2008140039/15A RU2008140039A RU2008140039A RU 2008140039 A RU2008140039 A RU 2008140039A RU 2008140039/15 A RU2008140039/15 A RU 2008140039/15A RU 2008140039 A RU2008140039 A RU 2008140039A RU 2008140039 A RU2008140039 A RU 2008140039A
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RU
Russia
Prior art keywords
mixing
zone
item
extruder
worm
Prior art date
Application number
RU2008140039/15A
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English (en)
Other versions
RU2448688C2 (ru
Inventor
Томас КЕССЛЕР (DE)
Томас Кесслер
Йорг БРАЙТЕНБАХ (DE)
Йорг Брайтенбах
Кристоф ШМИДТ (DE)
Кристоф ШМИДТ
Маттиас ДЕГЕНХАРДТ (DE)
Маттиас ДЕГЕНХАРДТ
Йорг РОЗЕНБЕРГ (DE)
Йорг Розенберг
Харальд КРУЛЛЬ (DE)
Харальд КРУЛЛЬ
Original Assignee
Эббетт ГмбХ унд Ко. КГ (DE)
Эббетт ГмбХ унд Ко. КГ
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36754000&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2008140039(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эббетт ГмбХ унд Ко. КГ (DE), Эббетт ГмбХ унд Ко. КГ filed Critical Эббетт ГмбХ унд Ко. КГ (DE)
Publication of RU2008140039A publication Critical patent/RU2008140039A/ru
Application granted granted Critical
Publication of RU2448688C2 publication Critical patent/RU2448688C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/04—Particle-shaped
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    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C48/80—Thermal treatment of the extrusion moulding material or of preformed parts or layers, e.g. by heating or cooling at the plasticising zone, e.g. by heating cylinders
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
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    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0038—Plasticisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29K2105/06—Condition, form or state of moulded material or of the material to be shaped containing reinforcements, fillers or inserts
    • B29K2105/16—Fillers

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Abstract

1. Способ получения твердой дисперсии активного ингредиента, который включает загрузку активного ингредиента и матрицеобразующего агента в экструдер и получение однородного экструдата, где экструдер включает, по меньшей мере, два вращающихся вала (2), где каждый из валов (2) несет множество обрабатывающих элементов, расположенных аксиально друг за другом, где обрабатывающие элементы образуют ! (i) зону загрузки и перемещения (А), ! (ii) по меньшей мере, одну зону смешивания (В) и ! (iii) зону выгрузки (Е), ! где обрабатывающие элемент(ы), образующие зону смешивания (В), содержит(ат) смешивающий элемент (11, 12, 13), который основан на червячном элементе. ! 2. Способ по п.1, где смешивающий элемент (11, 12, 13) имеет канавки в спиральной нарезке червяка червячного элемента. ! 3. Способ по п.1 или 2, где смешивающий элемент не имеет плоской поверхности с нормалью, параллельной и противоположной общему направлению движения. ! 4. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) не имеет поверхности, которая перпендикулярна общему направлению движения. !5. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) не имеет примыкающих поверхностей, которые перпендикулярны общему направлению движения. ! 6. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) имеет множество концентрических кольцевых зон (16; 25), образованных желобками, выточенными в червячном элементе. ! 7. Способ по п.1 или 2, где обрабатывающие элементы дополнительно содержат, по крайней мере, один элемент противодавления (14). ! 8. Способ по п.7, где элемент противодавления (14) расположен по направлению движения к зоне смешивания (D). ! 9. Способ по п.1 или 2, где валы (2) вращаются в одном направлении. !10.

