WO2006093322A3 - Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof - Google Patents
Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof Download PDFInfo
- Publication number
- WO2006093322A3 WO2006093322A3 PCT/JP2006/304423 JP2006304423W WO2006093322A3 WO 2006093322 A3 WO2006093322 A3 WO 2006093322A3 JP 2006304423 W JP2006304423 W JP 2006304423W WO 2006093322 A3 WO2006093322 A3 WO 2006093322A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- isoleucine
- hydroxy
- salt
- manufacturing
- acetaldehyde
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Present invention provides a method for manufacturing 4-hydroxy-L-isoleucine. A method for manufacturing 4-hydroxy-L-isoleucine or a salt thereof, characterized by comprising the steps of contacting the biocatalyst having activity in catalyzing a reaction producing 4-hydroxy-L-isoleucine from acetaldehyde and a-ketobutyric acid or a salt thereof in the presence of an amino group donor with acetaldehyde and a-ketobutyric acid or a salt thereof in the presence of an amino group donor, and producing 4-hydroxy-L-isoleucine
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007541511A JP2008530978A (en) | 2005-03-03 | 2006-03-01 | Process for producing 4-hydroxy-L-isoleucine or a salt thereof |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005-059510 | 2005-03-03 | ||
JP2005059510 | 2005-03-03 | ||
RU2005127811/13A RU2005127811A (en) | 2005-09-06 | 2005-09-06 | METHOD FOR ENZYMATIC PRODUCTION OF 4-HYDROXYISOLEUCINE |
RU2005127811 | 2005-09-06 | ||
JP2005-257629 | 2005-09-06 | ||
JP2005257629 | 2005-09-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006093322A2 WO2006093322A2 (en) | 2006-09-08 |
WO2006093322A3 true WO2006093322A3 (en) | 2006-10-19 |
Family
ID=36698773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2006/304423 WO2006093322A2 (en) | 2005-03-03 | 2006-03-01 | Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2008530978A (en) |
WO (1) | WO2006093322A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
RU2007142666A (en) | 2005-04-20 | 2009-05-27 | Карджилл, Инкорпорейтед (Us) | PRODUCTS AND METHODS FOR SECRET MONATINA IN VIVO |
US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
EP2112227B1 (en) | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
RU2338784C2 (en) * | 2006-03-24 | 2008-11-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | New aldolase, dna coding aldlase, cells transformed by dna, method of aldolase obtaining and method of obtaining of 4-hydroxy-l-isoleucine (versions) |
EP2066799B1 (en) | 2006-09-28 | 2013-12-11 | Ajinomoto Co., Inc. | Method for producing 4-hydroxy-l-isoleucine |
US7354746B1 (en) * | 2006-12-11 | 2008-04-08 | Ajinomoto Co., Inc. | Method for producing optically active IHOG and monatin |
WO2008154750A1 (en) * | 2007-06-21 | 2008-12-24 | Innodia Inc. | Conversion of isoleucine to 4-hydroxyisoleucine by microorganisms |
WO2009031565A1 (en) | 2007-09-04 | 2009-03-12 | Ajinomoto Co., Inc. | Amino acid-producing microorganism and method of producing amino acid |
RU2395580C2 (en) * | 2007-12-21 | 2010-07-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Method of building (2s,3r,4s)-4-hydroxy-l-isoleucine producing bacteria, (2s, 3r, 4s)-4-hydroxy-l-isoleucine producing bacteria and method of producing (2s, 3r, 4s)-hydroxy-l-isoleucine or salt thereof |
JP5332237B2 (en) | 2008-03-06 | 2013-11-06 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
KR101627095B1 (en) | 2008-09-08 | 2016-06-03 | 아지노모토 가부시키가이샤 | Microorganism capable of producing L-amino acid, and method for producing L-amino acid |
JP5359409B2 (en) | 2009-03-12 | 2013-12-04 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
JP5817529B2 (en) | 2009-11-30 | 2015-11-18 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
BR112013023465B1 (en) | 2011-04-01 | 2020-10-27 | Ajinomoto Co., Inc | method to produce l-cysteine |
JP6459962B2 (en) | 2013-10-21 | 2019-01-30 | 味の素株式会社 | Method for producing L-amino acid |
US10683493B2 (en) | 2016-05-18 | 2020-06-16 | Consejo Superior De Investigaciones Científicas | Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein |
EP3875590A4 (en) * | 2018-10-30 | 2023-02-15 | Green Earth Institute Co., Ltd. | Method for producing organic compound and coryneform bacterium |
-
2006
- 2006-03-01 JP JP2007541511A patent/JP2008530978A/en active Pending
- 2006-03-01 WO PCT/JP2006/304423 patent/WO2006093322A2/en active Application Filing
Non-Patent Citations (3)
Title |
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OGAWA ET AL: "Functional analysis of Escherichia coli 4-hydroxy-2-keto- pentanoic acid aldolase and its application to hydroxyl amino acid production", PAPER PRESENTED AT THE ANNUAL MEETING, [OF] THE SOCIETY FOR BIOTECHNOLOGY, NOVEMBER 15-17, 2005, TSUKUBA INTERNATIONAL CONGRESS CENTER, 2-20-3, TAKEZONO, TSUKUBA, IBARAKI, JAPAN, 2005, pages 17/80, XP002393124, Retrieved from the Internet <URL:http://www.nacos.com/sfbj/pages/taikai/2005program.html> [retrieved on 20060802] * |
ROLLAND-FULCRAND ET AL: "Chemoenzymatic synthesis of enantiomerically pure (2S,3R,4S)-4-hydroxyisoleucine, an insulinotropic amino acid isolated from fenugreek seeds", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2004, 2004, pages 873 - 877, XP002393122 * |
YAMANAKA ET AL: "Screening of microorganism produc(t)ing 4-hydroxyisoleucine by aldolase- transaminase coupling reaction", PAPER PRESENTED AT THE ANNUAL MEETING [OF] THE SOCIETY FOR BIOTECHNOLOGY, NOVEMBER 15-17, 2005, TSUKUBA INTERNATIONAL CONGRESS CENTER, 2-20-3, TAKEZONO, TSUKUBA, IBARAKI, JAPAN, 2005, pages 18/80, XP002393123, Retrieved from the Internet <URL:http://www.nacos.com/sfbj/pages/taikai/2005program.html> [retrieved on 20060802] * |
Also Published As
Publication number | Publication date |
---|---|
JP2008530978A (en) | 2008-08-14 |
WO2006093322A2 (en) | 2006-09-08 |
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