RU2007106870A - 6Н-[1]БЕНЗОПИРАНО[4,3-b]ХИНОЛИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЭСТРОГЕННЫХ АГЕНТОВ - Google Patents
6Н-[1]БЕНЗОПИРАНО[4,3-b]ХИНОЛИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЭСТРОГЕННЫХ АГЕНТОВ Download PDFInfo
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- RU2007106870A RU2007106870A RU2007106870/04A RU2007106870A RU2007106870A RU 2007106870 A RU2007106870 A RU 2007106870A RU 2007106870/04 A RU2007106870/04 A RU 2007106870/04A RU 2007106870 A RU2007106870 A RU 2007106870A RU 2007106870 A RU2007106870 A RU 2007106870A
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Classifications
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Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1667595B1 (en) | 2003-09-12 | 2014-01-01 | Vessix Vascular, Inc. | System for selectable eccentric remodeling and/or ablation of atherosclerotic material |
| EP1761513A1 (en) * | 2004-07-01 | 2007-03-14 | Wyeth | Tetracyclic compounds as estrogen ligands |
| US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
| US8396548B2 (en) | 2008-11-14 | 2013-03-12 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
| CA2613703A1 (en) | 2005-06-28 | 2007-01-04 | Cv Therapeutics, Inc. | Abca1 elevating compounds |
| US20070191442A1 (en) * | 2006-02-14 | 2007-08-16 | Wyeth | Aqueous Pharmaceutical Formulations of ER-beta Selective Ligands |
| US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
| CA2666660C (en) | 2006-10-18 | 2015-06-02 | Minnow Medical, Inc. | Inducing desirable temperature effects on body tissue |
| ES2407329T3 (es) | 2006-10-18 | 2013-06-12 | Vessix Vascular, Inc. | Sistema para inducir efectos de temperatura deseables sobre un tejido corporal |
| WO2008049084A2 (en) | 2006-10-18 | 2008-04-24 | Minnow Medical, Inc. | Tuned rf energy and electrical tissue characterization for selective treatment of target tissues |
| CA2672428A1 (en) * | 2006-12-27 | 2008-07-03 | Cv Therapeutics, Inc. | Abca1 elevating compounds |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| EA026578B1 (ru) | 2007-01-22 | 2017-04-28 | ДЖиТиЭкс, ИНК. | Вещества, связывающие ядерные рецепторы |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| JP5307900B2 (ja) | 2008-11-17 | 2013-10-02 | べシックス・バスキュラー・インコーポレイテッド | 組織トポグラフィの知識によらないエネルギーの選択的な蓄積 |
| KR20130108067A (ko) | 2010-04-09 | 2013-10-02 | 베식스 바스큘라 인코포레이티드 | 조직 치료를 위한 발전 및 제어 장치 |
| US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
| US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
| US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
| US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
| US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
| US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
| US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
| US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
| US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
| US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
| US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
| US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
| US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
| US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
| US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
| US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
| US20120157993A1 (en) | 2010-12-15 | 2012-06-21 | Jenson Mark L | Bipolar Off-Wall Electrode Device for Renal Nerve Ablation |
| US9220561B2 (en) | 2011-01-19 | 2015-12-29 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
| AU2012283908B2 (en) | 2011-07-20 | 2017-02-16 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
| CN103813829B (zh) | 2011-07-22 | 2016-05-18 | 波士顿科学西美德公司 | 具有可定位于螺旋引导件中的神经调制元件的神经调制系统 |
| EP2765942B1 (en) | 2011-10-10 | 2016-02-24 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
| US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
| US10085799B2 (en) | 2011-10-11 | 2018-10-02 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
| US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
| WO2013059202A1 (en) | 2011-10-18 | 2013-04-25 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
| US9162046B2 (en) | 2011-10-18 | 2015-10-20 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
