JP2008512458A5 - - Google Patents
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- JP2008512458A5 JP2008512458A5 JP2007531265A JP2007531265A JP2008512458A5 JP 2008512458 A5 JP2008512458 A5 JP 2008512458A5 JP 2007531265 A JP2007531265 A JP 2007531265A JP 2007531265 A JP2007531265 A JP 2007531265A JP 2008512458 A5 JP2008512458 A5 JP 2008512458A5
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- Prior art keywords
- halogen
- alkyl
- phenyl
- alkenyl
- compound according
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 58
- 208000024891 symptom Diseases 0.000 claims description 4
- 208000011231 Crohn disease Diseases 0.000 claims description 3
- 230000001457 vasomotor Effects 0.000 claims description 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 208000006820 Arthralgia Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 206010022998 Irritability Diseases 0.000 claims description 2
- 208000000112 Myalgia Diseases 0.000 claims description 2
- 206010036774 Proctitis Diseases 0.000 claims description 2
- 206010036783 Proctitis ulcerative Diseases 0.000 claims description 2
- 206010040799 Skin atrophy Diseases 0.000 claims description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 206010068168 androgenetic alopecia Diseases 0.000 claims description 2
- 206010013990 dysuria Diseases 0.000 claims description 2
- 208000000509 infertility Diseases 0.000 claims description 2
- 230000036512 infertility Effects 0.000 claims description 2
- 231100000535 infertility Toxicity 0.000 claims description 2
- 206010022437 insomnia Diseases 0.000 claims description 2
- 230000027939 micturition Effects 0.000 claims description 2
- 208000019206 urinary tract infection Diseases 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims 43
- 150000002367 halogens Chemical class 0.000 claims 43
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 28
- 125000003342 alkenyl group Chemical group 0.000 claims 23
- 125000004093 cyano group Chemical group *C#N 0.000 claims 23
- 125000000304 alkynyl group Chemical group 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 19
- 241000124008 Mammalia Species 0.000 claims 17
- -1 —C (═O) —OR ′ Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 13
- 125000002252 acyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 9
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229920001774 Perfluoroether Polymers 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000007455 central nervous system cancer Diseases 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 208000005641 Adenomyosis Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 208000001738 Nervous System Trauma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 125000003435 aroyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 208000011803 breast fibrocystic disease Diseases 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000016018 endometrial polyp Diseases 0.000 claims 2
- 201000009274 endometriosis of uterus Diseases 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 230000008467 tissue growth Effects 0.000 claims 2
- 201000007954 uterine fibroid Diseases 0.000 claims 2
- 206010046811 uterine polyp Diseases 0.000 claims 2
- DDZDVMGJAZGNDE-UHFFFAOYSA-N 3,9-dimethoxy-6,12-dihydrochromeno[4,3-b]quinolin-7-one Chemical compound COC1=CC=C2N=C3C4=CC=C(OC)C=C4OCC3=C(O)C2=C1 DDZDVMGJAZGNDE-UHFFFAOYSA-N 0.000 claims 1
- AFXOALIMGNXOGD-UHFFFAOYSA-N 7-(2-trimethylsilylethynyl)-6H-chromeno[4,3-b]quinoline-3,9-diol Chemical compound C1=C(O)C=C2C(C#C[Si](C)(C)C)=C(COC=3C4=CC=C(O)C=3)C4=NC2=C1 AFXOALIMGNXOGD-UHFFFAOYSA-N 0.000 claims 1
- PIOUWXXRGXCUIQ-UHFFFAOYSA-N 7-bromo-3,9-dimethoxy-6h-chromeno[4,3-b]quinoline Chemical compound COC1=CC=C2N=C3C4=CC=C(OC)C=C4OCC3=C(Br)C2=C1 PIOUWXXRGXCUIQ-UHFFFAOYSA-N 0.000 claims 1
- UVHMUFHGMKCDDU-UHFFFAOYSA-N 7-chloro-3,9-dimethoxy-6h-chromeno[4,3-b]quinoline Chemical compound COC1=CC=C2N=C3C4=CC=C(OC)C=C4OCC3=C(Cl)C2=C1 UVHMUFHGMKCDDU-UHFFFAOYSA-N 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000004746 Atrophic Vaginitis Diseases 0.000 claims 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 206010016825 Flushing Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 206010019755 Hepatitis chronic active Diseases 0.000 claims 1
- 206010019799 Hepatitis viral Diseases 0.000 claims 1
