RU2005127666A - Малонамидные производные в качестве ингибиторов гамма-секретазы - Google Patents
Малонамидные производные в качестве ингибиторов гамма-секретазы Download PDFInfo
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- RU2005127666A RU2005127666A RU2005127666/04A RU2005127666A RU2005127666A RU 2005127666 A RU2005127666 A RU 2005127666A RU 2005127666/04 A RU2005127666/04 A RU 2005127666/04A RU 2005127666 A RU2005127666 A RU 2005127666A RU 2005127666 A RU2005127666 A RU 2005127666A
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- methyl
- oxo
- malonamide
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- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title claims 2
- 239000003540 gamma secretase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 34
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 17
- -1 benzo [b] thiophenyl Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000006168 tricyclic group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- HXOPUXUYXNWCJU-UHFFFAOYSA-N 2-methyl-n-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)-n'-[(2,3,5-trifluorophenyl)methyl]propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC(F)=CC(F)=C1F HXOPUXUYXNWCJU-UHFFFAOYSA-N 0.000 claims 1
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- VEHTZQNYIWZNBK-SVBPBHIXSA-N N-[(3,5-difluorophenyl)methyl]-N'-[(2S,11S)-2-[[[2-(4-fluorophenyl)acetyl]amino]methyl]-12-oxo-1-azatricyclo[6.4.1.04,13]trideca-4,6,8(13)-trien-11-yl]-2,2-dimethylpropanediamide Chemical compound FC=1C=C(CNC(C(C(=O)N[C@H]2CCC=3C=CC=C4C[C@H](N(C=34)C2=O)CNC(CC2=CC=C(C=C2)F)=O)(C)C)=O)C=C(C=1)F VEHTZQNYIWZNBK-SVBPBHIXSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- RWLPAIFXJQBFIL-UHFFFAOYSA-N n-(5-benzoyl-1-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl)-n'-[(3,5-difluorophenyl)methyl]-2-methylpropanediamide Chemical compound C1N(C(=O)C=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC(F)=CC(F)=C1 RWLPAIFXJQBFIL-UHFFFAOYSA-N 0.000 claims 1
- DFWHHXKARVQVLV-UHFFFAOYSA-N n-(5-benzyl-1-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl)-n'-[(3,5-difluorophenyl)methyl]-2-methylpropanediamide Chemical compound C1N(CC=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC(F)=CC(F)=C1 DFWHHXKARVQVLV-UHFFFAOYSA-N 0.000 claims 1
- BPAHSIQPJKUXIR-UHFFFAOYSA-N n-[(2,5-difluorophenyl)methyl]-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC(F)=CC=C1F BPAHSIQPJKUXIR-UHFFFAOYSA-N 0.000 claims 1
- FBBPCHXJVMRLFI-UHFFFAOYSA-N n-[(2-fluorophenyl)methyl]-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=CC=C1F FBBPCHXJVMRLFI-UHFFFAOYSA-N 0.000 claims 1
- NEDPUDKYCQZPDL-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-2,2-dimethyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound O=C1N(C)C2=CC=CC=C2C2=CC=CC=C2C1NC(=O)C(C)(C)C(=O)NCC1=CC(F)=CC(F)=C1 NEDPUDKYCQZPDL-UHFFFAOYSA-N 0.000 claims 1
- PEVKDUMFGWFMNG-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-2-ethyl-n'-(1-methyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl)propanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(CC)C(=O)NCC1=CC(F)=CC(F)=C1 PEVKDUMFGWFMNG-UHFFFAOYSA-N 0.000 claims 1
- PPZAMCJTRDUVOG-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-2-fluoro-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound O=C1N(C)C2=CC=CC=C2C2=CC=CC=C2C1NC(=O)C(F)C(=O)NCC1=CC(F)=CC(F)=C1 PPZAMCJTRDUVOG-UHFFFAOYSA-N 0.000 claims 1
- IVPOPDLOBIZGEX-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-n'-(1-methyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl)-2-propylpropanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(CCC)C(=O)NCC1=CC(F)=CC(F)=C1 IVPOPDLOBIZGEX-UHFFFAOYSA-N 0.000 claims 1
- LRKNZXGABJUCOI-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)-2-propan-2-ylpropanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C(C)C)C(=O)NCC1=CC(F)=CC(F)=C1 LRKNZXGABJUCOI-UHFFFAOYSA-N 0.000 claims 1
- LJSQBHXWTBJLSW-UHFFFAOYSA-N n-[(3,5-difluorophenyl)methyl]-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)-2-propylpropanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(CCC)C(=O)NCC1=CC(F)=CC(F)=C1 LJSQBHXWTBJLSW-UHFFFAOYSA-N 0.000 claims 1