| CN104023662B (zh) | 2011-11-08 | 2018-02-09 | 波士顿科学西美德公司 | 孔部肾神经消融 |
| WO2013074813A1 (en) | 2011-11-15 | 2013-05-23 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
| US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
| CN102584841B (zh) * | 2011-12-16 | 2014-11-12 | 浙江工业大学 | 一种喹啉香豆素衍生物及其制备方法及用途 |
| US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
| CA2859989C (en) | 2011-12-23 | 2020-03-24 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
| WO2013101452A1 (en) | 2011-12-28 | 2013-07-04 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
| US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
| US10660703B2 (en) | 2012-05-08 | 2020-05-26 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
| CN104540465A (zh) | 2012-08-24 | 2015-04-22 | 波士顿科学西美德公司 | 带有含单独微孔隙区域的球囊的血管内导管 |
| EP2895095A2 (en) | 2012-09-17 | 2015-07-22 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
| WO2014047411A1 (en) | 2012-09-21 | 2014-03-27 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
| US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
| US10835305B2 (en) | 2012-10-10 | 2020-11-17 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices and methods |
| WO2014163987A1 (en) | 2013-03-11 | 2014-10-09 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
| US9693821B2 (en) | 2013-03-11 | 2017-07-04 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
| US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
| CN105228546B (zh) | 2013-03-15 | 2017-11-14 | 波士顿科学国际有限公司 | 利用阻抗补偿的用于治疗高血压的医疗器械和方法 |
| US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
| WO2014150553A1 (en) | 2013-03-15 | 2014-09-25 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
| US9943365B2 (en) | 2013-06-21 | 2018-04-17 | Boston Scientific Scimed, Inc. | Renal denervation balloon catheter with ride along electrode support |
| WO2014205399A1 (en) | 2013-06-21 | 2014-12-24 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation having rotatable shafts |
| US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
| US9833283B2 (en) | 2013-07-01 | 2017-12-05 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
| EP3019105B1 (en) | 2013-07-11 | 2017-09-13 | Boston Scientific Scimed, Inc. | Devices for nerve modulation |
| WO2015006573A1 (en) | 2013-07-11 | 2015-01-15 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
| US9925001B2 (en) | 2013-07-19 | 2018-03-27 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
| US10342609B2 (en) | 2013-07-22 | 2019-07-09 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
| EP3024405A1 (en) | 2013-07-22 | 2016-06-01 | Boston Scientific Scimed, Inc. | Renal nerve ablation catheter having twist balloon |
| WO2015027096A1 (en) | 2013-08-22 | 2015-02-26 | Boston Scientific Scimed, Inc. | Flexible circuit having improved adhesion to a renal nerve modulation balloon |
| EP3041425B1 (en) | 2013-09-04 | 2022-04-13 | Boston Scientific Scimed, Inc. | Radio frequency (rf) balloon catheter having flushing and cooling capability |
| CN105530885B (zh) | 2013-09-13 | 2020-09-22 | 波士顿科学国际有限公司 | 具有气相沉积覆盖层的消融球囊 |
| US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
| WO2015057521A1 (en) | 2013-10-14 | 2015-04-23 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
| AU2014334574B2 (en) | 2013-10-15 | 2017-07-06 | Boston Scientific Scimed, Inc. | Medical device balloon |
| US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
| WO2015057961A1 (en) | 2013-10-18 | 2015-04-23 | Boston Scientific Scimed, Inc. | Balloon catheters with flexible conducting wires and related methods of use and manufacture |
| US10271898B2 (en) | 2013-10-25 | 2019-04-30 | Boston Scientific Scimed, Inc. | Embedded thermocouple in denervation flex circuit |
| CN105899157B (zh) | 2014-01-06 | 2019-08-09 | 波士顿科学国际有限公司 | 抗撕裂柔性电路组件 |
| EP3102136B1 (en) | 2014-02-04 | 2018-06-27 | Boston Scientific Scimed, Inc. | Alternative placement of thermal sensors on bipolar electrode |
| US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
| CN105602548B (zh) * | 2015-12-19 | 2018-11-06 | 江西冠能光电材料有限公司 | 含呋喃的电致红色发光材料及其制备的有机电致发光器件 |
| CN106967076A (zh) * | 2017-03-30 | 2017-07-21 | 河南师范大学 | 一种具有6h‑二苯并吡喃结构化合物及其制备方法 |
