RU2007145595A - Способ приготовления тайгециклина - Google Patents
Способ приготовления тайгециклина Download PDFInfo
- Publication number
- RU2007145595A RU2007145595A RU2007145595/15A RU2007145595A RU2007145595A RU 2007145595 A RU2007145595 A RU 2007145595A RU 2007145595/15 A RU2007145595/15 A RU 2007145595/15A RU 2007145595 A RU2007145595 A RU 2007145595A RU 2007145595 A RU2007145595 A RU 2007145595A
- Authority
- RU
- Russia
- Prior art keywords
- water
- tigecycline
- ppm
- result
- oxygen content
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 10
- 239000001301 oxygen Substances 0.000 claims abstract 10
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 10
- 239000000243 solution Substances 0.000 claims abstract 10
- FPZLLRFZJZRHSY-HJYUBDRYSA-N tigecycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(NC(=O)CNC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FPZLLRFZJZRHSY-HJYUBDRYSA-N 0.000 claims abstract 10
- 229960004089 tigecycline Drugs 0.000 claims abstract 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 6
- 239000000843 powder Substances 0.000 claims abstract 6
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 238000000354 decomposition reaction Methods 0.000 claims abstract 2
- 238000004108 freeze drying Methods 0.000 claims abstract 2
- 239000012299 nitrogen atmosphere Substances 0.000 claims abstract 2
- 239000008215 water for injection Substances 0.000 claims abstract 2
- 238000010828 elution Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 238000004007 reversed phase HPLC Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69117305P | 2005-06-16 | 2005-06-16 | |
| US60/691,173 | 2005-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007145595A true RU2007145595A (ru) | 2009-07-27 |
Family
ID=37111782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007145595/15A RU2007145595A (ru) | 2005-06-16 | 2006-06-16 | Способ приготовления тайгециклина |
Country Status (22)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2007713A2 (en) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolation of tetracycline derivatives |
| PT2016045E (pt) * | 2006-04-24 | 2015-02-05 | Teva Pharma | Forma cristalina de tigeciclina e processos para a sua preparação |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| EP2086926A2 (en) * | 2006-11-29 | 2009-08-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
| MX2008009727A (es) * | 2006-11-30 | 2009-01-09 | Teva Pharma | Procesos para la preparacion de 9-haloacetamidominociclinas. |
| WO2008106234A1 (en) * | 2007-03-01 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
| WO2009052152A2 (en) * | 2007-10-16 | 2009-04-23 | Wyeth | Tigecycline and methods of preparing intermediates |
| US9107929B2 (en) | 2008-05-01 | 2015-08-18 | Ranbaxy Laboratories Limited | Stable parenteral formulations of tigecycline |
| ITMI20080807A1 (it) | 2008-05-05 | 2009-11-06 | Antibioticos Spa | Procedimento per la preparazione di tigeciclina in forma amorfa |
| WO2010017273A2 (en) * | 2008-08-06 | 2010-02-11 | Wyeth | Tigecycline formulations |
| PT104350A (pt) | 2009-01-23 | 2010-07-23 | Hovione Farmaci Ncia S A | Processo de isolamento de tigeciclina |
| EP2406213A1 (en) | 2009-03-12 | 2012-01-18 | Wyeth LLC | Nitration of tetracyclines |
| CN103417498B (zh) * | 2012-05-18 | 2017-09-12 | 山东新时代药业有限公司 | 一种替加环素冻干粉针剂的制备方法 |
| IN2013MU01127A (cg-RX-API-DMAC10.html) | 2013-03-26 | 2015-05-01 | Astron Res Ltd | |
| WO2014167575A2 (en) | 2013-03-26 | 2014-10-16 | Astron Research Limited | Stable tigecycline composition |
| CN103202814A (zh) * | 2013-04-23 | 2013-07-17 | 成都百裕科技制药有限公司 | 一种注射用替加环素的制备方法 |
| CN105924367B (zh) * | 2016-04-18 | 2017-12-29 | 镇江高海生物药业有限公司 | 多西环素一水物的有关物质及其分析检测方法 |
| US20190233153A1 (en) * | 2018-01-26 | 2019-08-01 | AL Pharma, Inc. | Manufacturing and packaging of a sterile drug product |