- NOOLHZQBHCVURF-UHFFFAOYSA-N n-[(3-fluorophenyl)methyl]-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=CC(F)=C1 NOOLHZQBHCVURF-UHFFFAOYSA-N 0.000 claims 1
- ORJXYBWSXQOSCA-UHFFFAOYSA-N n-[(4-chlorophenyl)methyl]-2-methyl-n'-(1-methyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl)propanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=C(Cl)C=C1 ORJXYBWSXQOSCA-UHFFFAOYSA-N 0.000 claims 1
- AXCNCARXJIKPHA-UHFFFAOYSA-N n-[(4-chlorophenyl)methyl]-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=C(Cl)C=C1 AXCNCARXJIKPHA-UHFFFAOYSA-N 0.000 claims 1
- MJEYTKXDVDXMEQ-UHFFFAOYSA-N n-[(4-fluorophenyl)methyl]-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=C(F)C=C1 MJEYTKXDVDXMEQ-UHFFFAOYSA-N 0.000 claims 1
- YLGSLUBKNGFPOB-UHFFFAOYSA-N n-[5-(benzenesulfonyl)-1-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-n'-[(3,5-difluorophenyl)methyl]-2-methylpropanediamide Chemical compound C1N(S(=O)(=O)C=2C=CC=CC=2)C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC(F)=CC(F)=C1 YLGSLUBKNGFPOB-UHFFFAOYSA-N 0.000 claims 1
- VRYUYXCAJGNNHF-UHFFFAOYSA-N n-benzyl-2-methyl-n'-(5-methyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)propanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(C)C(=O)C1NC(=O)C(C)C(=O)NCC1=CC=CC=C1 VRYUYXCAJGNNHF-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 0 CN(C1)CC2=C1C=C*(*)C=C2 Chemical compound CN(C1)CC2=C1C=C*(*)C=C2 0.000 description 2
- KFBFSZIBRDCFHS-UHFFFAOYSA-N CCNC(Cc1ccc[s]1)=O Chemical compound CCNC(Cc1ccc[s]1)=O KFBFSZIBRDCFHS-UHFFFAOYSA-N 0.000 description 1
- SVYKKECYCPFKGB-UHFFFAOYSA-N CN(C)C1CCCCC1 Chemical compound CN(C)C1CCCCC1 SVYKKECYCPFKGB-UHFFFAOYSA-N 0.000 description 1
- ILABWDUPVPANGS-UHFFFAOYSA-N CN(CC1)C(C2)c3c1cccc3C2O Chemical compound CN(CC1)C(C2)c3c1cccc3C2O ILABWDUPVPANGS-UHFFFAOYSA-N 0.000 description 1
- XCWXFEJLAVJBRP-UHFFFAOYSA-N CN(CC1)CCN1S(C)(O)=O Chemical compound CN(CC1)CCN1S(C)(O)=O XCWXFEJLAVJBRP-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1n[nH]cc1 Chemical compound Cc1n[nH]cc1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
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- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
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- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Claims (20)
1. Соединения общей формулы
представляет собой циклическое кольцо, выбранное из группы, состоящей из фенила, пиридинила, фуранила, бензо[b]тиофенила, тетрагидронафтила, инданила, 2,2-диметил-[1,3]диоксоланила или тетрагидрофуранила;
R1 и R1' являются одинаковыми или различными и представляют собой водород, низший алкил, галоген, бензил или низший алкенил;
(R2)1,2,3 независимо друг от друга представляют собой водород, гидрокси, галоген, низший алкил, низший алкокси или трифторметил;
R3 представляет собой
фенил или бензил, который является незамещенным или замещен одним или двумя заместителями, выбранными из группы, состоящей из галогена или циано, или представляет собой
низший алкил,
два атома водорода,
(СН2)1,2-S-низший алкил,
(СН2)1,2-циклоалкил,
(CH2)1,2-OH,
СН2ОСН2-фенил или группы
R4 представляет собой низший алкокси,
моно- или диалкиламино,
N(СН3)(СН2)1,2-С≡СН,
или представляет собой моно-, ди- или трициклическую группу,
незамещенную или замещенную R5-R10, и
где группы могут быть связаны с помощью -N(СН3)(СН2)0,1,2 с -С(O) группой в формуле IB, выбранные из группы, состоящей из
где (R5)1,2 независимо друг от друга представляет собой водород, галоген, низший алкил или -(СН2)1,2OH;
R6 представляет собой водород, галоген или низший алкокси;
R7 представляет собой водород или -СН2ОСН3;
R8 представляет собой водород или галоген;
R9 представляет собой водород, низший алкокси, низший алкил или амино;
(R10)1,2,3 независимо друг от друга представляет собой водород, низший алкил, низший алкокси, низший циклоалкил, галоген, гидрокси, =O, амино, нитро, -CH2CN, -ОСН2С6Н5,
где Х представляет собой -СН2, -S(O)2 или -С(О)-;
R11 представляет собой водород или низший алкил;
R12 представляет собой водород или галоген;
R14 представляет собой водород, низший алкил, -(СН2)2OH или -(CH2)2CN;
и их фармацевтически приемлемые кислотные аддитивные соли.