Claims (26)

1. Способ получения твердой дисперсии активного ингредиента, который включает загрузку активного ингредиента и матрицеобразующего агента в экструдер и получение однородного экструдата, где экструдер включает, по меньшей мере, два вращающихся вала (2), где каждый из валов (2) несет множество обрабатывающих элементов, расположенных аксиально друг за другом, где обрабатывающие элементы образуют
(i) зону загрузки и перемещения (А),
(ii) по меньшей мере, одну зону смешивания (В) и
(iii) зону выгрузки (Е),
где обрабатывающие элемент(ы), образующие зону смешивания (В), содержит(ат) смешивающий элемент (11, 12, 13), который основан на червячном элементе.
2. Способ по п.1, где смешивающий элемент (11, 12, 13) имеет канавки в спиральной нарезке червяка червячного элемента.
3. Способ по п.1 или 2, где смешивающий элемент не имеет плоской поверхности с нормалью, параллельной и противоположной общему направлению движения.
4. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) не имеет поверхности, которая перпендикулярна общему направлению движения.
5. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) не имеет примыкающих поверхностей, которые перпендикулярны общему направлению движения.
6. Способ по п.1 или 2, где смешивающий элемент (11, 12, 13) имеет множество концентрических кольцевых зон (16; 25), образованных желобками, выточенными в червячном элементе.
7. Способ по п.1 или 2, где обрабатывающие элементы дополнительно содержат, по крайней мере, один элемент противодавления (14).
8. Способ по п.7, где элемент противодавления (14) расположен по направлению движения к зоне смешивания (D).
9. Способ по п.1 или 2, где валы (2) вращаются в одном направлении.
10. Способ по п.1 или 2, где валы (2) вращаются в противоположных направлениях.
11. Способ по п.1 или 2, где обрабатывающие элементы образуют
(i) зону загрузки и перемещения (А),
(ii) первую зону смешивания (В),
(iii) промежуточную зону перемещения (С),
(iv) вторую зону смешивания (D) и
(v) зону выгрузки (Е).
12. Способ по п.11, где обрабатывающие элементы дополнительно содержат элемент противодавления (14), расположенный по направлению движения и рядом со второй зоной смешивания (D).
13. Способ по п.1, где, по крайней мере, часть матрицеобразующего агента загружают в бункер экструдера и, по крайней мере, один компонент, выбранный из
(i) оставшегося матрицеобразующего агента,
(ii) активного ингредиента,
(iii) добавки и
(iv) их сочетаний,
вводят в экструдер через отверстие (8) в цилиндре экструдера (1), расположенного против направления движения от зоны смешивания (В).
14. Способ по п.13, где, по крайней мере, один компонент вводят в экструдер в месте, близком к месту соединения зоны загрузки и перемещения и зоны смешивания (В).
15. Способ по п.13 или 14, где, по крайней мере, один компонент является жидким или сжиженным.
16. Способ по п.13 или 14, где, по крайней мере, один компонент содержит фармацевтически приемлемое поверхностно-активное вещество.
17. Способ по п.13 или 14, где активный ингредиент диспергирован в полимере в состоянии твердого раствора.
18. Способ по п.13 или 14, где матрицеобразующий агент содержит фармацевтически приемлемый полимер.
19. Способ по п.18, где фармацевтически приемлемый полимер выбирают из группы, включающей
гомополимеры N-виниллактамов,
сополимеры N-виниллактама и одного или более сомономеров, выбранных из азотсодержащих мономеров и кислородсодержащих мономеров,
сложные эфиры целлюлозы и простые эфиры целлюлозы,
оксиды высокомолекулярных полиалкиленоксидов,
полиакрилаты и полиметакрилаты,
олиго- и полисахариды,
поли(гидроксильные кислоты) или их смеси.
20. Способ по п.13 или 14, где матрицеобразующий агент содержит соединение, выбранное из полиолов, восков и липидов.
21. Способ по п.13 или 14, дополнительно включающий загрузку в экструдер, по крайней мере, одной добавки, выбранной из группы, включающей регуляторы потока, смазывающие агенты, наполнители, дезинтеграторы, пластификаторы, стабилизаторы или консерванты.
