KR101203402B1 - 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 - Google Patents

마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 Download PDF

Info

Publication number
KR101203402B1
KR101203402B1 KR1020057023458A KR20057023458A KR101203402B1 KR 101203402 B1 KR101203402 B1 KR 101203402B1 KR 1020057023458 A KR1020057023458 A KR 1020057023458A KR 20057023458 A KR20057023458 A KR 20057023458A KR 101203402 B1 KR101203402 B1 KR 101203402B1
Authority
KR
South Korea
Prior art keywords
delete delete
heat
heat exchange
microfluidic
amplification chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020057023458A
Other languages
English (en)
Korean (ko)
Other versions
KR20060017850A (ko
Inventor
웨인 브라이드포드
크리스티 에이 랑캐스터
존 월리스 헤이옌가
로날드 엘 바델
제프리 에프 톤
베른하르트 하 바이글
Original Assignee
마이크로닉스 인코포레이티드.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마이크로닉스 인코포레이티드. filed Critical 마이크로닉스 인코포레이티드.
Publication of KR20060017850A publication Critical patent/KR20060017850A/ko
Application granted granted Critical
Publication of KR101203402B1 publication Critical patent/KR101203402B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1877—Means for temperature control using chemical reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1020057023458A 2003-06-06 2004-06-07 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법 Expired - Lifetime KR101203402B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47635203P 2003-06-06 2003-06-06
US60/476,352 2003-06-06
PCT/US2004/017943 WO2004108287A1 (en) 2003-06-06 2004-06-07 System and method for heating, cooling and heat cycling on microfluidic device

Publications (2)

Publication Number Publication Date
KR20060017850A KR20060017850A (ko) 2006-02-27
KR101203402B1 true KR101203402B1 (ko) 2012-11-23

Family

ID=33511779

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057023458A Expired - Lifetime KR101203402B1 (ko) 2003-06-06 2004-06-07 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법

Country Status (9)

