RU2005141456A - Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве - Google Patents
Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве Download PDFInfo
- Publication number
- RU2005141456A RU2005141456A RU2005141456/13A RU2005141456A RU2005141456A RU 2005141456 A RU2005141456 A RU 2005141456A RU 2005141456/13 A RU2005141456/13 A RU 2005141456/13A RU 2005141456 A RU2005141456 A RU 2005141456A RU 2005141456 A RU2005141456 A RU 2005141456A
- Authority
- RU
- Russia
- Prior art keywords
- circuit
- container
- microfluidic device
- plate
- thermal contact
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims 6
- 238000005382 thermal cycling Methods 0.000 title claims 3
- 238000010438 heat treatment Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 claims 7
- 239000000463 material Substances 0.000 claims 4
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1877—Means for temperature control using chemical reactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/809—Incubators or racks or holders for culture plates or containers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47635203P | 2003-06-06 | 2003-06-06 | |
| US60/476,352 | 2003-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005141456A true RU2005141456A (ru) | 2006-06-10 |
Family
ID=33511779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005141456/13A RU2005141456A (ru) | 2003-06-06 | 2004-06-07 | Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7544506B2 (enExample) |
| EP (1) | EP1633481A1 (enExample) |
| JP (1) | JP4758891B2 (enExample) |
| KR (1) | KR101203402B1 (enExample) |
| CN (1) | CN1812839A (enExample) |
| AU (1) | AU2004245094A1 (enExample) |
| CA (1) | CA2528208A1 (enExample) |
| RU (1) | RU2005141456A (enExample) |
| WO (1) | WO2004108287A1 (enExample) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004029221A2 (en) | 2002-09-27 | 2004-04-08 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US7648835B2 (en) * | 2003-06-06 | 2010-01-19 | Micronics, Inc. | System and method for heating, cooling and heat cycling on microfluidic device |
| US20050047967A1 (en) * | 2003-09-03 | 2005-03-03 | Industrial Technology Research Institute | Microfluidic component providing multi-directional fluid movement |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| WO2006039293A2 (en) * | 2004-09-29 | 2006-04-13 | University Of Virginia Patent Foundation | Localized control of thermal properties on microdevices and applications thereof |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US7488596B2 (en) * | 2004-12-17 | 2009-02-10 | Samsung Electronics Co., Ltd. | Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same |
| WO2006076567A2 (en) * | 2005-01-13 | 2006-07-20 | Micronics, Inc. | Microfluidic rare cell detection device |
| JP4829252B2 (ja) * | 2005-01-25 | 2011-12-07 | オシロジー リミテッド ライアビリティ カンパニー | 異なる熱容量を有する微小流体試料用の温度制御装置 |
| JP4756880B2 (ja) * | 2005-03-02 | 2011-08-24 | キヤノン株式会社 | Pcr反応液の温度制御装置 |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| AU2006335290A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| FR2897873B1 (fr) * | 2006-02-24 | 2008-05-30 | Millipore Corp | Procede d'analyse microbiologique rapide. |
| FR2897872B1 (fr) * | 2006-02-24 | 2008-08-15 | Millipore Corp | Procede d'analyse microbiologique rapide. |
| FR2897941B1 (fr) * | 2006-02-24 | 2009-01-16 | Millipore Corp | Dispositif et procede pour l'analyse microbiologique rapide. |
| FR2897783B1 (fr) * | 2006-02-24 | 2008-05-30 | Millipore Corp | Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre |
| WO2007106580A2 (en) | 2006-03-15 | 2007-09-20 | Micronics, Inc. | Rapid magnetic flow assays |
