MX2007006896A - Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer. - Google Patents

Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.

Info

Publication number
MX2007006896A
MX2007006896A MX2007006896A MX2007006896A MX2007006896A MX 2007006896 A MX2007006896 A MX 2007006896A MX 2007006896 A MX2007006896 A MX 2007006896A MX 2007006896 A MX2007006896 A MX 2007006896A MX 2007006896 A MX2007006896 A MX 2007006896A
Authority
MX
Mexico
Prior art keywords
lower alkyl
halogen
treatment
glyt
alzheimer
Prior art date
Application number
MX2007006896A
Other languages
English (en)
Spanish (es)
Inventor
Emmanuel Pinard
Synese Jolidon
Roger David Norcross
Robert Narquizian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007006896A publication Critical patent/MX2007006896A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2007006896A 2004-12-15 2005-12-05 Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer. MX2007006896A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106597 2004-12-15
PCT/EP2005/012994 WO2006063709A1 (en) 2004-12-15 2005-12-05 Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer’s disease

Publications (1)

Publication Number Publication Date
MX2007006896A true MX2007006896A (es) 2007-06-26

Family

ID=35841863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006896A MX2007006896A (es) 2004-12-15 2005-12-05 Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.

Country Status (20)

Country Link
US (1) US7375226B2 (https=)
EP (1) EP1828200B1 (https=)
JP (1) JP4709849B2 (https=)
KR (1) KR100883003B1 (https=)
CN (1) CN100586951C (https=)
AR (1) AR052156A1 (https=)
AT (1) ATE457989T1 (https=)
AU (1) AU2005315914B2 (https=)
BR (1) BRPI0519054A2 (https=)
CA (1) CA2590316A1 (https=)
DE (1) DE602005019465D1 (https=)
ES (1) ES2338139T3 (https=)
IL (1) IL183592A0 (https=)
MX (1) MX2007006896A (https=)
NO (1) NO20072833L (https=)
NZ (1) NZ555476A (https=)
RU (1) RU2007121768A (https=)
TW (1) TWI299041B (https=)
WO (1) WO2006063709A1 (https=)
ZA (1) ZA200705044B (https=)

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Also Published As

Publication number Publication date
JP4709849B2 (ja) 2011-06-29
ES2338139T3 (es) 2010-05-04
AU2005315914B2 (en) 2011-03-03
ZA200705044B (en) 2008-09-25
TWI299041B (en) 2008-07-21
BRPI0519054A2 (pt) 2008-12-23
DE602005019465D1 (de) 2010-04-01
EP1828200B1 (en) 2010-02-17
CN100586951C (zh) 2010-02-03
NZ555476A (en) 2009-09-25
JP2008523126A (ja) 2008-07-03
TW200634017A (en) 2006-10-01
EP1828200A1 (en) 2007-09-05
WO2006063709A1 (en) 2006-06-22
CA2590316A1 (en) 2006-06-22
US20060128713A1 (en) 2006-06-15
KR20070086196A (ko) 2007-08-27
IL183592A0 (en) 2007-09-20
US7375226B2 (en) 2008-05-20
AU2005315914A1 (en) 2006-06-22
ATE457989T1 (de) 2010-03-15
NO20072833L (no) 2007-07-17
CN101076532A (zh) 2007-11-21
KR100883003B1 (ko) 2009-02-12
RU2007121768A (ru) 2009-01-27
AR052156A1 (es) 2007-03-07

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