RS50994B - Postupak za dobijanje (s)-3-cijano-5-5metilheksanoinske kiseline pomoću enzima - Google Patents

Postupak za dobijanje (s)-3-cijano-5-5metilheksanoinske kiseline pomoću enzima

Info

Publication number
RS50994B
RS50994B RSP-2009/0451A RSP20090451A RS50994B RS 50994 B RS50994 B RS 50994B RS P20090451 A RSP20090451 A RS P20090451A RS 50994 B RS50994 B RS 50994B
Authority
RS
Serbia
Prior art keywords
cyano
methylhexanoic acid
enzymatic preparation
succinonitrile
isobutyl
Prior art date
Application number
RSP-2009/0451A
Other languages
English (en)
Inventor
Michael Paul Burns
Justin Kaine Weaver
John Wing Wong
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of RS50994B publication Critical patent/RS50994B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/207497—Molecular oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Postupak za dobijanje (S)-3-cijano-5-metilheksanoinske kiseline, naznačen time, što se sastoji od koraka:(a) dovođenja u kontakt racemskog 2-izobutil-sukcinonitrila sa nekim enzimskim katalizatorom koji ima aktivnost nitrilaze u medijumu reakcije; i(b) izolovanja (S)-3-cijano-5-metilheksanoinske kiseline iz medijuma reakcije; i opciono, izolovanja neizmenjenog (R)-2-izobutil-sukcinonitrila.Prijava sadrži još 7 patentnih zahteva.
RSP-2009/0451A 2004-04-14 2005-04-01 Postupak za dobijanje (s)-3-cijano-5-5metilheksanoinske kiseline pomoću enzima RS50994B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56213304P 2004-04-14 2004-04-14
PCT/IB2005/000873 WO2005100580A1 (en) 2004-04-14 2005-04-01 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids

Publications (1)

Publication Number Publication Date
RS50994B true RS50994B (sr) 2010-10-31

Family

ID=34962755

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0451A RS50994B (sr) 2004-04-14 2005-04-01 Postupak za dobijanje (s)-3-cijano-5-5metilheksanoinske kiseline pomoću enzima

Country Status (44)