| US7569789B2 (en) * | 2006-03-16 | 2009-08-04 | Visiongate, Inc. | Cantilevered coaxial flow injector apparatus and method for sorting particles |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP4190448A3 (en) | 2006-05-11 | 2023-09-20 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| EP1878501A1 (en) * | 2006-07-14 | 2008-01-16 | Roche Diagnostics GmbH | Instrument for heating and cooling |
| EP1878502A1 (en) * | 2006-07-14 | 2008-01-16 | Roche Diagnostics GmbH | Instrument for heating and cooling |
| EP3536396B1 (en) | 2006-08-07 | 2022-03-30 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| WO2008147382A1 (en) * | 2006-09-27 | 2008-12-04 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| EP2137523A1 (en) | 2007-04-04 | 2009-12-30 | Network Biosystems, Inc. | Plastic microfluidic separation and detection platforms |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| FR2915487B1 (fr) | 2007-04-26 | 2009-06-05 | Millipore Corp | Ensemble et procede pour analyse microbiologique |
| EP2153295B1 (en) * | 2007-06-06 | 2014-11-05 | Path | Chemical temperature control |
| EP2152893B1 (en) * | 2007-06-11 | 2014-02-26 | Wako Pure Chemical Industries, Ltd. | Method for nucleic acid amplification using a microchip PCR with integrated real-time CE detection |
| WO2009002447A1 (en) | 2007-06-21 | 2008-12-31 | Gen-Probe Incorporated | Instrument and receptacles for use in performing processes |
| JP5852781B2 (ja) * | 2007-07-31 | 2016-02-03 | マイクロニクス, インコーポレイテッド | 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法 |
| US9724695B2 (en) | 2008-06-23 | 2017-08-08 | Canon U.S. Life Sciences, Inc. | Systems and methods for amplifying nucleic acids |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US8304185B2 (en) * | 2009-07-17 | 2012-11-06 | Canon U.S. Life Sciences, Inc. | Methods and systems for DNA isolation on a microfluidic device |
| US9540686B2 (en) * | 2008-09-18 | 2017-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for the amplification of DNA |
| CN102301002A (zh) | 2008-11-12 | 2011-12-28 | 卡里斯生命科学卢森堡控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| WO2010088514A1 (en) | 2009-01-30 | 2010-08-05 | Micronics, Inc. | Portable high gain fluorescence detection system |
| EP3415235B1 (en) | 2009-03-23 | 2025-11-12 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| DE212010000039U1 (de) * | 2009-04-03 | 2012-02-02 | Helixis, Inc. | Geräte zum erhitzen biologischer proben |
| CN102448612B (zh) * | 2009-04-13 | 2014-12-03 | 精密公司 | 微流体临床分析器 |
| WO2010144683A2 (en) | 2009-06-12 | 2010-12-16 | Micronics, Inc. | Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices |
| EP2440658B1 (en) | 2009-06-12 | 2014-10-08 | Micronics, Inc. | Rehydratable matrices for dry storage of taq polymerase in a microfluidic device |
| EP2443254A2 (en) | 2009-06-15 | 2012-04-25 | NetBio, Inc. | Improved methods for forensic dna quantitation |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| KR101143461B1 (ko) * | 2009-12-28 | 2012-05-23 | 주식회사 지앤시바이오 | 중합 효소 연쇄 반응 장치의 열전냉각기 제어장치 및 방법 |
| CA2786569C (en) | 2010-01-29 | 2019-04-09 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| WO2011100604A2 (en) | 2010-02-12 | 2011-08-18 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| CA2791905A1 (en) | 2010-03-01 | 2011-09-09 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarkers for theranostics |
| WO2011122216A1 (ja) * | 2010-03-31 | 2011-10-06 | コニカミノルタオプト株式会社 | マイクロチップ |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| CN106268992A (zh) * | 2010-12-17 | 2017-01-04 | Bjs Ip有限公司 | 用于快速pcr加热的方法及系统 |