| CN108653216B (zh) * | 2018-05-28 | 2020-12-18 | 福安药业集团湖北人民制药有限公司 | 注射用替加环素 |
| WO2021063468A1 (en) | 2019-10-02 | 2021-04-08 | Anfarm Hellas S.A. | Stable parenteral pharmaceutical composition containing tigecycline and process for the preparation thereof |
| CN116531322A (zh) * | 2023-06-27 | 2023-08-04 | 遂成药业股份有限公司 | 一种高稳定性呋塞米注射液及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3026248A (en) * | 1959-09-11 | 1962-03-20 | Pfizer & Co C | Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents |
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US6660267B1 (en) * | 1992-12-21 | 2003-12-09 | Promega Corporation | Prevention and treatment of sepsis |
| US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
| AU2003265241A1 (en) * | 2002-05-23 | 2003-12-12 | Activbiotics, Inc. | Methods of treating bacterial infections and diseases associated therewith |
| CN101039679A (zh) * | 2004-10-28 | 2007-09-19 | 惠氏公司 | 替加环素和地高辛的共投与 |
| EP1858488B2 (en) * | 2005-03-14 | 2022-07-20 | Wyeth LLC | Tigecycline compositions and methods of preparation |
| AR057034A1 (es) | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
-
2006
- 2006-06-15 PE PE2006000670A patent/PE20070072A1/es not_active Application Discontinuation
- 2006-06-15 AR ARP060102533A patent/AR055336A1/es unknown
- 2006-06-16 US US11/455,144 patent/US7705168B2/en not_active Expired - Fee Related
- 2006-06-16 GT GT200600259A patent/GT200600259A/es unknown
- 2006-06-16 JP JP2008517178A patent/JP2008543871A/ja active Pending
- 2006-06-16 WO PCT/US2006/023613 patent/WO2006138641A2/en not_active Ceased
- 2006-06-16 RU RU2007145595/15A patent/RU2007145595A/ru not_active Application Discontinuation
- 2006-06-16 TW TW095121834A patent/TW200716203A/zh unknown
- 2006-06-16 CA CA002610909A patent/CA2610909A1/en not_active Abandoned
- 2006-06-16 BR BRPI0612228-0A patent/BRPI0612228A2/pt not_active IP Right Cessation
- 2006-06-16 CN CNA2006800213849A patent/CN101198315A/zh active Pending
- 2006-06-16 AU AU2006261636A patent/AU2006261636A1/en not_active Abandoned
- 2006-06-16 PA PA20068680201A patent/PA8680201A1/es unknown
- 2006-06-16 MX MX2007015960A patent/MX2007015960A/es unknown
- 2006-06-16 SV SV2006002575A patent/SV2007002575A/es unknown
- 2006-06-16 KR KR1020087001124A patent/KR20080024201A/ko not_active Withdrawn
- 2006-06-16 EP EP06773424A patent/EP1898884A2/en not_active Withdrawn
-
2007
- 2007-12-05 NO NO20076264A patent/NO20076264L/no not_active Application Discontinuation
- 2007-12-06 IL IL187979A patent/IL187979A0/en unknown
- 2007-12-12 EC EC2007008005A patent/ECSP078005A/es unknown
- 2007-12-14 CR CR9594A patent/CR9594A/es unknown
- 2007-12-14 ZA ZA200710906A patent/ZA200710906B/xx unknown
-
2009
- 2009-06-05 JP JP2009136753A patent/JP2009191083A/ja not_active Withdrawn
- 2009-11-05 JP JP2009254475A patent/JP2010024252A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AR055336A1 (es) | 2007-08-22 |
| EP1898884A2 (en) | 2008-03-19 |
| JP2009191083A (ja) | 2009-08-27 |
| WO2006138641A3 (en) | 2007-05-18 |
| GT200600259A (es) | 2007-05-08 |
| SV2007002575A (es) | 2007-01-03 |
| CR9594A (es) | 2008-03-07 |
| JP2008543871A (ja) | 2008-12-04 |
| AU2006261636A1 (en) | 2006-12-28 |
| CN101198315A (zh) | 2008-06-11 |
| KR20080024201A (ko) | 2008-03-17 |
| BRPI0612228A2 (pt) | 2011-03-29 |
| WO2006138641A2 (en) | 2006-12-28 |
| CA2610909A1 (en) | 2006-12-28 |
| JP2010024252A (ja) | 2010-02-04 |
| US7705168B2 (en) | 2010-04-27 |
| MX2007015960A (es) | 2008-03-06 |
| TW200716203A (en) | 2007-05-01 |
| ZA200710906B (en) | 2009-03-25 |
| NO20076264L (no) | 2008-03-10 |
| PE20070072A1 (es) | 2007-02-25 |
| IL187979A0 (en) | 2008-03-20 |
| PA8680201A1 (es) | 2007-01-17 |
| ECSP078005A (es) | 2008-01-23 |
| US20070026080A1 (en) | 2007-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20100802 |