RU2006107552A - Комбинации, содержащие альфа-2-дельта лиганды и ингибиторы обратного захвата серотонина/норадреналина - Google Patents

Комбинации, содержащие альфа-2-дельта лиганды и ингибиторы обратного захвата серотонина/норадреналина Download PDF

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RU2006107552A
RU2006107552A RU2006107552/15A RU2006107552A RU2006107552A RU 2006107552 A RU2006107552 A RU 2006107552A RU 2006107552/15 A RU2006107552/15 A RU 2006107552/15A RU 2006107552 A RU2006107552 A RU 2006107552A RU 2006107552 A RU2006107552 A RU 2006107552A
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alpha
pain
delta ligand
combination according
pharmaceutically acceptable
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Дэвид Дж. ДУЛИ (US)
Дэвид Дж. ДУЛИ
Марк Джон ФИЛД (GB)
Марк Джон Филд
Ричард Гриффит УИЛЛЬЯМС (GB)
Ричард Гриффит Уилльямс
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Abstract

1. Комбинация, состоящая, по существу, из синергического количества альфа-2-дельта лиганда и S,S-ребоксетина или фармацевтически приемлемой соли любого из них.2. Комбинация по п.1, в которой альфа-2-дельта лиганд выбран из габапентина, прегабалина, [(1R,5R,6S)-6-(аминометил)бицикло[3.2.0]гепт-6-ил]уксусной кислоты, 3-(1-аминометилциклогексилметил)-4Н-[1,2,4]оксадиазол-5-она, С-[1-(1Н-тетразол-5-илметил)циклогептил]метиламина, (3S,4S)-(1-аминометил-3,4-диметилциклопентил)уксусной кислоты, (1α,3α,5α)(3-аминометилбицикло[3.2.0]гепт-3-ил)уксусной кислоты, (3S,5R)-3-аминометил-5-метилоктановой кислоты, (3S,5R)-3-амино-5-метилгептановой кислоты, (3S,5R)-3-амино-5-метилнонановой кислоты и (3S,5R)-3-амино-5-метилоктановой кислоты или фармацевтически приемлемой соли любого из них.3. Комбинация по п.1, в которой альфа-2-дельта лиганд представляет собой габапентин.4. Комбинация по п.1, в которой альфа-2-дельта лиганд представляет собой прегабалин.5. Комбинация по п.1 для терапевтического, профилактического или паллиативного лечения боли.6. Комбинация по п.5, в которой боль представляет собой невропатическую боль.7. Фармацевтическая композиция для терапевтического, профилактического или паллиативного лечения боли, включающая терапевтически эффективное количество комбинации по п.1 и подходящий носитель или наполнитель.8. Применение синергического эффективного количества альфа-2-дельта лиганда и (S,S)-ребоксетина или фармацевтически приемлемой соли любого из них для изготовления лекарственного средства для терапевтического, профилактического или паллиативного лечения боли.9. Применение по п.8, в котором боль представляет собой невропатическую боль.10. Набор, включающий(a) аль

Claims (10)

1. Комбинация, состоящая, по существу, из синергического количества альфа-2-дельта лиганда и S,S-ребоксетина или фармацевтически приемлемой соли любого из них.
2. Комбинация по п.1, в которой альфа-2-дельта лиганд выбран из габапентина, прегабалина, [(1R,5R,6S)-6-(аминометил)бицикло[3.2.0]гепт-6-ил]уксусной кислоты, 3-(1-аминометилциклогексилметил)-4Н-[1,2,4]оксадиазол-5-она, С-[1-(1Н-тетразол-5-илметил)циклогептил]метиламина, (3S,4S)-(1-аминометил-3,4-диметилциклопентил)уксусной кислоты, (1α,3α,5α)(3-аминометилбицикло[3.2.0]гепт-3-ил)уксусной кислоты, (3S,5R)-3-аминометил-5-метилоктановой кислоты, (3S,5R)-3-амино-5-метилгептановой кислоты, (3S,5R)-3-амино-5-метилнонановой кислоты и (3S,5R)-3-амино-5-метилоктановой кислоты или фармацевтически приемлемой соли любого из них.
3. Комбинация по п.1, в которой альфа-2-дельта лиганд представляет собой габапентин.
4. Комбинация по п.1, в которой альфа-2-дельта лиганд представляет собой прегабалин.
5. Комбинация по п.1 для терапевтического, профилактического или паллиативного лечения боли.
6. Комбинация по п.5, в которой боль представляет собой невропатическую боль.
7. Фармацевтическая композиция для терапевтического, профилактического или паллиативного лечения боли, включающая терапевтически эффективное количество комбинации по п.1 и подходящий носитель или наполнитель.
8. Применение синергического эффективного количества альфа-2-дельта лиганда и (S,S)-ребоксетина или фармацевтически приемлемой соли любого из них для изготовления лекарственного средства для терапевтического, профилактического или паллиативного лечения боли.
9. Применение по п.8, в котором боль представляет собой невропатическую боль.
10. Набор, включающий
(a) альфа-2-дельта лиганд или его фармацевтически приемлемую соль;
(b) (S,S)-ребоксетин или его фармацевтически приемлемую соль; и
(с) контейнер.
RU2006107552/15A 2003-09-12 2004-09-06 Комбинации, содержащие альфа-2-дельта лиганды и ингибиторы обратного захвата серотонина/норадреналина RU2320369C2 (ru)

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