WO2006093322A3 - Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof - Google Patents

Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof Download PDF

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Publication number
WO2006093322A3
WO2006093322A3 PCT/JP2006/304423 JP2006304423W WO2006093322A3 WO 2006093322 A3 WO2006093322 A3 WO 2006093322A3 JP 2006304423 W JP2006304423 W JP 2006304423W WO 2006093322 A3 WO2006093322 A3 WO 2006093322A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoleucine
hydroxy
salt
manufacturing
acetaldehyde
Prior art date
Application number
PCT/JP2006/304423
Other languages
French (fr)
Other versions
WO2006093322A2 (en
Inventor
Tomohiro Kodera
Kazuhiko Matsui
Noriki Nio
Hidehiko Wakabayashi
Sergey Vasilievich Smirnov
Natalia Nikolaevna Samsonova
Anna Evgenievna Novikova
Nikolay Georgievich Matrosov
Valeriya Avtandilovna Rakitina
Natalia Yurievna Rushkevich
Leonid Romanovich Ptitsyn
Original Assignee
Ajinomoto Kk
Tomohiro Kodera
Kazuhiko Matsui
Noriki Nio
Hidehiko Wakabayashi
Sergey Vasilievich Smirnov
Natalia Nikolaevna Samsonova
Anna Evgenievna Novikova
Nikolay Georgievich Matrosov
Valeriya Avtandilovna Rakitina
Natalia Yurievna Rushkevich
Leonid Romanovich Ptitsyn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2005127811/13A external-priority patent/RU2005127811A/en
Application filed by Ajinomoto Kk, Tomohiro Kodera, Kazuhiko Matsui, Noriki Nio, Hidehiko Wakabayashi, Sergey Vasilievich Smirnov, Natalia Nikolaevna Samsonova, Anna Evgenievna Novikova, Nikolay Georgievich Matrosov, Valeriya Avtandilovna Rakitina, Natalia Yurievna Rushkevich, Leonid Romanovich Ptitsyn filed Critical Ajinomoto Kk
Priority to JP2007541511A priority Critical patent/JP2008530978A/en
Publication of WO2006093322A2 publication Critical patent/WO2006093322A2/en
Publication of WO2006093322A3 publication Critical patent/WO2006093322A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Present invention provides a method for manufacturing 4-hydroxy-L-isoleucine. A method for manufacturing 4-hydroxy-L-isoleucine or a salt thereof, characterized by comprising the steps of contacting the biocatalyst having activity in catalyzing a reaction producing 4-hydroxy-L-isoleucine from acetaldehyde and a-ketobutyric acid or a salt thereof in the presence of an amino group donor with acetaldehyde and a-ketobutyric acid or a salt thereof in the presence of an amino group donor, and producing 4-hydroxy-L-isoleucine
PCT/JP2006/304423 2005-03-03 2006-03-01 Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof WO2006093322A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007541511A JP2008530978A (en) 2005-03-03 2006-03-01 Process for producing 4-hydroxy-L-isoleucine or a salt thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2005-059510 2005-03-03
JP2005059510 2005-03-03
RU2005127811/13A RU2005127811A (en) 2005-09-06 2005-09-06 METHOD FOR ENZYMATIC PRODUCTION OF 4-HYDROXYISOLEUCINE
RU2005127811 2005-09-06
JP2005-257629 2005-09-06
JP2005257629 2005-09-06

Publications (2)

Publication Number Publication Date
WO2006093322A2 WO2006093322A2 (en) 2006-09-08
WO2006093322A3 true WO2006093322A3 (en) 2006-10-19

Family

ID=36698773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/304423 WO2006093322A2 (en) 2005-03-03 2006-03-01 Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof

Country Status (2)

