RU2007121768A - Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера - Google Patents
Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера Download PDFInfo
- Publication number
- RU2007121768A RU2007121768A RU2007121768/04A RU2007121768A RU2007121768A RU 2007121768 A RU2007121768 A RU 2007121768A RU 2007121768/04 A RU2007121768/04 A RU 2007121768/04A RU 2007121768 A RU2007121768 A RU 2007121768A RU 2007121768 A RU2007121768 A RU 2007121768A
- Authority
- RU
- Russia
- Prior art keywords
- lower alkyl
- halogen
- compounds
- substituted
- formula
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- 239000004471 Glycine Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- LLLJLXQIMUXROW-UHFFFAOYSA-N (2-cyclopentyloxy-5-methylsulfonylphenyl)-(3,4-dihydro-1h-pyrazino[1,2-a]benzimidazol-2-yl)methanone Chemical compound C1CN(C2=CC=CC=C2N=2)C=2CN1C(=O)C1=CC(S(=O)(=O)C)=CC=C1OC1CCCC1 LLLJLXQIMUXROW-UHFFFAOYSA-N 0.000 claims 1
- KCJZTPWCLICMLQ-UHFFFAOYSA-N (5-methylsulfonyl-2-propan-2-yloxyphenyl)-(2-thiophen-2-yl-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridin-5-yl)methanone Chemical compound CC(C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(SC(=N2)C=3SC=CC=3)=C2CC1 KCJZTPWCLICMLQ-UHFFFAOYSA-N 0.000 claims 1
- CMMVMILISTUYCM-UHFFFAOYSA-N (5-methylsulfonyl-2-propan-2-yloxyphenyl)-[8-(trifluoromethoxy)-3,4,10,10a-tetrahydro-1h-pyrazino[1,2-a]indol-2-yl]methanone Chemical compound CC(C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(CC=2C3=CC=C(OC(F)(F)F)C=2)N3CC1 CMMVMILISTUYCM-UHFFFAOYSA-N 0.000 claims 1
- MULXNWGAMDNBRU-UHFFFAOYSA-N (5-methylsulfonyl-2-propan-2-yloxyphenyl)-[8-(trifluoromethoxy)-3,4-dihydro-1h-pyrazino[1,2-a]indol-2-yl]methanone Chemical compound CC(C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC2=CC3=CC(OC(F)(F)F)=CC=C3N2CC1 MULXNWGAMDNBRU-UHFFFAOYSA-N 0.000 claims 1
- DVBBSAHKWYTDFR-UHFFFAOYSA-N (6-chloro-3,4-dihydro-1h-[1]benzothiolo[2,3-c]pyridin-2-yl)-(5-methylsulfonyl-2-morpholin-4-ylphenyl)methanone Chemical compound C1CC(C2=CC(Cl)=CC=C2S2)=C2CN1C(=O)C1=CC(S(=O)(=O)C)=CC=C1N1CCOCC1 DVBBSAHKWYTDFR-UHFFFAOYSA-N 0.000 claims 1
- FBVXOUMFDUGSSU-UHFFFAOYSA-N (6-chloro-3,4-dihydro-1h-[1]benzothiolo[2,3-c]pyridin-2-yl)-(5-methylsulfonyl-2-propan-2-yloxyphenyl)methanone Chemical compound CC(C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(SC=2C3=CC(Cl)=CC=2)=C3CC1 FBVXOUMFDUGSSU-UHFFFAOYSA-N 0.000 claims 1
- XRTUWZXGIANIEF-UHFFFAOYSA-N (6-chloro-3,4-dihydro-1h-[1]benzothiolo[2,3-c]pyridin-2-yl)-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]methanone Chemical compound C1CC(C2=CC(Cl)=CC=C2S2)=C2CN1C(=O)C1=CC(S(=O)(=O)C)=CC=C1OCC1CC1 XRTUWZXGIANIEF-UHFFFAOYSA-N 0.000 claims 1
- UDUGWBZTBZDRMY-LBPRGKRZSA-N (6-chloro-3,4-dihydro-1h-[1]benzothiolo[2,3-c]pyridin-2-yl)-[5-methylsulfonyl-2-[(2s)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone Chemical compound FC(F)(F)[C@H](C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(SC=2C3=CC(Cl)=CC=2)=C3CC1 UDUGWBZTBZDRMY-LBPRGKRZSA-N 0.000 claims 1
- UHCMPERRHKPDHP-UHFFFAOYSA-N (7-chloro-3,4-dihydro-1h-pyrazino[1,2-a]indol-2-yl)-(5-methylsulfonyl-2-propan-2-yloxyphenyl)methanone Chemical compound CC(C)OC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC2=CC3=CC=C(Cl)C=C3N2CC1 UHCMPERRHKPDHP-UHFFFAOYSA-N 0.000 claims 1
- MMHXSZKIVSTETL-UHFFFAOYSA-N 3-(6-chloro-3,4-dihydro-1h-[1]benzothiolo[2,3-c]pyridine-2-carbonyl)-4-propan-2-yloxybenzonitrile Chemical compound CC(C)OC1=CC=C(C#N)C=C1C(=O)N1CC(SC=2C3=CC(Cl)=CC=2)=C3CC1 MMHXSZKIVSTETL-UHFFFAOYSA-N 0.000 claims 1
