RU2008134135A - Соединения-антагонисты белка rage и способы их применения - Google Patents
Соединения-антагонисты белка rage и способы их применения Download PDFInfo
- Publication number
- RU2008134135A RU2008134135A RU2008134135/13A RU2008134135A RU2008134135A RU 2008134135 A RU2008134135 A RU 2008134135A RU 2008134135/13 A RU2008134135/13 A RU 2008134135/13A RU 2008134135 A RU2008134135 A RU 2008134135A RU 2008134135 A RU2008134135 A RU 2008134135A
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- Prior art keywords
- seq
- antibody
- rage
- variable region
- hvl
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- 102000004169 proteins and genes Human genes 0.000 title claims 4
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78457506P | 2006-03-21 | 2006-03-21 | |
| US60/784,575 | 2006-03-21 | ||
| US89530307P | 2007-03-16 | 2007-03-16 | |
| US60/895,303 | 2007-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008134135A true RU2008134135A (ru) | 2010-04-27 |
Family
ID=38523302
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008134135/13A RU2008134135A (ru) | 2006-03-21 | 2007-03-21 | Соединения-антагонисты белка rage и способы их применения |
| RU2008137764/13A RU2008137764A (ru) | 2006-03-21 | 2007-03-21 | Способы предотвращения и лечения амилоидных заболеваний |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008137764/13A RU2008137764A (ru) | 2006-03-21 | 2007-03-21 | Способы предотвращения и лечения амилоидных заболеваний |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070286858A1 (enExample) |
| EP (2) | EP2004694A2 (enExample) |
| JP (2) | JP2009529920A (enExample) |
| KR (2) | KR20080110833A (enExample) |
| AU (2) | AU2007226863A1 (enExample) |
| BR (2) | BRPI0708998A2 (enExample) |
| CA (2) | CA2646643A1 (enExample) |
| CR (2) | CR10297A (enExample) |
| EC (1) | ECSP088750A (enExample) |
| MX (2) | MX2008011933A (enExample) |
| NO (2) | NO20083720L (enExample) |
| RU (2) | RU2008134135A (enExample) |
| WO (2) | WO2007109747A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| WO2005122712A2 (en) * | 2003-06-11 | 2005-12-29 | Socratech L.L.C. | Soluble low-density lipoprotein receptor related protein binds directly to alzheimer’s amyloid-beta peptide |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| AU2007226863A1 (en) * | 2006-03-21 | 2007-09-27 | Wyeth | Methods for preventing and treating amyloidogenic diseases |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US8841421B2 (en) * | 2007-04-26 | 2014-09-23 | Active Biotech, Ab | S100A9 interaction screening method |
| EP1986009A1 (en) * | 2007-04-26 | 2008-10-29 | Active Biotech AB | Screening method |
| CA2698343C (en) | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| US20110014624A1 (en) * | 2008-03-12 | 2011-01-20 | Wyeth Llc | Methods For Identifying Cells Suitable For Large-Scale Production of Recombinant Proteins |
| CN102076355B (zh) | 2008-04-29 | 2014-05-07 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| KR101603917B1 (ko) * | 2008-05-09 | 2016-03-17 | 애브비 인코포레이티드 | 최종 당화 산물의 수용체(ｒａｇｅ)에 대한 항체 및 이의 용도 |
| JP2009276245A (ja) * | 2008-05-15 | 2009-11-26 | Shiseido Co Ltd | 持続性皮膚炎症性疾患の改善剤をスクリーニングする方法及びその改善剤 |
| AU2009256246B2 (en) * | 2008-06-03 | 2013-07-18 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| AU2009268585C1 (en) | 2008-07-08 | 2014-10-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
| EP2313436B1 (en) * | 2008-07-22 | 2014-11-26 | Ablynx N.V. | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
| US20100143349A1 (en) * | 2008-08-12 | 2010-06-10 | Wyeth | Humanized anti-rage antibody |
| EP2364359A2 (en) | 2008-09-26 | 2011-09-14 | Wyeth LLC | Compatible display vector systems |
| EP2356231A2 (en) * | 2008-09-26 | 2011-08-17 | Wyeth LLC | Compatible display vector systems |
| KR20180026561A (ko) * | 2009-01-19 | 2018-03-12 | 비오메리으 | 환자가 병원감염에 걸릴 가능성을 결정하고 패혈 증후군 진행의 예후를 결정하는 방법 |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| EP2421892A1 (en) * | 2009-04-20 | 2012-02-29 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
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- 2007-03-21 WO PCT/US2007/064568 patent/WO2007109747A2/en not_active Ceased
- 2007-03-21 US US11/689,480 patent/US20070286858A1/en not_active Abandoned
- 2007-03-21 AU AU2007226861A patent/AU2007226861A1/en not_active Abandoned
- 2007-03-21 JP JP2009501725A patent/JP2009529920A/ja active Pending
- 2007-03-21 WO PCT/US2007/064571 patent/WO2007109749A2/en not_active Ceased
- 2007-03-21 EP EP07759060A patent/EP2004694A2/en not_active Withdrawn
- 2007-03-21 RU RU2008134135/13A patent/RU2008134135A/ru not_active Application Discontinuation
- 2007-03-21 KR KR1020087025473A patent/KR20080110833A/ko not_active Withdrawn
- 2007-03-21 US US11/689,501 patent/US20070253950A1/en not_active Abandoned
- 2007-03-21 MX MX2008011933A patent/MX2008011933A/es unknown
- 2007-03-21 MX MX2008012023A patent/MX2008012023A/es not_active Application Discontinuation
- 2007-03-21 CA CA002646643A patent/CA2646643A1/en not_active Abandoned
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- 2007-03-21 EP EP07759057A patent/EP2001907A2/en not_active Withdrawn
- 2007-03-21 BR BRPI0708998-8A patent/BRPI0708998A2/pt not_active IP Right Cessation
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- 2007-03-21 CA CA002638755A patent/CA2638755A1/en not_active Abandoned
- 2007-03-21 BR BRPI0708970-8A patent/BRPI0708970A2/pt not_active IP Right Cessation
- 2007-03-21 KR KR1020087025056A patent/KR20080113236A/ko not_active Withdrawn
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- 2008-09-19 EC EC2008008750A patent/ECSP088750A/es unknown
- 2008-09-19 CR CR10297A patent/CR10297A/es not_active Application Discontinuation
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| BRPI0708998A2 (pt) | 2011-06-21 |
| JP2009530423A (ja) | 2009-08-27 |
| JP2009529920A (ja) | 2009-08-27 |
| MX2008011933A (es) | 2008-12-18 |
| CA2646643A1 (en) | 2007-09-27 |
| CR10298A (es) | 2008-11-18 |
| CA2638755A1 (en) | 2007-09-27 |
| KR20080110833A (ko) | 2008-12-19 |
| WO2007109747A2 (en) | 2007-09-27 |
| KR20080113236A (ko) | 2008-12-29 |
| US20070253950A1 (en) | 2007-11-01 |
| NO20084039L (no) | 2008-12-15 |
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