2. Соединения общей формулы
где R1 и R1' являются одинаковыми или различными и представляют собой водород, низший алкил, галоген, бензил или низший алкенил;
(R2)1,2,3 независимо друг от друга представляет собой водород, галоген, низший алкил, низший алкокси или трифторметил;
R3 представляет собой фенил или бензил, которые являются незамещенными или замещены одним или двумя заместителями, выбранными из группы, состоящей из галогена или циано, или представляет собой
низший алкил,
два атома водорода,
(СН2)1,2-S-низший алкил,
(СН2)1,2-циклоалкил,
(CH2)1,2-OH,
СН2OCH2-фенил или группы
R4 представляет собой низший алкокси,
моно- или диалкиламино,
N(СН3)(СН2)1,2-С≡СН,
или представляет собой моно-, ди- или трициклическую группу,
незамещенную или замещенную R5-R10, и
где группы могут быть связаны с помощью -N(СН3)(СН2)0,1,2 с -С(O)-группой в формуле IB, выбранные из группы, состоящей из
где (R5)1,2 независимо друг от друга представляет собой водород, галоген, низший алкил или -(CH2)1,2OH;
R6 представляет собой водород, галоген или низший алкокси;
R7 представляет собой водород или -СН2ОСН3;
R8 представляет собой водород или галоген;
R9 представляет собой водород, низший алкокси, низший алкил или амино;
(R10)1,2,3 независимо друг от друга представляет собой водород, низший алкил, низший алкокси, низший циклоалкил, галоген, гидрокси, =O, амино, нитро, -CH2CN, -ОСН2С6Н5,
где Х представляет собой -СН2, -S(O)2 или -С(O)-;
R11 представляет собой водород или низший алкил;
R12 представляет собой водород или галоген;
и их фармацевтически приемлемые кислотные аддитивные соли.
3. Соединения формулы IA по п.2.
5. Соединения формулы IA по п.4, где соединения представляют собой
N-(3,5-дифторбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-2-фтор-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-2-изопропил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-2-этил-N'-(5-метил-6-оксо-6,7-гидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-2-фтор-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-2,2-диметил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3,5-дифторбензил)-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-2-пропил-малонамид,
N-бензил-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(4-фторбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(4-хлорбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(3-фторбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(2,5-дифторбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
2-метил-N-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-N'-(2,3,5-трифторбензил)-малонамид,
N-(2-фторбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-(2-хлорбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид или
N-(3-хлорбензил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид.
7. Соединения формулы IA по п.6, где соединения представляют собой
N-фуран-2-илметил-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид,
N-бензо[b]тиофен-3-илметил-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид или
N-(4,6-дифториндан-1-ил)-2-метил-N'-(5-метил-6-оксо-6,7-дигидро-5Н-дибензо[b,d]азепин-7-ил)-малонамид.
9. Соединения формулы IA по п.8, где соединения представляют собой
(N-(3,5-дифторбензил)-2-метил-N'-(1-метил-2-оксо-5-фенил-2,3-дигидро-1Н-бензо[e][1,4]диазепин-3-ил)-малонамид,
N-(3,5-дифторбензил)-2-фтор-2-метил-N'-(1-метил-2-оксо-5-фенил-2,3-дигидро-1Н-бензо[e][1,4]диазепин-3-ил)-малонамид,
N(3,5-дифторбензил)-N'-(1-метил-2-оксо-5-фенил-2,3-дигидро-1Н-бензо[e][1,4]диазепин-3-ил)-2-пропил-малонамид,
N-(3,5-дифторбензил)-2-этил-N'-(1-метил-2-оксо-5-фенил-2,3-дигидро-1Н-бензо[e][1,4]диазепин-3-ил)-малонамид или
N-(4-хлорбензил)-2-метил-N'-(1-метил-2-оксо-5-фенил-2,3-дигидро-1Н-бензо[e][1,4]диазепин-3-ил)-малонамид.