Country Link
US (1) US7544506B2 (enExample)
EP (1) EP1633481A1 (enExample)
JP (1) JP4758891B2 (enExample)
KR (1) KR101203402B1 (enExample)
CN (1) CN1812839A (enExample)
AU (1) AU2004245094A1 (enExample)
CA (1) CA2528208A1 (enExample)
RU (1) RU2005141456A (enExample)
WO (1) WO2004108287A1 (enExample)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
WO2006039293A2 (en) * 2004-09-29 2006-04-13 University Of Virginia Patent Foundation Localized control of thermal properties on microdevices and applications thereof
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7488596B2 (en) * 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
WO2006076567A2 (en) * 2005-01-13 2006-07-20 Micronics, Inc. Microfluidic rare cell detection device
JP4829252B2 (ja) * 2005-01-25 2011-12-07 オシロジー リミテッド ライアビリティ カンパニー 異なる熱容量を有する微小流体試料用の温度制御装置
JP4756880B2 (ja) * 2005-03-02 2011-08-24 キヤノン株式会社 Ｐｃｒ反応液の温度制御装置
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
AU2006335290A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
FR2897873B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897872B1 (fr) * 2006-02-24 2008-08-15 Millipore Corp Procede d'analyse microbiologique rapide.
FR2897941B1 (fr) * 2006-02-24 2009-01-16 Millipore Corp Dispositif et procede pour l'analyse microbiologique rapide.
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP4190448A3 (en) 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Microfluidic devices
EP1878501A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP1878502A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Instrument for heating and cooling
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP2137523A1 (en) 2007-04-04 2009-12-30 Network Biosystems, Inc. Plastic microfluidic separation and detection platforms
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
FR2915487B1 (fr) 2007-04-26 2009-06-05 Millipore Corp Ensemble et procede pour analyse microbiologique
EP2153295B1 (en) * 2007-06-06 2014-11-05 Path Chemical temperature control
EP2152893B1 (en) * 2007-06-11 2014-02-26 Wako Pure Chemical Industries, Ltd. Method for nucleic acid amplification using a microchip PCR with integrated real-time CE detection
WO2009002447A1 (en) 2007-06-21 2008-12-31 Gen-Probe Incorporated Instrument and receptacles for use in performing processes
JP5852781B2 (ja) * 2007-07-31 2016-02-03 マイクロニクス， インコーポレイテッド 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法
US9724695B2 (en) 2008-06-23 2017-08-08 Canon U.S. Life Sciences, Inc. Systems and methods for amplifying nucleic acids
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US8304185B2 (en) * 2009-07-17 2012-11-06 Canon U.S. Life Sciences, Inc. Methods and systems for DNA isolation on a microfluidic device
US9540686B2 (en) * 2008-09-18 2017-01-10 Canon U.S. Life Sciences, Inc. Systems and methods for the amplification of DNA
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
WO2010088514A1 (en) 2009-01-30 2010-08-05 Micronics, Inc. Portable high gain fluorescence detection system
EP3415235B1 (en) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation of microfluidic droplets
DE212010000039U1 (de) * 2009-04-03 2012-02-02 Helixis, Inc. Geräte zum erhitzen biologischer proben
CN102448612B (zh) * 2009-04-13 2014-12-03 精密公司 微流体临床分析器
WO2010144683A2 (en) 2009-06-12 2010-12-16 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
EP2440658B1 (en) 2009-06-12 2014-10-08 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
KR101143461B1 (ko) * 2009-12-28 2012-05-23 주식회사 지앤시바이오 중합 효소 연쇄 반응 장치의 열전냉각기 제어장치 및 방법
CA2786569C (en) 2010-01-29 2019-04-09 Micronics, Inc. Sample-to-answer microfluidic cartridge
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
WO2011122216A1 (ja) * 2010-03-31 2011-10-06 コニカミノルタオプト株式会社 マイクロチップ
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
CN106268992A (zh) * 2010-12-17 2017-01-04 Bjs Ip有限公司 用于快速pcr加热的方法及系统
WO2012109604A1 (en) * 2011-02-11 2012-08-16 Raindance Technologies, Inc. Thermocycling device for nucleic acid amplification and methods of use
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
CN102250751B (zh) * 2011-03-22 2013-05-22 博奥生物有限公司 一种用于生物芯片的接口装置
US9737891B2 (en) 2011-06-01 2017-08-22 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US20130137144A1 (en) * 2011-06-08 2013-05-30 Bio-Rad Laboratories, Inc. LSG - GXD Division Thermal block with built-in thermoelectric elements
WO2013013220A2 (en) 2011-07-20 2013-01-24 University Of Washington Through Its Center For Commercialization Photonic blood typing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20140295415A1 (en) * 2011-11-04 2014-10-02 Diagnostics For All, Inc. Low cost, disposable molecular diagnostic devices
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9279151B2 (en) * 2012-04-02 2016-03-08 David W. Wright Disposable thermal in-vitro diagnostic apparatus and method of conducting an in-vitro diagnostic test
US9579657B2 (en) 2012-05-24 2017-02-28 Bjs Ip Ltd Clamp for fast PCR heating
CA2879638A1 (en) 2012-08-10 2014-02-13 Streck, Inc. Real-time optical system for polymerase chain reaction
US20140099636A1 (en) * 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
ES2912033T3 (es) 2012-10-23 2022-05-24 Caris Science Inc Aptámeros y usos de los mismos
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP3919174A3 (en) 2012-10-24 2022-03-09 Genmark Diagnostics Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
DE202012104694U1 (de) 2012-12-03 2013-01-29 Bürkert Werke GmbH Mikrofluidisches System
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
US20150346097A1 (en) 2012-12-21 2015-12-03 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
CN104994957B (zh) 2012-12-21 2017-11-28 精密公司 用于微流体用途的低弹性膜
CN104919191B (zh) 2012-12-21 2019-07-09 精密公司 流体回路及相关的制造方法
WO2014112990A1 (en) * 2013-01-16 2014-07-24 Siemens Aktiengesellschaft Automated input simulation for simulated programmable logic controller
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CN105189784B (zh) 2013-05-07 2020-06-30 珀金埃尔默健康科学有限公司 用于制备和分析核酸的装置
AU2014262710B2 (en) 2013-05-07 2019-09-12 Revvity Health Sciences, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
AU2014302052B2 (en) 2013-06-28 2018-07-19 Streck, Inc. Devices for real-time polymerase chain reaction
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
CN104267766B (zh) * 2014-10-13 2017-02-15 中国科学技术大学 实时温控微型样品室
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
IL256634B2 (en) 2015-06-29 2025-08-01 Caris Science Inc Therapeutic oligonucleotides
CN113275057B (zh) 2015-07-23 2023-04-07 塞弗德公司 热控设备及其使用方法
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
EP4339288A3 (en) 2016-03-18 2024-06-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11293017B2 (en) 2016-05-25 2022-04-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN105954448B (zh) * 2016-06-22 2020-06-26 山东省计量科学研究院 一种恒温电导检测装置及检测方法
EP3305911A1 (en) 2016-10-07 2018-04-11 Fraunhofer Gesellschaft zur Förderung der Angewand Chemical heating system for diagnostic devices
DE102017205286A1 (de) 2017-03-29 2018-10-04 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zur Temperaturregelung eines Arbeitsfluids
EP3610947B1 (en) * 2018-08-17 2021-04-21 F. Hoffmann-La Roche AG Microfluidic system for digital polymerase chain reaction of a biological sample, and respective method
AU2019389175B2 (en) 2018-11-30 2025-03-06 Caris Mpi, Inc. Next-generation molecular profiling
US12303901B2 (en) 2019-01-09 2025-05-20 Precigenome, LLC Microfluidic device for deformable beads enrichment and self-regulated ordering and encapsulation in droplets
US20210008550A1 (en) * 2019-07-09 2021-01-14 Kryptos Biotechnologies, Inc. Microfluidic reaction vessel array with patterned films
US12220652B2 (en) 2019-08-01 2025-02-11 Georgia Tech Research Corporation Microfluidic platform for refrigeration induced phase separation of aqueous-acetonitrile solutions
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
EP4069865A4 (en) 2019-12-02 2023-12-20 Caris MPI, Inc. PLATINUM RESPONSE PREDICTOR IN A PAN-CANCER APPROACH
JP2024535381A (ja) * 2021-09-23 2024-09-30 エヌシックス・テック、インコーポレイテッド 試料分析のための方法およびシステム
EP4412812A4 (en) * 2021-10-04 2025-07-09 Univ Maryland POLYMER PROCESSING SYSTEMS AND METHODS USING PULSED HEATING
KR102759203B1 (ko) * 2023-10-26 2025-01-24 김현철 핵산의 추출 및 증폭장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002018271A (ja) 2000-07-05 2002-01-22 Kawamura Inst Of Chem Res 微小ケミカルデバイス
JP2002090357A (ja) 2000-09-12 2002-03-27 Kawamura Inst Of Chem Res 温度調節機構を有する微小ケミカルデバイス