Country Link
US (2) US7727749B2 (sr)
EP (1) EP1745136B1 (sr)
JP (1) JP4051082B2 (sr)
KR (1) KR100887777B1 (sr)
CN (1) CN1942587B (sr)
AP (1) AP2301A (sr)
AR (1) AR048690A1 (sr)
AT (1) ATE445019T1 (sr)
AU (1) AU2005233371B2 (sr)
BR (1) BRPI0509908A (sr)
CA (1) CA2563307C (sr)
CR (2) CR8686A (sr)
CY (1) CY1109556T1 (sr)
DE (1) DE602005017027D1 (sr)
DK (1) DK1745136T3 (sr)
DO (1) DOP2005000055A (sr)
EA (1) EA010305B1 (sr)
EC (1) ECSP066917A (sr)
ES (1) ES2331140T3 (sr)
GE (1) GEP20084530B (sr)
GT (1) GT200500086A (sr)
HK (1) HK1105215A1 (sr)
HN (1) HN2005000162A (sr)
HR (1) HRP20090562T1 (sr)
IL (1) IL177918A (sr)
MA (1) MA28536B1 (sr)
ME (1) ME01107B (sr)
MY (1) MY144296A (sr)
NL (1) NL1028762C2 (sr)
NO (1) NO335624B1 (sr)
NZ (1) NZ549698A (sr)
PA (1) PA8629801A1 (sr)
PE (1) PE20060252A1 (sr)
PL (1) PL1745136T3 (sr)
PT (1) PT1745136E (sr)
RS (1) RS50994B (sr)
SI (1) SI1745136T1 (sr)
SV (1) SV2005002085A (sr)
TN (1) TNSN06329A1 (sr)
TW (1) TWI304095B (sr)
UA (1) UA82292C2 (sr)
UY (1) UY28851A1 (sr)
WO (1) WO2005100580A1 (sr)
ZA (1) ZA200607476B (sr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
AT412092B (de) * 2003-02-27 2004-09-27 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung chiraler alpha-hydroxycarbonsäuren durch enzymatische hydrolyse von chiralen cyanhydrinen
US7417165B2 (en) 2005-04-06 2008-08-26 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
ATE486841T1 (de) 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
WO2006122255A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
MX2007014129A (es) 2005-05-10 2008-01-11 Teva Pharma Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico.
ES2398579T3 (es) 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
KR20080027880A (ko) 2006-05-24 2008-03-28 테바 파마슈티컬 인더스트리즈 리미티드 Ｒ-(+)-3-(카바모일메틸)-5-메틸헥산산 및 이의 염의 제조방법
KR20080036060A (ko) * 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
EP1881077A1 (en) * 2006-07-19 2008-01-23 Solvay Organics GmbH Process for the production of fluorine containing a-hydroxy carboxylic acids
EP2021318A2 (en) 2007-03-22 2009-02-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009087650A2 (en) * 2007-10-15 2009-07-16 V.B. Medicare Pvt. Ltd. A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin
MX2010012698A (es) 2008-05-21 2011-03-15 Sandoz Ag Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.
WO2011011630A2 (en) 2009-07-23 2011-01-27 Codexis, Inc. Nitrilase biocatalysts
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8604062B2 (en) * 2011-10-20 2013-12-10 Hoffman-La Roche Inc. Process for the preparation of isoxazolyl-methoxy nicotinic acids
CA2888877C (en) * 2012-11-07 2021-07-27 Hikal Limited A process for the preparation of pregabalin
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN105017072B (zh) * 2015-06-30 2017-10-03 河北诚信有限责任公司 异丁基琥珀腈的合成方法
CN105176955B (zh) 2015-08-27 2018-11-02 浙江工业大学 来源于高山南芥的腈水解酶、基因、载体、工程菌及其应用
CN108424900B (zh) * 2018-02-09 2020-11-03 浙江工业大学 一种腈水解酶突变体及其构建方法和应用
CN114164197B (zh) * 2020-01-13 2023-08-18 浙江工业大学 一种热稳定性和活力提高的腈水解酶突变体及其应用
CN113651717B (zh) * 2021-08-05 2024-08-30 浙江工业大学 一种光学纯异丁基丁二腈的消旋方法
CN116041214A (zh) * 2022-11-15 2023-05-02 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593871A (en) * 1990-09-20 1997-01-14 E. I. Du Pont De Nemours And Company Process for the preparation of enantiometric 2-alkanoic acid amides from nitriles
JP3218133B2 (ja) * 1993-02-03 2001-10-15 三菱レイヨン株式会社 フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5858736A (en) * 1996-05-17 1999-01-12 E. I. Du Pont De Nemours And Company Preparation of lactams from aliphatic α,ω-dinitriles
BR9813284B1 (pt) * 1997-10-27 2012-08-21 aminoácidos cìclicos e derivados dos mesmos úteis como agentes farmacêuticos e composição farmacêutica.
US6642398B2 (en) * 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
US6551804B2 (en) 1999-07-12 2003-04-22 E. I. Du Pont De Nemours And Company Process for preparing 4-cyanopentanoic acid
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
SI1250311T1 (en) * 2000-01-27 2004-10-31 Warner-Lambert Company Asymmetric synthesis of pregabalin
FR2824823A1 (fr) 2001-05-21 2002-11-22 Aventis Animal Nutrition Sa Procede de preparation d'acides carboxyliques aliphatiques par hydrolyse enzymatique de composes nitriles aliphatiques
MXPA05013754A (es) 2003-06-19 2006-03-08 Pfizer Prod Inc Una preparacion biocatalitica del acido 1-cianociclohexanoacetico.