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000013038 Hypocalcemia Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010038687 Respiratory distress Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047163 Vasospasm Diseases 0.000 claims 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000005476 astroblastoma Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- UHDQHUPIXKORDL-UHFFFAOYSA-N chembl250097 Chemical compound OC1=CC=C2N=C3C4=CC=C(O)C=C4OCC3=C(Br)C2=C1 UHDQHUPIXKORDL-UHFFFAOYSA-N 0.000 claims 1
- SDQIIVSWOGDEKO-UHFFFAOYSA-N chembl250300 Chemical compound OC1=CC=C2N=C3C4=CC=C(O)C=C4OCC3=C(C=C)C2=C1 SDQIIVSWOGDEKO-UHFFFAOYSA-N 0.000 claims 1
- NFDYBNVVFHAKIV-UHFFFAOYSA-N chembl250301 Chemical compound N1=C2C=CC(O)=CC2=C(C#C)C2=C1C1=CC=C(O)C=C1OC2 NFDYBNVVFHAKIV-UHFFFAOYSA-N 0.000 claims 1
- LIAQMIXVDMWARY-UHFFFAOYSA-N chembl250302 Chemical compound C=1C(O)=CC=C2C=1OCC1=C2N=C2C=CC(O)=CC2=C1C1=CC=CC(Cl)=C1 LIAQMIXVDMWARY-UHFFFAOYSA-N 0.000 claims 1
- BHOKKMXDSDEPGG-UHFFFAOYSA-N chembl250505 Chemical compound C=1C(O)=CC=C2C=1OCC1=C2N=C2C=CC(O)=CC2=C1C1=CC=C(Cl)C=C1 BHOKKMXDSDEPGG-UHFFFAOYSA-N 0.000 claims 1
- JAWNBJUVLYLZIH-UHFFFAOYSA-N chembl250506 Chemical compound C=1C(O)=CC=C2C=1OCC1=C2N=C2C=CC(O)=CC2=C1C1=CC=C(C(F)(F)F)C=C1 JAWNBJUVLYLZIH-UHFFFAOYSA-N 0.000 claims 1
- GKRORYXGWZWHID-UHFFFAOYSA-N chembl250507 Chemical compound C1=CC(OC)=CC=C1C1=C(COC=2C3=CC=C(O)C=2)C3=NC2=CC=C(O)C=C12 GKRORYXGWZWHID-UHFFFAOYSA-N 0.000 claims 1
- PVRYNAMCPXJOBS-UHFFFAOYSA-N chembl398814 Chemical group C=1C(O)=CC=C2C=1OCC1=C2N=C2C=CC(O)=CC2=C1C1=CC=CC(C#N)=C1 PVRYNAMCPXJOBS-UHFFFAOYSA-N 0.000 claims 1
- SAQPECWWGZJCNM-UHFFFAOYSA-N chembl398815 Chemical compound COC1=CC=CC(C=2C3=CC(O)=CC=C3N=C3C4=CC=C(O)C=C4OCC3=2)=C1 SAQPECWWGZJCNM-UHFFFAOYSA-N 0.000 claims 1
- RYBHKLZSHRZGQK-UHFFFAOYSA-N chembl402491 Chemical compound OC1=CC=C2N=C3C4=CC=C(O)C=C4OCC3=C(Cl)C2=C1 RYBHKLZSHRZGQK-UHFFFAOYSA-N 0.000 claims 1
- BEPBQWCCVBVLGI-UHFFFAOYSA-N chembl402492 Chemical compound N1=C2C=CC(O)=CC2=C(C#N)C2=C1C1=CC=C(O)C=C1OC2 BEPBQWCCVBVLGI-UHFFFAOYSA-N 0.000 claims 1
- OGDCTCUVBBYZTK-UHFFFAOYSA-N chembl402493 Chemical compound C1=C(O)C=C2C(CC)=C(COC=3C4=CC=C(O)C=3)C4=NC2=C1 OGDCTCUVBBYZTK-UHFFFAOYSA-N 0.000 claims 1
- IJQIDERUTAYBFL-UHFFFAOYSA-N chembl437390 Chemical compound C=1C(O)=CC=C2C=1OCC1=C2N=C2C=CC(O)=CC2=C1C1=CC=C(C#N)C=C1 IJQIDERUTAYBFL-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
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- 238000010276 construction Methods 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
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- 238000005115 demineralization Methods 0.000 claims 1
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- 208000035475 disorder Diseases 0.000 claims 1
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- 230000002357 endometrial effect Effects 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 150000002222 fluorine compounds Chemical class 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 230000000705 hypocalcaemia Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000001503 joint Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
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- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
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- 208000028412 nervous system injury Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000027831 neuroepithelial neoplasm Diseases 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 208000008423 pleurisy Diseases 0.000 claims 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 208000023516 stroke disease Diseases 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 201000001862 viral hepatitis Diseases 0.000 claims 1
- 208000014997 Crohn colitis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60776604P | 2004-09-07 | 2004-09-07 | |
| PCT/US2005/031696 WO2006029146A2 (en) | 2004-09-07 | 2005-09-06 | 6H-[1]BENZOPYRANO[4,3-b]QUINOLINES AND THEIR USE AS ESTROGENIC AGENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512458A JP2008512458A (ja) | 2008-04-24 |
| JP2008512458A5 true JP2008512458A5 (enExample) | 2008-10-23 |
Family
