RS52533B - Postupak za dobijanje kondenzovanih derivata piperazin-2-ona, kao i međuproizvodi ovog postupka - Google Patents

Postupak za dobijanje kondenzovanih derivata piperazin-2-ona, kao i međuproizvodi ovog postupka

Info

Publication number
RS52533B
RS52533B RS20120519A RSP20120519A RS52533B RS 52533 B RS52533 B RS 52533B RS 20120519 A RS20120519 A RS 20120519A RS P20120519 A RSP20120519 A RS P20120519A RS 52533 B RS52533 B RS 52533B
Authority
RS
Serbia
Prior art keywords
alkyl
compound
hydrogen
formula
group
Prior art date
Application number
RS20120519A
Other languages
English (en)
Serbian (sr)
Inventor
Adil Duran
Guenter Linz
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35923724&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS52533(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of RS52533B publication Critical patent/RS52533B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RS20120519A 2004-12-02 2005-11-29 Postupak za dobijanje kondenzovanih derivata piperazin-2-ona, kao i međuproizvodi ovog postupka RS52533B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Publications (1)

Publication Number Publication Date
RS52533B true RS52533B (sr) 2013-04-30

Family

ID=35923724

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20120519A RS52533B (sr) 2004-12-02 2005-11-29 Postupak za dobijanje kondenzovanih derivata piperazin-2-ona, kao i međuproizvodi ovog postupka

Country Status (34)

Country Link
US (9) US7238807B2 (enExample)
EP (2) EP2436685B1 (enExample)
JP (1) JP5164574B2 (enExample)
KR (2) KR101362131B1 (enExample)
CN (3) CN102070637B (enExample)
AR (1) AR053100A1 (enExample)
AU (1) AU2005311308B2 (enExample)
BR (1) BRPI0518601A2 (enExample)
CA (1) CA2588857C (enExample)
CL (1) CL2013002895A1 (enExample)
CY (1) CY1113625T1 (enExample)
DE (1) DE102004058337A1 (enExample)
DK (2) DK1819706T3 (enExample)
EA (1) EA012624B1 (enExample)
ES (2) ES2548680T3 (enExample)
HR (1) HRP20120980T1 (enExample)
HU (1) HUE027689T2 (enExample)
IL (1) IL183568A (enExample)
ME (1) ME01470B (enExample)
MX (1) MX2007006549A (enExample)
MY (1) MY147459A (enExample)
NO (1) NO20072283L (enExample)
NZ (1) NZ556182A (enExample)
PE (2) PE20090488A1 (enExample)
PL (2) PL1819706T3 (enExample)
PT (1) PT1819706E (enExample)
RS (1) RS52533B (enExample)
SG (2) SG141461A1 (enExample)
SI (1) SI1819706T1 (enExample)
TW (1) TWI362391B (enExample)
UA (1) UA89390C2 (enExample)
UY (1) UY29233A1 (enExample)
WO (1) WO2006058876A1 (enExample)
ZA (1) ZA200703368B (enExample)

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US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060035903A1 (en) * 2004-08-14 2006-02-16 Boehringer Ingelheim International Gmbh Storage stable perfusion solution for dihydropteridinones
US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
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US8329695B2 (en) * 2007-08-03 2012-12-11 Boehringer Ingelheim International Gmbh Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide
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CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
NZ599356A (en) 2009-09-25 2013-08-30 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
KR20120096474A (ko) 2009-09-25 2012-08-30 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피리미딘 유도체의 제조 방법
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
WO2012148548A1 (en) 2011-02-25 2012-11-01 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
TW201620904A (zh) 2014-01-09 2016-06-16 武田藥品工業有限公司 氮雜吲哚衍生物
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

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Also Published As

Publication number Publication date
KR20070092252A (ko) 2007-09-12
EA012624B1 (ru) 2009-10-30
ME01470B (me) 2014-04-20
HK1158199A1 (en) 2012-07-13
NO20072283L (no) 2007-06-28
KR101395591B1 (ko) 2014-05-16
EP1819706B1 (de) 2012-09-19
CL2013002895A1 (es) 2014-03-14
CA2588857C (en) 2013-10-08
JP2008521861A (ja) 2008-06-26
WO2006058876A1 (de) 2006-06-08
USRE43115E1 (en) 2012-01-17
DE102004058337A1 (de) 2006-06-14
MY147459A (en) 2012-12-14
HK1158200A1 (en) 2012-07-13
AR053100A1 (es) 2007-04-25
KR20120136414A (ko) 2012-12-18
TW200628471A (en) 2006-08-16
JP5164574B2 (ja) 2013-03-21
BRPI0518601A2 (pt) 2008-11-25
TWI362391B (en) 2012-04-21
PT1819706E (pt) 2012-12-06
HUE027689T2 (hu) 2021-12-28
US20070213531A1 (en) 2007-09-13
US20070208027A1 (en) 2007-09-06
PE20090488A1 (es) 2009-05-27
CA2588857A1 (en) 2006-06-08
AU2005311308A1 (en) 2006-06-08
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
HRP20120980T1 (hr) 2012-12-31
ZA200703368B (en) 2008-09-25
PE20061061A1 (es) 2006-11-10
PL2436685T3 (pl) 2015-11-30
CN102093361A (zh) 2011-06-15
IL183568A0 (en) 2007-09-20
UY29233A1 (es) 2006-07-31
ES2548680T3 (es) 2015-10-20
UA89390C2 (ru) 2010-01-25
CN102070637B (zh) 2012-09-26
EP2436685A1 (de) 2012-04-04
KR101362131B1 (ko) 2014-02-19
DK1819706T3 (da) 2013-01-02
HK1113489A1 (en) 2008-10-03
CY1113625T1 (el) 2016-06-22
MX2007006549A (es) 2007-06-18
US20070213529A1 (en) 2007-09-13
ES2395829T3 (es) 2013-02-15
EA200701164A1 (ru) 2007-12-28
SI1819706T1 (sl) 2013-01-31
CN101065381A (zh) 2007-10-31
US7238807B2 (en) 2007-07-03
US20070219369A1 (en) 2007-09-20
EP2436685B1 (de) 2015-07-01
US20070213534A1 (en) 2007-09-13
DK2436685T3 (en) 2015-09-14
AU2005311308B2 (en) 2012-04-12
SG141461A1 (en) 2008-04-28
IL183568A (en) 2015-02-26
SG158848A1 (en) 2010-02-26
CN102093361B (zh) 2014-05-07
EP1819706A1 (de) 2007-08-22
NZ556182A (en) 2009-08-28
US20060122393A1 (en) 2006-06-08
PL1819706T3 (pl) 2013-03-29
US20070213530A1 (en) 2007-09-13
US20070213528A1 (en) 2007-09-13
US7626019B2 (en) 2009-12-01

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