| WO2012109604A1 (en) * | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Thermocycling device for nucleic acid amplification and methods of use |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| CN102250751B (zh) * | 2011-03-22 | 2013-05-22 | 博奥生物有限公司 | 一种用于生物芯片的接口装置 |
| US9737891B2 (en) | 2011-06-01 | 2017-08-22 | Streck, Inc. | Rapid thermocycler system for rapid amplification of nucleic acids and related methods |
| DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US20130137144A1 (en) * | 2011-06-08 | 2013-05-30 | Bio-Rad Laboratories, Inc. LSG - GXD Division | Thermal block with built-in thermoelectric elements |
| WO2013013220A2 (en) | 2011-07-20 | 2013-01-24 | University Of Washington Through Its Center For Commercialization | Photonic blood typing |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US20140295415A1 (en) * | 2011-11-04 | 2014-10-02 | Diagnostics For All, Inc. | Low cost, disposable molecular diagnostic devices |
| US10031138B2 (en) | 2012-01-20 | 2018-07-24 | University Of Washington Through Its Center For Commercialization | Hierarchical films having ultra low fouling and high recognition element loading properties |
| US9279151B2 (en) * | 2012-04-02 | 2016-03-08 | David W. Wright | Disposable thermal in-vitro diagnostic apparatus and method of conducting an in-vitro diagnostic test |
| US9579657B2 (en) | 2012-05-24 | 2017-02-28 | Bjs Ip Ltd | Clamp for fast PCR heating |
| CA2879638A1 (en) | 2012-08-10 | 2014-02-13 | Streck, Inc. | Real-time optical system for polymerase chain reaction |
| US20140099636A1 (en) * | 2012-10-10 | 2014-04-10 | Baker Hughes Incorporated | FIELD-BASED qPCR MICROBIAL MONITORING |
| ES2912033T3 (es) | 2012-10-23 | 2022-05-24 | Caris Science Inc | Aptámeros y usos de los mismos |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP3919174A3 (en) | 2012-10-24 | 2022-03-09 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| DE202012104694U1 (de) | 2012-12-03 | 2013-01-29 | Bürkert Werke GmbH | Mikrofluidisches System |
| EP2935628B1 (en) | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Compositions and methods for aptamer screening |
| US20150346097A1 (en) | 2012-12-21 | 2015-12-03 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
| CN104994957B (zh) | 2012-12-21 | 2017-11-28 | 精密公司 | 用于微流体用途的低弹性膜 |
| CN104919191B (zh) | 2012-12-21 | 2019-07-09 | 精密公司 | 流体回路及相关的制造方法 |
| WO2014112990A1 (en) * | 2013-01-16 | 2014-07-24 | Siemens Aktiengesellschaft | Automated input simulation for simulated programmable logic controller |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス, インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| EP2994750B1 (en) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| CN105189784B (zh) | 2013-05-07 | 2020-06-30 | 珀金埃尔默健康科学有限公司 | 用于制备和分析核酸的装置 |
| AU2014262710B2 (en) | 2013-05-07 | 2019-09-12 | Revvity Health Sciences, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
| AU2014302052B2 (en) | 2013-06-28 | 2018-07-19 | Streck, Inc. | Devices for real-time polymerase chain reaction |
| CN105980615A (zh) | 2013-08-28 | 2016-09-28 | 卡里斯生命科学瑞士控股有限公司 | 寡核苷酸探针及其用途 |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| CN104267766B (zh) * | 2014-10-13 | 2017-02-15 | 中国科学技术大学 | 实时温控微型样品室 |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| AU2016229076B2 (en) | 2015-03-09 | 2022-01-20 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| IL256634B2 (en) | 2015-06-29 | 2025-08-01 | Caris Science Inc | Therapeutic oligonucleotides |
| CN113275057B (zh) | 2015-07-23 | 2023-04-07 | 塞弗德公司 | 热控设备及其使用方法 |
| US10941176B2 (en) | 2015-07-28 | 2021-03-09 | Caris Science, Inc. | Therapeutic oligonucleotides |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| EP4339288A3 (en) | 2016-03-18 | 2024-06-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| US11293017B2 (en) | 2016-05-25 | 2022-04-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| CN105954448B (zh) * | 2016-06-22 | 2020-06-26 | 山东省计量科学研究院 | 一种恒温电导检测装置及检测方法 |
