RU2007139634A - Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения - Google Patents

Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения Download PDF

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Publication number
RU2007139634A
RU2007139634A RU2007139634/04A RU2007139634A RU2007139634A RU 2007139634 A RU2007139634 A RU 2007139634A RU 2007139634/04 A RU2007139634/04 A RU 2007139634/04A RU 2007139634 A RU2007139634 A RU 2007139634A RU 2007139634 A RU2007139634 A RU 2007139634A
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RU
Russia
Prior art keywords
unsubstituted
compound according
methyl
alkyl
hydrogen
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RU2007139634/04A
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English (en)
Russian (ru)
Inventor
Сергей Олегович Бачурин (RU)
Сергей Олегович Бачурин
Анатолий Константинович Устинов (RU)
Анатолий Константинович Устинов
Богдан Константинович Безноско (RU)
Богдан Константинович Безноско
Елена Феофановна Шевцова (RU)
Елена Феофановна Шевцова
Владимир Викторович Григорьев (RU)
Владимир Викторович Григорьев
Original Assignee
Сергей Олегович Бачурин (RU)
Сергей Олегович Бачурин
Анатолий Константинович Устинов (RU)
Анатолий Константинович Устинов
Богдан Константинович Безноско (RU)
Богдан Константинович Безноско
Елена Феофановна Шевцова (RU)
Елена Феофановна Шевцова
Владимир Викторович Григорьев (RU)
Владимир Викторович Григорьев
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сергей Олегович Бачурин (RU), Сергей Олегович Бачурин, Анатолий Константинович Устинов (RU), Анатолий Константинович Устинов, Богдан Константинович Безноско (RU), Богдан Константинович Безноско, Елена Феофановна Шевцова (RU), Елена Феофановна Шевцова, Владимир Викторович Григорьев (RU), Владимир Викторович Григорьев filed Critical Сергей Олегович Бачурин (RU)
Priority to RU2007139634/04A priority Critical patent/RU2007139634A/ru
Priority to AU2008316560A priority patent/AU2008316560B2/en
Priority to UY31436A priority patent/UY31436A1/es
Priority to BRPI0816582-3A priority patent/BRPI0816582A2/pt
Priority to US12/259,234 priority patent/US8338408B2/en
Priority to PE2008001834A priority patent/PE20091346A1/es
Priority to CN2008801226525A priority patent/CN101952284A/zh
Priority to PCT/US2008/081390 priority patent/WO2009055828A1/en
Priority to CA2704008A priority patent/CA2704008A1/en
Priority to EP08841761A priority patent/EP2217598A1/en
Priority to CN201610525730.2A priority patent/CN106188043A/zh
Priority to JP2010531322A priority patent/JP5665543B2/ja
Publication of RU2007139634A publication Critical patent/RU2007139634A/ru
Priority to US13/679,873 priority patent/US8999978B2/en
Priority to US13/725,909 priority patent/US9181240B2/en
Priority to US13/791,750 priority patent/US9034880B2/en
Priority to US13/797,723 priority patent/US9096591B2/en
Priority to JP2013238503A priority patent/JP2014034579A/ja
Priority to US14/631,615 priority patent/US20150182509A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2007139634/04A 2007-10-25 2007-10-25 Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения RU2007139634A (ru)

Priority Applications (18)

Application Number Priority Date Filing Date Title
RU2007139634/04A RU2007139634A (ru) 2007-10-25 2007-10-25 Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
EP08841761A EP2217598A1 (en) 2007-10-25 2008-10-27 New tetracyclic compounds
CN201610525730.2A CN106188043A (zh) 2007-10-25 2008-10-27 四环化合物
BRPI0816582-3A BRPI0816582A2 (pt) 2007-10-25 2008-10-27 Composto, método para tratar um distúrbio cognitivo, distúrbio psicótico, distúrbio mediado por neurotransmissor ou distúrbio neuronal em um indivíduo, composição farmacêutica, uso de um composto e kit
US12/259,234 US8338408B2 (en) 2007-10-25 2008-10-27 Tetracyclic compounds
PE2008001834A PE20091346A1 (es) 2007-10-25 2008-10-27 Compuestos tretraciclicos como moduladores de un receptor aminergico acoplado a la proteina g
CN2008801226525A CN101952284A (zh) 2007-10-25 2008-10-27 新的四环化合物
PCT/US2008/081390 WO2009055828A1 (en) 2007-10-25 2008-10-27 New tetracyclic compounds
CA2704008A CA2704008A1 (en) 2007-10-25 2008-10-27 New tetracyclic compounds
AU2008316560A AU2008316560B2 (en) 2007-10-25 2008-10-27 New tetracyclic compounds
UY31436A UY31436A1 (es) 2007-10-25 2008-10-27 Nuevos compuestos tetracíclicos
JP2010531322A JP5665543B2 (ja) 2007-10-25 2008-10-27 新規四環系化合物
US13/679,873 US8999978B2 (en) 2007-10-25 2012-11-16 Tetracyclic compounds
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US8338408B2 (en) 2012-12-25
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