RU2003129068A - Штаммы вируса репродуктивного и респираторного синдрома свиней (prrs) с ослабленной жизнеспособностью - Google Patents
Штаммы вируса репродуктивного и респираторного синдрома свиней (prrs) с ослабленной жизнеспособностью Download PDFInfo
- Publication number
- RU2003129068A RU2003129068A RU2003129068/13A RU2003129068A RU2003129068A RU 2003129068 A RU2003129068 A RU 2003129068A RU 2003129068/13 A RU2003129068/13 A RU 2003129068/13A RU 2003129068 A RU2003129068 A RU 2003129068A RU 2003129068 A RU2003129068 A RU 2003129068A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- amino acid
- acid sequence
- prrs virus
- nucleic acid
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims 45
- 230000001850 reproductive effect Effects 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
- 230000035899 viability Effects 0.000 title 1
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 claims 41
- 150000001413 amino acids Chemical group 0.000 claims 39
- 102000039446 nucleic acids Human genes 0.000 claims 28
- 108020004707 nucleic acids Proteins 0.000 claims 28
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 238000000034 method Methods 0.000 claims 17
- 239000002773 nucleotide Substances 0.000 claims 17
- 125000003729 nucleotide group Chemical group 0.000 claims 17
- 238000012217 deletion Methods 0.000 claims 10
- 230000037430 deletion Effects 0.000 claims 10
- 230000002238 attenuated effect Effects 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 238000002741 site-directed mutagenesis Methods 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000405 serological effect Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27460301P | 2001-03-09 | 2001-03-09 | |
| US60/274,603 | 2001-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003129068A true RU2003129068A (ru) | 2005-04-10 |
Family
ID=23048885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003129068/13A RU2003129068A (ru) | 2001-03-09 | 2002-03-07 | Штаммы вируса репродуктивного и респираторного синдрома свиней (prrs) с ослабленной жизнеспособностью |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1421184A2 (cs) |
| JP (1) | JP2004534522A (cs) |
| KR (1) | KR20030082960A (cs) |
| BR (1) | BR0207988A (cs) |
| CA (1) | CA2439254A1 (cs) |
| CZ (1) | CZ20032743A3 (cs) |
| HU (1) | HUP0303431A2 (cs) |
| MX (1) | MXPA03007751A (cs) |
| PL (1) | PL370541A1 (cs) |
| RU (1) | RU2003129068A (cs) |
| SK (1) | SK11282003A3 (cs) |
| WO (1) | WO2002072802A2 (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1438969A1 (en) * | 2003-01-14 | 2004-07-21 | Universiteit Utrecht | Arterivirus marker vaccine |
| KR20050040172A (ko) * | 2003-10-27 | 2005-05-03 | 주식회사 중앙백신연구소 | 돼지 생식기호흡기 증후군 바이러스 불활화 백신의 제조방법 |
| AU2005306781B2 (en) * | 2004-11-19 | 2011-12-22 | Intervet International B.V. | Porcine reproductive and respiratory syndrome virus strains and compositions |
| EP1856141A1 (en) * | 2005-02-25 | 2007-11-21 | Pfizer Products Inc. | N protein mutants of porcine reproductive and respiratory syndrome virus |
| WO2009008924A2 (en) | 2007-04-05 | 2009-01-15 | Mount Sinai School Of Medicine Of New York University | Methods of preventing and treating viral infections by inhibiting the deisgylation activity of otu domain-containing viral proteins |
| CN101454442A (zh) * | 2007-06-15 | 2009-06-10 | 普泰克国际有限公司 | 嵌合体prrsv的构建，组合物及疫苗的制备 |
| US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
| ES2550258T3 (es) * | 2011-02-17 | 2015-11-05 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del PRRSV europea |
| KR101420850B1 (ko) * | 2011-05-30 | 2014-08-13 | 건국대학교 산학협력단 | 돼지 생식기 호흡기 증후군 바이러스 유사입자 및 이를 이용한 백신 |