Country Link
JP (1) JP2008530978A (en)
WO (1) WO2006093322A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
RU2007142666A (en) 2005-04-20 2009-05-27 Карджилл, Инкорпорейтед (Us) PRODUCTS AND METHODS FOR SECRET MONATINA IN VIVO
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2112227B1 (en) 2006-03-07 2013-05-15 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
RU2338784C2 (en) * 2006-03-24 2008-11-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) New aldolase, dna coding aldlase, cells transformed by dna, method of aldolase obtaining and method of obtaining of 4-hydroxy-l-isoleucine (versions)
EP2066799B1 (en) 2006-09-28 2013-12-11 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine
US7354746B1 (en) * 2006-12-11 2008-04-08 Ajinomoto Co., Inc. Method for producing optically active IHOG and monatin
WO2008154750A1 (en) * 2007-06-21 2008-12-24 Innodia Inc. Conversion of isoleucine to 4-hydroxyisoleucine by microorganisms
WO2009031565A1 (en) 2007-09-04 2009-03-12 Ajinomoto Co., Inc. Amino acid-producing microorganism and method of producing amino acid
RU2395580C2 (en) * 2007-12-21 2010-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method of building (2s,3r,4s)-4-hydroxy-l-isoleucine producing bacteria, (2s, 3r, 4s)-4-hydroxy-l-isoleucine producing bacteria and method of producing (2s, 3r, 4s)-hydroxy-l-isoleucine or salt thereof
JP5332237B2 (en) 2008-03-06 2013-11-06 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
KR101627095B1 (en) 2008-09-08 2016-06-03 아지노모토 가부시키가이샤 Microorganism capable of producing L-amino acid, and method for producing L-amino acid
JP5359409B2 (en) 2009-03-12 2013-12-04 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JP5817529B2 (en) 2009-11-30 2015-11-18 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
BR112013023465B1 (en) 2011-04-01 2020-10-27 Ajinomoto Co., Inc method to produce l-cysteine
JP6459962B2 (en) 2013-10-21 2019-01-30 味の素株式会社 Method for producing L-amino acid
US10683493B2 (en) 2016-05-18 2020-06-16 Consejo Superior De Investigaciones Científicas Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein
EP3875590A4 (en) * 2018-10-30 2023-02-15 Green Earth Institute Co., Ltd. Method for producing organic compound and coryneform bacterium

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OGAWA ET AL: "Functional analysis of Escherichia coli 4-hydroxy-2-keto- pentanoic acid aldolase and its application to hydroxyl amino acid production", PAPER PRESENTED AT THE ANNUAL MEETING, [OF] THE SOCIETY FOR BIOTECHNOLOGY, NOVEMBER 15-17, 2005, TSUKUBA INTERNATIONAL CONGRESS CENTER, 2-20-3, TAKEZONO, TSUKUBA, IBARAKI, JAPAN, 2005, pages 17/80, XP002393124, Retrieved from the Internet <URL:http://www.nacos.com/sfbj/pages/taikai/2005program.html> [retrieved on 20060802] *
ROLLAND-FULCRAND ET AL: "Chemoenzymatic synthesis of enantiomerically pure (2S,3R,4S)-4-hydroxyisoleucine, an insulinotropic amino acid isolated from fenugreek seeds", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2004, 2004, pages 873 - 877, XP002393122 *
YAMANAKA ET AL: "Screening of microorganism produc(t)ing 4-hydroxyisoleucine by aldolase- transaminase coupling reaction", PAPER PRESENTED AT THE ANNUAL MEETING [OF] THE SOCIETY FOR BIOTECHNOLOGY, NOVEMBER 15-17, 2005, TSUKUBA INTERNATIONAL CONGRESS CENTER, 2-20-3, TAKEZONO, TSUKUBA, IBARAKI, JAPAN, 2005, pages 18/80, XP002393123, Retrieved from the Internet <URL:http://www.nacos.com/sfbj/pages/taikai/2005program.html> [retrieved on 20060802] *

Also Published As

Publication number Publication date
JP2008530978A (en) 2008-08-14
WO2006093322A2 (en) 2006-09-08

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