| EP3305911A1 (en) | 2016-10-07 | 2018-04-11 | Fraunhofer Gesellschaft zur Förderung der Angewand | Chemical heating system for diagnostic devices |
| DE102017205286A1 (de) | 2017-03-29 | 2018-10-04 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Verfahren zur Temperaturregelung eines Arbeitsfluids |
| EP3610947B1 (en) * | 2018-08-17 | 2021-04-21 | F. Hoffmann-La Roche AG | Microfluidic system for digital polymerase chain reaction of a biological sample, and respective method |
| AU2019389175B2 (en) | 2018-11-30 | 2025-03-06 | Caris Mpi, Inc. | Next-generation molecular profiling |
| US12303901B2 (en) | 2019-01-09 | 2025-05-20 | Precigenome, LLC | Microfluidic device for deformable beads enrichment and self-regulated ordering and encapsulation in droplets |
| US20210008550A1 (en) * | 2019-07-09 | 2021-01-14 | Kryptos Biotechnologies, Inc. | Microfluidic reaction vessel array with patterned films |
| US12220652B2 (en) | 2019-08-01 | 2025-02-11 | Georgia Tech Research Corporation | Microfluidic platform for refrigeration induced phase separation of aqueous-acetonitrile solutions |
| US11008627B2 (en) | 2019-08-15 | 2021-05-18 | Talis Biomedical Corporation | Diagnostic system |
| EP4069865A4 (en) | 2019-12-02 | 2023-12-20 | Caris MPI, Inc. | PLATINUM RESPONSE PREDICTOR IN A PAN-CANCER APPROACH |
| JP2024535381A (ja) * | 2021-09-23 | 2024-09-30 | エヌシックス・テック、インコーポレイテッド | 試料分析のための方法およびシステム |
| EP4412812A4 (en) * | 2021-10-04 | 2025-07-09 | Univ Maryland | POLYMER PROCESSING SYSTEMS AND METHODS USING PULSED HEATING |
| KR102759203B1 (ko) * | 2023-10-26 | 2025-01-24 | 김현철 | 핵산의 추출 및 증폭장치 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185257U (ja) * | 1984-05-18 | 1985-12-09 | 株式会社島津製作所 | クロマトグラフ用恒温槽 |
| JPS6273062A (ja) * | 1985-09-25 | 1987-04-03 | 右近 村次郎 | 発熱または吸熱反応により飲料水または食品を自己加熱または自己冷却する罐 |
| US6787338B2 (en) * | 1990-06-04 | 2004-09-07 | The University Of Utah | Method for rapid thermal cycling of biological samples |
| US5587128A (en) * | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US5498392A (en) * | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5726026A (en) * | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5639423A (en) * | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
| JPH0682444A (ja) * | 1992-09-02 | 1994-03-22 | Fuji Photo Film Co Ltd | 電源を必要としない可搬型インキュベータ |
| US6613560B1 (en) * | 1994-10-19 | 2003-09-02 | Agilent Technologies, Inc. | PCR microreactor for amplifying DNA using microquantities of sample fluid |
| DE19519015C1 (de) * | 1995-05-24 | 1996-09-05 | Inst Physikalische Hochtech Ev | Miniaturisierter Mehrkammer-Thermocycler |
| AU6541596A (en) | 1995-06-16 | 1997-01-15 | University Of Washington | Microfabricated differential extraction device and method |
| US5922210A (en) * | 1995-06-16 | 1999-07-13 | University Of Washington | Tangential flow planar microfabricated fluid filter and method of using thereof |
| US5716852A (en) * | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
| US5724404A (en) * | 1995-07-03 | 1998-03-03 | Garcia; Max | Integrated international telephone circuit monitoring system |
| US5726751A (en) * | 1995-09-27 | 1998-03-10 | University Of Washington | Silicon microchannel optical flow cytometer |
| UA22030C2 (uk) | 1996-01-25 | 2002-04-15 | Юнайтед Технолоджіз Корп. Пратт Енд Уітні | Спосіб з'єдhаhhя титаhової деталі з другою металевою деталлю |
| US5741647A (en) * | 1996-02-16 | 1998-04-21 | Tam; Joseph Wing On | Flow through nucleic acid hybridisation uses thereof and a device thereof |