| KR101281361B1 (ko) * | 2011-07-18 | 2013-07-02 | 서울대학교산학협력단 | 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물 |
| KR101245029B1 (ko) * | 2012-01-18 | 2013-03-18 | 서울대학교산학협력단 | 한국형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 |
| WO2013173443A1 (en) * | 2012-05-17 | 2013-11-21 | Zoetis Llc | Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning |
| CN103290142B (zh) * | 2013-03-29 | 2015-03-11 | 云南农业大学 | 荧光定量rt-pcr检测猪蓝耳病弱毒疫苗病毒含量的方法 |
| KR101624485B1 (ko) | 2014-08-13 | 2016-05-26 | 전북대학교산학협력단 | 돼지생식기호흡기증후군 바이러스(prrsv) 변이주 및 이를 포함하는 돼지 생식기 호흡기 증후군 예방 또는 치료용 백신 조성물 |
| CN104694561B (zh) * | 2015-02-10 | 2018-02-23 | 中国农业科学院上海兽医研究所 | 表达海肾或萤火虫荧光素酶基因的prrsv重组质粒的构建方法以及应用 |
| AU2019463018A1 (en) * | 2019-08-29 | 2022-02-03 | Elanco Uk Ah Limited | Porcine reproductive and respiratory syndrome vaccine virus |
| KR102276341B1 (ko) * | 2020-01-29 | 2021-07-12 | 주식회사 바이오포아 | 유럽형 돼지 생식기 호흡기 증후군 바이러스의 제조 방법 및 이의 용도 |
| EP4098741A4 (en) * | 2020-01-29 | 2024-04-03 | Biopoa, Inc. | MUTANT STRAIN OF EUROPEAN SWINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, AND VACCINE USING SAME |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2290906C (en) * | 1991-06-06 | 2003-04-01 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
| US6592873B1 (en) * | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
| CN1259141B (zh) * | 1997-05-06 | 2013-03-27 | 勃林格殷格汉动物保健有限公司 | 用于疫苗或诊断测试中的鉴定prrs病毒的肽序列的prrsv抗原位点 |
| WO1998055626A2 (en) * | 1997-06-05 | 1998-12-10 | Origen, Inc. | Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine |
| EP1157121B1 (en) * | 1999-03-08 | 2013-04-24 | Boehringer Ingelheim Vetmedica GmbH | Prrsv replicon |
| WO2002095040A1 (en) * | 2001-05-21 | 2002-11-28 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Delections in arterivirus replicons |
| BR0107827A (pt) * | 2000-01-26 | 2002-11-05 | Boehringer Ingelheim Vetmed | Atenuação recombinante de prrsv |
| EP1156111A1 (en) * | 2000-05-19 | 2001-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Chimeric arterivirus-like particles |
| MXPA02011545A (es) * | 2000-05-24 | 2003-06-06 | Merial Sas | Virus del sindrome respiratorio y reproductor porcino (peesv), vacuna recombinante para el virus de la viruela. |
-
2002
- 2002-03-07 CZ CZ20032743A patent/CZ20032743A3/cs unknown
- 2002-03-07 SK SK1128-2003A patent/SK11282003A3/sk unknown
- 2002-03-07 KR KR10-2003-7011656A patent/KR20030082960A/ko not_active Withdrawn
- 2002-03-07 CA CA002439254A patent/CA2439254A1/en not_active Abandoned
- 2002-03-07 PL PL02370541A patent/PL370541A1/xx not_active Application Discontinuation
- 2002-03-07 HU HU0303431A patent/HUP0303431A2/hu unknown
- 2002-03-07 WO PCT/EP2002/002486 patent/WO2002072802A2/en not_active Application Discontinuation
- 2002-03-07 JP JP2002571858A patent/JP2004534522A/ja active Pending
- 2002-03-07 MX MXPA03007751A patent/MXPA03007751A/es unknown
- 2002-03-07 EP EP02726146A patent/EP1421184A2/en not_active Withdrawn
- 2002-03-07 BR BR0207988-7A patent/BR0207988A/pt not_active Application Discontinuation
- 2002-03-07 RU RU2003129068/13A patent/RU2003129068A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2439254A1 (en) | 2002-09-19 |
| PL370541A1 (en) | 2005-05-30 |
| WO2002072802A2 (en) | 2002-09-19 |
| HUP0303431A2 (hu) | 2004-01-28 |
| CZ20032743A3 (cs) | 2004-02-18 |
| JP2004534522A (ja) | 2004-11-18 |
| SK11282003A3 (sk) | 2004-02-03 |
| EP1421184A2 (en) | 2004-05-26 |
| MXPA03007751A (es) | 2004-11-12 |
| KR20030082960A (ko) | 2003-10-23 |
| WO2002072802A3 (en) | 2004-03-11 |
| BR0207988A (pt) | 2004-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20050321 |