RU2005112254A - Ацильные производные 5-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-она, обладающие нейролептической активностью - Google Patents
Ацильные производные 5-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-она, обладающие нейролептической активностью Download PDFInfo
- Publication number
- RU2005112254A RU2005112254A RU2005112254/04A RU2005112254A RU2005112254A RU 2005112254 A RU2005112254 A RU 2005112254A RU 2005112254/04 A RU2005112254/04 A RU 2005112254/04A RU 2005112254 A RU2005112254 A RU 2005112254A RU 2005112254 A RU2005112254 A RU 2005112254A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- alkyl
- specified
- acylating agent
- Prior art date
Links
- 0 C*(C)C(N1c2cc(Cl)c(CCN(CC3)CCN3c3n[s]c4ccccc34)cc2CC2OC12)=O Chemical compound C*(C)C(N1c2cc(Cl)c(CCN(CC3)CCN3c3n[s]c4ccccc34)cc2CC2OC12)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Claims (13)
2. Соединение по п.1, где R1 представляет собой этил.
8. Способ по п.6, где указанный ангидридный ацилирующий агент взаимодействует с соединением формулы V в присутствии эфирата магнийбромид-диэтилового эфира и органического основания.
10. Способ по п.8, где указанное органическое основание представляет собой триэтиламин.
11. Способ по п.3, где указанное основание выбрано из группы, состоящей из бикарбонатов щелочных металлов, карбонатов щелочных металлов, от С-1 до С-6-триалкиламинов; и гетероциклических оснований, выбранных из группы, состоящей из пиридина, лутидина и пиколина.
12. Способ по п.11, где указанное основание представляет собой бикарбонат натрия.
13. Фармацевтическая композиция, обладающая нейролептической активностью, содержащая соединение по п.1 в количестве, эффективном при лечении нейролептических заболеваний, и фармацевтически приемлемый носитель.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42084302P | 2002-10-24 | 2002-10-24 | |
US60/420,843 | 2002-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2005112254A true RU2005112254A (ru) | 2006-01-20 |
Family
ID=32176638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005112254/04A RU2005112254A (ru) | 2002-10-24 | 2003-10-13 | Ацильные производные 5-(1,2-бензизотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-она, обладающие нейролептической активностью |
Country Status (25)
Country | Link |
---|---|
US (1) | US7019009B2 (ru) |
EP (1) | EP1556378B1 (ru) |
JP (1) | JP2006505578A (ru) |
KR (1) | KR100755625B1 (ru) |
CN (1) | CN100340557C (ru) |
AR (1) | AR041695A1 (ru) |
AT (1) | ATE383357T1 (ru) |
AU (1) | AU2003269331B2 (ru) |
BR (1) | BR0315516A (ru) |
CA (1) | CA2500485C (ru) |
CO (1) | CO5550441A2 (ru) |
CY (1) | CY1107300T1 (ru) |
DE (1) | DE60318602T2 (ru) |
DK (1) | DK1556378T3 (ru) |
ES (1) | ES2297200T3 (ru) |
HK (1) | HK1081185A1 (ru) |
MX (1) | MXPA05002734A (ru) |
NO (1) | NO20052475L (ru) |
NZ (1) | NZ566615A (ru) |
PL (1) | PL376721A1 (ru) |
PT (1) | PT1556378E (ru) |
RU (1) | RU2005112254A (ru) |
TW (1) | TW200418850A (ru) |
WO (1) | WO2004037819A1 (ru) |
ZA (1) | ZA200502109B (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007517014A (ja) * | 2003-12-31 | 2007-06-28 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | N−置換ピペリジン及びピペラジン誘導体 |
JP5732453B2 (ja) * | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Nh酸性化合物のプロドラッグ |
US8431576B2 (en) | 2009-06-25 | 2013-04-30 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
US8592427B2 (en) * | 2010-06-24 | 2013-11-26 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
