WO2008081537A1 - Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same - Google Patents

Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same Download PDF

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Publication number
WO2008081537A1
WO2008081537A1 PCT/JP2006/326233 JP2006326233W WO2008081537A1 WO 2008081537 A1 WO2008081537 A1 WO 2008081537A1 JP 2006326233 W JP2006326233 W JP 2006326233W WO 2008081537 A1 WO2008081537 A1 WO 2008081537A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
lat1
inhibitory activity
producing
amino acid
Prior art date
Application number
PCT/JP2006/326233
Other languages
French (fr)
Japanese (ja)
Inventor
Hitoshi Endou
Yoshikatsu Kanai
Kunio Saito
Koji Oda
Original Assignee
Human Cell Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Cell Systems, Inc. filed Critical Human Cell Systems, Inc.
Priority to PCT/JP2006/326233 priority Critical patent/WO2008081537A1/en
Priority to JP2008551997A priority patent/JPWO2008081537A1/en
Publication of WO2008081537A1 publication Critical patent/WO2008081537A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

A useful and novel aromatic amino acid derivative which is soluble in water, has a selective inhibitory activity against LAT1 that is specifically expressed in a cancer cell, and has a high cancer cell growth inhibitory activity, an LAT1 inhibitor containing the same and a method for producing the same.
PCT/JP2006/326233 2006-12-28 2006-12-28 Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same WO2008081537A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2006/326233 WO2008081537A1 (en) 2006-12-28 2006-12-28 Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same
JP2008551997A JPWO2008081537A1 (en) 2006-12-28 2006-12-28 Aromatic amino acid derivative having LAT1 inhibitory activity, LAT1 inhibitory activator containing the same and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2006/326233 WO2008081537A1 (en) 2006-12-28 2006-12-28 Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same

Publications (1)

Publication Number Publication Date
WO2008081537A1 true WO2008081537A1 (en) 2008-07-10

Family

ID=39588228

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/326233 WO2008081537A1 (en) 2006-12-28 2006-12-28 Aromatic amino acid derivative with lat1 inhibitory activity, lat1 inhibitor containing the same and method for producing the same

Country Status (2)

Country Link
JP (1) JPWO2008081537A1 (en)
WO (1) WO2008081537A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011056916A1 (en) * 2009-11-05 2011-05-12 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of cancer
JP2012163332A (en) * 2011-01-28 2012-08-30 J-Pharma Co Ltd Kit for diagnosing malignancy of stomach cancer
JP5470665B1 (en) * 2013-08-20 2014-04-16 ジェイファーマ株式会社 Immunosuppressant
WO2014112646A1 (en) 2013-01-21 2014-07-24 国立大学法人大阪大学 Phenoxyalkylamine compound
WO2015173970A1 (en) * 2014-05-15 2015-11-19 ジェイファーマ株式会社 Anti-malignant tumor agent composition
WO2016103761A1 (en) * 2014-12-22 2016-06-30 ジェイファーマ株式会社 Circulating biomarker for cancer
JP2017155023A (en) * 2016-03-04 2017-09-07 ジェイファーマ株式会社 Parenteral solution comprising aromatic amino acid derivative having lat1 inhibitory activity
WO2019130637A1 (en) 2017-12-28 2019-07-04 ジェイファーマ株式会社 Cancer therapeutic
WO2020096041A1 (en) * 2018-11-09 2020-05-14 ジェイファーマ株式会社 (s)-2-amino-3-{4-[(5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy]-3,5-dichlorophenyl}propanoic acid·monochloride, monohydrate thereof, crystal thereof, and method for producing same
WO2021040042A1 (en) 2019-08-30 2021-03-04 ジェイファーマ株式会社 Pharmaceutical composition for cancer treatment in patient having specific gene marker
WO2021075585A1 (en) * 2019-10-17 2021-04-22 学校法人 杏林学園 Therapeutic agent for renal dysfunction
CN112972391A (en) * 2021-03-10 2021-06-18 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） bilirubin-JPH 203 nano-particles and preparation and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325263A (en) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd New 2-amino-3-phenylpropionic acid derivative
JP2000515133A (en) * 1996-07-01 2000-11-14 イーライ・リリー・アンド・カンパニー Hypoglycemic and hypolipidemic compounds
WO2003066574A1 (en) * 2002-02-07 2003-08-14 Hitoshi Endo Aromatic amino acid derivatives and medicinal compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325263A (en) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd New 2-amino-3-phenylpropionic acid derivative
JP2000515133A (en) * 1996-07-01 2000-11-14 イーライ・リリー・アンド・カンパニー Hypoglycemic and hypolipidemic compounds
WO2003066574A1 (en) * 2002-02-07 2003-08-14 Hitoshi Endo Aromatic amino acid derivatives and medicinal compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KANAI Y. ET AL.: "Amino acid transporter Yokusei ni yoru Koshuyo Koka no Kento", NIHON GAN GAKKAI GAKUJUTSU SOKAI KIJI, vol. 64TH, 15 August 2005 (2005-08-15), pages 312, XP003024475 *

