KR101362131B1 - 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체 - Google Patents

고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체 Download PDF

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KR101362131B1
KR101362131B1 KR1020077015136A KR20077015136A KR101362131B1 KR 101362131 B1 KR101362131 B1 KR 101362131B1 KR 1020077015136 A KR1020077015136 A KR 1020077015136A KR 20077015136 A KR20077015136 A KR 20077015136A KR 101362131 B1 KR101362131 B1 KR 101362131B1
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KR20070092252A (ko
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아딜 듀란
귄터 린츠
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베링거 인겔하임 인터내셔날 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020077015136A 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체 Expired - Fee Related KR101362131B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004058337.4 2004-12-02
DE102004058337A DE102004058337A1 (de) 2004-12-02 2004-12-02 Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
PCT/EP2005/056291 WO2006058876A1 (de) 2004-12-02 2005-11-29 Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020127028659A Division KR101395591B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체

Publications (2)

Publication Number Publication Date
KR20070092252A KR20070092252A (ko) 2007-09-12
KR101362131B1 true KR101362131B1 (ko) 2014-02-19

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KR1020077015136A Expired - Fee Related KR101362131B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체
KR1020127028659A Expired - Fee Related KR101395591B1 (ko) 2004-12-02 2005-11-29 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체

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US (9) US7238807B2 (enExample)
EP (2) EP2436685B1 (enExample)
JP (1) JP5164574B2 (enExample)
KR (2) KR101362131B1 (enExample)
CN (3) CN102093361B (enExample)
AR (1) AR053100A1 (enExample)
AU (1) AU2005311308B2 (enExample)
BR (1) BRPI0518601A2 (enExample)
CA (1) CA2588857C (enExample)
CL (1) CL2013002895A1 (enExample)
CY (1) CY1113625T1 (enExample)
DE (1) DE102004058337A1 (enExample)
DK (2) DK2436685T3 (enExample)
EA (1) EA012624B1 (enExample)
ES (2) ES2548680T3 (enExample)
HR (1) HRP20120980T1 (enExample)
HU (1) HUE027689T2 (enExample)
IL (1) IL183568A (enExample)
ME (1) ME01470B (enExample)
MX (1) MX2007006549A (enExample)
MY (1) MY147459A (enExample)
NO (1) NO20072283L (enExample)
NZ (1) NZ556182A (enExample)
PE (2) PE20061061A1 (enExample)
PL (2) PL1819706T3 (enExample)
PT (1) PT1819706E (enExample)
RS (1) RS52533B (enExample)
SG (2) SG141461A1 (enExample)
SI (1) SI1819706T1 (enExample)
TW (1) TWI362391B (enExample)
UA (1) UA89390C2 (enExample)
UY (1) UY29233A1 (enExample)
WO (1) WO2006058876A1 (enExample)
ZA (1) ZA200703368B (enExample)

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US7759485B2 (en) * 2004-08-14 2010-07-20 Boehringer Ingelheim International Gmbh Process for the manufacture of dihydropteridinones
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EP1630163A1 (de) * 2004-08-25 2006-03-01 Boehringer Ingelheim Pharma GmbH & Co.KG Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
ATE479434T1 (de) 2006-02-14 2010-09-15 Vertex Pharma Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
JP2010517989A (ja) 2007-02-01 2010-05-27 アストラゼネカ アクチボラグ Ｈｓｐ９０阻害剤としての５，６，７，８−テトラヒドロプテリジン誘導体
EP2185559A1 (en) * 2007-08-03 2010-05-19 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
EP2100894A1 (en) 2008-03-12 2009-09-16 4Sc Ag Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
MX2012003484A (es) 2009-09-25 2012-04-20 Vertex Pharma Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa.
SG179207A1 (en) 2009-09-25 2012-04-27 Vertex Pharma Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8546566B2 (en) 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
JP5931933B2 (ja) 2011-02-25 2016-06-08 武田薬品工業株式会社 Ｎ−置換オキサジノプテリジンおよびオキサジノプテリジノン
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
UY34893A (es) 2012-07-10 2014-02-28 Takeda Pharmaceutical Derivados de azaindol
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
US9371321B2 (en) 2014-01-09 2016-06-21 Astrazeneca Ab Azaindole derivatives
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Publication number Publication date
CN102093361A (zh) 2011-06-15
ZA200703368B (en) 2008-09-25
EP2436685A1 (de) 2012-04-04
US7626019B2 (en) 2009-12-01
SG158848A1 (en) 2010-02-26
US20060122393A1 (en) 2006-06-08
EP1819706A1 (de) 2007-08-22
RS52533B (sr) 2013-04-30
CY1113625T1 (el) 2016-06-22
KR20070092252A (ko) 2007-09-12
USRE43115E1 (en) 2012-01-17
NO20072283L (no) 2007-06-28
HK1113489A1 (en) 2008-10-03
DK2436685T3 (en) 2015-09-14
EA012624B1 (ru) 2009-10-30
US20070213534A1 (en) 2007-09-13
BRPI0518601A2 (pt) 2008-11-25
PL1819706T3 (pl) 2013-03-29
AR053100A1 (es) 2007-04-25
IL183568A (en) 2015-02-26
CL2013002895A1 (es) 2014-03-14
MX2007006549A (es) 2007-06-18
US20070213530A1 (en) 2007-09-13
EA200701164A1 (ru) 2007-12-28
US20070219369A1 (en) 2007-09-20
MY147459A (en) 2012-12-14
US20070213528A1 (en) 2007-09-13
EP2436685B1 (de) 2015-07-01
HRP20120980T1 (hr) 2012-12-31
US20070208027A1 (en) 2007-09-06
WO2006058876A1 (de) 2006-06-08
ES2548680T3 (es) 2015-10-20
UA89390C2 (ru) 2010-01-25
IL183568A0 (en) 2007-09-20
DE102004058337A1 (de) 2006-06-14
JP5164574B2 (ja) 2013-03-21
PL2436685T3 (pl) 2015-11-30
TWI362391B (en) 2012-04-21
US20070213531A1 (en) 2007-09-13
SI1819706T1 (sl) 2013-01-31
AU2005311308B2 (en) 2012-04-12
CN101065381A (zh) 2007-10-31
DK1819706T3 (da) 2013-01-02
NZ556182A (en) 2009-08-28
JP2008521861A (ja) 2008-06-26
HK1158199A1 (en) 2012-07-13
CN102093361B (zh) 2014-05-07
CA2588857C (en) 2013-10-08
KR101395591B1 (ko) 2014-05-16
HK1158200A1 (en) 2012-07-13
AU2005311308A1 (en) 2006-06-08
PE20061061A1 (es) 2006-11-10
CA2588857A1 (en) 2006-06-08
PE20090488A1 (es) 2009-05-27
CN101065381B (zh) 2011-03-30
CN102070637A (zh) 2011-05-25
ES2395829T3 (es) 2013-02-15
HUE027689T2 (hu) 2021-12-28
CN102070637B (zh) 2012-09-26
UY29233A1 (es) 2006-07-31
TW200628471A (en) 2006-08-16
EP1819706B1 (de) 2012-09-19
KR20120136414A (ko) 2012-12-18
SG141461A1 (en) 2008-04-28
US20070213529A1 (en) 2007-09-13
ME01470B (me) 2014-04-20
PT1819706E (pt) 2012-12-06
US7238807B2 (en) 2007-07-03

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