- BMMCFASUEOWKAB-UHFFFAOYSA-N [2-(2-methylpropoxy)-5-methylsulfonylphenyl]-(2-thiophen-2-yl-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridin-5-yl)methanone Chemical compound CC(C)COC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(SC(=N2)C=3SC=CC=3)=C2CC1 BMMCFASUEOWKAB-UHFFFAOYSA-N 0.000 claims 1
- PHYFGNDDNLXSCU-UHFFFAOYSA-N [2-(2-methylpropoxy)-5-methylsulfonylphenyl]-[2-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridin-5-yl]methanone Chemical compound CC(C)COC1=CC=C(S(C)(=O)=O)C=C1C(=O)N1CC(SC(=N2)C=3C=CC(=CC=3)C(F)(F)F)=C2CC1 PHYFGNDDNLXSCU-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106597.0 | 2004-12-15 | ||
| EP04106597 | 2004-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007121768A true RU2007121768A (ru) | 2009-01-27 |
Family
ID=35841863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007121768/04A RU2007121768A (ru) | 2004-12-15 | 2005-12-05 | Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7375226B2 (https=) |
| EP (1) | EP1828200B1 (https=) |
| JP (1) | JP4709849B2 (https=) |
| KR (1) | KR100883003B1 (https=) |
| CN (1) | CN100586951C (https=) |
| AR (1) | AR052156A1 (https=) |
| AT (1) | ATE457989T1 (https=) |
| AU (1) | AU2005315914B2 (https=) |
| BR (1) | BRPI0519054A2 (https=) |
| CA (1) | CA2590316A1 (https=) |
| DE (1) | DE602005019465D1 (https=) |
| ES (1) | ES2338139T3 (https=) |
| IL (1) | IL183592A0 (https=) |
| MX (1) | MX2007006896A (https=) |
| NO (1) | NO20072833L (https=) |
| NZ (1) | NZ555476A (https=) |
| RU (1) | RU2007121768A (https=) |
| TW (1) | TWI299041B (https=) |
| WO (1) | WO2006063709A1 (https=) |
| ZA (1) | ZA200705044B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7485637B2 (en) * | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
| RU2338537C2 (ru) * | 2006-01-25 | 2008-11-20 | Сергей Олегович Бачурин | СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
| KR102107954B1 (ko) | 2007-03-12 | 2020-05-07 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| EP2527328A1 (en) | 2008-04-01 | 2012-11-28 | Abbott GmbH & Co. KG | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| EP2393878B1 (de) | 2009-02-06 | 2012-12-12 | Styrolution GmbH | Thermoplastische formmassen auf basis von styrolcopolymeren und polyamiden mit verbesserter witterungsbeständigkeit |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| TW201038569A (en) * | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CA2806103A1 (en) * | 2010-08-31 | 2012-03-08 | Vanderbilt University | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mglur5 receptors |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8853196B2 (en) | 2011-08-05 | 2014-10-07 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN104011028A (zh) | 2011-11-18 | 2014-08-27 | 艾伯维德国有限责任两合公司 | N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途 |
| AU2012357169B2 (en) * | 2011-12-22 | 2017-03-30 | Merck Patent Gmbh | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN104203951B (zh) * | 2012-03-16 | 2016-11-02 | 生命医药公司 | 肝x受体调节剂 |
| WO2013138568A1 (en) * | 2012-03-16 | 2013-09-19 | Vitae Pharmaceuticals, Inc. | Liver x reception modulators |
| KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2015055770A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| SG11201602935PA (en) | 2013-10-17 | 2016-05-30 | Abbvie Deutschland | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| KR102373288B1 (ko) | 2013-12-03 | 2022-03-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA2944755A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| DK3407889T3 (da) | 2016-03-25 | 2021-08-09 | Intra Cellular Therapies Inc | Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet |