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011056916A1 (en) * 2009-11-05 2011-05-12 Lexicon Pharmaceuticals, Inc. Tryptophan hydroxylase inhibitors for the treatment of cancer
JP2012163332A (en) * 2011-01-28 2012-08-30 J-Pharma Co Ltd Kit for diagnosing malignancy of stomach cancer
WO2014112646A1 (en) 2013-01-21 2014-07-24 国立大学法人大阪大学 Phenoxyalkylamine compound
JP5470665B1 (en) * 2013-08-20 2014-04-16 ジェイファーマ株式会社 Immunosuppressant
US10172835B2 (en) 2014-05-15 2019-01-08 J-Pharma Co., Ltd. Anticancer agent composition
WO2015173970A1 (en) * 2014-05-15 2015-11-19 ジェイファーマ株式会社 Anti-malignant tumor agent composition
JPWO2015173970A1 (en) * 2014-05-15 2017-04-20 ジェイファーマ株式会社 Antineoplastic composition
WO2016103761A1 (en) * 2014-12-22 2016-06-30 ジェイファーマ株式会社 Circulating biomarker for cancer
CN105934672A (en) * 2014-12-22 2016-09-07 J制药股份有限公司 circulating biomarker for cancer
JPWO2016103761A1 (en) * 2014-12-22 2017-11-02 ジェイファーマ株式会社 Cancer blood biomarkers
JP2017155023A (en) * 2016-03-04 2017-09-07 ジェイファーマ株式会社 Parenteral solution comprising aromatic amino acid derivative having lat1 inhibitory activity
WO2019130637A1 (en) 2017-12-28 2019-07-04 ジェイファーマ株式会社 Cancer therapeutic
JP6546367B1 (en) * 2017-12-28 2019-07-17 ジェイファーマ株式会社 Cancer medicine
JP2019151672A (en) * 2017-12-28 2019-09-12 ジェイファーマ株式会社 Cancer therapeutic agent
EP3733175A4 (en) * 2017-12-28 2021-08-18 J-Pharma Co., Ltd. Cancer therapeutic
JP2020073586A (en) * 2017-12-28 2020-05-14 ジェイファーマ株式会社 Cancer therapeutic agent
CN111491632A (en) * 2017-12-28 2020-08-04 J制药股份有限公司 Cancer therapeutic agent
KR20200101960A (en) 2017-12-28 2020-08-28 제이 파마 가부시끼가이샤 Cancer treatment
WO2020096041A1 (en) * 2018-11-09 2020-05-14 ジェイファーマ株式会社 (s)-2-amino-3-{4-[(5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy]-3,5-dichlorophenyl}propanoic acid·monochloride, monohydrate thereof, crystal thereof, and method for producing same
JPWO2020096041A1 (en) * 2018-11-09 2021-09-24 ジェイファーマ株式会社 (S) -2-Amino-3-{4-[(5-amino-2-phenylbenzo [d] oxazole-7-yl) methoxy] -3,5-dichlorophenyl} propanoic acid · 1 hydrochloride, part 1 Hydrate, its crystals and its manufacturing method
WO2021040043A1 (en) 2019-08-30 2021-03-04 ジェイファーマ株式会社 Pharmaceutical composition used in patients having specific gene marker
JP2021038214A (en) * 2019-08-30 2021-03-11 ジェイファーマ株式会社 Pharmaceutical composition for cancer treatment in patient having specific gene marker
WO2021040042A1 (en) 2019-08-30 2021-03-04 ジェイファーマ株式会社 Pharmaceutical composition for cancer treatment in patient having specific gene marker
CN114340621A (en) * 2019-08-30 2022-04-12 J制药股份有限公司 Pharmaceutical composition for patients with specific genetic markers
CN114364381A (en) * 2019-08-30 2022-04-15 J制药股份有限公司 Pharmaceutical composition for cancer treatment for patients with specific gene markers
KR20220054312A (en) 2019-08-30 2022-05-02 제이 파마 가부시끼가이샤 Pharmaceutical composition for cancer treatment used for a patient having a specific genetic marker
KR20220054603A (en) 2019-08-30 2022-05-03 제이 파마 가부시끼가이샤 Pharmaceutical composition for use in patients with specific genetic markers
WO2021075585A1 (en) * 2019-10-17 2021-04-22 学校法人 杏林学園 Therapeutic agent for renal dysfunction
CN112972391A (en) * 2021-03-10 2021-06-18 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） bilirubin-JPH 203 nano-particles and preparation and application thereof
CN112972391B (en) * 2021-03-10 2022-06-21 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） bilirubin-JPH 203 nano-particles and preparation and application thereof

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Publication number Publication date
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