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60185257U (ja) * 1984-05-18 1985-12-09 株式会社島津製作所 クロマトグラフ用恒温槽
JPS6273062A (ja) * 1985-09-25 1987-04-03 右近　村次郎 発熱または吸熱反応により飲料水または食品を自己加熱または自己冷却する罐
US6787338B2 (en) * 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5639423A (en) * 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
JPH0682444A (ja) * 1992-09-02 1994-03-22 Fuji Photo Film Co Ltd 電源を必要としない可搬型インキュベータ
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
AU6541596A (en) 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5724404A (en) * 1995-07-03 1998-03-03 Garcia; Max Integrated international telephone circuit monitoring system
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
UA22030C2 (uk) 1996-01-25 2002-04-15 Юнайтед Технолоджіз Корп. Пратт Енд Уітні Спосіб з'єдhаhhя титаhової деталі з другою металевою деталлю
US5741647A (en) * 1996-02-16 1998-04-21 Tam; Joseph Wing On Flow through nucleic acid hybridisation uses thereof and a device thereof
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US6054277A (en) * 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
EP0910474B1 (en) * 1996-06-14 2004-03-24 University of Washington Absorption-enhanced differential extraction method
US5748827A (en) * 1996-10-23 1998-05-05 University Of Washington Two-stage kinematic mount
US5958349A (en) * 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
WO1998050147A1 (en) 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US5974867A (en) * 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
AU746098B2 (en) 1997-09-02 2002-04-18 Caliper Life Sciences, Inc. Microfluidic system with electrofluidic and electrothermal controls
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
US6007775A (en) * 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
EP1042061A1 (en) * 1997-12-24 2000-10-11 Cepheid Integrated fluid manipulation cartridge
US6420143B1 (en) * 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6018616A (en) * 1998-02-23 2000-01-25 Applied Materials, Inc. Thermal cycling module and process using radiant heat
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6192596B1 (en) * 1999-03-08 2001-02-27 Battelle Memorial Institute Active microchannel fluid processing unit and method of making
US6303343B1 (en) * 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
WO2001031053A1 (en) * 1999-10-22 2001-05-03 Aclara Biosciences, Inc. Microfluidic card thermal control
EP1237655A2 (en) 1999-12-09 2002-09-11 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6699713B2 (en) * 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
ATE305331T1 (de) 2000-02-14 2005-10-15 Cpc Cellular Process Chemistry Mikroreaktor mit verbessertem wärmetauscher
US20010048900A1 (en) * 2000-05-24 2001-12-06 Bardell Ronald L. Jet vortex mixer
US6509186B1 (en) * 2001-02-16 2003-01-21 Institute Of Microelectronics Miniaturized thermal cycler
US6432695B1 (en) * 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
WO2002081729A2 (en) * 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
DE10217335A1 (de) * 2001-04-21 2002-10-24 Vodafone Pilotentwicklung Gmbh Vorrichtung zum Erzeugen und/oder Aufbereiten eines Brennstoffs für eine Brennstoffzelle
CA2468260A1 (en) 2001-07-02 2003-01-16 Matthew Torres Flow-thru chip cartridge, chip holder, system & method thereof
US6762049B2 (en) * 2001-07-05 2004-07-13 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
EP1492887A1 (en) * 2002-04-11 2005-01-05 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002018271A (ja) 2000-07-05 2002-01-22 Kawamura Inst Of Chem Res 微小ケミカルデバイス
JP2002090357A (ja) 2000-09-12 2002-03-27 Kawamura Inst Of Chem Res 温度調節機構を有する微小ケミカルデバイス