22. Способ по п.1 или 13, где экструдат формуют непосредственно в лекарственную форму.
23. Способ по п.22, где формование проводят каландрованием, литьем под давлением или экструзией профилированных изделий.
24. Способ по п.22, дополнительно включающий измельчение отвержденного экструдата.
25. Способ по п.24, дополнительно включающий прессование указанной твердой дисперсии в таблетку или заполнение капсулы указанной твердой дисперсией.
26. Способ по п.25, дополнительно включающий нанесение пленочного покрытия на таблетку.
RU2008140039/15A 2006-03-10 2007-03-12 Устройство для получения твердой дисперсии активного ингредиента RU2448688C2 (ru)

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Publication number Priority date Publication date Assignee Title
EP1832281A1 (en) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
JP4746014B2 (ja) * 2007-07-09 2011-08-10 株式会社日本製鋼所 溶融混練脱揮押出機
JP5750266B2 (ja) * 2008-02-28 2015-07-15 アッヴィ・インコーポレイテッド 錠剤およびその調製
AU2009291764A1 (en) * 2008-09-10 2010-03-18 Transcu Ltd. Apparatus and method to dispense HPC-based viscous liquids into porous substrates, e.g., continuous web-based process
US20110201575A1 (en) * 2008-09-17 2011-08-18 Cj Cheiljedang Corporation Stabilized solid dispersion of adefovir dipivoxil and preparation method thereof
US20110034489A1 (en) * 2009-07-31 2011-02-10 Ranbaxy Laboratories Limited Solid dosage forms of hiv protease inhibitors
DE102009040047A1 (de) * 2009-09-04 2011-03-17 Bayer Materialscience Ag Verfahren zur Einarbeitung von Feststoffen in Polymere
WO2012049253A1 (en) * 2010-10-14 2012-04-19 Abbott Gmbh & Co. Kg Curcuminoid solid dispersion formulation
ES2598235T3 (es) 2010-12-23 2017-01-26 AbbVie Deutschland GmbH & Co. KG Formulaciones de retardo sólidas basadas en dispersiones sólidas
US10968129B1 (en) * 2011-04-26 2021-04-06 Mansour S. Bader Minimizing wastes: method for de-oiling, de-scaling and distilling source water
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated
WO2013080148A1 (en) * 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited A process for the preparation of solid dispersion of lopinavir and ritonavir
US20130172375A1 (en) * 2011-12-13 2013-07-04 Hoffmann-La Roche Inc. Pharmaceutical composition
GB2503710A (en) * 2012-07-05 2014-01-08 Res Ct Pharmaceutical Engineering Gmbh System for producing a solid preparation from a suspension
RU2502599C1 (ru) * 2012-11-14 2013-12-27 Станислав Васильевич Володин Способ изготовления пластмассовых изделий
PE20151778A1 (es) 2013-01-31 2015-12-16 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales
WO2014192026A2 (en) 2013-05-27 2014-12-04 Steer Engineering Private Limited A hot melt fragmentation extruder and process
FR3007685B1 (fr) * 2013-06-27 2016-02-05 Clextral Element de vis pour une extrudeuse bivis corotative, ainsi qu'extrudeuse bivis corotative correspondante
PT3038601T (pt) 2013-08-27 2020-06-30 Gilead Pharmasset Llc Formulação combinada de dois compostos antivirais
GB201316023D0 (en) * 2013-09-09 2013-10-23 Res Ct Pharmaceutical Engineering Gmbh Continuous low dosing of an active ingredient
WO2015128853A1 (en) * 2014-02-28 2015-09-03 Sun Pharmaceutical Industries Limited Dapagliflozin compositions