| CN106977523A (zh) * | 2017-03-30 | 2017-07-25 | 河南师范大学 | 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法 |
| CN106928243A (zh) * | 2017-03-30 | 2017-07-07 | 毛阿龙 | 具有生物活性的苯并哌啶并苯胺基类化合物的制备方法 |
| JP7085056B2 (ja) * | 2018-07-12 | 2022-06-15 | イーライ リリー アンド カンパニー | 選択的エストロゲン受容体分解剤 |
| CN112225744A (zh) * | 2020-08-31 | 2021-01-15 | 兰州大学 | 一种6H-苯并吡喃并[3,4-b]喹啉类化合物及其制备方法和用途 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3518273A (en) | 1966-08-03 | 1970-06-30 | Warner Lambert Pharmaceutical | Benzopyranquinolinol derivatives and process for their production |
| US3518258A (en) | 1967-05-09 | 1970-06-30 | Warner Lambert Pharmaceutical | Pyrano(3,2-i)quinolizine and process for the production |
| US3493579A (en) | 1967-05-29 | 1970-02-03 | Little Inc A | 1,4-ethano-5h-(1)benzopyrano (3,4-b)pyridines |
| US3541100A (en) | 1967-12-14 | 1970-11-17 | American Cyanamid Co | Benzheteroazolo(2,3-a)isoquinolium salts |
| US3518272A (en) | 1968-02-05 | 1970-06-30 | Warner Lambert Pharmaceutical | Tetrahydro benzopyranoquinolines and process for their production |
| US3600375A (en) | 1968-03-25 | 1971-08-17 | Dow Chemical Co | Azomethanodioxocins |
| US3551565A (en) | 1968-04-26 | 1970-12-29 | Geigy Chem Corp | Pharmaceutical compositions and uses of oxazinoisoquinoline derivatives |
| US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| SU1051092A1 (ru) | 1982-07-05 | 1983-10-30 | Ростовский Ордена Трудового Красного Знамени Государственный Университет Им.М.А.Суслова | Способ получени тиохиндолинов |
| GB8500605D0 (en) | 1985-01-10 | 1985-02-13 | Secretary Trade Ind Brit | Damped spring |
| JPS63238079A (ja) | 1987-03-24 | 1988-10-04 | Masatoshi Yamato | キノリン系化合物、その製造法及びその化合物を有効成分とする抗癌剤 |
| JPH0720867B2 (ja) | 1987-05-26 | 1995-03-08 | キッセイ薬品工業株式会社 | 骨粗鬆症治療剤 |
| MX13270A (es) | 1987-10-05 | 1993-06-01 | Pfizer | Procedimiento para la preparacion de derivados de 4-aminopiridina |
| JPH02256667A (ja) | 1988-12-27 | 1990-10-17 | Masatoshi Yamato | 縮合キノリン系化合物およびその製造方法 |
| US5223506A (en) | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
| WO1994020869A1 (en) | 1993-03-12 | 1994-09-15 | Ppg Industries, Inc. | Novel benzopyrans |
| US5428040A (en) | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| WO1996010015A1 (en) | 1994-09-28 | 1996-04-04 | Shaman Pharmaceuticals, Inc. | Cryptolepine analogs with hypoglycemic activity |
| DE69531998T2 (de) * | 1994-12-22 | 2004-07-22 | Ligand Pharmaceuticals, Inc., San Diego | Steroidrezeptor-modulator verbindungen und methoden |
| WO1997009348A2 (en) | 1995-09-08 | 1997-03-13 | Karo Bio Ab | Orphan receptor |
| US5998402A (en) | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
| WO1998045272A1 (en) | 1997-04-07 | 1998-10-15 | Latrobe University | Topoisomerase inhibitors |
| US7157568B1 (en) | 1997-08-05 | 2007-01-02 | American Home Products Corporation | Human estrogen receptor-β |
| US6110962A (en) | 1998-05-12 | 2000-08-29 | American Home Products Corporation | 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia |
| GB9814620D0 (en) | 1998-07-06 | 1998-09-02 | Karobio Ab | Vasculoprotector |
| AU3964400A (en) | 1999-04-06 | 2000-10-23 | Akzo Nobel N.V. | Selective estrogenic compounds |
| PT1165184E (pt) | 1999-04-09 | 2004-04-30 | Karobio Ab | Antagonismo do receptor-beta do estrogenio e doencas de ossos |
| WO2000062765A2 (en) | 1999-04-16 | 2000-10-26 | Astrazeneca Ab | ESTROGEN RECEPTOR-β LIGANDS |
| GB9913649D0 (en) | 1999-06-11 | 1999-08-11 | Karobio Ab | Estrogen receptor |
| AU7622000A (en) | 1999-10-01 | 2001-05-10 | Institute Of Molecular And Cell Biology | Compounds for the treatment of viral-mediated diseases |
| PE20011077A1 (es) | 2000-03-01 | 2001-12-12 | Akzo Nobel Nv | Derivados de cromano que tiene afinidad por receptores de estrogenos |
| ATE374752T1 (de) | 2000-03-27 | 2007-10-15 | Organon Nv | Nicht-steroidale tetracyclische verbindungen für östrogen-verwandte behandlungen |
| US7226945B2 (en) | 2000-10-13 | 2007-06-05 | Astrazeneca Ab | Estrogen receptor-β ligands |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| EP1341765A1 (en) | 2000-12-07 | 2003-09-10 | AstraZeneca AB | Therapeutic compounds |
| EP1341768A1 (en) | 2000-12-07 | 2003-09-10 | AstraZeneca AB | Therapeutic benzimidazole compounds |
