RU2004130435A - Десмопрессин в лекарственной форме, диспергируемой во рту - Google Patents
Десмопрессин в лекарственной форме, диспергируемой во рту Download PDFInfo
- Publication number
- RU2004130435A RU2004130435A RU2004130435/15A RU2004130435A RU2004130435A RU 2004130435 A RU2004130435 A RU 2004130435A RU 2004130435/15 A RU2004130435/15 A RU 2004130435/15A RU 2004130435 A RU2004130435 A RU 2004130435A RU 2004130435 A RU2004130435 A RU 2004130435A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- desmopressin
- solvent
- gelatin
- form according
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Claims (12)
1. Диспергируемая во рту фармацевтическая лекарственная форма десмопрессина.
2. Лекарственная форма по п.1, которая представляет собой диспергируемую во рту твердую фармацевтическую лекарственную форму.
3. Твердая фармацевтическая лекарственная форма, включающая десмопрессин и открытую матричную сеть, несущую десмопрессин, причем эта открытая матричная сеть содержит водорастворимое или вододиспергируемое вещество-носитель, инертное по отношению к десмопрессину.
4. Лекарственная форма по п.3, в которой открытая матричная сеть содержит желатин.
5. Лекарственная форма по п.4, в которой желатин представляет собой желатин рыб.
6. Лекарственная форма по п.5, в которой желатин рыб является нежелирующим.
7. Способ изготовления твердой фармацевтической лекарственной формы, при котором сублимируют растворитель из композиции, включающей десмопрессин и раствор вещества-носителя в растворителе, причем эта композиция в форме для изготовления находится в твердом состоянии.
8. Способ по п.7, при котором сублимацию осуществляют путем лиофильной сушки композиции, включающей десмопрессин и раствор вещества-носителя в растворителе.
9. Способ по п.7, где растворителем является вода.
10. Способ по пп.7, 8 или 9, где рН раствора находится в интервале от 3 до 6, предпочтительно от 3,5 до 5,5 и наиболее предпочтительно от 4 до 5.
11. Лекарственная форма по любому из пп.1-6 для применения в медицине.
12. Лекарственная форма по любому из пп.1-6 для применения для задержки опорожнения, или лечения или предупреждения недержания, первичного ночного энуреза (PNE), никтурии или несахарного диабета центрального происхождения.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0210397.6A GB0210397D0 (en) | 2002-05-07 | 2002-05-07 | Pharmaceutical formulations |
GB0210397.6 | 2002-05-07 | ||
PCT/IB2002/004036 WO2003094885A1 (en) | 2002-05-07 | 2002-09-20 | Sublingual pharmaceutical formulation of desmopressin |
IBPCT/IB02/04036 | 2002-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2004130435A true RU2004130435A (ru) | 2005-08-10 |
RU2292903C2 RU2292903C2 (ru) | 2007-02-10 |
Family
ID=9936186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004130435/15A RU2292903C2 (ru) | 2002-05-07 | 2003-05-07 | Десмопрессин в лекарственной форме, диспергируемой во рту |
Country Status (22)
Country | Link |
---|---|
US (14) | US7560429B2 (ru) |
EP (1) | EP1501534B1 (ru) |
KR (1) | KR100632455B1 (ru) |
CN (2) | CN1319592C (ru) |
AR (3) | AR039092A1 (ru) |
AT (1) | ATE333886T1 (ru) |
AU (2) | AU2002337419A1 (ru) |
DK (1) | DK1501534T5 (ru) |
ES (1) | ES2266820T4 (ru) |
GB (1) | GB0210397D0 (ru) |
HK (1) | HK1074393A1 (ru) |
IL (1) | IL164519A (ru) |
MX (1) | MXPA04010926A (ru) |
MY (1) | MY131153A (ru) |
PL (1) | PL208482B1 (ru) |
RU (1) | RU2292903C2 (ru) |
SI (1) | SI1501534T1 (ru) |
TW (1) | TWI315202B (ru) |
UA (1) | UA85664C2 (ru) |
UY (2) | UY27683A1 (ru) |
WO (2) | WO2003094885A1 (ru) |
ZA (1) | ZA200408596B (ru) |
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- 2003-05-06 AU AU2003299480A patent/AU2003299480A1/en not_active Abandoned
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- 2003-05-07 KR KR1020047017821A patent/KR100632455B1/ko active IP Right Grant
- 2003-05-07 AT AT03727870T patent/ATE333886T1/de active
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- 2003-05-07 ES ES03727870.2T patent/ES2266820T4/es not_active Expired - Lifetime
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- 2003-05-07 DK DK03727870.2T patent/DK1501534T5/da active
- 2003-05-07 PL PL375497A patent/PL208482B1/pl unknown
- 2003-05-07 CN CNA200610172805XA patent/CN1981745A/zh active Pending
- 2003-11-12 US US10/706,100 patent/US7799761B2/en active Active
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2004
- 2004-10-12 IL IL164519A patent/IL164519A/en active IP Right Grant
- 2004-10-22 ZA ZA200408596A patent/ZA200408596B/en unknown
-
2005
- 2005-07-20 HK HK05106142A patent/HK1074393A1/xx not_active IP Right Cessation
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2007
- 2007-05-04 US US11/744,615 patent/US7405203B2/en not_active Expired - Lifetime
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2008
- 2008-07-15 US US12/173,074 patent/US7579321B2/en not_active Expired - Fee Related
- 2008-07-15 US US12/173,072 patent/US8143225B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 US US12/487,116 patent/US7947654B2/en not_active Expired - Lifetime
- 2009-11-06 US US12/613,855 patent/US20100056436A1/en not_active Abandoned
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2011
- 2011-05-18 US US13/110,619 patent/US8802624B2/en not_active Expired - Lifetime
-
2012
- 2012-08-30 US US13/599,768 patent/US20120322734A1/en not_active Abandoned
-
2014
- 2014-07-09 US US14/326,939 patent/US9220747B2/en not_active Expired - Lifetime
-
2015
- 2015-11-20 US US14/947,261 patent/US9504647B2/en not_active Expired - Lifetime
-
2016
- 2016-02-16 AR ARP160100416A patent/AR107948A2/es not_active Application Discontinuation
- 2016-10-25 US US15/333,503 patent/US9919025B2/en not_active Expired - Lifetime
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2018
- 2018-01-26 US US15/881,123 patent/US10307459B2/en not_active Expired - Lifetime
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2020
- 2020-07-09 US US16/924,843 patent/US20210161810A1/en not_active Abandoned
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