Also Published As

Publication number Publication date
CA2528208A1 (en) 2004-12-16
RU2005141456A (ru) 2006-06-10
US20050129582A1 (en) 2005-06-16
EP1633481A1 (en) 2006-03-15
KR20060017850A (ko) 2006-02-27
JP2006527369A (ja) 2006-11-30
CN1812839A (zh) 2006-08-02
WO2004108287A1 (en) 2004-12-16
AU2004245094A1 (en) 2004-12-16
US7544506B2 (en) 2009-06-09
JP4758891B2 (ja) 2011-08-31

Similar Documents

Publication Publication Date Title
KR101203402B1 (ko) 마이크로 유체 장치상에서의 가열, 냉각 및 열 순환 시스템및 방법
US7648835B2 (en) System and method for heating, cooling and heat cycling on microfluidic device
AU746098B2 (en) Microfluidic system with electrofluidic and electrothermal controls
US8329433B2 (en) Thermal cycler for PCR including temperature control bladder
US6174675B1 (en) Electrical current for controlling fluid parameters in microchannels
AU2017277334B2 (en) Rapid thermal cycling for sample analyses and processing
US11235324B2 (en) Temperature-cycling microfluidic devices
US9939170B2 (en) Methods and compositions for rapid thermal cycling
US20050186585A1 (en) Thermal cycling device
US20110207632A1 (en) Temperature control device with a flexible temperature control surface
JP2011523345A (ja) 核酸増幅用のマイクロ流体高速サーマルサイクラー
EP3463669B1 (en) Rapid thermal cycling for sample analyses and processing
JP2012242118A (ja) 流体デバイスを用いる熱処理装置、および流体の処理方法
EP3658841A1 (en) Temperature-controlling microfluidic devices
Lastra¹ et al. Design and Heat Transfer Simulation of a Thermal Block for the Integration of a DNA
Chen et al. Modeling and Experiment of Shuttling Speed Effects on the Oscillatory Thermal Cycler Chamber (OSTRYCH)
CA2510539A1 (en) Microfluidic system with electrofluidic and electrothermal controls
Mock et al. Demonstration of a Flow-Through Micro-PCR in an Annular Pyrex Channel

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20051206

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20090605

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20110223

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20120926

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20121115

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20121116

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20151027

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20151027

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20161027

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20161027

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20171026

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20171026

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20201015

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20231004

Start annual number: 12

End annual number: 12

PC1801 Expiration of term

Termination date: 20241207

Termination category: Expiration of duration