| EP3436455A4 (en) | 2016-03-28 | 2019-09-04 | Intra-Cellular Therapies, Inc. | NOVEL SALTS AND CRYSTALS |
| US11014925B2 (en) | 2016-03-28 | 2021-05-25 | Intra-Cellular Therapies, Inc. | Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3525763B1 (en) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| EP3562484B1 (en) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
| EP3658144B1 (en) | 2017-07-26 | 2022-01-26 | Intra-Cellular Therapies, Inc. | Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy |
| WO2019023062A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| AU2019280850C1 (en) | 2018-06-06 | 2025-02-13 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| EP3801527B1 (en) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
| CA3240552A1 (en) | 2018-06-11 | 2019-12-19 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| JP7520013B2 (ja) | 2018-12-17 | 2024-07-22 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 置換複素環縮合γ－カルボリンの合成 |
| IL315005B2 (en) | 2018-12-17 | 2026-04-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| WO2021007245A1 (en) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Novel methods |
| EP4072554A4 (en) | 2019-12-11 | 2023-12-20 | Intra-Cellular Therapies, Inc. | ORGANIC CONNECTION |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423847A1 (de) * | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2611705A1 (de) * | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| JPH08325234A (ja) * | 1995-05-30 | 1996-12-10 | Yamanouchi Pharmaceut Co Ltd | 安息香酸誘導体又はその塩 |
| US6001854A (en) * | 1996-05-31 | 1999-12-14 | Allelix Neuroscience Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
| PL343435A1 (en) * | 1998-03-06 | 2001-08-13 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
| EP1058684A1 (en) * | 1998-03-06 | 2000-12-13 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
| EP1296950A2 (en) * | 2000-04-20 | 2003-04-02 | NPS Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| ATE449090T1 (de) | 2001-07-02 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
| WO2003035602A1 (en) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Lipid modulators |
| TWI329111B (en) * | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| WO2004037800A1 (en) | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
| RS53252B (sr) * | 2003-08-11 | 2014-08-29 | F.Hoffmann-La Roche Ag. | Piperazin sa or-supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1 |
| CN1874777B (zh) * | 2003-09-09 | 2012-07-04 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸摄取抑制剂用于治疗精神病的1-(2-氨基-苯甲酰基)-哌嗪衍生物 |
| WO2005023261A1 (en) * | 2003-09-09 | 2005-03-17 | F. Hoffmann-La Roche Ag | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
-
2005
- 2005-12-05 AT AT05823127T patent/ATE457989T1/de active
- 2005-12-05 JP JP2007545891A patent/JP4709849B2/ja not_active Expired - Fee Related
- 2005-12-05 AU AU2005315914A patent/AU2005315914B2/en not_active Ceased
- 2005-12-05 CN CN200580042730A patent/CN100586951C/zh not_active Expired - Fee Related
- 2005-12-05 ES ES05823127T patent/ES2338139T3/es not_active Expired - Lifetime
- 2005-12-05 MX MX2007006896A patent/MX2007006896A/es active IP Right Grant
- 2005-12-05 DE DE602005019465T patent/DE602005019465D1/de not_active Expired - Lifetime
- 2005-12-05 NZ NZ555476A patent/NZ555476A/en not_active IP Right Cessation
- 2005-12-05 RU RU2007121768/04A patent/RU2007121768A/ru not_active Application Discontinuation
- 2005-12-05 WO PCT/EP2005/012994 patent/WO2006063709A1/en not_active Ceased