ID=35677606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531265A Pending JP2008512458A (ja) | 2004-09-07 | 2005-09-06 | ６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7354927B2 (enExample) |
| EP (1) | EP1789420A2 (enExample) |
| JP (1) | JP2008512458A (enExample) |
| KR (1) | KR20070061536A (enExample) |
| CN (1) | CN101052641A (enExample) |
| AU (1) | AU2005282554A1 (enExample) |
| BR (1) | BRPI0514974A (enExample) |
| CA (1) | CA2578164A1 (enExample) |
| EC (1) | ECSP077302A (enExample) |
| IL (1) | IL181514A0 (enExample) |
| MX (1) | MX2007002789A (enExample) |
| NO (1) | NO20071364L (enExample) |
| RU (1) | RU2007106870A (enExample) |
| WO (1) | WO2006029146A2 (enExample) |
| ZA (1) | ZA200701950B (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1667595B1 (en) | 2003-09-12 | 2014-01-01 | Vessix Vascular, Inc. | System for selectable eccentric remodeling and/or ablation of atherosclerotic material |
| EP1761513A1 (en) * | 2004-07-01 | 2007-03-14 | Wyeth | Tetracyclic compounds as estrogen ligands |
| US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
| US8396548B2 (en) | 2008-11-14 | 2013-03-12 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
| CA2613703A1 (en) | 2005-06-28 | 2007-01-04 | Cv Therapeutics, Inc. | Abca1 elevating compounds |
| US20070191442A1 (en) * | 2006-02-14 | 2007-08-16 | Wyeth | Aqueous Pharmaceutical Formulations of ER-beta Selective Ligands |
| US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
| CA2666660C (en) | 2006-10-18 | 2015-06-02 | Minnow Medical, Inc. | Inducing desirable temperature effects on body tissue |
| ES2407329T3 (es) | 2006-10-18 | 2013-06-12 | Vessix Vascular, Inc. | Sistema para inducir efectos de temperatura deseables sobre un tejido corporal |
| WO2008049084A2 (en) | 2006-10-18 | 2008-04-24 | Minnow Medical, Inc. | Tuned rf energy and electrical tissue characterization for selective treatment of target tissues |
| CA2672428A1 (en) * | 2006-12-27 | 2008-07-03 | Cv Therapeutics, Inc. | Abca1 elevating compounds |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| EA026578B1 (ru) | 2007-01-22 | 2017-04-28 | ДЖиТиЭкс, ИНК. | Вещества, связывающие ядерные рецепторы |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| JP5307900B2 (ja) | 2008-11-17 | 2013-10-02 | べシックス・バスキュラー・インコーポレイテッド | 組織トポグラフィの知識によらないエネルギーの選択的な蓄積 |
| KR20130108067A (ko) | 2010-04-09 | 2013-10-02 | 베식스 바스큘라 인코포레이티드 | 조직 치료를 위한 발전 및 제어 장치 |
| US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
| US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
| US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
| US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
| US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
| US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
| US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
| US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
| US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
| US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
| US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
| US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
| US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
| US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
| US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
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- 2005-09-06 CN CNA2005800379553A patent/CN101052641A/zh active Pending
- 2005-09-06 BR BRPI0514974-6A patent/BRPI0514974A/pt not_active IP Right Cessation
- 2005-09-06 WO PCT/US2005/031696 patent/WO2006029146A2/en not_active Ceased
- 2005-09-06 US US11/219,940 patent/US7354927B2/en not_active Expired - Fee Related
- 2005-09-06 JP JP2007531265A patent/JP2008512458A/ja active Pending
- 2005-09-06 KR KR1020077005450A patent/KR20070061536A/ko not_active Withdrawn
- 2005-09-06 MX MX2007002789A patent/MX2007002789A/es active IP Right Grant
- 2005-09-06 CA CA002578164A patent/CA2578164A1/en not_active Abandoned
- 2005-09-06 AU AU2005282554A patent/AU2005282554A1/en not_active Abandoned
-
2007
- 2007-02-22 IL IL181514A patent/IL181514A0/en unknown
- 2007-03-06 ZA ZA200701950A patent/ZA200701950B/xx unknown
- 2007-03-07 EC EC2007007302A patent/ECSP077302A/es unknown
- 2007-03-14 NO NO20071364A patent/NO20071364L/no not_active Application Discontinuation
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