Also Published As

Publication number Publication date
US20100204503A1 (en) 2010-08-12
PT1745136E (pt) 2009-11-26
UA82292C2 (uk) 2008-03-25
IL177918A0 (en) 2006-12-31
AP2006003764A0 (en) 2006-10-31
ES2331140T3 (es) 2009-12-22
TW200533756A (en) 2005-10-16
KR20070020009A (ko) 2007-02-16
GT200500086A (es) 2006-01-10
HN2005000162A (es) 2007-11-16
DK1745136T3 (da) 2009-11-30
NO335624B1 (no) 2015-01-12
WO2005100580A1 (en) 2005-10-27
PA8629801A1 (es) 2005-11-25
ME01107B (me) 2012-12-20
CA2563307A1 (en) 2005-10-27
TNSN06329A1 (fr) 2008-02-22
NL1028762A1 (nl) 2005-10-17
CR8686A (es) 2006-11-21
EA200601574A1 (ru) 2007-04-27
BRPI0509908A (pt) 2007-09-18
ZA200607476B (en) 2008-05-28
SI1745136T1 (sl) 2009-12-31
ECSP066917A (es) 2006-12-20
MA28536B1 (fr) 2007-04-03
AR048690A1 (es) 2006-05-17
NZ549698A (en) 2009-10-30
EP1745136B1 (en) 2009-10-07
HK1105215A1 (en) 2008-02-06
DE602005017027D1 (de) 2009-11-19
KR100887777B1 (ko) 2009-03-09
PE20060252A1 (es) 2006-04-01
CA2563307C (en) 2011-02-08
JP2007532125A (ja) 2007-11-15
HRP20090562T1 (en) 2009-11-30
AU2005233371B2 (en) 2007-12-20
EP1745136A1 (en) 2007-01-24
CY1109556T1 (el) 2014-08-13
TWI304095B (en) 2008-12-11
US8304252B2 (en) 2012-11-06
UY28851A1 (es) 2005-11-30
CR20110356A (es) 2011-07-21
PL1745136T3 (pl) 2010-02-26
AP2301A (en) 2011-10-31
US20070196905A1 (en) 2007-08-23
ATE445019T1 (de) 2009-10-15
DOP2005000055A (es) 2005-12-15
JP4051082B2 (ja) 2008-02-20
US7727749B2 (en) 2010-06-01
SV2005002085A (es) 2005-12-13
NO20065181L (no) 2006-11-10
GEP20084530B (en) 2008-11-10
AU2005233371A1 (en) 2005-10-27
MY144296A (en) 2011-08-29
IL177918A (en) 2013-11-28
CN1942587B (zh) 2010-05-05
EA010305B1 (ru) 2008-08-29
CN1942587A (zh) 2007-04-04
NL1028762C2 (nl) 2006-07-25

Similar Documents

Publication Publication Date Title
RS50994B (sr) Postupak za dobijanje (s)-3-cijano-5-5metilheksanoinske kiseline pomoću enzima
DK1664318T3 (da) L-aminosyre-producerende mikroorganisme og fremgangsmåde til fremstilling af L-aminosyre
NO20021931L (no) L-pantolacton-hydrolase og en fremgangsmåte for fremstilling av D-pantolacton
DK1680516T3 (da) Ruminddelt autonom mærkning
MY159420A (en) Method for the enzymatic production of 3-hydroxy-3 methylbutyric acid from acetone and acetyl coa
DK1651758T3 (da) Fremgangsmåde tl fremstilling af L-lysin eller L-threonin ved anvendelse af Escherichia bakterier med svækket æblesyreenzymaktivitet
ATE318926T1 (de) Verfahren zur herstellung von cadaverindicarboxylat und dessen verwendung zur herstellung von nylon
EP1571223A3 (en) L-cysteine-producing microorganism and a method for producing L-cysteine
DE60301031D1 (de) Verfahren zur Herstellung von L-Aminosäuren
ATE474910T1 (de) L-glutaminsäure produzierender mikroorganismus sowie verfahren zur produktion von l- glutaminsäure
WO2010069319A3 (en) Method and device for industrial biolayer cultivation
WO2006093322A3 (en) Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof
NZ590603A (en) Method for preparation of lactic acid bacterium having anti-allergic activity comprising culturing bacterium in casein hydrolysate
DK1929001T3 (da) Nye dehydrogenaser, disses derivater og en fremgangsmåde til fremstilling af optisk aktive alkanoler
DE10345772A1 (de) Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
TW200724112A (en) Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same
DE502006005179D1 (de) Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
EP1831350A4 (en) MICROORGANISM OF AN ESCHERICHIA OR CORYNEBACTERIUM SPECIES WITH A FOREIGN FOR NADP-DEPENDENT GLYCERINALDEHYDE-3-PHOSPHATE DEHYDROGENASE AND METHOD FOR THE PREPARATION OF L-LYSINE THEREWITH
DE60307615D1 (de) Zellkulturmedium
PL1706493T3 (pl) Sposób wytwarzania L-treoniny lub L-lizyny obejmujący rekombinowane enterobacteriaceae o ulepszonej aktywności enolazy
ATE373100T1 (de) Herstellung von milchsäure aus einem pentose- enthaltenden substrat
WO2007099254A3 (fr) Procede pour l'identification d'au moins deux groupes de microorganismes
DE502004006579D1 (de) L-carnitin dehydrogenasen, deren derivate und ein verfahren zur herstellung von substituierten (s)-alkanolen
DK1395662T3 (da) Fremgangsmåde til fremstilling af D-pantothensyre og/eller salte deraf
WO2003080855A3 (en) Deracemisation of amines