- 2005-12-05 KR KR1020077013440A patent/KR100883003B1/ko not_active Expired - Fee Related
- 2005-12-05 CA CA002590316A patent/CA2590316A1/en not_active Abandoned
- 2005-12-05 BR BRPI0519054-1A patent/BRPI0519054A2/pt not_active IP Right Cessation
- 2005-12-05 EP EP05823127A patent/EP1828200B1/en not_active Expired - Lifetime
- 2005-12-08 US US11/297,597 patent/US7375226B2/en not_active Expired - Fee Related
- 2005-12-12 TW TW094143890A patent/TWI299041B/zh not_active IP Right Cessation
- 2005-12-13 AR ARP050105207A patent/AR052156A1/es not_active Application Discontinuation
-
2007
- 2007-05-31 IL IL183592A patent/IL183592A0/en unknown
- 2007-06-04 NO NO20072833A patent/NO20072833L/no not_active Application Discontinuation
- 2007-06-07 ZA ZA200705044A patent/ZA200705044B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE457989T1 (de) | 2010-03-15 |
| NZ555476A (en) | 2009-09-25 |
| AU2005315914B2 (en) | 2011-03-03 |
| AR052156A1 (es) | 2007-03-07 |
| IL183592A0 (en) | 2007-09-20 |
| CN101076532A (zh) | 2007-11-21 |
| TWI299041B (en) | 2008-07-21 |
| KR100883003B1 (ko) | 2009-02-12 |
| DE602005019465D1 (de) | 2010-04-01 |
| ZA200705044B (en) | 2008-09-25 |
| AU2005315914A1 (en) | 2006-06-22 |
| EP1828200B1 (en) | 2010-02-17 |
| ES2338139T3 (es) | 2010-05-04 |
| WO2006063709A1 (en) | 2006-06-22 |
| KR20070086196A (ko) | 2007-08-27 |
| US7375226B2 (en) | 2008-05-20 |
| BRPI0519054A2 (pt) | 2008-12-23 |
| JP4709849B2 (ja) | 2011-06-29 |
| NO20072833L (no) | 2007-07-17 |
| JP2008523126A (ja) | 2008-07-03 |
| US20060128713A1 (en) | 2006-06-15 |
| CN100586951C (zh) | 2010-02-03 |
| EP1828200A1 (en) | 2007-09-05 |
| CA2590316A1 (en) | 2006-06-22 |
| TW200634017A (en) | 2006-10-01 |
| MX2007006896A (es) | 2007-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2007121768A (ru) | Би- и трициклически замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 (glyt-1) для лечения болезни альцгеймера | |
| JP6594570B2 (ja) | ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物 | |
| TWI680128B (zh) | 二氫吡咯並吡啶衍生物 | |
| KR20150100879A (ko) | Ａ2ａ 길항제 성질을 갖는 헤테로비시클로-치환된-[1,2,4]트리아졸로[1,5-ｃ]퀴나졸린-5-아민 화합물 | |
| NZ586579A (en) | Fused heterocyclic derivatives and methods of use as c-met inhibitors | |
| JP2016504363A5 (https=) | ||
| RU2008145660A (ru) | Фармацевтические соединения | |
| JP2011500774A5 (https=) | ||
| JP2000502723A (ja) | 置換された６，５―ヘテロ―二環式誘導体 | |
| RU2007107910A (ru) | Гетероциклические соединения | |
| RU2007128625A (ru) | Гетероциклические замещенные фенилметаноны в качестве ингибиторов переносчика глицина 1 | |
| JP2011500774A (ja) | Ｐｉ３ｋ阻害剤としてのチエノピリミジエン誘導体 | |
| JP2010531344A5 (https=) | ||
| CN109384803A (zh) | Atx抑制剂及其制备方法和应用 | |
| CN110662536A (zh) | 激酶网络抑制剂及其用途 | |
| CN102388055A (zh) | 咪唑并[2,1-b][1,3,4]噻二唑衍生物 | |
| CA3191362A1 (en) | Pyrazolopyridazinone compound, and pharmaceutical composition and use thereof | |
| EP4634183A1 (en) | Substituted tetrahydropyrrolo-pyridinone compounds and their use in treating medical conditions | |
| ES2309398T3 (es) | Derivados 3,4-dihidro-tieno (2,3-d)pirimidin-4-ona-3-sustituidos, produccion y sus usos. | |
| EP4634193A1 (en) | Substituted dihydropyrrolo[3, 4-d]pyrimidine compounds and their use in treating medical conditions | |
| RU2007114763A (ru) | Галогенозамещенные производные бензодиазепинов | |
| JP6345651B2 (ja) | ヘテロアリール化合物及びその使用方法 | |
| CN105163760B (zh) | 肝纤维化的预防或治疗试剂 | |
| JP2008542376A5 (https=) | ||
| ES2909537T3 (es) | Compuesto de diaril[a,g]quinolizidina, método de preparación para el mismo, composición farmacéutica y usos del mismo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20091201 |