| US5747349A (en) * | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
| US5948684A (en) * | 1997-03-31 | 1999-09-07 | University Of Washington | Simultaneous analyte determination and reference balancing in reference T-sensor devices |
| US6054277A (en) * | 1996-05-08 | 2000-04-25 | Regents Of The University Of Minnesota | Integrated microchip genetic testing system |
| EP0910474B1 (en) * | 1996-06-14 | 2004-03-24 | University of Washington | Absorption-enhanced differential extraction method |
| US5748827A (en) * | 1996-10-23 | 1998-05-05 | University Of Washington | Two-stage kinematic mount |
| US5958349A (en) * | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
| DE19717085C2 (de) * | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| WO1998050147A1 (en) | 1997-05-09 | 1998-11-12 | The Regents Of The University Of California | Peltier-assisted microfabricated reaction chambers for thermal cycling |
| US5974867A (en) * | 1997-06-13 | 1999-11-02 | University Of Washington | Method for determining concentration of a laminar sample stream |
| AU746098B2 (en) | 1997-09-02 | 2002-04-18 | Caliper Life Sciences, Inc. | Microfluidic system with electrofluidic and electrothermal controls |
| US6126804A (en) * | 1997-09-23 | 2000-10-03 | The Regents Of The University Of California | Integrated polymerase chain reaction/electrophoresis instrument |
| US6007775A (en) * | 1997-09-26 | 1999-12-28 | University Of Washington | Multiple analyte diffusion based chemical sensor |
| EP1042061A1 (en) * | 1997-12-24 | 2000-10-11 | Cepheid | Integrated fluid manipulation cartridge |
| US6420143B1 (en) * | 1998-02-13 | 2002-07-16 | Caliper Technologies Corp. | Methods and systems for performing superheated reactions in microscale fluidic systems |
| US6018616A (en) * | 1998-02-23 | 2000-01-25 | Applied Materials, Inc. | Thermal cycling module and process using radiant heat |
| US6572830B1 (en) * | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
| US6261431B1 (en) * | 1998-12-28 | 2001-07-17 | Affymetrix, Inc. | Process for microfabrication of an integrated PCR-CE device and products produced by the same |
| US6171850B1 (en) * | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
| US6192596B1 (en) * | 1999-03-08 | 2001-02-27 | Battelle Memorial Institute | Active microchannel fluid processing unit and method of making |
| US6303343B1 (en) * | 1999-04-06 | 2001-10-16 | Caliper Technologies Corp. | Inefficient fast PCR |
| WO2001031053A1 (en) * | 1999-10-22 | 2001-05-03 | Aclara Biosciences, Inc. | Microfluidic card thermal control |
| EP1237655A2 (en) | 1999-12-09 | 2002-09-11 | Motorola, Inc. | Multilayered microfluidic devices for analyte reactions |
| US6699713B2 (en) * | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
| US6403037B1 (en) * | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
| ATE305331T1 (de) | 2000-02-14 | 2005-10-15 | Cpc Cellular Process Chemistry | Mikroreaktor mit verbessertem wärmetauscher |
| US20010048900A1 (en) * | 2000-05-24 | 2001-12-06 | Bardell Ronald L. | Jet vortex mixer |
| JP2002018271A (ja) * | 2000-07-05 | 2002-01-22 | Kawamura Inst Of Chem Res | 微小ケミカルデバイス |
| JP2002090357A (ja) * | 2000-09-12 | 2002-03-27 | Kawamura Inst Of Chem Res | 温度調節機構を有する微小ケミカルデバイス |
| US6509186B1 (en) * | 2001-02-16 | 2003-01-21 | Institute Of Microelectronics | Miniaturized thermal cycler |
| US6432695B1 (en) * | 2001-02-16 | 2002-08-13 | Institute Of Microelectronics | Miniaturized thermal cycler |
| WO2002081729A2 (en) * | 2001-04-06 | 2002-10-17 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| DE10217335A1 (de) * | 2001-04-21 | 2002-10-24 | Vodafone Pilotentwicklung Gmbh | Vorrichtung zum Erzeugen und/oder Aufbereiten eines Brennstoffs für eine Brennstoffzelle |