FR3022823B1 (fr) * 2014-06-30 2017-03-10 Michelin & Cie Extrudeuse comportant un fourreau filete
US9586371B2 (en) * 2014-09-02 2017-03-07 Empire Technology Development Llc Method of bonding material layers in an additive manufacturing process
US10933572B2 (en) 2015-07-29 2021-03-02 The Boeing Company 2-stage extrusion apparatus and method of extrusion
US10195779B2 (en) * 2015-07-29 2019-02-05 The Boeing Company Systems and methods for making composite structures
US10086548B2 (en) 2015-07-29 2018-10-02 The Boeing Company Extrusion apparatus and method using variable extrusion gate
US10105889B2 (en) * 2015-07-29 2018-10-23 The Boeing Company 2-stage extrusion apparatus and method of extrusion
ES2915324T3 (es) * 2015-07-31 2022-06-21 Steerlife India Private Ltd Proceso y aparato para granulación continua de material en polvo
RU2619981C2 (ru) * 2015-08-24 2017-05-22 Федеральное Государственное Бюджетное Научное Учреждение "Аграрный Научный Центр "Донской" Способ производства экструдированного комбикорма с добавкой зеленой массы кормовых трав и экструдер-измельчитель
CN106539689B (zh) 2015-09-18 2020-05-22 天士力医药集团股份有限公司 一种连续性的液体凝固的智能滴丸机
US11045977B2 (en) * 2015-12-16 2021-06-29 Covestro Deutschland Ag Device and method for dispersing solids, liquids and gases in an extruder
US10327994B2 (en) * 2016-05-02 2019-06-25 Dose Pack Llc System and methods for customized medicine dosages in a capsule
DE102017114841B4 (de) * 2017-07-04 2022-09-15 Aim3D Gmbh Vorrichtung und Verfahren zur Extrusion von thermo-mechanisch verformbaren granulatförmigen Materialien
EP3459527B1 (en) 2017-09-20 2022-11-23 Tillotts Pharma Ag Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization
KR102104257B1 (ko) * 2018-05-18 2020-04-24 강원대학교산학협력단 열용융압출법을 이용하여 제조된 망간 나노콜로이드 분산체 및 이의 용도
DE102018004355A1 (de) * 2018-06-01 2019-12-05 Entex Rust & Mitschke Gmbh Mischen von extrudierbaren Kunststoffen mit geringen Mengen anderer Stoffe
JP2022502418A (ja) * 2018-09-26 2022-01-11 インベンティア ヘルスケア リミテッド クルクミノイドコンポジット
CN111941798A (zh) * 2020-06-08 2020-11-17 东南大学 一种双螺杆挤出机的双头-三头捏合块的组合
CN112931317B (zh) * 2021-03-23 2022-04-12 浙江省海洋水产研究所 一种提高刀鲚育苗成活率的方法
CN116330616B (zh) * 2023-05-30 2023-08-29 河北凯力华维包装科技有限公司 一种改性pet材料及其制备方法与应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829733B2 (ja) 1977-11-19 1983-06-24 積水化学工業株式会社 押出機
DE3612211A1 (de) 1986-04-11 1987-10-15 Basf Ag Kontinuierliches verfahren zum tablettieren
DE3612212A1 (de) 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
US5075291A (en) * 1989-11-22 1991-12-24 Ici Americas Inc. Crystalline sugar alcohol containing uniformly dispersed particulate pharmaceutical compound
AU1537292A (en) * 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
DE4134026C2 (de) * 1991-10-15 1994-04-21 Werner & Pfleiderer Gleichdrallschneckenkneter
DE4226753A1 (de) * 1992-08-13 1994-02-17 Basf Ag Wirkstoffe enthaltende Zubereitungen in Form fester Teilchen
US5266256A (en) * 1993-02-16 1993-11-30 Rohm And Haas Company Extruder and process modifying residence time distribution
DE4316537A1 (de) * 1993-05-18 1994-11-24 Basf Ag Zubereitungen in Form fester Lösungen
US6238710B1 (en) * 1993-09-24 2001-05-29 Wm. Wrigley, Jr. Company Method for continuous gum base manufacture
GB9415810D0 (en) * 1994-08-04 1994-09-28 Jerrow Mohammad A Z Composition