11. Соединения формулы IA по п.10, где соединения представляют собой
N-(5-бензил-1-метил-2-оксо-2,3,4,5-тетрагидро-1Н-бензо[b][1,4]диазепин-3-ил)-N'-(3,5-дифторбензил)-2-метил-малонамид,
N-(5-бензолсульфонил-1-метил-2-оксо-2,3,4,5-тетрагидро-1Н-бензо[b][1,4]диазепин-3-ил)-N'-(3,5-дифторбензил)-2-метил-малонамид или
N-(5-бензоил-1-метил-2-оксо-2,3,4,5-тетрагидро-1Н-бензо[b][1,4]диазепин-3-ил)-N'-(3,5-дифторбензил)-2-метил-малонамид.
13. Соединения формулы IA по п.12, где соединения представляют собой
(2S-цис)-N-(3,5-дифторбензил)-2-метил-N'-{4-оксо-2-[(2-тиофен-2-ил-ацетиламино)-(2R,S)-метил]-1,2,4,5,6,7-гексагидроазепино[3,2,1-hi]индол-5-ил}-малонамид или
(2S-цис)-N-(3,5-дифторбензил)-N'-(2-{[2-(4-фторфенил)ацетиламино]метил}-4-оксо-1,2,4,5,6,7-гексагидроазепино[3,2,1-hi]индол-5-ил)-2,2-диметил-малонамид.
14. Соединения формулы IB по п.1 или 2.
15. Соединения формул IA или IB по п.1 или 2, где по крайней мере один из (R2)1,2,3 представляет собой фтор.
16. Способ получения соединения формул IA или IB по пп.1-15, где способ включает
а) реакцию соединения формулы
с соединением формулы
с получением соединения формулы
где заместители являются такими, как определено в п.1, или
б) реакцию соединения формулы
с соединением формулы
с получением соединения формулы
где заместители являются такими, как определено в п.1,
в) реакцию соединения формулы
с соединением формулы
с получением соединения формулы
где заместители являются такими, как определено в п.1, и
при необходимости, превращение полученных соединений в фармацевтически приемлемые кислотные аддитивные соли.
17. Соединение по любому из пп.1-15, полученное способом по п.16 или эквивалентным способом.
18. Лекарственное средство, содержащее одно или несколько соединений по любому из пп.1-15 и фармацевтически приемлемые эксципиенты.
19. Лекарственное средство по п.18 для лечения болезни Альцгеймера.
20. Применение соединения по любому одному из пп.1-15 для изготовления лекарственных средств для лечения болезни Альцгеймера.
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CN1745076A (zh) | 2006-03-08 |
WO2004069826A1 (en) | 2004-08-19 |
JP4662914B2 (ja) | 2011-03-30 |
DE602004015415D1 (de) | 2008-09-11 |
AU2004210036A1 (en) | 2004-08-19 |
HRP20050663A2 (en) | 2006-12-31 |
US7375099B2 (en) | 2008-05-20 |
ZA200506212B (en) | 2006-05-31 |
MXPA05008172A (es) | 2005-10-05 |
BRPI0407262A (pt) | 2006-01-31 |
ES2311795T3 (es) | 2009-02-16 |
CA2514267C (en) | 2011-05-17 |
CL2004000174A1 (es) | 2005-01-14 |
NZ541324A (en) | 2008-10-31 |
CN100480248C (zh) | 2009-04-22 |
PL378405A1 (pl) | 2006-04-03 |
JP2006516556A (ja) | 2006-07-06 |
ATE402934T1 (de) | 2008-08-15 |
KR20050105452A (ko) | 2005-11-04 |
TW200423928A (en) | 2004-11-16 |
EP1592684B1 (en) | 2008-07-30 |
AR042996A1 (es) | 2005-07-13 |
NO20053627L (no) | 2005-08-10 |
IL169691A (en) | 2011-03-31 |
CO5580761A2 (es) | 2005-11-30 |
KR100810810B1 (ko) | 2008-03-06 |
EP1592684A1 (en) | 2005-11-09 |
IL169691A0 (en) | 2007-07-04 |
RU2330849C2 (ru) | 2008-08-10 |
TWI293070B (en) | 2008-02-01 |
CA2514267A1 (en) | 2004-08-19 |
US20040220222A1 (en) | 2004-11-04 |
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