| CA2468260A1 (en) | 2001-07-02 | 2003-01-16 | Matthew Torres | Flow-thru chip cartridge, chip holder, system & method thereof |
| US6762049B2 (en) * | 2001-07-05 | 2004-07-13 | Institute Of Microelectronics | Miniaturized multi-chamber thermal cycler for independent thermal multiplexing |
| US7338760B2 (en) * | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip |
| EP1492887A1 (en) * | 2002-04-11 | 2005-01-05 | Sequenom, Inc. | Methods and devices for performing chemical reactions on a solid support |
| US7338637B2 (en) * | 2003-01-31 | 2008-03-04 | Hewlett-Packard Development Company, L.P. | Microfluidic device with thin-film electronic devices |
-
2004
- 2004-06-07 JP JP2006515242A patent/JP4758891B2/ja not_active Expired - Lifetime
- 2004-06-07 CN CNA2004800181641A patent/CN1812839A/zh active Pending
- 2004-06-07 RU RU2005141456/13A patent/RU2005141456A/ru not_active Application Discontinuation
- 2004-06-07 WO PCT/US2004/017943 patent/WO2004108287A1/en not_active Ceased
- 2004-06-07 EP EP04776322A patent/EP1633481A1/en not_active Withdrawn
- 2004-06-07 CA CA002528208A patent/CA2528208A1/en not_active Abandoned
- 2004-06-07 AU AU2004245094A patent/AU2004245094A1/en not_active Abandoned
- 2004-06-07 KR KR1020057023458A patent/KR101203402B1/ko not_active Expired - Lifetime
- 2004-06-07 US US10/862,826 patent/US7544506B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2528208A1 (en) | 2004-12-16 |
| US20050129582A1 (en) | 2005-06-16 |
| EP1633481A1 (en) | 2006-03-15 |
| KR20060017850A (ko) | 2006-02-27 |
| JP2006527369A (ja) | 2006-11-30 |
| CN1812839A (zh) | 2006-08-02 |
| WO2004108287A1 (en) | 2004-12-16 |
| AU2004245094A1 (en) | 2004-12-16 |
| KR101203402B1 (ko) | 2012-11-23 |
| US7544506B2 (en) | 2009-06-09 |
| JP4758891B2 (ja) | 2011-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005141456A (ru) | Система и способ нагревания, охлаждения и термоциклирования в микрожидкостном устройстве | |
| JP2006527369A5 (enExample) | ||
| JP7634508B2 (ja) | 流体検査用カセット | |
| AU733101B2 (en) | Apparatus for a fluid impingement thermal cycler | |
| US9266109B2 (en) | Thermal control system and method for chemical and biochemical reactions | |
| US20080038163A1 (en) | Systems and Methods for Cooling in Biological Analysis Instruments | |
| DE60041264D1 (de) | Durchfluss-Mikroreaktor in dem lokale Temperaturzyklen auf eine fliessende Probe einwirken | |
| JP2011530059A5 (enExample) | ||
| BR112019020876A2 (pt) | cassete de teste fluídico | |
| WO2002072267A1 (en) | Convectively driven pcr thermal-cycling | |
| DE60014967D1 (de) | Vorrichtung zur durchführung von wärmetauschenden chemischen reaktionen | |
| Chen et al. | Analytical study of a microfludic DNA amplification chip using water cooling effect | |
| CN204202237U (zh) | 温控装置 | |
| US8865457B2 (en) | Active, micro-well thermal control subsystem | |
| US7431891B2 (en) | Device for controlling the temperature of chemical microreactors | |
| ATE401126T1 (de) | Heizung von mehrkammerbehältern | |
| CN107988044A (zh) | 一种大反应体积流道式pcr扩增装置 | |
| EP3867221B1 (en) | Method and system for localized heating by illumination for patterned thin films | |
| WO2022195289A2 (en) | An apparatus and associated methods for thermal cycling | |
| CN207845625U (zh) | 一种大反应体积卡片式pcr扩增装置 | |
| RU2816358C1 (ru) | Термоэлектрический охладитель жидкости | |
| CN115595255A (zh) | 一种微小空间快速变温pcr系统 | |
| CN107916212A (zh) | 一种大反应体积卡片式pcr扩增装置 | |
| KR101204910B1 (ko) | 폐회로로 구성된 냉각 장치 | |
| CN117801944A (zh) | 离心式快速pcr系统及反应芯片 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20070723 |