HUT77777A (hu) 1994-08-04 1998-08-28 Quadrant Holdings Cambridge Limited Szilárd vivőrendszerek molekulák kontrollált kibocsátására és eljárások a vivőrendszerek előállítására
US5472733A (en) * 1994-11-14 1995-12-05 Warner-Lambert Company Dry extrusion cooking of sugar or sugarless products
US5549920A (en) * 1994-12-22 1996-08-27 University Of Alaska Extrusion inactivation of protease enzyme in fish and fish food products
PL189122B1 (pl) * 1995-11-23 2005-06-30 Janssen Pharmaceutica Nv Sposób wytwarzania mieszaniny stałej zawierającejjedną lub wiele cyklodekstryn, mieszanina stała ikompozycja farmaceutyczna
HRP970485A2 (en) * 1996-09-13 1998-08-31 Joerg Rosenberg Process for producing solid pharmaceutical forms
DE19641235A1 (de) * 1996-10-07 1998-05-28 Compex Gmbh Compoundier Und Ex Mehrwellige kontinuierlich arbeitende Mischmaschine für plastifizierbare Massen
US8828432B2 (en) * 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
ES2565163T3 (es) * 1996-10-28 2016-03-31 General Mills, Inc. Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
IT1308870B1 (it) * 1999-11-09 2002-01-11 L M P Impianti S R L Procedimento per la produzione di materiali polimerici espansi eestrusore per la sua attuazione.
US6499984B1 (en) * 2000-05-22 2002-12-31 Warner-Lambert Company Continuous production of pharmaceutical granulation
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
JP2003011193A (ja) * 2001-07-03 2003-01-15 Ono Sangyo Kk 射出および押出成形用スクリュ
WO2003077827A1 (fr) * 2002-03-19 2003-09-25 Nippon Shinyaku Co., Ltd. Procede de production de medicament solide en dispersion
DE10233213B4 (de) * 2002-07-22 2004-09-09 3+Extruder Gmbh Extruder
DE10242062B4 (de) 2002-09-11 2007-02-15 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Hydrierte kondensierte Palatinose, Verfahren zu deren Herstellung und deren Verwendung
US7188992B2 (en) * 2003-07-30 2007-03-13 Americhem, Inc. Kneading element and related articles
DE10338180B3 (de) * 2003-08-17 2005-04-28 Erich Roos Verfahren zur Herstellung einer Extruderschnecke, sowie eine danach hergestellte Extruderschnecke
US20050048112A1 (en) * 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US20050186427A1 (en) * 2004-02-19 2005-08-25 The Procter & Gamble Company Lubricious coated applicator
ES2452733T3 (es) * 2004-05-28 2014-04-02 Abbvie Deutschland Gmbh & Co Kg Forma de dosificación obtenible a partir de una mezcla pulverulenta que comprende un pigmento inorgánico
GB2418854B (en) * 2004-08-31 2009-12-23 Euro Celtique Sa Multiparticulates
DE102005005173A1 (de) * 2005-01-31 2006-09-14 Beiersdorf Ag Wirkstoffhaltige Selbstklebemassen und deren Herstellung
US20060193896A1 (en) * 2005-02-25 2006-08-31 Cadbury Adams Usa Llc Process for manufacturing a delivery system for active components as part of an edible composition
US7655728B2 (en) * 2005-06-27 2010-02-02 Exxonmobil Chemical Patents Inc. Preparation of thermoplastic elastomers by dynamic vulcanization in multi-screw extruders
EP1832281A1 (en) 2006-03-10 2007-09-12 Abbott GmbH & Co. KG Process for producing a solid dispersion of an active ingredient
JP2011501050A (ja) 2007-10-26 2011-01-06 新日鉄エンジニアリング株式会社 構造物の免震構造

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