DK0790236T3 (da) * | 1996-02-13 | 2004-02-23 | Pfizer | Prolægemidler af 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chlor-1,3-dihydro-2H-indol-2-on |
CA2340701C (en) * | 1998-08-20 | 2009-05-26 | Sumitomo Pharmaceuticals Co., Ltd. | Oxindole derivatives as growth hormone releasers |
-
2003
- 2003-10-13 DK DK03751112T patent/DK1556378T3/da active
- 2003-10-13 BR BR0315516-1A patent/BR0315516A/pt not_active IP Right Cessation
- 2003-10-13 ES ES03751112T patent/ES2297200T3/es not_active Expired - Lifetime
- 2003-10-13 DE DE60318602T patent/DE60318602T2/de not_active Expired - Fee Related
- 2003-10-13 CA CA2500485A patent/CA2500485C/en not_active Expired - Fee Related
- 2003-10-13 RU RU2005112254/04A patent/RU2005112254A/ru not_active Application Discontinuation
- 2003-10-13 PT PT03751112T patent/PT1556378E/pt unknown
- 2003-10-13 KR KR1020057006938A patent/KR100755625B1/ko not_active IP Right Cessation
- 2003-10-13 PL PL376721A patent/PL376721A1/pl not_active Application Discontinuation
- 2003-10-13 NZ NZ566615A patent/NZ566615A/en not_active IP Right Cessation
- 2003-10-13 WO PCT/IB2003/004519 patent/WO2004037819A1/en active IP Right Grant
- 2003-10-13 JP JP2004546256A patent/JP2006505578A/ja not_active Withdrawn
- 2003-10-13 AT AT03751112T patent/ATE383357T1/de not_active IP Right Cessation
- 2003-10-13 EP EP03751112A patent/EP1556378B1/en not_active Expired - Lifetime
- 2003-10-13 CN CNB2003801017404A patent/CN100340557C/zh not_active Expired - Fee Related
- 2003-10-13 AU AU2003269331A patent/AU2003269331B2/en not_active Ceased
- 2003-10-13 MX MXPA05002734A patent/MXPA05002734A/es not_active Application Discontinuation
- 2003-10-21 US US10/689,773 patent/US7019009B2/en not_active Expired - Fee Related
- 2003-10-22 AR ARP030103846A patent/AR041695A1/es unknown
- 2003-10-23 TW TW092129426A patent/TW200418850A/zh unknown
-
2005
- 2005-03-14 ZA ZA200502109A patent/ZA200502109B/en unknown
- 2005-04-22 CO CO05038502A patent/CO5550441A2/es not_active Application Discontinuation
- 2005-05-23 NO NO20052475A patent/NO20052475L/no not_active Application Discontinuation
-
2006
- 2006-01-25 HK HK06101121A patent/HK1081185A1/xx not_active IP Right Cessation
-
2008
- 2008-03-12 CY CY20081100276T patent/CY1107300T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AR041695A1 (es) | 2005-05-26 |
KR100755625B1 (ko) | 2007-09-04 |
ATE383357T1 (de) | 2008-01-15 |
HK1081185A1 (en) | 2006-05-12 |
CY1107300T1 (el) | 2012-11-21 |
NZ566615A (en) | 2009-08-28 |
ES2297200T3 (es) | 2008-05-01 |
CN1705663A (zh) | 2005-12-07 |
PT1556378E (pt) | 2008-02-21 |
MXPA05002734A (es) | 2005-05-23 |
CO5550441A2 (es) | 2005-08-31 |
DE60318602T2 (de) | 2009-01-15 |
CA2500485C (en) | 2010-03-23 |
US7019009B2 (en) | 2006-03-28 |
EP1556378B1 (en) | 2008-01-09 |
DK1556378T3 (da) | 2008-03-17 |
CN100340557C (zh) | 2007-10-03 |
BR0315516A (pt) | 2005-08-23 |
KR20050065618A (ko) | 2005-06-29 |
WO2004037819A1 (en) | 2004-05-06 |
ZA200502109B (en) | 2006-05-31 |
DE60318602D1 (de) | 2008-02-21 |
TW200418850A (en) | 2004-10-01 |
US20040138232A1 (en) | 2004-07-15 |
PL376721A1 (pl) | 2006-01-09 |
EP1556378A1 (en) | 2005-07-27 |
NO20052475D0 (no) | 2005-05-23 |
NO20052475L (no) | 2005-07-25 |
AU2003269331A1 (en) | 2004-05-13 |
JP2006505578A (ja) | 2006-02-16 |
CA2500485A1 (en) | 2004-05-06 |
AU2003269331B2 (en) | 2010-02-18 |
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Legal Events
Date | Code | Title | Description |
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FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080519 |