| US7045539B2 (en) | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| JP3562481B2 (ja) | 2001-04-02 | 2004-09-08 | 株式会社村田製作所 | 射出成形方法および射出成形機 |
| GB2374412A (en) | 2001-04-11 | 2002-10-16 | Karobio Ab | Hypertension treatment and assay |
| US6559177B2 (en) | 2001-04-19 | 2003-05-06 | Wyeth | 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents |
| US6589980B2 (en) | 2001-05-17 | 2003-07-08 | Wyeth | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents |
| JP4381810B2 (ja) | 2001-11-19 | 2009-12-09 | イーライ リリー アンド カンパニー | 選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン |
| EP1478631A1 (en) | 2001-11-28 | 2004-11-24 | AstraZeneca AB | Therapeutic compounds |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| US6903238B2 (en) | 2001-12-13 | 2005-06-07 | Wyeth | Substituted indenones as estrogenic agents |
| TW200301107A (en) | 2001-12-13 | 2003-07-01 | Wyeth Corp | Substituted 6H-dibenzo[c,h]chromenes as estrogenic agents |
| US6960607B2 (en) | 2001-12-13 | 2005-11-01 | Wyeth | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents |
| US6835745B2 (en) | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
| WO2003061701A2 (en) | 2002-01-24 | 2003-07-31 | Wyeth | Method of treating hemorrhagic shock or systemic inflammatory response syndrome |
| US20040002524A1 (en) | 2002-06-24 | 2004-01-01 | Richard Chesworth | Benzimidazole compounds and their use as estrogen agonists/antagonists |
| WO2004073610A2 (en) * | 2003-02-13 | 2004-09-02 | Merck & Co., Inc. | Estrogen receptor modulators |
| WO2004094401A1 (en) | 2003-04-21 | 2004-11-04 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| WO2004094400A2 (en) | 2003-04-21 | 2004-11-04 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| DE10318896A1 (de) | 2003-04-22 | 2004-11-25 | Schering Ag | 8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene |
| US7279600B2 (en) | 2003-05-02 | 2007-10-09 | Wyeth | Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents |
| CL2004000985A1 (es) | 2003-05-16 | 2005-01-14 | Wyeth Corp | Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc |
| US7250440B2 (en) | 2003-08-12 | 2007-07-31 | Wyeth | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents |
| JP2007512344A (ja) | 2003-11-24 | 2007-05-17 | メルク エンド カムパニー インコーポレーテッド | エストロゲン受容体調節剤 |
| US7157492B2 (en) | 2004-02-26 | 2007-01-02 | Wyeth | Dibenzo chromene derivatives and their use as ERβ selective ligands |
| CN1968960A (zh) | 2004-06-10 | 2007-05-23 | 默克公司 | 雌激素受体调节剂 |
-
2005
- 2005-09-06 RU RU2007106870/04A patent/RU2007106870A/ru not_active Application Discontinuation
- 2005-09-06 EP EP05813086A patent/EP1789420A2/en not_active Withdrawn
- 2005-09-06 CN CNA2005800379553A patent/CN101052641A/zh active Pending
- 2005-09-06 BR BRPI0514974-6A patent/BRPI0514974A/pt not_active IP Right Cessation
- 2005-09-06 WO PCT/US2005/031696 patent/WO2006029146A2/en not_active Ceased
- 2005-09-06 US US11/219,940 patent/US7354927B2/en not_active Expired - Fee Related
- 2005-09-06 JP JP2007531265A patent/JP2008512458A/ja active Pending
- 2005-09-06 KR KR1020077005450A patent/KR20070061536A/ko not_active Withdrawn
- 2005-09-06 MX MX2007002789A patent/MX2007002789A/es active IP Right Grant
- 2005-09-06 CA CA002578164A patent/CA2578164A1/en not_active Abandoned
- 2005-09-06 AU AU2005282554A patent/AU2005282554A1/en not_active Abandoned
-
2007
- 2007-02-22 IL IL181514A patent/IL181514A0/en unknown
- 2007-03-06 ZA ZA200701950A patent/ZA200701950B/xx unknown
- 2007-03-07 EC EC2007007302A patent/ECSP077302A/es unknown
- 2007-03-14 NO NO20071364A patent/NO20071364L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008512458A (ja) | 2008-04-24 |
| BRPI0514974A (pt) | 2008-07-01 |
| EP1789420A2 (en) | 2007-05-30 |
| AU2005282554A1 (en) | 2006-03-16 |
| ZA200701950B (en) | 2009-11-25 |
| ECSP077302A (es) | 2007-04-26 |
| US7354927B2 (en) | 2008-04-08 |
| NO20071364L (no) | 2007-04-30 |
| KR20070061536A (ko) | 2007-06-13 |
| IL181514A0 (en) | 2007-07-04 |
| CA2578164A1 (en) | 2006-03-16 |
| MX2007002789A (es) | 2007-04-24 |
| CN101052641A (zh) | 2007-10-10 |
| US20060052410A1 (en) | 2006-03-09 |
| WO2006029146A2 (en) | 2006-03-16 |
| WO2006029146A3 (en) | 2006-04-27 |
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